MichaelAlanSavinMD

PubMed

• 394 citations
  Docetaxel With Cyclophosphamide Is Associated With an Overall Survival Benefit Compared With Doxorubicin and Cyclophosphamide: 7-Year Follow-Up of US Oncology Research...
  Stephen E. Jones, Frankie A. Holmes, Joyce O'Shaughnessy, Joanne L. Blum, Svetislava J. Vukelja
  Journal of Clinical Oncology. 2009-03-10
• 375 citations
  Phase III Trial Comparing Doxorubicin Plus Cyclophosphamide With Docetaxel Plus Cyclophosphamide As Adjuvant Therapy for Operable Breast Cancer
  Stephen E. Jones, Michael Savin, Frankie A. Holmes, Joyce O'Shaughnessy, Joanne L. Blum
  Journal of Clinical Oncology. 2006-12-01
• 44 citations
  Patient-reported and objectively measured physical function in older breast cancer survivors and cancer-free controls.
  Kerri M. Winters-Stone, Mary E. Medysky, Michael A. Savin
  Journal of Geriatric Oncology. 2019-03-01

Journal Articles

• Quantitative measurement of HER2 expression in breast cancers: comparison with ‘real-world’ routine HER2 testing in a multicenter Collaborative Biomarker...  
  Yardley DA, Kaufman PA, Huang W, Krekow L, Savin MA, Lawler WE, Zrada S, Starr A, Einhorn H, Schwartzberg LS, Adams JW, Lie Y, Paquet AC, Sperinde J,..., Breast Cancer Research, 1/1/2015
• A Phase II Study of Eribulin Mesylate (E7389) in Patients With Advanced, Previously-Treated Non-Small Cell Lung Cancer  
  Spira AI, Iannotti NO, Savin MA, Neubauer M, Gabrail NY, Yanagihara RH, Zang EA, Cole PE, Shuster D, Das A, Clinical Lung Cancer, 1/1/2012
• Docetaxel With Cyclophosphamide Is Associated With an Overall Survival Benefit Compared With Doxorubicin and Cyclophosphamide: 7- Year Follow-Up of US Oncology Researc...  
  Jones S, Holmes FA, O’Shaughnessy J, Blum JL, Vukelja SJ, McIntyre KJ, Pippen JE, Bordelon JH, Kirby RL, Sandbach J, Hyman WJ, Richards DA, Mennel RG, Boehm KA, Meyer ..., Journal of Clinical Oncology, 1/1/2009
• Pemetrexed in relapsed small cell lung cancer and the impact of shortened vitamin supplementation lead-in time: Results of a phase II trial  
  Socinski M, Raju RN, Neubauer M, Smith DA, Richards DA, Savin MA, Ruxer RL, Reynolds CH, Zhan F, Bromund JL, Chen R, Obasaju C, Journal of Thoracic Oncology, 1/1/2008
• Phase II study of weekly albumin-bound paclitaxel for patients with metastatic breast cancer heavily pretreated with taxanes  
  Blum JL, Savin MA, Edelman G, Pippen JE, Robert NJ, Geister BV, Kirby RL, Clawson A, and O’Shaughnessy JA, Clinical Breast Cancer, 1/1/2007
• Phase III trial comparing doxorubicin plus cyclophosphamide with docetaxel plus cyclophosphamide as adjuvant therapy for operable breast cancer  
  Jones SE, Savin MA, Holmes FA, O’Shaughnessy JA, Blum JL, Vukelja SJ, McIntyre KJ, Pippen JE, Bordelon JH, Kirby RL, Sandbach J, Hyman WJ, Khandelwal P, Negron..., Journal of Clinical Oncology, 1/1/2006
• Feasibility of quantifying the effects of epoetin alfa therapy on cognitive function in women with breast cancer undergoing adjuvant or neoadjuvant chemotherapy  
  O'Shaughnessy JA, Vukelja SJ, Holmes FA, Savin M, Jones M, Royall D, George M, Von Hoff D, Clinical Breast Cancer, 1/1/2005
• Adjuvant chemotherapy with doxorubicin and cyclophosphamide in women with rapidly proliferating node- negative breast cancer  
  Jones SE, Clark G, Koleszar S, Ethington G, Mennel R, Paulson S, Brooks B, Kerr R, Denham C, Savin M, Blum J, Kirby R, Stone M, Pippen J, George T, Orr D, Knox S, Gran..., Clinical Breast Cancer, 1/1/2002
• Comparable efficacy and safety profiles of once-per-cycle pegfilgrastim and daily injection filgrastim in chemotherapy- induced neutropenia: a multicenter dose-finding...  
