MichaelALevineMD

PubMed

• An activating calcium-sensing receptor variant with biased signaling reveals a critical residue for Gα11 coupling.
  Matthew R Benson, Rachael A Wyatt, Michael A Levine, Caroline M Gorvin
  Journal of Bone and Mineral Research. 2025-02-02
• Unusualvariants implicate uncommon genetic mechanisms for X-linked hypophosphatemic rickets.
  Lama Alzoebie, Dong Li, Xiang Wang, David R Weber, Michael A Levine
  JBMR Plus. 2025-01-01
• Letter to the editor in response to Duan X, et al, CYP4A22 loss-of-function causes a new type of vitamin D-dependent rickets (VDDR1C).
  Michael A Levine, Dong Li, Jeffrey Roizen, David Weber
  Journal of Bone and Mineral Research. 2024-12-23

Journal Articles

• Diagnosis and Management of Vitamin D Dependent Rickets  
  Michael Levine, MD, Frontiers in Pediatrics
• Obesity Decreases Hepatic 25‐Hydroxylase Activity Causing Low Serum 25‐Hydroxyvitamin D  
  Michael A Levine, Jeffrey D Roizen, Journal of Bone and Mineral Research
• Heterozygous Mutations in TBX1 as a Cause of Isolated Hypoparathyroidism  
  Hakon Hakonarson, Michael A Levine, The Journal of Clinical Endocrinology and Metabolism
• Diagnosis and Management of Pseudohypoparathyroidism and Related Disorders: First International Consensus Statement  
  Robert Pignolo, Ashley H Shoemaker, Michael A Levine, Nature
• Decreased Serum 25-Hydroxyvitamin D in Aging Male Mice Is Associated with Reduced Hepatic Cyp2r1 Abundance  
  Jeffrey D Roizen, Michael A Levine, Endocrinology
• Exome sequencing reveals a nonsense mutation in MMP13 as a new cause of autosomal recessive metaphyseal anadysplasia  
  Li D, Weber DR, Deardorff MA, Hakonarson H, Levine MA, Eur J Hum Genet, 4/30/2014
• Cinacalcet Monotherapy in Neonatal Severe Hyperparathyroidism  
  Gannon, A.W., Monk, H.M, Levine, M.A., J Clin Endocrinol Metab, 1/1/2014
• Determination of Reference Intervals for Serum Total Calcium in the Vitamin D-Replete Pediatric Population  
  Roizen, J.D., Shah, V,. Levine, M.A., Carlow, D.C., J Clin Endocrinol Metab, 1/1/2014
• Ketotic Hypercalcemia: A Case Series and Description of a Novel Entity  
  Hawkes CP, Levine MA, J. Clin Endocrinol Metab, 1/1/2014
• Mutations in SLC34A3/NPT2c Are Associated with Kidney Stones and Nephrocalcinosis  
  Dasgupta D, Wee MJ, Reyes M, Li Y, Simm PJ, Sharma A, Schlingmann KP, Janner M, Biggin A, Lazier J, Gessner M, Chrysis D, Tuchman S, Baluarte HJ, Levine MA, Tiosano D,..., J. Am. Soc. Nephrol., 1/1/2014
• Evaluating children with fractures for child physical abuse  
  Flaherty EG, Perez-Rossello JM, Levine MA, Hennrikus WL, Pediatrics, 1/1/2014
