MichaelWKonstanMD

Pediatric Pulmonology • Cleveland, OH

Professor of Pediatrics, Case West Res Univ

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Office
11100 Euclid Ave
Cleveland, OH 44106
Phone+1 216-844-7700

Fax+1 216-844-7960

Education & Training

Case Western Reserve University/University Hospitals Cleveland Medical CenterFellowship, Pulmonary Disease and Critical Care Medicine, 1985 - 1988
University at BuffaloResidency, Pediatrics, 1982 - 1985
Case Western Reserve University School of MedicineClass of 1982

Certifications & Licensure

OH State Medical License 1982 - 2026
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Pulmonology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2004-2014
Northern Ohio Live Castle Connolly, 2006-2009

Clinical Trials

Study of Ibuprofen to Preserve Lung Function in Patients With Cystic Fibrosis Start of enrollment: 1996 Aug 01
Completed
Not Applicable
A Study of the Safety and Efficacy of Tobramycin for Inhalation in Young Children With Cystic Fibrosis Start of enrollment: 2000 Feb 01
Completed
Phase 2
Safety and Efficacy of Pioglitazone as an Anti-inflammatory for the Treatment of Cystic Fibrosis (CF) Lung Disease Start of enrollment: 2006 Apr 01
Completed
Not Applicable
Safety of Tobramycin Inhalation Powder (TIP) vs Tobramycin Solution for Inhalation in Patients With Cystic Fibrosis Start of enrollment: 2006 Feb 01
Completed
Phase 3
Safety and Efficacy Study of ULTRASE® MT20 in Participants With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (PI) Start of enrollment: 2006 Nov 01
Completed
Phase 3
Evaluation of the Safety and Efficacy of Pancrecarb® MS-16 in Cystic Fibrosis Start of enrollment: 2007 Jan 01
Completed
Phase 3
Efficacy and Safety of Ultrase® MT20 in Improving the Coefficient of Fat Absorption (CFA) in Children With Cystic Fibrosis (CF) and Pancreatic Insufficiency (PI) Start of enrollment: 2007 Jul 01
Completed
Phase 3
Pilot Mouthwash Study of Pioglitazone and Simvastatin in Healthy Volunteers Start of enrollment: 2007 Sep 01
Completed
Not Applicable
Use of Ultrase® MT12 in Young Cystic Fibrosis Children (CF) Start of enrollment: 2009 Apr 01
Completed
Phase 3
Study to Evaluate Arikace™ in CF Patients With Chronic Infection Due to Pseudomonas Aeruginosa
Withdrawn
Phase 3
Extension Study of Liposomal Amikacin for Inhalation in Cystic Fibrosis (CF) Patients With Chronic Pseudomonas Aeruginosa (Pa) Infection Start of enrollment: 2012 Oct 05
Completed
Phase 3
G551D Observational Study- Expanded to Additional Genotypes and Extended for Long Therm Follow up (GOAL-e2) Start of enrollment: 2014 Jan 01
Completed
Study of Ataluren in Nonsense Mutation Cystic Fibrosis (ACT CF) Start of enrollment: 2014 Aug 01
Completed
Phase 3
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Publications & Presentations

PubMed

Sweat chloride reflects CFTR function and correlates with clinical outcomes following CFTR modulator treatment.
Edith T Zemanick, Bonnie Ramsey, Dorota Sands, Edward F McKone, Isabelle Fajac
Journal of Cystic Fibrosis. 2025-01-03
Efficacy and safety of LAU-7b in a Phase 2 trial in adults with cystic fibrosis.
Michael W Konstan, Deepika Polineni, James F Chmiel, Lara Bilodeau, Peter G Middleton
Journal of Cystic Fibrosis. 2025-01-01
1 citations
Equity-Focused Evaluation of a Medicaid-Funded Statewide Diabetes Quality Improvement Project Collaborative.
Joshua J Joseph, Adam T Perzynski, Kathleen M Dungan, Elizabeth A Beverly, Douglas Einstadter
Diabetes Care. 2025-01-01

Journal Articles

Opportunities for Life Course Research Through the Integration of Data Across Clinical and Translational Research Institutes
Michael W Konstan, Shari L Barkin, James E Heubi, Journal of Clinical and Translational Science