  Holmes FA, Jones SE, O’Shaughnessy J, Vukelja S, George T, Savin M, Richards D, Glaspy J, Meza L, Cohen G, Dhami M, Budman DR, Hackett J, Brassard M, Yang BB, Liang BC, Annals of Oncology, 1/1/2002
• Blinded, randomized, multicenter study to evaluate single administration pegfilgrastim once per cycle versus daily filgrastim as an adjunct to chemotherapy in patients...  
  Holmes FA, O’Shaughnessy JA, Vukelja S, Jones SE, Shogan J, Savin M, Glaspy J, Moore M, Meza L, Wiznitzer I, Neumann TA, Hill LR, Liang BC, Journal of Clinical Oncology, 1/1/2002
• Low proliferative rate of invasive node-negative breast cancer predicts for a favorable outcome: a prospective evaluation of 669 patients  
  Jones S, Clark G, Koleszar S, Ethington G, Mennel R, Paulson S, Brooks B, Kerr R, Denham C, Savin M, White C, Blum J, Kirby R, Stone M, Pippen J, Kitchens L, George T..., Clinical Breast Cancer, 1/1/2001
• Adenovirus- Mediated p53 Gene Transfer in Advanced Non-Small-Cell Lung Cancer  
  Swisher SG, Roth JA, Nemunaitis J, Lawrence DD Kemp BL, Carrasco CL, Connors DG, El-Naggar AK, Fossella F, Glisson BS, Hong WK, Khuri FR, Kurie JM, Lee JJ, Lee JS, Mac..., Journal of the National Cancer Institute, 1/1/1999
• A pilot study of intra-arterial chemotherapy with cisplatin in locally advanced head and neck cancers  
  Cheung DK, Regan J, Savin M, Gibberman V, and Woessner W, Cancer, 1/1/1988
• Mucosal iron transport by rat intestine  
  Savin MA, and Cook JD, Blood, 1/1/1980
• Growth suppression of human leukemic cells in vitro by L-ascorbic acid  
  Park CH, Amare M, Savin MA, and Hoogstraten B, Cancer Research, 1/1/1980
• Iron transport by isolated rat intestinal mucosal cells  
  Savin MA, and Cook JD, Gastroenterology, 1/1/1978
• A practical approach to the treatment of iron deficiency  
  Savin MA, Rational Drug Therapy, 1/1/1977
• New tumor cell culture used to test drug effects  
  Park CH, Savin MA, Amare M, and Hoogstraten B, Communicator, 1/1/1977
• Improved growth of in vitro colonies in human acute leukemia using the feeding culture method  
  Park CH, Savin MA, Hoogstraten B, Amare M, and Hathaway P, Cancer Research, 1/1/1977
• Cystathionine synthesis in yeast: An alternative pathway for homocysteine biosynthesis  
  Savin MA, and Flavin M, Journal of Bacteriology, 1/1/1972
• Regulation of homocysteine biosynthesis in Salmonella typhimurium  
  Savin MA, Flavin M, and Slaughter C, Journal of Bacteriology, 1/1/1972
• synchronization of converging metabolic pathways: Activation of the cystathionine gamma-synthase of Neurosporacrassa by methyl tetrahydrofolate  
  Selhub J, Savin MA, Sakami W, and Flavin M, Proceedings of the National Academy of Sciences, 1/1/1971
• Studies in glycogen storage disease IV Leukocyte Phosphorylase in a family with type VI GSD  
  Schwartz D, Savin MA, Drash A, and Fields J, Metabolism, 1/1/1970
• Tissue Culture and Experimental Embryology: The relationship between a science and a technique (Senior Honors Thesis)  
  Savin MA, 1/1/1965
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Books/Book Chapters

• AMA Drug Evaluations 
  Chapter: Nutritional anemias 
  Savin MAEdition 7th,1991
• Conn’s Current Therapy 1982 
  Chapter: Anemia due to iron deficiency 
  Savin MAEditors: HF Conn.W.B. Saunders Co., Philadelphia, PA1982
• Harrison’s Principles Of Internal Medicine-Patient Management Problems: Pre-Test, Self-Assessment And Review 
  Chapter: “Problem Number 14” (Hemolytic Anemia, Hemoglobinopathy) 
  Savin MA, and Levere RDEditors: AJ Bollet.McGraw Hill, New York, NY1981

