MichaelRickelsMDMS

Diabetes

Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases, University of Pennsylvania Perelman School of Medicine

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Office
12-134 Smilow Center for Translational Research
3400 Civic Center Boulevard
Philadelphia, PA 19104
Phone+1 215-746-0025

Fax+1 215-898-5408

Education & Training

Perelman School of Medicine at the University of Pennsylvania MS, Translational Research, 2002 - 2007
University of Pennsylvania Health SystemFellowship, Endocrinology, Diabetes, and Metabolism, 2001 - 2005
University of Pennsylvania Health SystemResidency, Internal Medicine, 1999 - 2001
Perelman School of Medicine at the University of PennsylvaniaClass of 1999

Certifications & Licensure

FL State Medical License 2022 - Present
PA State Medical License 2000 - 2024
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Awards, Honors, & Recognition

Philip E. Cryer Lectureship Washington University in St. Louis, MO, 2022
D. Walter Cohen, D.D.S. Lectureship in Diabetes Drexel University College of Medicine, Philadelphia, PA, 2017
Best of JCEM 2016 The Endocrine Society, 2017
Appreciation Award T1D Exchange, JAEB Center for Health Research, Tampa, FL, 2015
Health Care Hero University of Pennsylvania Health System, 2015
President's Oral Session Presentation American Diabetes Association, 2013
Schiffrin Award for research in autoimmune disorders Perelman School of Medicine at the University of Pennsylvania, 2010
Robert Austrian Junior Faculty Research Award Department of Medicine, Hospital of the University of Pennsylvania, 2007
Stanley E. Bradley Fellow Research Award Department of Medicine, Hospital of the University of Pennsylvania, 2004
Pfizer's Scholars in Endocrinology Award Division of Endocrinology, Diabetes & Metabolism, Hospital of the University of Pennsylvania, 2002
Maurice F. Attie Resident Teaching Award Department of Medicine, Hospital of the University of Pennsylvania, 2001
Merck Manual Award Perelman School of Medicine at the University of Pennsylvania, 1999
William Osler Society Hospital of the University of Pennsylvania, 1999
Alpha Omega Alpha Perelman School of Medicine at the University of Pennsylvania, 1998
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Clinical Trials

Effect of Exenatide, Sitagliptin or Glimepiride on Functional ß -Cell Mass Start of enrollment: 2008 Oct 01
Completed
Not Applicable
Glucose Counterregulation in Long Standing Type 1 Diabetes Start of enrollment: 2011 Oct 01
Completed
Not Applicable
Beta-cell Response to Incretin Hormones in Cystic Fibrosis Start of enrollment: 2013 May 01
Recruiting
Not Applicable
Genetics of Insulin and Incretins in Cystic Fibrosis Start of enrollment: 2013 May 01
Recruiting
Effect of Chronic Incretin-based Therapy in Cystic Fibrosis Start of enrollment: 2013 Jun 01
Completed
Not Applicable
Efficacy and Safety of Nasal Glucagon for Treatment of Hypoglycemia in Adults Start of enrollment: 2013 Nov 01
Completed
Phase 3
Adrenergic System in Islet Transplantation Start of enrollment: 2017 Jan 20
Active, not recruiting
Early Phase 1
A Study of Oral Ladarixin in Recent Onset Type 1 Diabetes and a Low Residual β-cell Function Start of enrollment: 2020 Dec 21
Active, not recruiting
Phase 3
Roles: Contact
GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance Start of enrollment: 2021 Apr 20
Recruiting
Phase 2
Hybrid Closed Loop Insulin Delivery System in Hypoglycemia Start of enrollment: 2017 Aug 01
Active, not recruiting
Not Applicable
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Publications & Presentations

PubMed

Automated Insulin Delivery in Older Adults with Type 1 Diabetes.
Yogish C Kudva, Robert J Henderson, Lauren G Kanapka, Ruth S Weinstock, Michael R Rickels
NEJM Evidence. 2025-01-01
Interoceptive Awareness Is Associated With Impaired Awareness of Hypoglycemia in Adults With Type 1 Diabetes.
Austin M Matus, Barbara Riegel, Michael R Rickels
Diabetes Care. 2025-01-01
Impaired Awareness and Symptomatology of Hypoglycemia in Adults with Type 1 Diabetes using Continuous Glucose Monitoring.
Yu Kuei Lin, Wen Ye, Emily Hepworth, Michael R Rickels, Stephanie A Amiel
The Journal of Clinical Endocrinology and Metabolism. 2024-12-05

Press Mentions

Scientific Sessions Reviewed by ADA Podcast Co-Hosts! In This Special Episode, the Co-Hosts of DiabetesBio, Diabetes Care “On Air,” Diabetes Core Update, and Diabetes Day by Day Get Together to Discuss Highlights from the ADA’s 2024 Scientific SessiAugust 16th, 2024
Islet Transplants in Type 1 Diabetes Durable up to 8 YearsOctober 19th, 2022
New Islet Transplant Method Leads to Insulin IndependenceOctober 17th, 2022
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Grant Support

