Michael W Mulholland MD Ph.D.

PubMed

• Reduction of specific enterocytes from loss of intestinal LGR4 improves lipid metabolism in mice.
  Yuan Liang, Chao Luo, Lijun Sun, Tiange Feng, Wenzhen Yin
  Nature Communications. 2024-05-23
• Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway.
  Yanghui Bi, Liping Zhang, Yan Song, Lijun Sun, Michael W Mulholland
  Gastroenterologia y Hepatologia. 2024-04-01
• Hepatic LGR4 aggravates cholestasis-induced liver injury in mice.
  Yuan Gao, Wenbo Zhai, Lijun Sun, Xueqian Du, Xianfeng Wang
  American Journal of Physiology. Gastrointestinal and Liver Physiology. 2024-04-01

Journal Articles

• mTOR Signaling in X/A‐like Cells Contributes to Lipid Homeostasis in Mice  
  Michael Mulholland, MD, Hepatology
• Restaging of locally advanced rectal cancer with magnetic resonance imaging and endoluminal ultrasound after preoperative chemoradiotherapy: a systemic review and meta...  
  Zhao RS, Wang H, Zhou ZY, Zhou Q, Mulholland MW, Dis Colon Rectum, 1/1/2014
• Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease  
  Fritze D, Zhang W, Li J-Y, Chai B, Mulholland M, J Gastro Surg, 1/1/2014
• TNFAlpha causes thrombin-dependent vagal neuron apoptosis in inflammatory bowel disease  
  Fritze D, Zhang W, Li J-Y, Chai B, Mulholland M, J Gastro Surg, 1/1/2014
• Modulation of food intake by mTOR signaling in the dorsal motor nucleus of the vagus in rats: focus on ghrelin and nesfatin-1  
  Zhang W, Zhang C, Fritze D. Chai B, Li J,Mulholland MW, Exp Physiol, 12/1/2013
• A novel transcript is up-regulated by fasting in the hypothalamus and enhances insulin signaling  
  Chai B, Li J, Fritze D, Zhang W, Xia Z, Mulholland MW, J Neuroendocrinology, 1/1/2013
• Analytic morphometric assessment of patients undergoing colectomy for colon cancer  
  Sabel MS, Terjimanian M, Conlon A, Griffith KA, Morris AM, Mulholland MW, Englesbe MJ, Holcombe S, Wang, SC, J Surgical Oncology, 1/1/2013
• Regulation of gastric nesfatin-1/NUCB2  
  Li Z,Mulholland M, Zhang W, Curr Pharmaceutical Design., 1/1/2013
• Ghrelin contributes to derangements of glucose metabolism induced by rapamycin in mice  
  Xu G, Wang Z, Li Y, Li Z, Tang H, Zhao J, Xiang X, Ding L, MaL, Yuan F, Fei J, Wang W, Wang N, Guan Y, Tang C, Mulholland M, Zhang W, Diabetologia, 1/1/2012
• Nesfatin-1 inhibits gastric acid secretion via a central vagal mechanism in rats  
  Xia ZF. Fritze DM. Li JY. Chai B. Zhang C. Zhang W. Mulholland MW, Am J Physiol, 1/1/2012
• mTOR-dependent modulation of gastric nesfatin-1/NUCB2  
  Li Z, Xu G, Li Y, Zhao J, Mulholland MW, Zhang, W, Cellular Physiology & Biology, 1/1/2012
• Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation  
  Li Y, Chai B, Zhang W, Wu X, Zhang C, Fritz D, Xia Z, Patterson C, Mulholland MW, BMC Neurosc, 1/1/2011
• Expression of ankyrin repeat and suppressor of cytokine signaling box protein 4 (Asb-4) inproopiomelanocortin neurons of the arcuate nucleus of mice produces a hyperph...  