Abstracts/Posters

• Scalp Cooling Alopecia Prevention Trial (SCALP) for Patients with Early Stage Breast Cancer
  Nangia JR, Wang, T Rude, M Osborne, C Papish, M Abraham, J, Holmes F, Savin M, Paxman R, Hilsenbeck SG, Osborne K, Rimawi MF, ASCO 2016 Annual Meeting, 1/1/2016
• Abstract OT3-02-08: Scalp cooling alopecia prevention trial (SCALP) for patients with early stage breast cancer
  Nangia JR, Wang T, Rude M, Osborne C, Papish M, Abraham J, Holmes F, Savin M, Paxman R, Hilsenbeck SG, Osborne K, Rimawi MF, Ongoing Trials-Chemotherapy, San Antonio Breast Cancer Symposium, 1/1/2015
• Quantitative measurement of HER2 expression in breast cancers: comparison with “real world” testing in a multi-center Collaborative Biomarker Study (CBS) and correlati...
  Yardley DA, Kaufman PA, Adams JW, Krekow L, Savin, M, Lawler WE, Zrada S, Starr A, Einhorn H, Schwartzberg LS, Huang W, Weidler J, Lie Y, Paquet A, Haddad M,..., 35th Annual CTRC-AACR San Antonio Breast Cancer Symposium, 1/1/2012
• CD30 expression in nonlymphomatous malignancies
  Sharman, J.P., Goldschmidt, J.H., Burke, J.M., Hellerstedt, B.A., McIntyre, K., Yasenchak, C.A., Boyd, T.E., Ruxer, R.L., Patel- Donnelly, D., Braiteh, F.S., Fo..., Annual meeting, American Society of Clinical Oncology, 1/1/2012
• Extended follow-up and analysis by age of the US Oncology Adjuvant trial 973%: docetaxel/cyclophosphamide is associated with an overall survival benefit compared to do...
  Jones S, Holmes F, O’Shaughnessy J, Blum J, Vukelaj S, McIntyre K, Pippen J, Bordelon J, Kirby R, Sandbach J, Hyman W, Khandelwal P, Negron A, Richards D, Mennel R, Bo..., 30th Annual San Antonio Breast Cancer Symposium, 1/13/2007
• Phase II study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced non-small- cell lung cancer (NSCLC)
  Spira A, Iannotti N, Savin M, Neubauer M, Gabrail N, Yanagihara R, Datta K, Zang E, Das A, Proceedings of the American Society of Clinical Oncology, 1/1/2007
• A phase II study of a novel anti-tubulin, E7389, in patients with advanced non-small cell lung cancer (NSCLC)
  Spira A, Iannotti N, Savin M, Das A, Zang E, Datta K, Shapiro G, Patturajan M, Silberman S, Proceedings of the American Society of Clinical Oncology, 1/1/2006
• Final analysis: TC (docetaxel/cyclophosphamide, 4 cycles) has a superior disease-free survival compared to standard AC (doxorubicin/cyclophosphamide) in 1016 women wit...
  Jones SE, Savin MA, Holmes FA, O'Shaughnessy JA, Blum JL, Vukelja SJ, George TK, McIntyre KJ, Pippen JE, Sandbach J, Kirby RL, Bordelon JH, Hyman WJ, Negron AG, Khande..., 28th Annual San Antonio Breast Cancer Symposium, 1/1/2005
• Long term disease control in taxane-refractory metastatic breast cancer treat with nab paclitaxel
  Blum JL, Savin MA, Pippen JE, Robert N, Sandbach J, Carrasco S, O’Shaughnessy JA, Breast Cancer I Session, 1/1/2004
• Weekly nanoparticle albumin paclitaxel (Abraxane) results in long-term disease control in patients with taxane- refractory metastatic breast cancer
  O’Shaughnessy JA, Blum JL, Sandbach JF, Savin M, Fenske E, Hawkins MJ, 27th Annual San Antonio Breast Cancer Symposium, 1/1/2004
• Three year results of a prospective randomized trial of adjuvant chemotherapy for patients (pts) with stage I-III operable, invasive breast cancer comp...
  Jones SE, Savin MA, Asmar L, Holmes FA, O’Shaughnessy JA, Blum JL, Vukelja SJ, George TK, McIntyre KJ, Pippen JE, Proceedings of the American Society of Clinical Oncology, 1/1/2003
• Impact of epoetin alfa on cognitive function, asthenia, and quality of life in women with breast cancer receiving adjuvant or neoadjuvant chemotherapy: analysis of 6-m...
  O'Shaughnessy J, Vukelja S, Savin M, Holmes FA, Jones M, Royall D, George M, von Hoff D, 25th Annual San Antonio Breast Cancer Symposium, 1/1/2002
