MiguelAngelPappollaMDPhD(He/Him)

PubMed

• 572 citations
  RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer's Disease
  Akihiko Nunomura, George Perry, Miguel A. Pappolla, Ramon Wade, Keisuke Hirai
  The Journal of Neuroscience. 1999-03-15
• 261 citations
  Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid *
  Yau Jan Chyan, Burkhard Poeggeler, Rawhi A. Omar, Daniel G. Chain, Blas Frangione
  The Journal of Biological Chemistry. 1999-07-30
• 44 citations
  Changes in Apolipoprotein E Expression in Response to Dietary and Pharmacological Modulation of Cholesterol
  Suzana Petanceska, Steven DeRosa, Ali Sharma, Nichole S. Diaz, Karen Duff
  Journal of Molecular Neuroscience. 2003-01-01

Journal Articles

• Targets for AD treatment: conflicting messages from Gamma-secretase inhibitors.  
  Sambamurti K, Greig NH, Utsuki T, Barnwell EL, Sharma E, Mazell C, Bhat NR, Kindy MS, Lahiri DK, Pappolla MA, J Neurochem, 5/1/2011
• Amphiphilic amide nitrones: a new class of protective agents acting as modifiers of mitochondrial metabolism.  
  J Med Chem, 7/1/2010
• Differential Accumulation of Secreted AbetaPP Metabolites in Ocular Fluids.  
  Prakasam A, Muthuswamy A, Ablonczy Z, Greig NH, Fauq A, Rao KJ, Pappolla MA, Sambamurti K, J Alzheimers Dis, 4/22/2010
• A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan.  
  Poeggeler B, Sambamurti K, Siedlak SL, Perry G, Smith MA, Pappolla MA, PLoS One, 4/21/2010
• Higher Incidence of Mild Cognitive Impairment in Familial Hypercholesterolemia.  
  Am J Med, 3/1/2010
• Leptin and the skin: a new frontier.  
  Exp Dermatol, 1/1/2010
• Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease.  
  Siedlak SL, Casadesus G, Webber KM, Pappolla MA, Atwood CS, Smith MA, Perry G, Free Radic Res, 2/1/2009
• Frontiers in the pathogenesis of Alzheimer's disease. (Invited Article)  
  Sambamurti, K., Rao, K. J. and Pappolla, M. A., Indian Journal of Psychiatry, 1/1/2009
• Statins, incident Alzheimer disease, change in cognitive function, and neuropathology.  
  Pappolla MA, Neurology, 12/1/2008
• Beta-secretase: structure, function, and evolution. (Review)  
  Venugopal C, Demos CM, Rao KS, Pappolla MA, Sambamurti K, CNS Neurol Disord Drug Targets, 6/1/2008
• Value in development of a TAPIR-like mouse monoclonal antibody to Abeta.  
  Sambamurti K, Pappolla MA, Jagannatha Rao KS, J Alzheimers Dis., 6/1/2008
• Insulysin cleaves the APP cytoplasmic fragment at multiple sites.  
  Venugopal C, Pappolla MA, Sambamurti K, Neurochem Res., 1/1/2007
• A unique case of limb-girdle muscular dystrophy type 2A carrying novel compound heterozygous mutations in the human CAPN3 gene.  
  Matsubara E, Tsuchiya A, Minami N, Nishino I, Pappolla MA, Shoji M, Abe K, Eur J Neurol., 1/1/2007
• Fine-Tuning the Amphiphilicity: A Crucial Parameter in the Design of Potent alpha-Phenyl-N-tert-butylnitrone Analogues.  
  Durand G, Poeggeler B, Boker J, Raynal S, Polidori A, Pappolla MA, Hardeland R, Pucci B, J Med Chem, 1/1/2007
• Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents.  
  Ortial S, Durand G, Poeggeler B, Polidori A, Pappolla MA, Boker J, Hardeland R, Pucci B, J Med Chem, 5/1/2006
• Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice.  
