Michael B Kastan MD

PubMed

• 5 citations
  A Novel Dual ATM/DNA-PK Inhibitor, XRD-0394, Potently Radiosensitizes and Potentiates PARP and Topoisomerase I Inhibitors.
  Tona M Gilmer, Chun-Hsiang Lai, Kexiao Guo, Katherine Deland, Kathleen A Ashcraft
  Molecular Cancer Therapeutics. 2024-06-04
• 1 citations
  Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway.
  Jennifer J McCann, Donald E Fleenor, Jing Chen, Chun-Hsiang Lai, Thomas E Bass
  Radiation Research. 2023-04-01
• 1 citations
  ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks.
  Thomas E Bass, Donald E Fleenor, Paige E Burrell, Michael B Kastan
  Molecular Cancer Research. 2023-03-01

Journal Articles

• The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy  
  Goldstein M, Kastan MB, Annual Review of Medicine, 1/1/2015
• Repair versus checkpoint functions of Brca1 are differentially regulated by site of chromatin binding  
  Goldstein M, Kastan MB, Cancer Res, 1/1/2015
• ATM Functions at the Peroxisome to Induce Pexophagy in Response to ROS  
  Zhang J,, Tripathi DN, Jing, J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee J-H, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL, Nature Cell Biology, 1/1/2015
• Rad17 Recruits the MRE11-RAD50-NBS1 Complex to Regulate the Cellular Response to DNA Double-Strand Breaks  
  Wang Q, Alexander PB, Goldstein M, Wakeman TP, Sun T, Feng J, Lou Z, Kastan MB, Wang X-F, EMBO J, 1/1/2014
• The scaffold protein WRAP53beta orchestrates the ubiquitin response critical for DNA double-strand break repair  
  Henriksson S, Hedstrom S, Rassoolzadeh H, Julner A, Goldstein M, Imreh G, Zhivotovsky B, Jirstrom K, Kastan MB, Brennan DJ, Helleday T, Farnebo M, Genes and Development, 1/1/2014
• Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells using a bacterial CRISPR/Cas RNA-guided endonuclease  
  Kennedy EM, Kornepati AVI, Goldstein M, Bogerd HP, Poling BC, Whisnant AW, Kastan MB, and Cullen BR, Journal of Virology, 1/1/2014
• A tuberous sclerosis complex signaling node at the peroxisome regulates mTORC1 and autophagy in response to ROS  
  Zhang J, Jinhee K, Alexander A, Cai S, Tee A, Tait-Mulder J, Di Nardo A, Han J, Kwiatkowski E, Dunlop E, Dodd K, Folkerth R, Faust P, Kastan MB, Sahin M, Walker C, Nature Cell Biology, 1/1/2013
• Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies  
  Sandlund JT, Hudson MM, Kennedy W, Onciu M, Kastan MB, Pediatric Blood Cancer, 1/1/2013
• Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair  
  Goldstein M, Derheimer FA, Tait-Mulder J, Kastan MB, Proc Natl Acad Sci, 1/1/2013
• A new role for ATM, Regulating mitochondrial function and mitophagy  
  Valentin-Vega Y, Kastan MB, Autophagy, 1/1/2012
• Mitochondrial Dysfunction in Ataxia-Telangiectasia  
  Valentin-Vega YA, Maclean KH, Tait-Mulder J, Milasta S, Steeves M, Dorsey FC, Cleveland JL, Green DR, and Kastan MB, Blood, 1/1/2012
• Autophagy Links Inflammasomes to Atherosclerotic Progression  
  Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting J, Virgin HW, Kastan MB, and Semenkovich CF, Cell Metabolism, 1/1/2012
• Chloroquine improves hematopoietic recovery and survival following lethal low dose-rate radiation  
  Lim Y, Hedayati M, Merchant A, Zhang Y, Kastan MB, Matsui W, Deweese T, Intl J Radiat Oncol Biol Phys, 1/1/2012
• Interactions of nucleolin and ribosomal protein RPL26 in the translational control of human p53 mRNA  
  Chen J, Guo K, Kastan MB, J Biol Chem, 1/1/2012
• Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemia  
  Leung W, Neale G, Behm F, Iyengar R, Finkelstein D, Kastan MB, Pui CH, Cancer Epidemiology, 1/1/2010
• Multiple roles of ATM in Monitoring and Maintaining DNA Integrity  
  Derheimer FA and Kastan MB, FEBS Letters, 1/1/2010
• 5' - 3' UTR Interactions Regulate p53 mRNA Translation and Provide a Target for Modulating p53 Induction After DNA Damage  
  Chen J and Kastan MB, Genes and Development, 1/1/2010
• ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS  
  Alexander A, Cai SL, Kim J, Nanez A, Sahin M, Maclean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL, Proc Nat Acad Sci, 1/1/2010
• Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis  
  Maclean KH, Dorsey FC, Cleveland JL, and Kastan MB, Journal of Clinical Investigation, 1/1/2008
• 2007 GHA Clowes Memorial Award Lecture, DNA Damage Responses: Mechanisms and Roles in Human Disease  
  Kastan MB, Mol Cancer Res, 1/1/2008
• Mdm2 regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26  
  Ofir-Rosenfeld Y, Boggs K, Michael D, Kastan MB, Oren M, Molecular Cell, 1/1/2008
• Assessment of Protein Dynamics and DNA Repair Following Generation of DNA Double-Strand Breaks at Defined Genomic Sites  
  Berkovich E, Monnat, RJ, Kastan MB, Nature Protocols, 1/1/2008
• Our Cells Get Stressed Too! Implications for Human Disease  
  Kastan MB, Blood Cells, Molecules & Diseases, 1/1/2007
• Atm Deficiency Affects both Apoptosis and Proliferation to Augment myc-Induced Lymphomagenesis  
  Maclean KH, Kastan MB, Cleveland JL, Molecular Cancer Research, 1/1/2007
• Roles of ATM and NBS1 in chromatin structure modulation and double strand break repair  
  Berkovich E, Monnat RJ, Kastan MB, Nature Cell Biology, 1/1/2007
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Books/Book Chapters