• Mutations in the ABCC6 Gene as a Cause of Generalized Arterial Calcification of Infancy-Genotypic Overlap with Pseudoxanthoma Elasticum  
  Li Q, Brodsky JL, Conlin LK, Pawel B, Glatz AC, Gafni RI, Schurgers L, Uitto J, Hakonarson H, Deardorff MA, Levine MA, J Invest Dermatol, 1/1/2013
• NHANES whole body DXA reference data for GE-Lunar systems  
  Shepherd, J.A. Fan, B.D. Steinberg, D. Wacker, W. Barden, H.S., Ergun, D, Wu, X.P., Levine, M.A., J Clin Densitometry, 1/1/2013
• A Novel Mutation in the GCM2 Gene Generates a Null Allele That Leads to Severe Autosomal Recessive Isolated Hypoparathyroidism  
  Doyle D, Kirwin S, Sol-Church K, and Levine MA, J Ped Endocrinol Metab, 1/1/2012
• Mapping structural determinants within 3rd intracellular loop reveals residues that direct signalling specificity of type 1 corticotropin releasing hormone receptor  
  Punn A., Chen J, Delidaki M, Tang J, Liapakis G, Lehnert H, Levine MA and Grammatopoulos DK, J Biol Chem, 1/1/2012
• A novel intronic mutation in SHOX causes short stature by disrupting a splice acceptor site: Direct demonstration of aberrant splicing by expression of a minigene in H...  
  Danzig J and Levine MA, J Ped Endocrinol Metab, 1/1/2012
• Vitamin D Status in Abused and Non-Abused Children Less Than Two-Years-Old with Fractures  
  Schilling S, Wood JN, Levine MA, Langdon D, and Christian CW, Pediatrics, 1/1/2011
• Decreased SH3BP2 inhibits osteoclast differentiation and function  
  Fan C, Gaivin RJ, Levine MA, Lietman SA, J Orthop Res, 1/1/2011
• Three novel mutations in the PHEX gene in Chinese subjects with hypophosphatemic rickets extends genotypic variability  
  Jap T-S, Chiu C-Y, Niu D-M, and Levine MA, Calcified Tissue International, 1/1/2011
• Comparison of metabolism of vitamin D2 with vitamin D3 in children with nutritional rickets  
  Thacher TD, Fischer PR, Obadofin MO, Levine MA, Singh RJ, Pettifor JM, J Bone Min Res, 1/1/2010
• Bone Mineral Density in Pseudohypoparathyroidism Type 1a  
  Long DN., Levine MA, Germain-Lee E, J Clin Endocrinol Metab, 1/1/2010
• SH3BP2 mutations potentiate osteoclastogenesis via PLCgamma  
  Lietman SA, Yin L, Levine MA, J Orthop Res, 1/1/2010
• Hypercalcemia in children and adolescents  
  Lietman SA, Germain-Lee EL, Levine, MA, Curr Opin Pediatr, 1/1/2010
• Pseudohypoparathyroidism type 1A and morbid obesity in infancy  
  Dekelbab BH, Aughton DJ, Levine MA, . Endocr Pract, 1/1/2009
• Hypophosphatemic rickets with hypercalciuria due to mutations in SLC34A3/NaPi-IIc: Presentation as Hypercalciuria and Nephrolithiasis  
  Tencza AL, Ichikawa S, Dang A, Kenagy D, McCarthy E, Econs MJ, Levine MA, J Clin Endocrinol Metab, 1/1/2009
• Join now to see all