  Casadesus G, Webber KM, Atwood CS, Pappolla MA, Perry G, Bowen RL, Smith MA., Biochim Biophys Acta., 4/1/2006
• Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels.  
  Pacheco-Quinto J, Rodriguez de Turco EB, Derosa S, Howard A, Cruz-Sanchez F, Sambamurti K, Refolo L, Petanceska S, Pappolla MA, Neurobiol Dis., 1/1/2006
• Mitochondrial medicine: neuroprotection and life extension by the newamphiphilic nitrone LPBNAH acting as a highly potent antioxidant agent.  
  Poeggeler B, Durand G, Polidori A, Pappolla MA, Vega-Naredo I, Coto-Montes A, Boker J, Hardeland R, Pucci B, J Neurochem., 11/1/2005
• Alzheimer's disease-a dysfunction in cholesterol and lipid metabolism.  
  Lukiw WJ, Pappolla M, Pelaez RP, Bazan NG, Cell Mol Neurobiol., 6/1/2005
• Melatonin Relieves the Neural Oxidative Burden that Contributes to Dementias.  
  Reiter RJ, Tan DX, Pappolla MA, Ann N Y Acad Sci., 12/1/2004
• Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging.  
  Y.Z. Wadghiri, E.M. Sigurdsson, M. Sadowski , J.L.Elliott ,Y. Li , H. Scholtzova , C.Y. Tang , G. Aguinaldo , M. Pappolla, K. Duff , T. Wisniewski ,D.H. Turnbull, Magn Reson Med., 1/1/2003
• Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).  
  Marlow L, Cain M, Pappolla MA, Sambamurti K, J Mol Neurosci, 1/1/2003
• Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease.  
  Matsubara E, Bryant-Thomas T, Pacheco Quinto J, Henry TL, Poeggeler B, Herbert D, Cruz-Sanchez F, Chyan YJ, Smith MA, Perry G, Shoji M, Abe K, Leone A, Grun..., J Neurochem, 1/1/2003
• Hypercholesterolemia is an Early Risk Factor for the Development of Alzheimer Amyloid Pathology.  
  Pappolla MA, Bryant-Thomas TK, Herbert D, Pacheco J, Fabra Garcia M, Manjon M, Girones X, Henry TL, Matsubara E, Zambon D, Wolozin B, Petanceska SS, Sano M,..., Neurology, 1/1/2003
• Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol.  
  Petanceska SS, DeRosa S, Sharma A, Diaz N, Duff K, Tint SG, Refolo LM, Pappolla M, J Mol Neurosci, 1/1/2003
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Books/Book Chapters

• Neuropathologia Diagnostico Y Clinica 
  Chapter: Molecular Biology and Neuropathology of Alzheimer's Disease. 
  Pappolla MAEditors: F. Cruz-Sanchez.Edimsa2000
• Free Radicals in Brain Pathophysiology. 
  Chapter: The role of Transgenic models for the Study of Oxidative Neurotoxicity in Alzheimer’s Disease. 
  M. A. Pappolla, Y-J Chyan, G. Perry, M.A. SmithEditors: Poli G and Cadenas E..2000
• Alzheimer’s Disease: Biology, Diagnosis and Therapeutics 
  Chapter: Dual Anti-amyloidogenic and Anti-oxidant Properties of Melatonin. A New Therapy for Alzheimer’s Disease? 
  Page 661 - 669Pappolla MA, Bozner P, Soto C, Shao H, Brewer G. Robakis NK, Zagorski M, Frangione B, Ghiso JEditors: K. Iqbal, B. Winblad, and H.M. Wisniewski.John Wiley & Sons Ltd.1999
• Handbook of Neurochemistry and Molecular Neurobiology 
  Chapter: Amyloid and Neurodegeneration: Alzheimer’s disease and retinal degeneration. 