• Effects of epoetin alfa (Procrit) on cognitive function, mood, asthenia, and quality of life in women with breast cancer undergoing adjuvant or neoadjuvant ch...
  O’Shaughnessy J, Vukelja S, Savin M, Holmes FA, Jones M, Royall D, George M, Von Hoff D, Proceedings of the American Society of Clinical Oncology, 1/1/2002
• Preliminary results of a prospective randomized trial of adjuvant chemotherapy for patients (pts) with stage I-III operable, invasive breast cancer com...
  Jones SE, Savin M, Holmes FA, O’Shaughnessy JA, Blum JL, Vukelja SJ, George TK, McIntyre KJ, Pippen JE, Kirby RL, Bordelon JH, Sandbach JF, Hyman WJ, Schottstaedt MW, ..., Proceedings of the American Society of Clinical Oncology, 1/1/2001
• A single dose of pegylated Filgrastim (SD/01) is as effective as daily Filgrastim for hematologic support of chemotherapy in breast cancer patients: Results of a r...
  Holmes FA, O’Shaughnessy J, Vukelja S, Shogan J, Savin M, Glaspy J, Moore M, Meza L, Wiznitzer I, Neumann TA, Hill LR, and Liang B, Proceedings of American Society of Clinical Oncology, 1/1/2001
• Older adolescents vary greatly from children in their route of referral to the Pediatric Oncologist and national trials
  Goldman S, Stafford C, Weinthal J, Kerr R, White C, Savin M, Brooks B, Rosenfeld C, and Lenarsky C, Proceedings of the American Society of Clinical Oncology, 1/1/2000
• Adjuvant chemotherapy prior to ASCT for breast cancer: Less is more?
  Rosenfeld CS, Kerr R, Brooks BD, White CS, and Savin MA, Proceedings of the American Society of Clinical Oncology, 1/1/2000
• Prospective randomized trial of adjuvant chemotherapy comparing 4 courses of Adriamycin/Cyclophosphamide (AC) to 4 courses of Taxotere/Cyclophosphamide (TC) in patient...
  Savin MA and Jones SE, Taxotere Investigator’s Meeting, West Palm Beach, FL, 1/1/1999
• A randomized, double-blinded trial of single-dose sustained duration Filgrastim (SD/01) versus Filgrastim (G) for hematologic support of patients treated with Docetaxe...
  Holmes FA, Neumann TA, Vukelja S, George T, Khandelwal P, Savin M, Kirby R, Hyman W, McIntyre K, Melnyk A, Jr., Huslig R, Budman DR, O’Shaughnessy JA, Jones SE, Hil..., Proceedings of the American Society of Clinical Oncology, 1/1/1999
• Low proliferative rate of invasive node negative breast cancer predicts for a favorable outcome without adjuvant chemotherapy
  Jones S, Clark G, Koleszar S, Ethington G, Mennel R, Paulson S, Brooks B, Kerr R, Denham C, Savin M, White C, Blum J, Kirby R, Stone M, Pippen J, Kitchens L, George T,..., Proceedings of the American Society of Clinical Oncology, 1/1/1999
• Phase II evaluation of carboplatinum and VP-16 for patients with metastatic breast cancer and only one prior chemotherapy regimen
  Barker L, Jones S, Savin M, Mennel R, Proceedings of the American Society of Clinical Oncology, 1/1/1992
• Intra-arterial chemotherapy in advanced oropharyngeal carcinoma
  Cheung DK, Regan J, Savin M, Woessner W. and Gibberman V, Society of Head and Neck Surgeons Annual Meeting, Colorado Springs, 1/1/1986
• Intra-arterial chemotherapy in advanced oral and oropharyngel carcinoma
  Cheung DK, Regan J, Savin M, Woessner W, and Gibberman V, American Radium Society, 1/1/1985
• Intra-arterial cisplatinum (DDP) and intra-venous Methotrexate (MTX) as preoperative therapy in advanced stage head and neck cancer
  Regan J, Savin M, and Cheung D, American Cancer Society, Virginia Division, Cancer Research Meeting, 1/1/1985
• Intra-arterial cisplatinum (DDP) and intra-venous Methotrexate (MTX) as preoperative therapy in advanced stage head and neck cancer
  Regan J, Savin M, and Cheung D, Proceedings of the American Society of Clinical Oncology, 1/1/1985
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