MichaelSParmacekMD

PubMed

• 131 citations
  Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells.
  Kevin L. Du, Mary Chen, Jian Li, John J. Lepore, Patricia Mericko
  The Journal of Biological Chemistry. 2004-04-23
• 112 citations
  Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development.
  Jian Li, Xiaohong Zhu, Mary Chen, Lan Cheng, Deying Zhou
  Proceedings of the National Academy of Sciences of the United States of America. 2005-06-21
• 10 citations
  Genetic variation in MKL2 and decreased downstream PCTAIRE1 expression in extreme, fatal primary human microcephaly
  Enrique Ramos, G.A. Bien‐Willner, J. Li, Andrew E. O. Hughes, Joseph C. Giacalone
  Clinical Genetics. 2014-05-01

Journal Articles

• An epigenetic roadmap for cardiac myocyte differentiation  
  Parmacek MS and Epstein JA, Circ Res, 3/15/2013
• Smooth muscle cell plasticity: Fact or Fiction?  
  Anh N T, Gomez D, Bell RD, Campbell JH, Clowes AW, Gabbiani G, Giachelli CM, Parmacek MS, Raines EW, Rusch NJ, Speer MY, Sturek M, Thyberg J, Towler DA, Weiser-Evans M..., Circ Res, 1/4/2013
• Myocardin regulates BMP10 expression and is required for heart development  
  Huang J, Elicker J, Bowens N, Liu X, Chen L, Cappola TP, Zhu X, Parmacek MS, J Clin Invest, 10/1/2012
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  Li J, Bowens N, Cheng L, Zhu X, Chen M, Hannenhalli S, Cappola TP, Parmacek M, Development, 10/1/2012
• GATA6 promotes cell survival by up-regulating BMP-2 expression during embryonic stem cell differentiation  
  Rong Li, Liu J, Qi Y, Graham AM, Parmacek MS, Li S, Mol Biol Cell, 9/1/2012
• Modulation of smooth muscle cell phenotype: The Other Side of the Story  
  Huang J, Parmacek MS, Circ Res, 8/31/2012
• Secreted miRNAs suppress atherogenesis  
  Rader DJ, Parmacek MS, Nat Cell Biol, 1/1/2012
• Aortic Aneurysm Generation in Mice with Targeted Deletion of Integrin Linked Kinase (ILK) in Vascular Smooth Muscle Cells  
  Shen D, Li J, Lepore JJ, Anderson TJT, Sinha S, Yin AY, Cheng L, Dedhar S, Parmacek MS*, Gerszten RE, Circ Res, 9/2/2011
• Genetic analysis of Down syndrome-associated heart defects in mice  
  Liu C, Morishima M, Yu T, Matsui SI, Zhang L, Fu D, Pao A, Costa AC, Gardiner KJ, Cowell JK, Nowak NJ, Parmacek MS, Liang P, Baldini A, Yu YE, Hum Genet, 1/1/2011
• Myocardin-Related Transcription Factor-A: Mending a Broken Heart  
  Parmacek MS, Circ Res, 1/1/2010
• BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis  
  Beppu H, Malhotra R, Beppu Y, Lepore JJ, Parmacek MS, Bloch KD, Dev Biol, 1/1/2009
• Diabetes reduces bone marrow and circulating porcine endothelial progenitor cells, an effect ameliorated by atorvastatin and independent of cholesterol  
  Mohler ER, Shi Y, Moore J, Bantly A, Hamamdzic D, Yoder M, Rader DJ, Putt M, Zhang L, Parmacek MS, Wilensky RL, Cytometry, 1/1/2009
• Myocardin is required for cardiomyocyte survival and maintenance of heart function  
  Huang J, Lu MM, Cheng L, Yuan LJ, Zhu X, Stout AL, Chen M, Li J, Parmacek MS, Proc Natl Acad Sci USA, 1/1/2009
• Cardiomyocyte renewal  
  Parmacek MS, Epstein JA, N Engl J Med, 1/1/2009
• MicroRNA-modulated targeting of vascular smooth muscle cells  
  Parmacek MS, J Clin Invest, 1/1/2009
• Myocardin: Dominant driver of the smooth muscle cell contractile phenotype  
  Parmacek MS, Aterioscler Thromb Vasc Biol, 1/1/2008
• A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration  
  Zhang Z, Goss AM, Cohen ED, Kadzik R, Lepore JJ, Muthukumaraswamy K, Yang J, DeMayo F, Whitsett JA, Parmacek MS, Morrisey EE, Nat Genet, 1/1/2008
• Myocardin regulates smooth muscle cell contractile genes required for closure of the ductus arteriosus  
  Huang J, Cheng L, Li J, Chen M, Zhou D, Lu MM, Proweller A, Epstein JA, Parmacek MS, J Clin Invest, 1/1/2008
• Myocardin-related transcription factors: Critical coactivators regulating cardiovascular development and adaptation  
  Parmacek MS, Circ Res, 1/1/2007
• Notch signaling in vascular smooth muscle cells is required to pattern the cerebral vasculature  
  Proweller A, Wright AC, Horng D, Cheng L, Lu MM, Lepore JJ, Pear WS, Parmacek MS, Proc Natl Acad Sci USA, 1/1/2007
• Hypercholesterolemia suppresses Kir channels in porcine bone marrow progenitor cells in-vivo  
  Mohler ER, Fang Y, Shaffer RG, Moore J, Wilensky RL, Parmacek MS, Levitan I, Biochem Biophys Res Commun, 1/1/2007
• An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation  
  High FA, Zhang M, Proweller A, Tu L, Parmacek MS, Pear WS, Epstein JA, J Clin Invest, 1/1/2007
• Serum response factor MADS box serine-162 phosphorylation switches proliferation and myogenic gene programs  
  Iyer D, Chang D, Marx J, Wei L, Olson EN, Parmacek MS, Balasubramanyam A, Schwartz RJ, Proc Natl Acad Sci USA, 1/1/2006
• GATA-6 regulates Semaphorin 3C and is required for cardiac outflow tract patterning  
  Lepore JJ, Mericko PA, Cheng L, Lu MM, Morrisey EE, Parmacek MS, J Clin Invest, 1/1/2006
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  Camoretti-Mercado B, Fernandes DJ, Dewundara S, Churchill J, Ma L, Kogut PC, McConville JF, Parmacek MS, Solway J, J Biol Chem, 1/1/2006
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Books/Book Chapters