  Prakasam, A., Venugopal, C., Suram, A., Pacheco-Quinto, J., Pappolla, M.A., Sharpe, K.A., Lahiri, D.K., Greig, N.H., Rohrer, B., Sambamurti, KEditors: Editor-in-chief: Lajtha, Abel, Volume Editors Banik, N and Ray, S.K..Edition 3rd ,1999
• Alzheimer’s Disease: Biology, Diagnosis and Therapeutics 
  Chapter: Oxidative Damage and Cell Death Induced by an Amyloid Peptide Fragment is Completely Prevented by Melatonin. 
  Page 741 - 749Pappolla MA, Sos M, Bick RJ, Omar RA, Hickson-Bick DLM, Reiter RJ, Efthimiopoulos S, Sambamurti K, Robakis NKEditors: K. Iqbal, B. Winblad, T. Nisimura, M. Takeda and H.M. Wisniewski.John Wiley & Sons Ltd.1997
• Perspectives on Behavioral Medicine 
  Chapter: Neuropathology and Molecular Biology of Alzheimer's Disease. 
  Pappolla MA, Robakis NKEditors: Stein M, Baum A.Lawrence Erlbaum Associates Publishers, New Jersey1995
• Ann New York Acad Sci.: Proteases and Protease Inhibitors in Alzheimer's Disease Pathogenesis. 
  Chapter: The Alzheimer's Amyloid Precursor is Cleaved Intracellularly in the Tran-Golgi Network or in a Post-Golgi Compartment. 
  Page 118 - 128Sambamurti K, Refolo LM, Shioi J, Pappolla MA, Robakis NKEditors: Banner, C.D.B. and Nixon, R.A..1992
• Healing Back And Joint Injuries: A Proven Approach To Ending Chronic Pain And Avoiding Unnecessary Surgery (Hardcover) 
  Joseph Valdez (Author), Miguel Pappolla (Co-author
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Abstracts/Posters

• Cognitive Impairment in Familial Heterozygous Hypercholesterolemia.
  Pappolla MA, Sambamurti K, Pacheco J, et al, World Congress of Alzheimer’s Congress, Chicago, IL., 7/1/2008
• Changes in the Alzheimer’s Amyloid Protein Precursor Metabolism During Light-Induced Retinal Degeneration.
  Prakasam A, Pappolla MA, Rohrer B, Sambamurti K, Annual ARVO meeting, FT. Lauderdale, FL., 1/1/2008
• Alzheimer's Amyloid Protein Precursor and Neurotrophins in Age Related Retinal Degeneration.
  Sambamurti K, Pappolla MA, Granholm A-C, A. Prakasam A, Annual ARVO meeting, FT. Lauderdale, FL., 1/1/2008
• Isoprenoids Phenocopy Familial AD Mutations And Regulate Gamma Secretase.
  Sambamurti K, Parkasam A, Venugopal, C, Jayachandran AD, Rao KS, Lahiri DK, Greig NH, Pappolla MA, Zhou Y, The Alzheimer's Association International Conference on Alzheimer's Disease (ICAD) McCormick Place, , 1/1/2008
• Protein misprocessing in Neurodegeneration.
  Sambamurti K, Venugopal C, Greig N, Pappolla M, Rohrer B, Prakasam A, Silver Jubilee Conference of Indian Academy of Neurosciences, Varanasi, India., 12/1/2007
• Common mechanism of neurodegeneration: role of Alzheimer's APP in light-induced retinal degeneration.
  Venugopal C, Haugabook S, Canet-Aviles R, Suram A, Pappolla M, Sambamurti K, 37th annual meeting of the Society for Neuroscience., 1/1/2007
• Amyloid Precursor Protein Metabolism in Retinal Degeneration.