  Li JY, Chai BX, Zhang W, Wang H, Mulholland MW, Endocrinology, 1/1/2010
• Functional protease-activated receptors in the motor nucleus of the vagus  
  Wang H, Wu X, Li JY, Wang J, Mulholland MW, Zhang W, Neurogastroenterology Motil, 1/1/2010
• Modulation of Ghrelin O Acyltransferase Expression in Pancreatic Islets  
  An W, Li Y, Xu G, Zhao J, Xiang X, Ding L, Li J, Guan Y, Wang X, Tang C, Li X, Mulholland MW, Zhang W, Cell Phy and Biochem, 1/1/2010
• Induction of apoptosis by thrombin dorsal motor nucleus of the vagus  
  Wu X, Zhang W, Peng J, Wang H, Li J-Y, Chai B-X, Mulholland MW, Neurogastroenterol Motil, 1/1/2010
• Regulation of food intake and body weight by recombinant proghrelin  
  Zhang W, Majumder A, Wu X, Mulholland, MW, Am J Physiol, Endocrinology and Metabolism, 1/1/2009
• Adult Type I Choledochal Cyst Resection  
  Ammori, JB, Mulholland MW, J Gastro Surg, 1/1/2009
• Surgical Privileging and credentialing: A report of a discussion and study group of the American Surgical Association  
  Bass BL, Polk HC, Jones RS, Townsend CM, Whittemore AD, Carlos A. Pellegrini CA, Busuttil RW, Lillemoe KD, Trunkey DD, mulholland MW, Grosfeld JL, J Am Coll Surg, 1/1/2009
• Effect of intestinal inflammation on neuronal survival and function in the dorsal motor nucleus of the vagus  
  Ammori JB, Zhang W, Li J, Chai B, Mulholland MW, Surgery, 8/1/2008
• Effects of Des-Acyl Ghrelin on Adiposity and Glucose Metabolism  
  Zhang W, Chai B, Li JY, Endocrinology, 1/1/2008
• Interluekin-1Beta and interluekin-6 stimulate matrix metalloproteinase-9 secretion in cultured myenteric glia  
  Lin T, Weizhen Z, Yuexian Hu, Fan Y, Zhao L, Mulholland M, J Surg Res, 1/1/2007
• Melanocortin-3 receptor activates MAP kinase via P13 kinase  
  Biaoxin C, Li J, Zhang W, Ammori JB, Mulholland MW, Reg Peptides, 1/1/2007
• Akyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity  
  Li, J, Chai, B, Zhang W, Liu Y, Ammori JB, Mulholland MW, Cellular Signaling, 1/1/2007
• Ghrelin stimulates myocyte development  
  Zhang W, Zhao L, Mulholland MW, Cellular Phys & Biochemistry, 1/1/2007
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Books/Book Chapters

• Chassin’s Operative Strategy in General Surgery 
  Chapter: Concepts in Surgery of the Small Intestine and Appendix 
  Page 385 - 393Fritze DM, Welsh JL, Cullen JJ, Mulholland MWSpringerEdition Four,2014
• Operative Techniques in Surgery: Transplantation Surgery. 
  Mulholland MW, Hawn M, Sabel M, Hughes, S, Albo D, Englesbe, MWolters-Kluwer, Philadelphia2014
• Operative Techniques in Surgery: Vascular Surgery. 
  Mulholland MW, Hawn M, Sabel M, Hughes, S, Albo D, Englesbe, MWolters-Kluwer, Philadelphia2014
• Operative Techniques in Surgery: Breast, Endocrine System and Surgical Oncology. 
  Mulholland MW, Hawn M, Sabel M, Hughes, S, Albo D, Englesbe, MWolters-Kluwer, Philadelphia2014
• Operative Techniques in Surgery: Colorectal Surgery. 
  Mulholland MW, Hawn M, Sabel M, Hughes, S, Albo D, Englesbe, MWolters-Kluwer, Philadelphia2014
• Operative Techniques in Surgery: Pancreas, Liver and Biliary System. 
