Michael R Knowles MD
Pleural Disease
Professor, Medicine, University of North Carolina at Chapel Hill School of Medicine
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101 Manning DrChapel Hill, NC 27514
Phone+1 919-966-4996
Fax+1 919-843-5515
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Education & Training
Duke University HospitalResidency, Internal Medicine, 1973 - 1975
Ohio State University HospitalResidency, Internal Medicine, 1971 - 1973
University of North Carolina at Chapel Hill School of MedicineClass of 1971
Certifications & Licensure
NC State Medical License 1971 - 2023
MD State Medical License 1975 - 1978
OH State Medical License 1972 - 1974
American Board of Internal Medicine Internal Medicine- American Board of Internal Medicine Pulmonary Disease
Clinical Trials
Publications & Presentations
PubMed
- Progression of Otologic and Nasal Symptoms in Primary Ciliary Dyskinesia Throughout Childhood.Isabelle Dagher, Adam J Kimple, Thomas W Ferkol, Scott D Sagel, Sharon D Dell
OTO Open. 2025-02-21 - Overlapping Clinical Phenotypes in Patients with Primary Ciliary Dyskinesia or Activated Phosphoinositide 3-Kinase Delta Syndrome.Adam J Shapiro, Eveline Y Wu, Deborah J Morris-Rosendahl, Kenneth N Olivier, Sharon D Dell
The Journal of Pediatrics. 2025-02-06 - Promoter Deletion Leading to Allele Specific Expression in a Genetically Unsolved Case of Primary Ciliary Dyskinesia.M Makenzie Beaman, Weining Yin, Amanda J Smith, Patrick R Sears, Margaret W Leigh
American Journal of Medical Genetics. Part A. 2025-02-01
Journal Articles
- Mutation of CFAP57, a Protein Required for the Asymmetric Targeting of a Subset of Inner Dynein Arms in Chlamydomonas, Causes Primary Ciliary DyskinesiaMichael Knowles, MD, PLOS Genetics
Authored Content
- Analysis of a Large Cohort of Cystic Fibrosis Patients with Severe Liver Disease Indicates Lung Function Decline Does Not Significantly Differ from That of the General Cystic Fibrosis PopulationOctober 2018
Press Mentions
Consortium Spotlight: Advancing Discoveries in Mucociliary Clearance DiseasesMarch 11th, 2022- Portlaoise Hospital's X-ray Team Hit the Mark in Health Watchdog's New ReviewJune 25th, 2020
Help Is at Hand for Covid-19 Staff Stress Says Portlaoise Hospital ManagerApril 29th, 2020- Join now to see all
Grant Support
- Pathogenesis Of PCD Lung DiseaseNational Heart, Lung, And Blood Institute2004–2012
- Genetic Disorder Of Mucocilary ClearanceNational Heart, Lung, And Blood Institute2009–2011
- Molecular Phenotypes For Cystic Fibrosis Lung DiseaseNational Heart, Lung, And Blood Institute2008–2011
- Gene Modifiers In CF Lung DiseaseNational Heart, Lung, And Blood Institute2001–2010
- Association Of Genotype And Circulating Levels Of Tgf?1 In Cystic Fibrosis PANational Center For Research Resources2008
- RARE Genetic Disorders Of The AirwaysNational Center For Research Resources2007–2008
- Genetic Modifiers Of CF Liver DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases2004–2008
- Genetic Mutations In Patients With Primary Ciliary Dyskinesia And FamilyNational Center For Research Resources2004–2008
- Genetic Disorders Of Mucociliary Clearance: RARE Diseases: Pcd, Cf, &PhaNational Center For Research Resources2004–2008
- Genetic Disorders Of Mucociliary ClearanceNational Center For Research Resources2004–2008
- Genetic Modifiers Of Inherited Liver DiseaseNational Center For Research Resources2007
- Gene Modifiers In Cystic Fibrosis Lung DiseaseNational Center For Research Resources2007
- Measurement Of Airway Transepithelial Potential Difference In CFNational Center For Research Resources2005–2007
- Multicenter Study Of Nontuberculous Mycobacteria In PTS With Cystic FibrosisNational Center For Research Resources1999–2002
- Airway Inflammation &Mediators In Chronic BronchitisNational Center For Research Resources1999–2002
- Airway Surface Liquid Composition Of Humans In VivoNational Heart, Lung, And Blood Institute1998–2002
- Measurement Of Airway Transepithelial Potential Difference In Cystic FibrosisNational Center For Research Resources1996–2002
- Nontuberculous Mycobacteria In PTS W/ Cystic FibrosisNational Center For Research Resources2000
- Glucocorticoids &Mineralocorticoids On Electrical Potential DifferenceNational Center For Research Resources2000
- CPX In Adult W/ Mild To Moderately Severe Cystic FibrosisNational Center For Research Resources2000
- Airway Transepithelial Potential Difference In CFNational Center For Research Resources2000
- Human Respiratory Epithelial Function In VivoNational Heart, Lung, And Blood Institute1995–2000
- Measurement Of Airway Electrical Potential DifferenceNational Center For Research Resources1996–1999
- Gene Transfer In Vivo In Cystic Fibrosis PatientsNational Heart, Lung, And Blood Institute1996–1997
- Gene Transfer In Cystic Fibrosis Using E1 Deleted AdenovirusNational Center For Research Resources1996–1997
- Acute Safety And Efficacy Of Aerosolized Nucleotides As Therapy For CFNational Center For Research Resources1995–1996
- Pharmacokinetics Of Amiloride Administration In Cyctic Fibrosis PatientsNational Center For Research Resources1995
- Acute Effects Of Aerosolized Amiloride In Cystic Fibrosis And Normal SubjectsNational Center For Research Resources1995
- Clinical Investigator AwardNational Heart, Lung, And Blood Institute1985
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