  Sambamurti K, Venugopal C, Suram A, Pappolla M, Rohrer B, Annamalai P, Annual ARVO meeting, FT. Lauderdale, FL., 1/1/2007
• Cholesterol metabolism: A risk factor and potential therapeutic target for Alzheimer’s disease. Abstract # 551
  Refolo, L, Petanceska, S, DeRosa, S, Diaz, N, Bryant-Thomas, T, Sharma, A, Manjon, M, Cruz-Sanchez, F, Pappolla, M, 8th International Conference on Alzheimer’s Disease and Related Disorders., 1/1/2002
• In vivo detection of Alzheimer's amyloid by magnetic resonance imaging. Abstract # 1307
  Sigurdsson, EM, Wadghiri, YZ, Li, Q, Tang, CY, Aguilnaldo, JG, Duff, K, Pappolla, M, Elliott, JI, Watanabe, M, Scholtzova, H, Turnbull, DH, Wisniewski, T, 8th International Conference on Alzheimer’s Disease and Related Disorders, 1/1/2002
• Hypercholesterolemia is an early risk factor in the development of human amyloid pathology. Abstract # 583.10
  Pappolla MA, Manjon M, Bryant-Thomas T, Girones X, Ross A, Creekmore T, Matsubara E, Duff K, Cruz-Sanchez F, Refolo L, Society for Neuroscience, 11/1/2001
• Cholesterol metabolism: a potential target for Alzheimer’s disease therapy. Abstract #583.7
  Refolo LM, Petanceska SS, Derosa S, Olm V, La Francois J, Malester B, Bryant-Thomas T, Tint GS, Wang R, Ramabhadran R, Duff KEK, Pappolla MA, Society for Neuroscience, 11/1/2001
• Detection of Alzheimer’s amyloid by magnetic resonance imaging. Abstract #463.7
  Wisniewski TM, Wadghiri YZ, Elliott JI, Pappolla MA, Duff K, Turnbull DH, Sigurdsson EM, Society for Neuroscience, 11/1/2001
• Melatonin Dramatically Inhibits the Time Dependent Elevation of Beta-amyloid in a Transgenic Mouse Model of Alzheimer’s Disease.
  Matsubara E, Poeggeler B, Manjon M, Thomas T, Cruz-Sanchez F, Chyan Y-J, Leone A, Shoji M, Buxbaum J, Herbert D, Frangione B, Ghiso J, Pappolla MA, International Congress of Neuropathology., 9/1/2000
• Amyloid ABeta (1-40) and ABeta(1-42) Adopt Remarkably Stable, Monomeric, and Extended Structures in Water Solution at Neutral pH. Abstract #48
  Zagorski MG, Shao H, Ma K, Yang, Li H, Zeng H, Zhang Y, Pappolla MA, Neurobiol Disease, 5/1/2000
• Melatonin Reverses the Pro-Fibrillogenic Activity of Apolipoprotein E. Abstract #856
  Pappolla MA, Poeggeler B, J-Y Chyan, Bryant-Thomas T, Miravalle L, Neurobiol Disease, 5/1/2000
• Hypercholesterolemia Accelerates Amyloid Pathology in a Transgenic Mouse Model of Alzheimer’s Amyloidosis. Abstract #566
  Refolo LM, Pappolla MA, Wang R, Tint S, Sambamurti, Malester BT, Francois JL, Duff K, Neurobiol Disease, 5/1/2000
• Direct Scavenging of Carbonate Radicals by Melatonin. Identification of a New Neuroprotective Pathway Against Beta-amyloid Toxicity. Abstract #10
  Poeggeler B, MA Pappolla et al, J Neuropathol Exp Neurol, 1/1/1999
• Induction of NADPH Cytochrome P450 Reductase by Amyloid Beta Protein: Friend or Foe of Neurons? Abstract #88
  MA Pappolla, Y-J Chyan, P Bozner, B Poeggeler, B Frangione, K Hsiao, RA Omar, G Perry, MA Smith, J Ghiso, J Neuropathol Exp Neurol, 1/1/1999
• Neuroprotection by Melatonin Against ABeta toxicity is not Mediated by Melatonin Receptors. Abstract #86
  Chyan Y-C, Poeggeler B, Omar RA, Ghiso J, Pappolla, J Neuropathol Exp Neurol, 1/1/1999
• Oxidative Stress in a Transgenic Model of Alzheimer’s Disease.
