MichaelA.LopezMDPhD

PubMed

• X-linked myopathy with excessive autophagy: characterization and therapy testing in a zebrafish model.
  Lily Huang, Rebecca Simonian, Michael A Lopez, Muthukumar Karuppasamy, Veronica M Sanders
  EMBO Molecular Medicine. 2025-02-24
• Conditionalablation in the skeletal muscle and brain causes profound effects on muscle function, neurobehavior, and extracellular matrix pathways.
  Muthukumar Karuppasamy, Katherine G English, James R Conner, Shelby N Rorrer, Michael A Lopez
  Biorxiv. 2025-02-09
• 1 citations
  Long-read genome sequencing and variant reanalysis increase diagnostic yield in neurodevelopmental disorders.
  Susan M Hiatt, James M J Lawlor, Lori H Handley, Donald R Latner, Zachary T Bonnstetter
  Genome Research. 2024-11-20

Journal Articles

• Angiostrongylus cantonensis Infection: A Cause of Fever of Unknown Origin in Pediatric Patients  
  Foster CE, Nicholson EG, Chun AC, et al, Clinical infectious diseases, 1/30/2016
• Genome-wide Mechanosensitive MicroRNA (MechanomiR) Screen Uncovers Dysregulation of Their Regulatory Networks in the mdm Mouse Model of Muscular Dystrophy  
  Mohamed J, Hajira A, Lopez M, Boriek A, Journal of Biological Chemistry, 1/1/2015
• Novel deletion of lysine 7 expands the clinical, histopathological and genetic spectrum of TPM2-related myopathies  
  Davidson AE, Siddiqui FM, Lopez MA, et al, Brain: a journal of neurology, 1/1/2013
• Ankyrin repeat domain protein 2 and inhibitor of DNA binding 3 cooperatively inhibit myoblast differentiation by physical interaction  
  Mohamed JS, Lopez MA, Cox GA, Boriek AM, Journal of Biological Chemistry, 1/1/2013
• Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response  
  Pardo PS, Mohamed JS, Lopez MA, Boriek AM, Journal of Biological Chemistry, 1/1/2011
• Diaphragm muscle shortening modulates kinematics of lower rib cage in dogs  
  Chu I, Fernandez C, Rodowicz KA, et al, American journal of physiology-Regulatory, integrative and comparative physiology, 1/1/2010
• Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch  
  Mohamed JS, Lopez MA, Cox GA, Boriek AM, FASEB Journal, 1/1/2010
• Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3beta  
  Mohamed JS, Lopez MA, Boriek AM, Journal of Biological Chemistry, 1/1/2010
• The Respiratory Pump in Muscular Dystrophy: Dysregulation of Mechanosensitive Signaling Pathways, Baylor College of Medicine  
  Lopez MA, Program of Structural and Computational Biology and Molecular Biophysics, 1/1/2010
• Early mechanical dysfunction of the diaphragm in the muscular dystrophy with myositis (Ttnmdm) model  
  Lopez MA, Pardo PS, Cox GA, Boriek AM, American journal of physiology-Cell physiology, 1/1/2008
• FOXO transcription factors are mechanosensitive and their regulation is altered with aging in the respiratory pump  
  Pardo PS, Lopez MA, Boriek AM, American journal of physiology-Cell physiology, 1/1/2008
• Force transmission, compliance, and viscoelasticity are altered in the alpha7-integrin-null mouse diaphragm  
  Lopez MA, Mayer U, Hwang W, et al, American journal of physiology-Cell physiology, 1/1/2005
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Abstracts/Posters

