MichaelJOmbrelloMDFACR

Pediatric Rheumatology • Saint Louis, MO

Juvenile Rheumatoid Arthritis and Related Rheumatology, Pediatric Systemic Pain and Inflammatory Syndromes and Related Rheumatology, Pediatric Vasculitis Rheumatology

Principal Investigator, Head of the Translational Genetics and Genomics Section, and Combined Adult and Pediatric Rheumatologist at the National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health

Join to view full profile

Dr. Ombrello is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Gain access to free telehealth tools, such as our “call shielding” and one-way patient texting.
Connect with colleagues in the same hospital or clinic.
Read the latest clinical news, personalized to your specialty.

See Dr. Ombrello's full profile

Already have an account?

Office
3660 Vista Ave
Ste 203
Saint Louis, MO 63110
Phone+1 314-977-8833

Fax+1 314-977-8818

Summary

Clinically trained and board certified in both adult and pediatric rheumatology, I obtained postdoctoral training in advanced genetic and genomic techniques in the laboratory of Dan Kastner. I now lead a translational research group that, by employing contemporary genetics, genomics and bioinformatics approaches, seeks to identify the underpinnings of both Mendelian and genetically-complex forms of autoinflammatory and autoimmune diseases. At this time, the primary focus of my group is investigating systemic arthritis, a rare, severe, and poorly understood condition that may affect people of all ages. When present in children it is called systemic juvenile idiopathic arthritis, whereas when present in adults it is called Adult-onset Still's disease.

Education & Training

SSM Health/Saint Louis University School of MedicineFellowship, Rheumatology, 2006 - 2009
SSM Health/Saint Louis University School of MedicineFellowship, Pediatric Rheumatology, 2006 - 2009
St Louis University School of MedicineResidency, Internal Medicine/Pediatrics, 2002 - 2006
Saint Louis University School of MedicineClass of 2002

Certifications & Licensure

MO State Medical License 2009 - 2025

Awards, Honors, & Recognition

Young Physician Scientist Award American Society of Clinical Investigation, 2018
Best Genetics and Pathogenesis Abstract (to Victoria Arthur) Pediatric Rheumatology Symposium, American College of Rheumatology, 2017
Pediatric Rheumatology European Society Early Career Investigator Travel Award Childhood Arthritis Rheumatology Research Alliance (CARRA), 2016
NIH Director's Award National Institutes of Health, 2012
NIAID Merit Award National Institute of Allergy and Infectious Diseases, 2012
NIH Fellows' Award for Research Excellence National Institute of Health, 2012
Bedside to Bench and Back Lecture Series Award Federation of Clinical Immunology Societies (FOCIS) and NIH Center for Human Immunology (CHI), 2012
NIAMS Group Merit Award National Institute of Arthritis, Muscoluskeletal and Skin Diseases, 2010
Distinguished Fellow Award American College of Rheumatology, 2009
Physician Scientist Development Award (declined) American College of Rheumatology, Research and Education Foundation, 2009
Pediatric Rheumatology Research Award American College of Rheumatology, Research and Education Foundation (REF), 2009-2010
Henry Metzger Scholar in Translational Research National Institute of Arthritis, Musculoskeletal and Skin Diseases, 2009-2012
Rheumatology Fellowship Research Award Arthritis Foundation, Eastern Missouri Chapter, 2007-2009
Join now to see all

Clinical Trials

Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions Start of enrollment: 2018 May 21
Recruiting

Publications & Presentations

PubMed

392 citations
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1
Yohei Kirino, George Bertsias, Yoshiaki Ishigatsubo, Nobuhisa Mizuki, Ilknur Tugal-Tutkun
Nature Genetics. 2013-02-01
398 citations
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet's disease
Elaine F. Remmers, Fulya Cosan, Yohei Kirino, Michael J. Ombrello, Neslihan Abaci
Nature Genetics. 2010-08-01
117 citations
Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behçet disease
Yohei Kirino, Qing Zhou, Yoshiaki Ishigatsubo, Nobuhisa Mizuki, Ilknur Tugal-Tutkun
Proceedings of the National Academy of Sciences of the United States of America. 2013-05-14

Press Mentions

Nobody Has My Condition But MeJanuary 23rd, 2023
CC Grand Rounds: Adventures in Autoinflammatory Genetics: From Genetically Complex Syndromes to Mendelian Diseases: 1) Systemic Juvenile Idiopathic Arthritis: One Name, Many Faces and 2) the Deficiency of Adenosine Deaminase 2: A Master of MimicryJanuary 23rd, 2020
My Experience at the 2019 Rheumatology Research Workshop: Opportunity to Meet Peers & Role ModelsDecember 13th, 2019
Join now to see all

Grant Support

Genetics and pathophysiology of systemic juvenile idiopathic arthritis and other complex autoinflammatory diseasesNational Institute of Arthritis and Musculoskeletal and Skin Disease2014–2023

Committees

Voting member, Juvenile Idiopathic Arthritis Treatment Guideline Development Committee 2017 - 2022
Committee Member, Early Career Investigator Subcommittee of the Committee on Research, American College of Rheumatology 2016 - 2020