  Mulholland MW, Hawn M, Sabel M, Hughes, S, Albo D, Englesbe, MWolters-Kluwer, Philadelphia2014
• Operative Techniques in Surgery: Thoracic and Upper GI Tract 
  Mulholland MW, Hawn M, Sabel M, Hughes, S, Albo D, Englesbe, MWolters-Kluwer, Philadelphia2014
• Hospital Operations Principles of High Efficiency Health Care 
  Hopp WJ, Lovejoy WS, Desmond J, Friese C, Kronick S, Mulholland MW, Myers JFY Press2013
• Hospital Operations Principles of High Efficiency Health Care 
  Chapter: Operating Rooms. 
  Page 243 - 338Mulholland, MFT Press2013
• Master Techniques in Surgery; Gastric Surgery 
  Chapter: Truncal Vagotomy with Antrectomy and Billroth II Reconstruction. 
  Page 45 - 60Mulholland, MLippincott, Williams & Wilkins2013
• Clinical Scenarios in Surgery 
  Chapter: Bleeding Gastric Ulcer. 
  Page 72 - 76Fritze D, Mulholland MWLippincott, Williams & Wilkins2012
• Greenfield’s Surgery: Scientific Principles and Practice. 
  Mulholland MW, Lillemoe KD, Doherty GM, Maier RV, Simeone DM, Upchurch GRLippincott, Williams & WilkinsEdition 5th,2011
• Greenfield’s Surgery: Scientific Principles & Practice 
  Chapter: Gastric Anatomy and Physiology 
  Page 685 - 698Mulholland MWLippincott, Williams & WilkinsEdition Fift,2011
• Greenfield’s Surgery: Scientific Principles & Practice 
  Chapter: Gastroduodenal Ulceration 
  Page 699 - 712Mulholland MWLippincott, Williams & WilkinsEdition Fift,2011
• Complications in Surgery 
  Chapter: Surgical Complications. 
  Page 3 - 4Mulholland MW, Doherty GLippincott, Williams & WilkinsEdition Seco,2011
• Current Procedures-Surgery 
  Chapter: Operative Management of Gastric Lesions 
  Page 42 - 56Newman EL, Mulholland MWMcGraw Hill Medical2010
• Current Procedures-Surgery 
  Chapter: Emergency Operations for Peptic Ulcer Disease 
  Page 67 - 74Tsai S, Mulholland MWMcGraw Hill Medical2010
• Key Topics in Surgical Research and Methodology 
  Chapter: Research governance and research funding-What the surgeon needs to know-The USA perspective, In Key Topics in Surgical Research and Methodology 
  Page 657 - 667Mulholland MW, Bell JASpringer Scientific2010
• Shackelford’s Surgery of the Alimentary Tract 
  Chapter: Hepatic Cyst Disease 
  Page 1630 - 1639Mulholland MW, Hussain HK, Simeone DMElsevier PublishingEdition Sixt,2007
• Maingot’s Abdominal Operations 
  Chapter: Benign Gastric Disorders 
  Page 333 - 351Mulholland MW, Simeone DMMcGraw-Hill PublishingEdition Elev,2007
• Shackelford’s Surgery of the Alimentary Tract 
  Chapter: Gastric Resection and Reconstruction 
  Page 831 - 861Turner DJ, Mulholland MWElsevier PublishingEdition Sixt,2007
• Complications in Surgery 
  Chapter: Surgical Complications 
  Page 3 - 4Mulholland, MW, Doherty GMLippincott, Williams & Wilkins2006
• Complications in Surgery 
  Chapter: Complications of Gastric Surgery. 
  Page 385 - 406Mulholland MWLippincott, Williams & Wilkins2006
• Greenfield’s Surgery: Scientific Principles & Practice 
  Chapter: Gastric Anatomy and Physiology. 
  Page 709 - 721Mulholland MWLippincott, Williams & WilkinsEdition Four,2006
• Greenfield’s Surgery: Scientific Principles and Practice 
  Chapter: Gastroduodenal Ulceration. 
  Page 722 - 735Mulholland MWLippincott, Williams & WilkinsEdition Four,2006
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Abstracts/Posters

• Epidermiology of surgically treated gastric cancer in the United States, 1988-2000.