  Bozner P, Chyan Y-J, Hsiao K, Omar R, Perry G, Smith M, Ghiso J, Pappolla MA, Society for Neuroscience 28th Annual Meeting, Los Angeles, CA., 11/1/1998
• Chyan Y-J, Poeggeler B, Dubocovich M, Bick R, Omar RA, Frangione B, Soto C, Ghiso J, Pappolla MA, Society for Neuroscience 28th Annual Meeting, Los Angeles, CA., 11/1/1998
• NADPH Cytochrome P450 Reductase Mediates Oxidative Stress Induced by the Amyloid Beta Protein.
  Pappolla MA, Chyan Y-J, Bozner P, Martin B, Frangione B, Hsiao K, Omar RA, Perry G, Smith MA, Shiso J, Society for Neuroscience 28th Annual Meeting, Los Angeles, CA., 11/1/1998
• Releasing Hormone (GnRH) Binding in Lung Cancer.
  Theodoropoulos, J Vrioni & M Pappolla, T. Gerontological Society of America Meeting, 1/1/1998
• Inhibition of Alzheimer Beta-fibrillogenesis by Melatonin. Abstract #480
  Pappolla MA, Bozner P, Soto C, Shao H, Zaborski MG, Chyan Y-J, Robakis NK, Frangione B, Ghiso J, Neurobiology of Aging, 1/1/1998
• Oxidative Stress in Alzheimer’s Disease: A Transgenic Mouse Model. Abstract #1216
  Omar R, Bozner P, Chyan Y-J, Hsiao K, Perry G, Smith M, Ghiso J, Pappolla MA, Neurobiology of Aging, 1/1/1998
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Lectures

• "Interventional Pain Modalities for Spine Care. A Short Review". (Invited Speaker) 
  Charleston Spine Symposium. - 8/24/2007
• Cholesterol metabolism, hyperhomocysteinemia and oxidative stress: Novel therapeutic targets for Alzheimer’s disease. (Invited Symposium Speaker) 
  9th International Conference on Alzheimer’s Disease and Related Disorders, Philadelphia, PA. - 7/1/2004
• Cholesterol metabolism: A risk factor and potential therapeutic target for Alzheimer’s disease. (Invited Symposium Speaker) 
  8th International Conference on Alzheimer’s Disease and Related Disorders, Stockholm, Sweden. - 7/20/2002
• Hypercholesterolemia is an early risk factor in the development of human amyloid pathology. (Symposium Speaker) 
  31st Annual Meeting of the Society for Neuroscience, San Diego, CA. - 11/10/2001
• Hypercholesterolemia Accelerates Amyloid Pathology In A Transgenic Mouse Model Of Alzheimer’s Amyloidosis. (Invited Speaker) 
  001 European Congress of Clinical Investigation, Barcelona, Spain. - 5/5/2001
• Melatonin Reduces ABeta Accumulation in a Transgenic Mouse Model of Alzheimer’s Disease. 
  Selected presentation for the Hot Topics Symposium of the 2000 World Congress of Alzheimer’s Disease - 1/16/2001
• Biological Bases of Current Therapeutic Trends in Alzheimer’s Disease. (Invited Grand Rounds Speaker) 
  University of Alabama at Birmingham, Birmingham, AL. - 1/1/2001
• Amyloid ABeta (1-40) and ABeta(1-42) Adopt Remarkably Stable, Monomeric, and Extended Structures in Water Solution at Neutral pH. 
  World Alzheimer’s Congress. Washington, DC. - 7/1/2000
• Melatonin Reverses the Pro-Fibrillogenic Activity of Apolipoprotein E. 
