Mortimer Poncz MD
Professor, Pediatrics, Perelman School of Medicine
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3401 Civic Center Blvd# ChildrenPhiladelphia, PA 19104
Phone+1 215-590-3535
Fax+1 215-590-3992
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Education & Training
Children's Hospital of PhiladelphiaFellowship, Pediatric Hematology/Oncology, 1979 - 1982- Children's Hospital of PhiladelphiaResidency, Pediatrics, 1976 - 1979
Perelman School of Medicine at the University of PennsylvaniaClass of 1976
Certifications & Licensure
PA State Medical License 1977 - 2026
NJ State Medical License 1981 - 1991
American Board of Pediatrics Pediatrics- American Board of Pediatrics Pediatric Hematology-Oncology
Awards, Honors, & Recognition
- Elected Member The American Society for Clinical Investigation, 1991
- Super Doctor SuperDoctors.com
Publications & Presentations
PubMed
- Destabilization of PF4-antigenic complexes in heparin-induced thrombocytopenia.Lubica Rauova, Khalil Bdeir, Ann H Rux, Manu Thomas Kalathottukaren, Jenna Oberg
Blood. 2025-03-25 - Endothelial cell activation enhances thromboinflammation in vaccine-induced immune thrombotic thrombocytopenia.Alexander Dupuy, Xiaoming Liu, Yvonne X Kong, Miao Qi, Jose Perdomo
Blood Advances. 2025-03-14 - Complement activation as a biomarker for platelet-activating antibodies in heparin-induced thrombocytopenia.Sooho S Myoung, Samuel J Francis, Jonah Chen, Grace Lee, Lubica Rauova
Journal of Thrombosis and Haemostasis. 2025-03-01
Journal Articles
- Dynamic Intercellular Redistribution of HIT Antigen Modulates Heparin-Induced ThrombocytopeniaDouglas B Cines, Mortimer Poncz, Blood
- Polyreactive IgM Initiates Complement Activation by PF4/heparin Complexes Through the Classical PathwayGrace M Lee, Michael Frank, Mortimer Poncz, Jennifer B Gilner, Douglas B Cines, Gowthami M Arepally, Blood
Abstracts/Posters
- A Novel Approach for Generating Platelet-Delivered FVIII: Role of Transient LRP1 Expression during MegakaryopoiesisMortimer Poncz, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
- A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in _-Granules and Is Functional In Vivo in a Murine Model of Thromb...Mortimer Poncz, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
- The Inherited Platelet Disorder of RUNX1 Haploinsufficiency (Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM)) Has a Marked Deficiency of Megakary...Mortimer Poncz, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Press Mentions
- Children's Hospital of Philadelphia Appoints New Chief of HematologyJanuary 6th, 2022
- Remembering Joel S. Bennett, and MoreAugust 2nd, 2021
- J&J and AZ Studying if Modifying COVID-19 Vaccines Can Reduce the Risk of Rare Blood ClotsJuly 13th, 2021
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Grant Support
- New Mechanistic Insights & Therapeutic Applications of Megakaryocytes/PlateletsCHILDREN'S HOSP OF PHILADELPHIA2020–2027
- Pediatric Hematology Research Training ProgramCHILDREN'S HOSP OF PHILADELPHIA1976–2027
- Pediatric Hematology Research Training ProgramCHILDREN'S HOSP OF PHILADELPHIA1976–2027
- Embryonic Stem Cell-Derived Platelets As Cellular TherapeuticsNational Heart, Lung, And Blood Institute2009–2012
- Platelet Factor 8 As A Novel Therapy For Hemophilia ANational Heart, Lung, And Blood Institute2011
- 2011 Grc &Grs On Cell Biology Of Megakaryocytes And PlateletsNational Heart, Lung, And Blood Institute2011
- Research BaseNational Institute Of Diabetes And Digestive And Kidney Diseases2010–2011
- Human Hematopoietic Stem Cell Center Of ExcellenceNational Institute Of Diabetes And Digestive And Kidney Diseases2010–2011
- A Negative Paracrine Loop In MegakaryopoiesisNational Heart, Lung, And Blood Institute2008–2011
- Etiologic And Therapeutic Studies Of Heparin-Induced Thrombocytopenia (HIT)National Heart, Lung, And Blood Institute2007–2011
- Megakaryocyte Chemokines &Post-Irradiation ThrombocytopeniaNational Institute Of Allergy And Infectious Diseases2009
- Non-Donor-Dependent Production Of Wildtype And Modified PlateletsNational Heart, Lung, And Blood Institute2009
- Ectopic F.VIII Expression In Megakaryocytes: Treatment Of Hemophilia ANational Heart, Lung, And Blood Institute2005–2009
- Molecular Biology Of The Platelet Alpha Iib/Beta3 ReceptorNational Heart, Lung, And Blood Institute2007
- Molecular Biology Of Heparin Associated ThrombocytopeniaNational Heart, Lung, And Blood Institute1996–2005
- Molecular Basis Of Heparin-Associated ThrombocytopeniaNational Heart, Lung, And Blood Institute2004
- Ectopic Gene Expression Of Fviii In MegakaryocytesNational Heart, Lung, And Blood Institute2004
- Molecular Biology Of The Alpha Iib/Betaplatelet ReceptorNational Heart, Lung, And Blood Institute2003
- Fluorescent Microscope For Thrombosis StudiesNational Center For Research Resources2003
- Molecular Basis Of Heparin-Associated ThrombocytopeniaNational Heart, Lung, And Blood Institute2001–2003
- Ectopic Gene Expression Of Fviii In MegakaryocytesNational Heart, Lung, And Blood Institute2000–2002
- Molecular Biology Of Platelet Alphaiib-Beta3 ReceptorNational Heart, Lung, And Blood Institute1998–2002
- Short-Term Training For Minority StudentsNational Heart, Lung, And Blood Institute2001
- Short-Term Training In The Health ProfessionsEunice Kennedy Shriver National Institute Of Child Health &Human Development2001
- Molecular Basis Of Heparin Associated ThrombocytopeniaNational Heart, Lung, And Blood Institute1995–1999
- Molecular Biology Of Glycoproteins ComplexNational Heart, Lung, And Blood Institute1996–1997
- Platelet Factor 4 And Beta-ThromboglobulinNational Heart, Lung, And Blood Institute1992–1995
- Platelet Factor 4 And Beta ThromboglobulinNational Heart, Lung, And Blood Institute1994
- Studies Of Platelet Factor 4 And Beta-ThromboglobulinNational Heart, Lung, And Blood Institute1993
- Studies Of Platelet Factor 4 And B-ThromboglobulinNational Heart, Lung, And Blood Institute1987–1991
- Efficacy Of Cetiedil Citrate In Sickle Cell TreatmentNational Center For Research Resources1985–1986
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