  Upchurch GR, Cowan JA, Mulholland MW, J Gastro Surg, 11/1/2003
• Development of an integrated, web-based, graduate medical education management system based on compliance with ACGME guidelines.
  Gauger PG, Orr PJ, Davis JW, Colletti LM, Mulholland MW, ACGME, 1/1/2000
• Cocaine and amphetamine regulated transcript stimulates pancreatic exocrine secretion via a neural pathway.
  Cowles RA, Segura BJ, Mulholland MW, Gastroenterology, 1/1/2000
• Intercellular calcium signaling in enteric glia occurs through release of intracellular calcium stores via a phospholipase C-dependent mechanism.
  Cowles RA, Segura BJ, Zhang W, Mulholland MW, FASEB J, 1/1/2000
• Diversity of sphingolipid-induced calcium signaling in cultured glia of the enteric nervous system.
  Segura BJ, Cowles RA, Turner DJ, Mulholland MW, FASEB J, 1/1/2000
• Sphingosine-1-phosphate and related lipids stimulate c-fos mRNA expression in C6 glioma cells via pertussis toxin-sensitive and insensitive mechanisms.
  Segura BJ, Leach KC, Cowles RA, Mulholland MW, J Neurochem, 1/1/2000
• Neuronal regulation of pancreatic exocrine secretion and early response gene transcription.
  Turner DJ, Segura BJ, Cowles RA, Zhang WZ, Romanchuck GL, Leach KC, Mulholland MW, Gastroenterology, 1/1/1999
• Spingosine-1-phosphate-induced calcium signaling in cultured myenteric glia.
  Segura BJ, Turner DJ, Zhang WZ, Cowles RA, Mulholland MW, J Neurochem, 1/1/1999
• Endothelin-1 stimulated c-fos mRNA expression in C6 glioma cells.
  Turner DJ, Leach KC, Mulholland, MW, Digestive Diseases and Sciences, 8/1/1998
• Capacitative calcium entry in myenteric glia.
  Sarosi GA, BarnhartDC, Mulholland, MW, Gastroenterology, 1/1/1997
• Endothelin-activated calcium signaling in enteric glia.
  Zhang, WZ, BarnhartDC, SarosiGA, Mulholland MW, Dig Dis Sci, 9/1/1996
• Caffeine- and ryanodine-sensitive calcium stores in myenteric neurons.
  Kimball BC, Mulholland MW, Gastroenterology, 4/1/1996
• Extracellular ATP mobilizes cytosolic calcium in enteric glia via a phospholipase C-dependent mechanism.
  Kimball BC, Mulholland MW, Digestive Disease Week Scientific Program, 5/14/1995
• Noninvasive measurement of postprandial splanchnic blood flow: effect of meal composition.
  Moneta GL, Taylor DC, Helton WS, Mulholland MW, Strandness DE, Gastroenterology Supplement, 5/1/1988
• Effective in vivo and in vitro inhibition of stimulated pancreatic secretion by dipentyl 3-dichloroproglumide (DDP).
  Mulholland MW, Garcia I, Garcia RM, Debas ET, Gastroenterology Supplement, 5/1/1988
• Stimulated gastric acid secretion in patients with reflux esophagitis.
  Mulholland MW, Melendez RL, Reid BJ, Levine DS, Rubin CE, Gastroenterology Supplement, 5/1/1988
• Effects of cimetidine (Cim) and methscopolamine (MS) on stimulated acid secretion and esophageal acid exposure in patients with Barrett's esophagus.
  Mulholland MW, Melendez RL, Reid BJ, Levine DS, Rubin CE, Gastroenterology Supplement, 5/1/1988
• Stimulation of pancreatic exocrine secretion by insulin-like growth factors.
  Mulholland MW, McGillDC, Garcia RM, Debas HT, Gastroenterology Supplement, 5/1/1988
• Inhibition of pancreatic exocrine secretion in the rat by calcitonin gene-related peptide (CGRP): involvement of circulating somatostatin (SS).