Books/Book Chapters

• The Parathyroids: Basic and Clinical Concepts 
  Michael A. Levine, MDEditors: John Bilezikian Robert Marcus, John Potts, Robert Marcus, Shonni J Silverberg, Michael Levine, Claudio Marcocci.Elsevier, San DiegoEdition Thir,2014
• Pediatric Endocrinology 
  Chapter: Receptor Transduction Pathways Mediating Hormone Action. 
  Kublaoui B, Levine MAEditors: Mark A. Sperling.SaundersEdition 4th,2014
• Diseases of the Parathyroid Glands 
  Calabria, AC and MA LevineEditors: AA Licata and EV Lerma.Springer2011
• Oxford Textbook of Endocrinology and Diabetes 
  Chapter: Molecular and clinical characteristics of McCune Albright syndrome. 
  Lietman S and Levine MAEditors: Wass JAH and Stewart PM.Oxford University Press, OxfordEdition Seco,2011
• Netter's Pediatrics 
  Chapter: Disorders of Calcium and Bone Metabolism. 
  Page 429 - 435Brodsky JL and Levine MAEditors: Florin TA, Ludwig S, Aronson PL and Werner HC.Elsevier Saunders, Philadelphia2011
• Pediatric Practice: Endocrinology 
  Chapter: Disorders of calcium, phosphate, parathyroid hormone and vitamin D. 
  Page 191 - 256Kelly A. and Levine MAEditors: Kappy, MS, Allen, DB, and Geffner, ME.Charles C. Thomas Publisher, LTD, Springfield2009
• Manual of Endocrinology and Metabolism 
  Chapter: Common Bone and Mineral Disorder of Childhood. 
  Levine, MAEditors: Lavin, N.Lippincott Williams & WilkinsEdition Four,2009
• Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 
  Chapter: Hypoparathyroidism and Pseudohypoparathyroidism. 
  Rubin M. and Levine, MAEditors: Clifford J. Rosen.American Society for Bone and Mineral Research, Washington, DCEdition Seve,2008
• Pediatric Hospital Medicine 
  Chapter: Disorders involving the Parathyroid Gland. 
  Barr S, Levine MAEditors: Perkin R, Swift J, Newton D, Anas N.Lippincott Williams & WilkinsEdition Seco,2007
• Bone Densitometry in Growing Patients: Guidelines for Clinical Practice 
  Chapter: Clinical Indications for the Use of DXA in Pediatrics. 
  Bachrach LK, Levine MA, Cowell CT, Shaw NJEditors: Sawyer AJ, Bachrach LK, Fung EB.Humana Press2006
• Principles of Molecular Medicine 
  Chapter: Disorders of the parathyroid gland. 
  Arnold A, Levine MAEditors: Runge MS, Patteron C.Humana Press, Totowa, NJEdition Seco,2006
• Principles and Practice of Pediatric 
  Chapter: Disorders of calcium, phosphate, parathyroid hormone and vitamin D. 
  Page 695 - 814Levine MA, Zapalowski C, Kappy MSEditors: Kappy, MS, Allen, DB, and Geffner, ME.Charles C. Thomas Publisher, LTD, Springfield2005
• Molecular Biology of the Parathyroid 
  Chapter: Genetic causes of hypoparathyroidism. 
  Page 159 - 178Gafni RI, Levine MAEditors: Naveh-Many T.Landes Bioscience & Kluwer Academic/Plenum Publishers, Georgetown & New York2005
• Encyclopedia of Endocrine Diseases 
  Chapter: Primary hyperparathyroidism. 
  Page 558 - 566Levine MA, Streeten EAEditors: L. Martini.Elsevier/Academic Press, San Diego2004
• Vitamin D and Rickets, Endocrine Development 
  Chapter: Normal mineral homeostasis: Interplay of parathyroid hormone and vitamin D. 
  Levine MAEditors: Ze'ev Hochberg.Karger, Basel2003
• Vitamin D and Rickets, Endocrine Development 
  Chapter: Consensus development for the supplementation of vitamin D in childhood and adolescence. 
  Hochberg Z, Bereket A, Davenport M, Delemarre-Van de Waal HA, De Schepper J, Levine MA, Shaw N, Schoenau E, van Coeverden SC, Weisman Y, Zadik ZEditors: Ze'ev Hochberg.Karger, Basel2003
• Developmental Endocrinology: From Research to Clinical Practice 
  Chapter: Genetic control of parathyroid gland development and molecular insights into hypoparathyroidism. 
  Levine MAHumana Press, Totowa, NJ2002
• Oxford Textbook of Endocrinology and Diabetes 
  Chapter: Molecular and clinical characteristics of the McCune-Albright syndrome. 
  Levine MAOxford University Press, Oxford, England2002
• The Parathyroids: Basic and Clinical Concepts 
  Michael A. Levine, MDEditors: Bilezikian JP, Marcus R, Levine MA.Academic Press, San DiegoEdition Seco,2001
• The Parathyroids 
  Chapter: Signal transduction of PTH and PTHrP. 
  Weinstein LS, Levine MAAcademic Press, San DiegoEdition Seco,2001
• Conn's Current Therapy 2001 
  Chapter: Hyperparathyroidism and hypoparathyroidism. 
  Streeten EA, Levine MAW.B. Saunders Co., Philadelphia, PA2001
• Endocrinology 
  Chapter: Hypoparathyroidism and Pseudohypoparathyroidism. 
  Levine MAW.B. Saunders Co., Philadelphia, PAEdition Four,2001
• The Parathyroids 
  Chapter: Guidelines for the medical and surgical management of primary hyperparathyroidism. 
  Kleerekoper M, Udelsman R, Levine MAAcademic Press, San DiegoEdition Seco,2001
• The Parathyroids 
  Chapter: Pseudohypoparathyroidism: Clinical, biochemical, and molecular features. 
  Jan de Beur SM, Levine MAAcademic Press, San DiegoEdition Seco,2001
• Principles and Practice of Endocrinology and Metabolism 
  Chapter: Hypoparathyroidism and Other Causes of Hypocalcemia. 
  Jan de Beur S, Streeten EA, Levine MAJ.B. Lippincott, New York, NYEdition Thir,2001
• Join now to see all