• Muscle: Fundamental Biology and Mechanisms of Disease 
  Chapter: Development of the smooth muscle cell lineage 
  Bowens N and Parmacek MSEditors: Hill JA and Olson EN.Elsevier, Amsterdam, Netherlands2011
• Molecular and Subcellular Cardiology: Effects on Structure and Function 
  Chapter: The GATA-4 transcription factor transactivates the cardiac specific troponin C promoter-enhancer in non-muscle cells 
  Ip HS, Wilson DB, Heikinheimo M, Leiden JM, Parmacek MSEditors: Sideman S, Beyer R.Plenum Publishing, New York, NY1998
• Heart Development 
  Page 291 - 306Parmacek MS, Leiden JMEditors: Harvey RP, Rosenthal N.Academic Press, San Diego, CA1998

Abstracts/Posters

• Conditional Deletion of the BMP Type II Receptor Reveals Multiple Tissue-Specific Roles in Cardiovascular Development
  Beppu H, Beppu Y, Malhotra R, Yu PB, Lepore JL, Parmacek MS, Bloch K, American Heart Association Scientific Sessions, Orlando, FL, 1/1/2007
• MRTF-A and MRTF-B Mediate Redundant Functions Required for Cardiac Development
  Li J, Zhu Z, Cheng L, Minmin L, Chen M, Parmacek MS, American Heart Association Scientific Sessions, Chicago, IL, 1/1/2006
• Serum response factor “MADS Box” phosphorylation is a switch that regulates proliferation and differentiation gene programs during myogenesis
  Iyer D, Chang D, Olson E, Parmacek MS, Balasubramanyam A, Schwartz RJ, American Heart Association Scientific Sessions, Dallas TX, 1/1/2005
• Cardiac outflow tract and aortic arch patterning defects in mice lacking GATA-6 in neural crest derived smooth muscle cells
  Lepore JL, Mericko, PA, Morrisey EE, Parmacek MS, American Heart Association Scientific Sessions, Dallas TX, 1/1/2005
• GATA-6 regulates genes promoting synthetic vascular smooth muscle phenotype
  Lepore JJ, Cappola TP, Mericko PA, Morrisey EE, Parmacek MS, Circ Suppl, 1/1/2004
• Novel predictors of cardiac allograft rejection determined by peripheral blood gene expression
  Horwitz P, Epstein JA, Lepore JJ, Parmacek MS, Kao A, Desai S, Goldberg LH, Jessup ML, Cappola TP, Circ Suppl, 1/1/2003
• Vascular dysfunction occurs early after diabetic state in mini-pig model
  Mohler ER, Shih A, Osman H, Ferrari VA, Parmacek MS, Sehgal C, Lech G, Im J, Kime R, Chance B, Wilensky RL, 4th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology, 1/1/2003
• Myocardin is a critical activator of the SRF-dependent transcriptional program regulating smooth muscle cell differentiation
  Du KL, Jian L, Chen M, Lu MM, Parmacek MS, Circulation Suppl, 1/1/2002
• A novel ultrasound method for evaluation of angiogenesis
  Mohler ER III, Sehgal CM, Ferrari VA, Parmacek MS, Wilensky RL, J Am Coll Cardiol, 1/1/2001
• Characteristics of mice harboring a targeted mutation in the gene encoding the smooth muscle cell-specific protein SM22
  Zhang JCL, Kim S, Shum A, Strobeck M, Du K, Musco S, Parmacek MS, Circulation Suppl, 1/1/2000
• CArG box-specificity restricts gene expression to arterial smooth muscle cells in transgenic mice
  Strobeck M, Du K, Zhang JCL, Tang Z, Kim S, Parmacek MS, Circulation Suppl, 1/1/2000
• Transcriptional regulation of vascular smooth muscle cell development
  Parmacek MS, Kim S, Zhang J, Powell-Braxton LM, Davidson NO, Keystone Symposia, Molecular Biology of the Cardiovascular System, 1/1/2000
• SM22 promoter targets gene expression to vascular smooth muscle cells
  Akyurek LM, Yang Z-Y, Aoki K, Hong S, Nabel GS, Parmacek MS, Nabel EG, Circulation Suppl, 1/1/1999
