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Office
55 Fruit St 149 6403
Massachusetts General Hospital
Boston, MA 02114Phone+1 617-726-8442Fax+1 617-726-2894
Summary
- I am Board Certified in Internal Medicine and Neurology. My major interest is research in stroke and migraine. My research training took place at M.I.T. where my research in migraine led to the development of the CGRP receptor antagonists. My lab discovered and introduced the concept of the trigeminovascular system as a final common path for headache pain and proposed neuropeptides as targets for therapy. My lab also showed a mechanism of action for the ergot alkaloids that largely replaced the vasoconstrictor theories regarding their action. For this I won the Brain Prize from the Lundbeck Foundation and presented by the Crown Prince of Denmark. This is the largest prize given in neuroscience and 1.5 million Danish Kroner was shared with 3 other investigators from Sweden, Denmark and Australia. My research in stroke laid the basis for using nitric oxide targeting drugs for therapy. That therapeutic application is just beginning.
Education & Training
Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Neurology, 1971 - 1974
Yale-New Haven Medical CenterResidency, Internal Medicine, 1968 - 1971
Tufts University School of MedicineClass of 1968
Certifications & Licensure
MA State Medical License 1971 - 2023
PA State Medical License 1971 - 1976- American Board of Psychiatry and Neurology Neurology
Awards, Honors, & Recognition
- Doctor Honoris Causa Clermont Auvergne University, 2022
- Brain Prize 2021 Lundbeck Foundation, 2021
- Doctor Honoris Causa University of Athens, Greece, 2019
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Publications & Presentations
PubMed
- Extra-axial inflammatory signal and its relationship to peripheral and central immunity in depression.Brandi Eiff, Edward T Bullmore, Menna R Clatworthy, Tim D Fryer, Carmine M Pariante
Brain. 2024-12-10 - 23 citationsSkull bone marrow channels as immune gateways to the central nervous system.Jose A Mazzitelli, Fadi E Pulous, Leon C D Smyth, Zeynep Kaya, Justin Rustenhoven
Nature Neuroscience. 2023-12-01 - 3 citationsThe 5-HTreceptor as the target of ditans in migraine - from bench to bedside.Dimos D Mitsikostas, Christian Waeber, Margarita Sanchez-Del-Rio, Bianca Raffaelli, Håkan Ashina
Nature Reviews. Neurology. 2023-08-01
Journal Articles
- Direct Vascular Channels Connect Skull Bone Marrow and the Brain Surface Enabling Myeloid Cell MigrationMichael A Moskowitz, Ralph Weissleder, Nature
Press Mentions
Skull Channels Shown to Protect Brain from InfectionMay 2nd, 2022- Hallmarks of Alzheimer’s Found Well Before DiagnosisMay 2nd, 2022
Grant Support
- Administrative CoreNational Institute Of Neurological Disorders And Stroke2007–2011
- Migraine Pathophysiology And Treatment MechanismsNational Institute Of Neurological Disorders And Stroke2001–2011
- Migraine Drug ProphylaxisNational Institute Of Neurological Disorders And Stroke2008–2010
- Cortical Spreading Depression, Proteases And IschemiaNational Institute Of Neurological Disorders And Stroke2008
- HMG1 Signaling In Inflammation Following Brain IschemiaNational Institute Of Neurological Disorders And Stroke2007–2008
- Cortical Spreading Depression, Proteases And IschemiaNational Institute Of Neurological Disorders And Stroke2004–2008
- Interdepartmental Stroke ProgramNational Institute Of Neurological Disorders And Stroke1989–2008
- Migraine Drug ProphylaxisNational Institute Of Neurological Disorders And Stroke2006–2007
- Cortical Spreading Depression, Proteases And IschemiaNational Institute Of Neurological Disorders And Stroke2004–2007
- Interdepartmental Stroke ProgramNational Institute Of Neurological Disorders And Stroke1991–2007
- Caspase Mechanisms After Brain InjuryNational Institute Of Neurological Disorders And Stroke2002–2006
- Core--AdministrativeNational Institute Of Neurological Disorders And Stroke2004
- Interdepartmental Stroke Program ProjectNational Institute Of Neurological Disorders And Stroke1999–2003
- Roll Of Dural Inos Expression In MigraineNational Institute Of Neurological Disorders And Stroke2001–2002
- Prophylactic Hmg-Coa Reductase Inhibitors In StrokeNational Institute Of Neurological Disorders And Stroke1999–2002
- Caspase Inhibitors Protect Ischemic BrainNational Institute Of Neurological Disorders And Stroke1998–2001
- Trigeminal Nerve--Control Of The Brain VasculatureNational Institute Of Neurological Disorders And Stroke1996–2000
- Migraine--Pathophysiology And Treatment MechanismsNational Institute Of Neurological Disorders And Stroke1996–2000
- Core--ScientificNational Institute Of Neurological Disorders And Stroke1996–1999
- Nitric Oxide As Mediator In Cerebrovascular DilationNational Institute Of Neurological Disorders And Stroke1996–1998
- Interdepartment Stroke ProgramNational Institute Of Neurological Disorders And Stroke1994–1998
- Trigeminal Vasomotor Effects On The Cerebral CirculationNational Institute Of Neurological Disorders And Stroke1988–1995
- Trigeminal Nerve--Control Of The Brain VasculatureNational Institute Of Neurological Disorders And Stroke1985–1995
- 19th Conference On Cerebrovascular DiseaseNational Institute Of Neurological Disorders And Stroke1994
- Trigeminal Nerve: Control Of The Brain VasculatureNational Institute Of Neurological Disorders And Stroke1993
- Opioid Peptide Gene Expression In Nucleus CaudalisNational Institute Of Neurological Disorders And Stroke1989–1992
- Trigeminal Vasomotor Effects On The Cerebral CirculationNational Institute Of Neurological Disorders And Stroke1991
- Trigeminal Nerve: Control Of The Brain VasculatureNational Institute Of Neurological Disorders And Stroke1991
- CNS Vascular Cells In Cultures: Arachidonate MetabolismNational Institute Of Neurological Disorders And Stroke1985–1986
- Trigeminovascular Control Of Cerebral Blood VesselsNational Institute Of Neurological Disorders And Stroke1985
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