Lectures

• Guided Presidential Posters: Genetics and Development (including gene regulation) 
  ENDO 2019 - New Orleans, LA - 3/24/2019
• What's New in the Assessment of Bone Metabolism in Children" 
  5/1/2014
• "Lessons from the genome: an update on hypoparathyroidism" 
  Chicago, IL - 3/1/2014
• Endocrine Grand Rounds: "Update on Hypoparathyroidism" 
  Stanford University - 2/1/2014
• Pediatrics Grand Rounds: "Hypercalcemia in Children and Adolescents" 
  Stanford University - 2/1/2014
• Pediatrics Grand Rounds: "Optimizing and Measuring Bone Mass in Children" 
  University of Florida - 2/1/2014
• "Exome Sequencing in the Characterization of Bone and Mineral Disorders" 
  11/1/2013
• Invited Speaker, "Molecular Genetic Analysis of Gorham Stout and Lymphangiomatosis" 
  6/1/2013
• Keynote Speaker, "Parathyroid Disease in Children and Adolescents" 
  Beijing Children's Hospital, Beijing, China - 5/1/2013
• Keynote Speaker, "Approach to the Diagnosis and Management of Bone Loss in Children" 
  5/1/2013
• Pediatrics Grand Rounds: "Bone Health and Disorders Affecting Pediatric Populations" 
  University of Alabama - 3/1/2013
• Invited Speaker, "Rickets in the 21 Century" 
  2/1/2013
• Invited Speaker, "AssessingstBone Health in Children and Adolescents" 
  2/1/2013
• Invited Keynote Speaker, "Optimizing and Assessing Bone Mass in Children and Adolescents" 
  12/1/2012
• "Update on Hypercalcemia and Hypocalcemia." 
  9/1/2012
• Invited Speaker, "Fractures in Children" 
  5/1/2012
• "Update on Vitamin D" 
  5/1/2012
• "Update on Metabolic Bone Disease in Children." Keynote Symposium Speaker 
  5/1/2012
• "Hypercalcemia." 
  5/1/2012
• Endocrinology Grand Rounds: "Pseudohypoparathyroidism: Man, Mouse, and Mystery." 
  Perelman School of Medicine at University of Pennsylvania - 4/1/2012
• "Metabolic Bone Disease in the NICU" 
  5/1/2011
• "Update on Vitamin D Physiology and Pharmacology" Keynote Address 
  5/1/2011
• "Calcium and Rickets" 
  Denver, CO - 5/1/2011
• Endocrine Grand Rounds: "Rickets in the Year 2011: Nature and Nurture" 
  University of Maryland Medical Center, Baltimore, MD - 2/1/2011
• "Update on PTH Measurement and Analysis" Keynote Address 
  11/1/2010
• Join now to see all

Other

• Monitoring Bone Health in Children and Adolescents. 
  Levine, MA, Arab Health Magazine, Issue 3, pp 36-40
  1/1/2011
• Demonstration that Gcm2 Haploinsufficiency Causes Parathyroid Dysfunction. 
  Ziqiang Y, Opas EE, Vrikshajanani C, Libutti SK, and Levine MA