• Investigation of smooth muscle (SM) cell differentiation in vitro using SM22 promoter-reporter constructs
  Ding R, Parmacek MS, D’Amore PA, FASEB, 1/1/1998
• The GATA4 transcription factor is required for heart tube formation in mice
  Kuo CT, Soudais C, Parmacek MS, Clendenin C, Leiden JM, Keystone Symposia, Molecular Biology of Muscle Development, 1/1/1997
• GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development
  Morrisey EE, Ip HS, Tang Z, Lu MM, Parmacek MS, Keystone Symposia, Molecular Biology of Muscle Development, 1/1/1997
• The GATA-4/5/6 subfamily of transcription factors and cardiovascular development
  Morrisey EE, Ip HS, Kuo C, Leiden JM, Parmacek MS, Keystone Symposia, Molecular Biology of Muscle Development, 1/1/1997
• Kim S, Parmacek MS, Circulation Suppl, 1/1/1996
• Novel transcriptional activation domains regulate activity of the cardiac muscle lineage-restricted transcription factor, GATA-4
  Morrisey EE, Ip HS, Tang Z, Leiden JM, Parmacek MS, Keystone Symposia, 1/1/1996
• GATA-4 and GATA-6 have distinct patterns of expression during murine embryogenesis and postnatal development
  Ip HS, Morrisey E, Tang Z, Parmacek MS, Keystone Symposia, The Molecular Biology of the Cardiovascular System, 1/1/1996
• The GATA-4/5/6 subfamily of transcription factors and cardiovascular development
  Morrisey EE, Ip HS, Kuo C, Soudais C, Tang Z, Leiden JM, Parmacek MS, Keystone Symposia, The Molecular Biology of the Cardiovascular System: A001, 1/1/1996
• A novel transcriptional activation domain regulates activity of the cardiac muscle lineage-restricted transcription factor, GATA-4
  Morrisey EE, Ip HS, Tang Z, Leiden JM, Parmacek MS, Circulation Suppl, 1/1/1995
• Isolation and structural characterization of cDNA and genomic clones encoding the smooth muscle specific protein SM22
  Solway J, Samaha FF, Seltzer J, Ip HS, Niu Q, Parmacek MS, Am J Respir Crit Care Med, 1/1/1995
• Structure and expression of a smooth muscle cell-specific gene, SM22
  Solway J, Seltzer J, Samaha FF, Kim S, Morrisey EE, Ip H, Parmacek MS, Circulation Suppl, 1/1/1995
• Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by a replication-defective adenovirus encoding a non-phosphorylatable retinoblastoma gene ...
  Seltzer J, Chang M, Barr E, Parmacek MS, Leiden JM, Circulation Suppl, 1/1/1994
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Lectures

• Transcriptional Programs Regulating Cardiovascular Development and Disease 
  University of California, Los Angeles, Anna and Harry Borun, Los Angeles, CA - 4/1/2013
• Developmental of the Cardiac Conduction System: 2013 
  Monaco USA Arrhythmia Course, Princess Grace Hospital, Monaco - 3/1/2013
• Transcriptional Programs Resulting Cardiovascular Development and Disease 
  Duke University, Cardiovascular Research Center Retreat, Durham, NC - 1/1/2013
• Developmental insights into the Cardiac Conduction System 
  Northwestern University Grand Rounds, Chicago, IL - 4/1/2012
• Developmental Insights into Atrial Arrhythmias 
  Monaco USA Arrhythmia Course, Princess Grace Hospital, Monaco - 3/1/2011
• The Molecular and Genetic Basis of Congenital Heart Disease 
  Yale University, Cardiology Grand Rounds, New Haven, CT - 4/1/2010
• Myocardin a Coactivator Poised at the Precipice of Death or Differentiation 
  Yale University, Yale University, Vascular Biology Therapeutics Seminar, New Haven, CT - 4/1/2010
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