Press Mentions

First Wave BioPharma Announces Phase 2 Adrulipase Combination Trial Data to Be Presented at the 2023 Digestive Disease Week (DDW) ConferenceFebruary 21st, 2023
#NACFC2022 – LAU-7b May Prevent Lung Function Decline in CFNovember 9th, 2022
AzurRx BioPharma Announces Formation of Scientific Advisory BoardOctober 21st, 2020
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Grant Support

Research Career Development In Child HealthEunice Kennedy Shriver National Institute Of Child Health &Human Development2011–2012
Clinical StudiesNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2011
PTC124 As An Oral Treatment For Nonsense-Mutation-Mediated Cystic FibrosisNational Center For Research Resources2006
Tobramycin For Inhalation (TOBI) In Young Children With Cystic FibrosisNational Center For Research Resources2005
Oral Theraclec-Total In CF Patients With Exocrine Pancreatic InsufficiencyNational Center For Research Resources2005
Biil284bs In Adult And Pediatric Cystic Fibrosis PatientsNational Center For Research Resources2004–2005
Oral Theraclec-Total In Adult And Pediatric Subjects With Cystic FibrosisNational Center For Research Resources2004
Neutrophil Imaging Of The Lung For Characterizing Pulmonary Infection In CF PTSNational Center For Research Resources2004
Fat And Protein Absorption In Cystic Fibrosis PTS With Pancreatic InsufficiencyNational Center For Research Resources2004
Lower Airway Deposit Of Inhaled Tobramycin In Cystic FibNational Center For Research Resources2000–2002
Ins365 In Adult &Pediatric Cystic FibrosisNational Center For Research Resources2000–2002
Ib367 In Adult Patients With Cystic FibrosisNational Center For Research Resources2000–2002
Free Elastase Concentration In BAL Fluid In Cystic FibrosisNational Center For Research Resources2000–2002
Lung Specific Bioefficacy Of Oral DMP 777 In Adults W/ CFNational Center For Research Resources1999–2002
CPX (Oral, Multidose) In Adults W/ Mild To Moderately Severe Cystic FNational Center For Research Resources1999–2002
Dmp777 In Adult Patients 18 Yrs Of Age And Older With Cystic FibrosisNational Center For Research Resources1998–2000
CPX In Adult Patients With Mild Cystic FibrosisNational Center For Research Resources1998–2000
Prolastin Aerosol Therapy In Patients With Cystic FibrosisNational Institute Of Diabetes And Digestive And Kidney Diseases1996–2000
In Vivo Studies Of Ibuprofen In Patients With Cystic FibrosisNational Center For Research Resources1994–2000
Trial In Patients With Mild Cystic Fibrosis To Determine Efficacy Of PulmozymeNational Center For Research Resources1996–1997
Bronchoalveolar Lavage Studies In Cystic FibrosisNational Center For Research Resources1996–1997
Inhalation Administration Of Alpha1-Pl By Aerosol In Cystic FibrosisNational Center For Research Resources1996
In Vivo Studies Of Ibuprofen In Patients With Cystic FibrosisNational Center For Research Resources1992–1996
Pharmacokinetics Of Tobramycin Administered By Different Nebulizers To CF PTSNational Center For Research Resources1995
Pilot Study--Antiproteases And The Treatment Of Inflammation Of The Lung In CFNational Institute Of Diabetes And Digestive And Kidney Diseases1992–1995
Intravenous ICI 200,880 In Stable Cystic Fibrosis OutpatientsNational Center For Research Resources1994
Clinical Trial Of Ibuprofen In Patients With Cystic FibrosisNational Center For Research Resources1994
Secretory Leukocyte Protease Inhibitor Augmentation Therapy In CF PatientsNational Center For Research Resources1993
Intravenous Elastase Inhibitor In Stable Cyctic Fibrosis OutpatientsNational Center For Research Resources1993
Intravenous ICI 200,880 In Stable Cystic Fibrosis OutpatientsNational Center For Research Resources1992–1993
Clinical Trial Of Ibuprofen In Patients With Cystic FibrosisNational Center For Research Resources1990–1993
Pilot Study-- Antiproteases And The Treatment Of Inflammation Of The Lung In CFNational Institute Of Diabetes And Digestive And Kidney Diseases1991