MitchellJWeissMD

Pediatric Hematology & Oncology • Memphis, TN

Pediatric Anemia and Red Blood Cell Hematology

Chair & Member, Department of Hematology, St. Jude Children's Research Hospital

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Office
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105

Education & Training

Boston Children’s Hospital/Boston Medical CenterFellowship, Pediatric Hematology/Oncology, 1992 - 1994
Boston Children’s Hospital/Boston Medical CenterResidency, Pediatrics, 1989 - 1992
Perelman School of Medicine at the University of PennsylvaniaClass of 1989

Certifications & Licensure

TN State Medical License 2014 - 2025
PA State Medical License 2000 - 2014
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 2003

Publications & Presentations

PubMed

1 citations
Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34cell therapy to induce fetal hemoglobin for sickle cell disease.
Varun Katta, Kiera O'Keefe, Yichao Li, Thiyagaraj Mayuranathan, Cicera R Lazzarotto
Molecular Therapy. 2024-10-02
11 citations
Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells.
Xizhen Lian, Sumanta Chatterjee, Yehui Sun, Sean A Dilliard, Stephen Moore
Nature Nanotechnology. 2024-09-01
Generation of iPSC lines and isogenic gene-corrected lines from two individuals with RPS19-mutated Diamond-Blackfan anemia syndrome.
Maria Angeles Lillo Osuna, Lei Han, Jon P Connelly, Shondra Miller-Preutt, Mitchell J Weiss
Stem Cell Research. 2024-09-01

Abstracts/Posters

Regulation of Fetal Hemoglobin through the Insulin Signaling Pathway
Mitchell J. Weiss, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Safe and Efficient Peripheral Blood Stem Cell Collection in Patients with Sickle Cell Disease Using Plerixafor
Mitchell J. Weiss, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Durable and Robust Fetal Globin Induction without Anemia in Rhesus Monkeys Following Autologous Hematopoietic Stem Cell Transplant with BCL11A Erythroid Enhancer Editing
Mitchell J. Weiss, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Disease Modeling and Phenotype Rescue Using Inducible Pluripotent Stem Cells from Patients with Diamond-Blackfan Anemia
Mitchell J. Weiss, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
CRISPR-Cas9 Genome Editing of _-Globin Promoters in Human Hematopoietic Stem Cells to Induce Erythrocyte Fetal Hemoglobin for Treatment of _-Hemoglobinopathies
Mitchell J. Weiss, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Lentiviral Gene Therapy with Low Dose Busulfan for Infants with X-SCID Results in the Development of a Functional Normal Immune System: Interim Results of an Ongoing P...
Mitchell J. Weiss, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Press Mentions

Glutamine Metabolic Switch Is Key to Red Blood Cell Development and DiseaseNovember 15th, 2024
St. Jude Explores Curative Therapies for Sickle Cell DiseaseAugust 22nd, 2024
Base Editor Effectively Treats Sickle-Cell Disease in MiceJune 7th, 2021
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Grant Support

Global Predictions And Tests Of Erythroid RegulationNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2012
Molecular And Biological Activities Of Alpha Hemoglobin Stabilizing ProteinNational Institute Of Diabetes And Digestive And Kidney Diseases2008–2012
Core B: Human Stem Cell CoreNational Institute Of Diabetes And Digestive And Kidney Diseases2010–2011
Hematopoiesis From Normal And Patient-Derived Induced Pluripotent Stem CellsNational Heart, Lung, And Blood Institute2009–2010
The Role Of Alpha Hemoglobin Stabilizing Protein In Human Beta ThalassemiaNational Heart, Lung, And Blood Institute2007–2010
Transcription Factor GATA-1 In Erythro-Megakaryocytic Development And LeukemiaNational Institute Of Diabetes And Digestive And Kidney Diseases2007
The Function And Regulation Of Alpha Hemoglobin Stabilizing Protein (AHSP) In HEMNational Institute Of Diabetes And Digestive And Kidney Diseases2007
Transcription Factor GATA-1 In Erythro-Megakaryocytic DENational Institute Of Diabetes And Digestive And Kidney Diseases2006
Characterization Of A Alpha-Globin Chaperone ProteinNational Institute Of Diabetes And Digestive And Kidney Diseases2004–2006
Antiproliferative Actions Of GATA-1 During HematopoiesisNational Institute Of Diabetes And Digestive And Kidney Diseases2004–2006
Characterization Of A Alpha-Globin Chaperone ProteinNational Institute Of Diabetes And Digestive And Kidney Diseases2002–2003
Unique Roles For GATA 1 And GATA 2 In ErythropoiesisNational Heart, Lung, And Blood Institute1995–1996