  Mulholland MW, Garcia R, Garcia I, Taborsky GJ, Helton WS, Gastroenterology Supplement, 5/1/1988
• Proximal diverting jejunostomy for compromised small bowel.
  Mulholland MW, Delaney JP, YearBook of Surgery, Medical Publishers, 1/1/1984
• In-continuity gastrointestinal stapling.
  Mulholland MW, Magallanes F, Quigley TM, Delaney JP, YearBook of Surgery, Medical Publishers, 1/1/1984
• Gastrointestinal complications of chronic granulomatous disease: surgical implications.
  Mulholland MW, Delaney JP, Simmons RL, YearBook of Surgery, Medical Publishers, 1/1/1984
• Portal gastrin and somatostatin levels and antral endocrine cell populations during fasting and refeeding.
  Mulholland MW, Bonsack MW, Delaney JP, Dig Dis Sci, 1/1/1984
• Proximal diverting jejunostomy for compromised small bowel.
  Mulholland MW, Delaney JP, Curr Surg, 1/1/1984
• The influence of vagal denervation on gastrin and somatostatin cell proliferation.
  Mulholland MW, Bonsack M, Delaney JP, Gastroenterology, 1/1/1983
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Lectures

• “Surgical Research in the Digital Age” 
  Washington, DC - 4/9/2014
• “Surgical Research in the Wiki World” 
  Beth Israel Medical Center, Harvard Medical School, Boston, MA - 3/26/2014
• “What does the Modern Portfolio of an Academic Research Department Look Like” 
  Washington, DC - 10/4/2013
• “Elements of a good academic plan” 
  UMMS, Ann Arbor, MI - 9/6/2013
• “Surgical Research in our Ditigal World” 
  Northwestern University, Chicago, IL - 6/21/2013
• “Wickedemic Surgery” 
  Boston Medical Center, MA - 2/25/2013
• “Metagenomics, New Diseases and Surgery – Some Things to Think About” 
  Boston Medical Center, MA - 2/25/2013
• “Why being a surgeon scientist is the greatest job ever!” 
  Ann Arbor, MI - 6/16/2012
• “Surgery at the University of Michigan” 
  Ann Arbor, MI - 6/14/2012
• “Protcase-Activated Receptors with Dorsal Vagel Complex” 
  Beijing, China - 11/4/2011
• “Acute Care Surgery” 
  Wuhan, China - 10/27/2011
• “Quality Improvement Through Statewide Collaborative Networks” 
  Palo Alto, CA - 10/20/2011
• “Surgical Management of Chronic Pancreatitis” 
  9/18/2011
• “Creating Collaborative Networks to Improve Patient Safety” 
  9/17/2011
• “Acute Care Surgery in Large Hospitals” 
  Atlanta, GA - 9/16/2011
• “Pancreatic Surgery in the General Surgery Residency” 
  University of Minnesota - 6/4/2010
• “Restrictions on Industry-Academic Relationships: Opportunity or Tragedy?” 
  Chicago, IL - 3/12/2010
• “Collaboration and Surgery in the Wiki World” 
  Durham, NC - 11/19/2009
• “Postgraduate Surgical Education” 
  Nairobi, Kenya - 11/12/2009
• “General Surgery in the Age of Twitter” 
  Madison, WI - 9/23/2009
• “Digital Collaboration for Surgical Quality Improvement” 
  Wuhan, China - 5/29/2009
• “Hypothalamic – Gastric Control of Food Intake” 
  University of Washington, Seattle, WA - 2/20/2009
• “Pancreatic resection for chronic pancreatitis" 
  7/14/2008
• “Treatment of choledochal cyst in adults” 
  7/12/2008
• “Pancreatic resection for chronic pancreatitis” 
  7/12/2008
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Other

• Concepts in GI surgery: a case-based management approach to bleeding duodenal ulcer. 
  Mulholland MW, SSAT Postgraduate Course Synopsis
  1/1/2000
• Gastrin Cell and Somatostatin Cell Populations of the Stomach: A Thesis. 
  Mulholland MW, Faculty of the Graduate School of the University of Minnesota
  3/1/1985