• Clinical Oncology 
  Editors: Niederhuber, Armitage, Doroshow, Kastan, and Tepper.Edition 5th,2014
• Clinical Oncology 
  Chapter: DNA Damage Response Pathways and Cancer. 
  Page 139 - 152Ford JM and Kastan MBEditors: Abeloff, Armitage, Niederhuber, Kastan, and McKenna.Edition 4th,2008
• Clinical Oncology 
  Editors: Abeloff, Armitage, Niederhuber, Kastan, and McKenna.Edition 4th,2008
• 25 Years of p53 Research. 
  Chapter: 20 Years of DNA Damage Signaling to p53. Chapter 3 
  Page 53 - 71McLure K, Kastan MBEditors: Pierre Hainaut and Klas G. Wiman.Springer, Netherlands2005
• Methods in Molecular Biology, Vol 281, Checkpoint Controls and Cancer, Volume 2: Activation and Regulation Protocols. 
  Chapter: Analyzing cell cycle checkpoints after ionizing radiation. Chapter 20 
  Page 283 - 292Xu B and Kastan MBEditors: Axel H. Schonthal.Humana Press, Totowa, NJ2004
• Clinical Oncology 
  Editors: Abeloff, Armitage, Niederhuber, Kastan, and McKenna.2004
• Principles and Practice of Pediatric Oncology 
  Chapter: Biology of Childhood Cancer. 
  Page 89 - 119Thiele CJ and Kastan MBEditors: Pizzo and Poplack.Edition 4th,2002
• Cancer: Principles and Practice of Oncology 
  Chapter: Molecular Cell Biology of Cancer: The Cell Cycle. 
  Page 91 - 109Kastan MB and Skapek SXEditors: DeVita, Hellman, and Rosenberg.Edition 6th,2001
• Clinical Oncology 
  Chapter: Regulation of the Cell Cycle. 
  Page 10 - 28Bedi A and Kastan MBEditors: Abeloff, Armitage, Lichter, and Niederhuber.Edition 2nd,2000
• Principles and Practice of Oncology 
  Chapter: Molecular biology of cancer: the cell cycle 
  Page 121 - 134Kastan MBEditors: DeVita, Hellman, Rosenberg.Edition 5th,1997
• Current Topics in Microbiology and Immunology. 
  Chapter: Genetic instability and Tumorigenesis. 
  Editors: Kastan MB.Springer-Verlag, Berlin Heidelberg1997
• Cancer Surveys V:29 
  Chapter: Checkpoint controls and cancer. 
  Editors: Kastan MB.1997
• Molecular controls of cell cycle progression following DNA damage: roles of p53 and ataxia-telangiectasia gene products. 
  Kastan MBEditors: E. Mihich and R.T. Schimke.Plenum Press1994
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Lectures

• Genome Dynamics in Neuroscience 
  Hong Kong - 1/1/2017
• Ataxia Telangiectasia Workshop 
  Milan, Italy - 1/1/2017
• Mitochondria and Cancer 
  1/1/2015
• DNA Repair Symposium 
  Washington State University - 1/1/2015
• Particle/Photon Radiotherapy Symposium 
  Denver, CO - 1/1/2014
• Frontiers in Oncology series 
  University of Maryland Cancer Center - 1/1/2014
• Frontiers in Cancer Science 
  Singapore - 1/1/2014
• Frontiers in Cancer Prevention 
  New Orleans, LA - 1/1/2014
• DNA Damage Responses Symposium 
  1/1/2014
• Cancer Biology Seminar Series 
  University of Wisconsin, Madison, WI - 1/1/2013
• International Workshop on A-T/ATM 
  Birmingham, United Kingdom - 1/1/2013
• Model Organisms to Human Biology 
  Washington, DC - 1/1/2012
• Cell Cycle and Cancer 
  Saint Malo, France - 1/1/2011
• Oncology at the Limits 
  Stockholm, Sweden - 1/1/2011
• Genome Instability and DNA Repair 
  Keystone, CO - 1/1/2011
• Synthetic Lethality and Therapeutically Exploiting the Addictions of Cancer 
  Orlando, FL - 1/1/2010
• Protein Translation and Cancer 
  Coronado, CA - 1/1/2010
• Energy Metabolism, Cell Cycle and Cancer 
  1/1/2010
• Telomere Biology and DNA Repair 
  Brisbane, Australia - 1/1/2009
• Emerging Tumor Suppressors 
  Taos, NM - 1/1/2009
• DNA Damage and Cell Cycle Checkpoints Symposium 
  Denver, CO - 1/1/2009
• Genomics and Post-Genomics of Hematological Malignancies Symposium 
  Chaim Sheba Hospital, Israel - 1/1/2007
• Genome Instability and Repair 
  Breckenridge, CO - 1/1/2007
• Mechanisms and Models of Cancer 
  La Jolla, CA - 1/1/2007
• Regulation by Intrinsic and Microenvironmental Factors 
  Portland, OR - 1/1/2006
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Other

• Ataxia-telangiectasia: defective in a p53-dependent signal transduction pathway. 
  Kastan MB, Ataxia-Telangiectasia Workshop V
  1/1/1993
• DNA Methylation in Human Fibroblasts Following DNA Damage and Repair 
  Kastan MB, Ph.D. Thesis
  Washington University School of Medicine, St. Louis, MO - 1/1/1984