Restoring Awareness of Hypoglycemia in Type 1 DiabetesNIH/NIDDK2022–2027
Radioimmunoassay and Biomarkers Core/Diabetes Research CenterNIH/NIDDK2015–2027
Evaluation of the Entero-Insular (Incretin) Axis in Cystic FibrosisNIH/NIDDK2012–2025
A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of 400 mg Twice a Day Oral Ladarixin in Patients with New-Onset Type 1 DiabetesDompé Farmaceutici S.p.A.2021–2024
A Randomized Cross-Over Trial Evaluating Automated Insulin Delivery Technologies on Glycemic Outcomes and Quality of Life in Older Adults with Type 1 Diabetes (T1D)NIH/NIDDK2019–2024
Type 1 Diabetes and Exercise Initiative (TI-DEXI)Helmsley Charitable Trust2017–2024
Glucose Counterregulation in Long Standing Type 1 DiabetesNIH/NIDDK2011–2023
Supporting Individuals in Need with T1D Impacted by the COVID-19 PandemicHelmsley Charitable Trust2020–2021
Glucose-Dependent Insulinotropic Polypeptide and CFTR Loss-of-FunctionCystic Fibrosis Foundation2019–2021
Fixed Rate Continuous Subcutaneous Glucagon Infusion (CSGI) vs Placebo in Type 1 Diabetes Mellitus Patients With Recurrent Severe HypoglycemiaXeris Pharmaceuticals2018–2020
Type 1 Diabetes Exchange Clinic NetworkHelmsley Charitable Trust2011–2020
Integrated and Long-Term Analysis of Islet Product and Recipient Outcomes in the CIT Consortium TrialsJuvenile Diabetes Research Foundation International2019
B-Lymphocyte Immunotherapy in Islet TransplantationNIH/NIDDK2004–2017
Insulin and Incretin Secretion in Cystic FibrosisCystic Fibrosis Foundation2012–2015
Atypical Antipsychotics: Effects on Hepatic Glucose and Lipid Metabolism in HumansNIH/NIDDK2009–2014
Center of Excellence for Regenerative MedicinePA Department of Health2008–2012
Metabolic Consequences of Islet TransplantationJuvenile Diabetes Research Foundation International2002–2008
Beta-Cell Function and Glucagon-Like Peptide-1 in Pancreas and Kidney TransplantationNIH/NIDDK2005–2007
University of Pennsylvania School of Medicine Training Grant in Patient-Oriented ResearchNIH/NCRR2003–2006
University of Pennsylvania School of Medicine Training Grant in Diabetes, Endocrine and Metabolic DiseasesNIH/NIDDK2002–2003

Committees

Member, Steering Committee, Impaired Awareness of Hypoglycemia Consortium, NIDDK 2022 - Present
Member, Steering Committee, A Phase 1/2 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-880 in Subjects Who Have Type 1 Diabetes Mellitus, Vertex Pharmaceuticals 2021 - Present
Co-Chair (2017 - Present), Type 1 Diabetes EXercise Initiative (T1-DEXI), Jaeb Center for Health Research 2016 - Present
Member, Advisory Committee, NIDDK Medical Student Research Program 2009 - Present
Chair (2010 - Present), Publications and Presentations Committee, Collaborative Islet Transplant Registry, NIDDK 2009 - Present
Member, Research Advisory Committee, Type 1 Diabetes Outcomes Program, JDRF International 2015 - 2017
Member, Clinical and Integrative Diabetes and Obesity Study Section, NIH 2014 - 2018
Chair (2018 - 2019), Data & Safety Monitoring Board, Restoring Insulin Secretion (RISE) Consortium, NIDDK 2012 - 2019
Member, SBIR to Develop New Therapeutics and Monitoring Technologies for Type 1 Diabetes (T1D) Toward an Artificial Pancreas SEP, NIDDK 2012 - 2014
Vice-Chair (2015 - 2019), Type 1 Diabetes (T1D) Exchange Clinic Network and Registry, Jaeb Center for Health Research 2011 - 2020
Member, Clinical Investigations Study Section, JDRF International 2006 - 2008
Chair, Metabolic Study Subcommittee, Clinical Islet Transplantation Consortium, NIH 2004 - 2018

Professional Memberships

American Association of Clinical Endocrinologists - AACE
Member, 2001 - Present
American Diabetes Association - ADA
Scientific Sessions Planning Committee, 2012 - 2014, 2020 - 2022; Associate Editor, Diabetes Care, 2022 - Present
Endocrine Society
Editorial Board, Journal of Clinical Endocrinology & Metabolism, 2009 - 2013; Associate Editor, Endocrine Reviews, 2015 - 2018
International Pancreas and Islet Transplant Association
Elected Councilor, 2015 - 2021; Elected Treasurer, 2023 - Present
International Hypoglycemia Study Group
Member, 2022 - Present