• A Case Series Expanding the Phenotypic Variations in Spinal Muscular Atrophy Type I
  Lopez MA, American Academy of Neurology, 68th Annual Meeting, Vancouver, Canada, 1/1/2016
• Clinical and Radiographic Features of a Pediatric Case of Tumefactive Demyelination
  Lopez MA, American Academy of Neurology, 68th Annual Meeting, Vancouver, Canada, 1/1/2016
• Does Midcostal Diaphragm Curvature Correlate with Severity of COPD? C29 - Skeletal Muscle Function and Dysfunction.
  Lopez MA, Sharafkhaneh A, Velasco CA, Hoffman EA, and Boriek AM, J Respir Crit Care Med, 1/1/2009
• Does the Mechanosensitive NF-kB Regulate ANKRD1 in the Muscular Dystrophy with Myositis (mdm) Diaphragm D97 – Mediators of Skeletal Muscle Injury and Repair
  Lopez MA, Mohamed JS, Pardo PS, and Boriek AM, J Respir Crit Care Med, 1/1/2009
• Diaphragm Dysfunction Caused by the Titin mdm Mutation Correlates with an Early Inflammation.
  Lopez MA, Respiratory Muscles In Health And Disease, American Thoracic Society International Conference, Toronto, Canada, 1/18/2008
• Diaphragm Dysfunction Caused by the Titin mdm Mutation Correlates with an Early Inflammation.
  Lopez MA, Mohamed JS, Pardo PS, and Boriek AM, J Respir Crit Care Med, 1/1/2008
• Titin MDM Mutation Causes Altered Contractile Force Generating Capacity in Mouse Diaphragm.
  Lopez MA, American Thoracic Society International Conference, San Francisco, CA, 1/1/2007
• Titin MDM Mutation Causes Altered Contractile Force Generating Capacity in Mouse Diaphragm.
  Lopez MA, J Vega, GA Cox, and AM Boriek, J Respir Crit Care Med, 1/1/2007
• Muscle shortening, mode of ventilation and posture are determinants of volume displacement of the diaphragm.
  AM Boriek, CP McNamara, MA Lopez, M Wettergreen, RD Hubmayr, and B Greybeck, J Respir Crit Care Med, 1/1/2007
• In vitro mechanical properties of respiratory muscles in the a7 integrin- null mouse.
  Lopez MA, Mayer U, Hwang W, Taylor T, Hashmi MA, Jannapureddy SR, A. M. Boriek, Bristol-Myers Squibb Fellowship Program in Academic Medicine, 19th annual research symposium, University of Virginia, 1/10/2005
• In vitro Mechanical Properties of Respiratory Muscles in the alpha 7 Integrin-Null Mouse.
  Lopez MA, Bristol-Myers Squibb Fellowship in Academic Medicine Conference / National Medical Fellowships, University of Virginia, Charlottesville, VA, 1/1/2005
• In vitro passive and active properties of diaphragm from alpha 7 integrin null mice.
  Lopez MA, American Thoracic Society International Conference, San Francisco, CA, 1/1/2002
• Increased muscle extensibility of abdominal wall of alpha7 integrin null mice.
  Lopez MA, Chaudhry I, Lee O, Sylvester M, Mayer U, and Boriek AM, FASEB Journal, 1/1/2002
• Contrasting the In vitro passive mechanical properties of the abdominal wall and the diaphragm muscles in the mouse.
  Lopez MA, Chaudhry I, Al-Mohammed S, and Boriek AM, FASEB Journal, 1/1/2002
• Increased muscle extensibility of abdominal wall of alpha 7 integrin null mice.
  Lopez MA, FASEB International Conference, New Orleans, LA, 1/1/2002
• In vitro passive and active properties of diaphragm from a7 integrin null mice.
  Lopez MA, Chaudhrhy I, Jannapureddy SR, Mayer U, and Boriek AM, J Respir Crit Care Med, 1/1/2001
• a7 integrin and merosin contribute to viscoelasticity in the transverse plane of the diaphragm.
  Jannapureddy SR, Lopez MA, Mayer U, Boriek AM, J Respir Crit Care Med, 1/1/2001
• Increased transverse compliance in diaphragm muscle of desmin-deficient mice.
  Jannapureddy SR, Lopez MA, Capetanaki Y, Tidball JG and Boriek AM, J Respir Crit Care Med, 1/1/2001
• Isometric contractile properties of a-sarcoglycan deficient diaphragm during uniaxial and biaxial loading.
  Chaudhry I, MA Lopez, A Jain, E. Engvall, and Boriek AM, J Respir Crit Care Med, 1/1/2001
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Lectures

• Pediatric Neurological Emergencies 
  Baylor College of Medicine - 1/18/2016
• A Brief Tour of Neuromuscular Disease 
  Baylor College of Medicine - 1/12/2015
• The Role of Inflammation in Diaphragm Dysfunction 
  Shenandoah, Houston, TX - 1/18/2011
• Pathways to a Career in Medicine 
  Shenandoah, Houston, TX - 1/17/2011
• Muscular Dystrophy with Myositis: A Titinopathy 
  M.D. Anderson Biomedical Research Building, Houston, TX - 1/10/2010
• Does the Mechanosensitive NF-[kappa]B Regulate ANKRD1 in the Muscular Dystrophy with Myositis (mdm) Diaphragm? D97 – Mediators of skeletal muscle injury and repair. 
  San Diego, CA - 1/20/2009
• Open House – Panel Discussion 
  One Baylor Plaza, Baylor College of Medicine, Houston, TX - 1/5/2009
• Diaphragm Dysfunction Caused by the Titin mdm Mutation Correlates with an Early Inflammation. 
  University of Houston, Houston, TX - 1/8/2008
• Scholarship and the Keys to Success in Academics 
  Houston, TX - 1/1/2006
• Micromechanics of Skeletal Muscles 
  Atlanta, GA - 1/1/2002
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Other

• Case of the Month: Bronchopulmonary Sequestration – intralobar type. 
  Lopez, MA. Agarwal, P, Society of Thoracic Radiology, Peer-Reviewed Electronic Case
  1/1/2012
• The Respiratory Pump in Muscular Dystrophy: Dysregulation of Mechanosensitive Signaling Pathways 
  Lopez MA, Ph.D. Dissertation
  Baylor College of Medicine, Houston, TX - 1/1/2010