MichaelRKnowlesMD

Pulmonology • Chapel Hill, NC

Pleural Disease

Professor, Medicine, University of North Carolina at Chapel Hill School of Medicine

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Office
101 Manning Dr
Chapel Hill, NC 27514
Phone+1 919-966-4996

Fax+1 919-843-5515

Education & Training

Duke University HospitalResidency, Internal Medicine, 1973 - 1975
Ohio State University HospitalResidency, Internal Medicine, 1971 - 1973
University of North Carolina at Chapel Hill School of MedicineClass of 1971

Certifications & Licensure

NC State Medical License 1971 - 2023
MD State Medical License 1975 - 1978
OH State Medical License 1972 - 1974
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Pulmonary Disease

Clinical Trials

Gene Modifiers of Cystic Fibrosis Lung Disease Start of enrollment: 2001 Sep 01
Active, not recruiting
Rare Genetic Disorders of the Breathing Airways Start of enrollment: 2006 May 01
Completed
Genetic Modifiers of Cystic Fibrosis (CF) Liver Disease Start of enrollment: 2004 Mar 01
Active, not recruiting
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease Start of enrollment: 2004 Jan 01
Recruiting
Molecular Phenotypes for Cystic Fibrosis Lung Disease Start of enrollment: 2009 Jul 01
Completed
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Publications & Presentations

PubMed

Promoter Deletion Leading to Allele Specific Expression in a Genetically Unsolved Case of Primary Ciliary Dyskinesia.
M Makenzie Beaman, Weining Yin, Amanda J Smith, Patrick R Sears, Margaret W Leigh
American Journal of Medical Genetics. Part A. 2025-02-01
Long G4-rich enhancers target promoters via a G4 DNA-based mechanism.
Jeffrey D DeMeis, Justin T Roberts, Haley A Delcher, Noel L Godang, Alexander B Coley
Nucleic Acids Research. 2024-12-10
Comparison of Longitudinal Outcomes in Children with Primary Ciliary Dyskinesia and Cystic Fibrosis.
BreAnna Kinghorn, Margaret Rosenfeld, Erin Sullivan, Frankline M Onchiri, Marshall D Brown
Annals of the American Thoracic Society. 2024-12-01

Journal Articles

Mutation of CFAP57, a Protein Required for the Asymmetric Targeting of a Subset of Inner Dynein Arms in Chlamydomonas, Causes Primary Ciliary Dyskinesia
Michael Knowles, MD, PLOS Genetics

Authored Content

Analysis of a Large Cohort of Cystic Fibrosis Patients with Severe Liver Disease Indicates Lung Function Decline Does Not Significantly Differ from That of the General Cystic Fibrosis PopulationOctober 2018

Press Mentions

Consortium Spotlight: Advancing Discoveries in Mucociliary Clearance DiseasesMarch 11th, 2022
Portlaoise Hospital's X-ray Team Hit the Mark in Health Watchdog's New ReviewJune 25th, 2020
Help Is at Hand for Covid-19 Staff Stress Says Portlaoise Hospital ManagerApril 29th, 2020
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Grant Support

Pathogenesis Of PCD Lung DiseaseNational Heart, Lung, And Blood Institute2004–2012
Genetic Disorder Of Mucocilary ClearanceNational Heart, Lung, And Blood Institute2009–2011
Molecular Phenotypes For Cystic Fibrosis Lung DiseaseNational Heart, Lung, And Blood Institute2008–2011
Gene Modifiers In CF Lung DiseaseNational Heart, Lung, And Blood Institute2001–2010
Association Of Genotype And Circulating Levels Of Tgf?1 In Cystic Fibrosis PANational Center For Research Resources2008
RARE Genetic Disorders Of The AirwaysNational Center For Research Resources2007–2008
Genetic Modifiers Of CF Liver DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases2004–2008
Genetic Mutations In Patients With Primary Ciliary Dyskinesia And FamilyNational Center For Research Resources2004–2008
Genetic Disorders Of Mucociliary Clearance: RARE Diseases: Pcd, Cf, &PhaNational Center For Research Resources2004–2008
Genetic Disorders Of Mucociliary ClearanceNational Center For Research Resources2004–2008
Genetic Modifiers Of Inherited Liver DiseaseNational Center For Research Resources2007
Gene Modifiers In Cystic Fibrosis Lung DiseaseNational Center For Research Resources2007
Measurement Of Airway Transepithelial Potential Difference In CFNational Center For Research Resources2005–2007
Multicenter Study Of Nontuberculous Mycobacteria In PTS With Cystic FibrosisNational Center For Research Resources1999–2002
Airway Inflammation &Mediators In Chronic BronchitisNational Center For Research Resources1999–2002
Airway Surface Liquid Composition Of Humans In VivoNational Heart, Lung, And Blood Institute1998–2002
Measurement Of Airway Transepithelial Potential Difference In Cystic FibrosisNational Center For Research Resources1996–2002
Nontuberculous Mycobacteria In PTS W/ Cystic FibrosisNational Center For Research Resources2000
Glucocorticoids &Mineralocorticoids On Electrical Potential DifferenceNational Center For Research Resources2000
CPX In Adult W/ Mild To Moderately Severe Cystic FibrosisNational Center For Research Resources2000
Airway Transepithelial Potential Difference In CFNational Center For Research Resources2000
Human Respiratory Epithelial Function In VivoNational Heart, Lung, And Blood Institute1995–2000
Measurement Of Airway Electrical Potential DifferenceNational Center For Research Resources1996–1999
Gene Transfer In Vivo In Cystic Fibrosis PatientsNational Heart, Lung, And Blood Institute1996–1997
Gene Transfer In Cystic Fibrosis Using E1 Deleted AdenovirusNational Center For Research Resources1996–1997
Acute Safety And Efficacy Of Aerosolized Nucleotides As Therapy For CFNational Center For Research Resources1995–1996
Pharmacokinetics Of Amiloride Administration In Cyctic Fibrosis PatientsNational Center For Research Resources1995
Acute Effects Of Aerosolized Amiloride In Cystic Fibrosis And Normal SubjectsNational Center For Research Resources1995
Clinical Investigator AwardNational Heart, Lung, And Blood Institute1985