  World Alzheimer’s Congress. Washington, DC. - 7/1/2000
• Hypercholesterolemia Accelerates Amyloid Pathology in a Transgenic Mouse Model of Alzheimer’s Amyloidosis. 
  Annual Meeting of the American Association of Neuropathologists, Atlanta, GA. - 6/10/2000
• Biological Bases of Current Therapeutic Trends in Alzheimer’s disease. (Invited Speaker) 
  Mobile Neurological Society, Mobile, AL. - 5/1/2000
• The oxidative stress hypothesis of Alzheimer’s disease. (Invited Speaker) 
  European Congress of Neuropathology, Barcelona, Spain. - 1/1/1999
• The role of melatonin in Alzheimer’s. (Invited Speaker) 
  European Congress of Neuropathology, Barcelona, Spain. - 1/1/1999
• Neuroprotection by Melatonin Against ABeta toxicity is not Mediated by Melatonin Receptors. 
  Annual Meeting of the American Society of Neuropathologists, Portland, OR. - 1/1/1999
• Induction of NADPH Cytochrome P450 Reductase by Amyloid Beta Protein: Friend or Foe of Neurons? 
  Annual Meeting of the American Society of Neuropathologists, Portland, OR. - 1/1/1999
• Direct Scavenging of Carbonate Radicals by Melatonin. Identification of a New Neuroprotective Pathway Against Beta-amyloid Toxicity. 
  Annual Meeting of the American Society of Neuropathologists, Portland, OR. - 1/1/1999
• Indole Analogues as Potential Therapeutic Agents in Neurodegenerative Disease. (Invited Speaker) 
  Harvard Club-New York University, New York, NY. - 1/1/1998
• Role of Melatonin on Oxidative Neurotoxicity. (Invited Speaker) 
  New York University, Department of Pathology, New York, NY, 1997; (Invited Groundrounds Speaker) Mou - 1/1/1997
• Melatonin and its possible role in Alzheimer’s disease. (Invited Symposium Speaker) 
  The Gerontological Society of America 49th Annual Scientific Meeting, Washington, DC. - 1/1/1996
• Grading of Central Nervous System Tumors. (Invited Speaker) 
  Argentine Congress of Pathology, Buenos Aires, Argentina. - 1/1/1995
• The Oxidative Stress/Heat Shock Connection. Relevance to Alzheimer's Disease. (Invited Speaker) 
  Neurodegenerative Disorders: Common Molecular Mechanisms, Decade of the Brain Midpoint, Ocho Rios, J - 1/1/1995
• The Heat-Shock/Oxidative Stress Connection: Production Of Free, Radicals By Hyperthermia. 
  Fourth International Conference on Alzheimer's Disease and Related Disorders. - 1/1/1994
• Heat Shock Induces Miscompartmentalization of the Amyloid Precursor Protein (APP). 
  XIIth International Congress of Neuropathology. - 1/1/1994
• Glycosylation is not Required for Secretory Processing of the Alzheimer's Amyloid Precursor Protein (APP). 
  XIIth International Congress of Neuropathology. - 1/1/1994
• Neuropathology of Epilepsy. (Invited Speaker) 
  Argentine Congress of Pathology-Cordoba, Argentina. - 1/1/1994
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Other

• Cholesterol, Oxidative Stress and Alzheimer’s disease. Expanding the Horizons of Pathogenesis. (Review) 
  Pappolla MA, Smith MA, Bryant-Thomas T, Bazan N, Petanceska S, Perry G, Thal LJ, Sano M, Refolo LM, Free Radic Biol Med
  1/1/2002
• Inhibition of Alzheimer’s Beta Amyloid Fibril Formation. 
  Pappolla M, Bozner P, Zagorski M, Shao H, Frangione B, Ghiso J, Emerging Therapeutic Targets.
  1/1/1997
• Oxygen Free Radicals and Amyloidosis in Alzheimer's Disease: Is There a Connection? Editorial. 
  Robakis NK, Pappolla MA, Neurobiol Aging
  1/1/1994