Overview of Dr. Kaplitt
Dr. Kaplitt combines surgical expertise with advanced training in state-of-the-art stereotactic techniques to provide patients with effective, minimally invasive treatments for degenerative disorders, including Parkinson’s disease, essential tremor, and dystonia. He also uses these methods to provide novel treatments for psychiatric disorders such as obsessive-compulsive disorder as well as for experimental treatment of major depression and drug addiction. In addition, he is an expert in the use of implanted devices for the treatment of medication-resistant complex pain, spasticity and adult hydrocephalus.
Dr. Kaplitt is also an expert in various surgical therapies for trigeminal neuralgia as well as novel therapies for more complex craniofacial pain. He is recognized for his contributions by leading medical and patient associations, and has repeatedly been named to Castle Connolly’s America’s Top Doctors and New York Metro Top Doctors and regularly appears on the New York Super Doctors list. He is a member of the Executive Committee of the American Society for Stereotactic and Functional Neurosurgery, the society for physicians who specialize in this type of surgery, and he is on the editorial board of the journal Stereotactic and Functional Neurosurgery, the primary international journal in this area.
Dr. Kaplitt has pioneered human gene therapy for neurodegenerative disorders, having performed as a student the first rodent study that used the adeno-associated virus (AAV) vehicle for gene transfer to the brain. He performed the world’s first human gene therapy procedure for Parkinson’s disease, and more recently helped to guide the first successful randomized, double-blind, sham-controlled trial of this experimental treatment, which was the first positive trial of this kind for gene therapy in any brain disorder. He is also pioneering the development of novel deep brain stimulation treatments for psychiatric diseases, including refractory drug addiction.
Office
1275 York Avenue
New York, NY 10065
Education & Training
- New York Presbyterian Hospital (Cornell Campus)Chief Residency, Neurological Surgery, 1999 - 2000
- New York Presbyterian Hospital (Cornell Campus)Residency, Neurological Surgery, 1996 - 2000
- Rockefeller UniversityPost-Doctoral Fellowship, 1995 - 1998
- New York Presbyterian Hospital (Cornell Campus)Internship, Neurological Surgery, 1995 - 1996
- Rockefeller UniversityPost-Doctoral Fellowship, 1993 - 1995
- Weill Cornell MedicineClass of 1995
Certifications & Licensure
- FL State Medical License 2022 - Present
- NY State Medical License 1998 - 2025
- CT State Medical License 2022 - 2024
- American Board of Neurological Surgery Neurological Surgery
Awards, Honors, & Recognition
- America's Top Doctors Castle Connolly
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2013
- Super Doctor SuperDoctors.com
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Clinical Trials
- Safety Study of Subthalamic Nucleus Gene Therapy for Parkinson's Disease Start of enrollment: 2003 Aug 01
- ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease Start of enrollment: 2018 Sep 28
Publications & Presentations
PubMed
- 56 citationsImpact of skull density ratio on efficacy and safety of magnetic resonance–guided focused ultrasound treatment of essential tremorMarissa D'Souza, Kevin S. Chen, Jarrett Rosenberg, W. Jeffrey Elias, Howard M. Eisenberg
Journal of Neurosurgery. 2020-05-01 - 74 citationsLong-Term Expression and Safety of Administration of AAVrh.10hCLN2 to the Brain of Rats and Nonhuman Primates for the Treatment of Late Infantile Neuronal Ceroid Lipof...Dolan Sondhi, Linda K. Johnson, Keith P. Purpura, Sebastien Monette, Mark M. Souweidane
Human Gene Therapy Methods. 2012-09-27 - 96 citationsAAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's DiseaseJonathan B. Rosenberg, Michael G. Kaplitt, Bishnu P. De, Alvin Chen, Thomas Flagiello
Human Gene Therapy. Clinical Development. 2018-03-01
Journal Articles
- Clinical Quantitative Susceptibility Mapping (QSM): Biometal Imaging and Its Emerging Roles in Patient CareGary M Brittenham, Apostolos John Tsiouris, Lawrence Tanenbaum, Ajay Gupta, Martin R Prince, Jonathan W Weinsaft, Susan A Gauthier, Brian H Kopell, Michael G Kaplitt, ..., Journal of Magnetic Resonance Imaging
Authored Content
- Safe and Stable Noninvasive Focal Gene Delivery to the Mammalian Brain Following Focused Ultrasound RelatedApril 2018
- Safe and Stable Noninvasive Focal Gene Delivery to the Mammalian Brain Following Focused Ultrasound RelatedApril 2018
Press Mentions
- A New Lease on Life: Procedure Relieves Patients’ Tremors in Both HandsOctober 24th, 2024
- Magnetic Gene Therapy Enables Precise Brain ControlOctober 15th, 2024
- A Promising Trial Targets a Genetic Risk for Alzheimer’sDecember 2nd, 2022
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Grant Support
- Gene Therapy for Huntington’s DiseaseNIH/NINDS2010–2015
Professional Memberships
- Member
- Fellow
- Member
- Fellow
- Society for Neuro-oncologyMember
- American Society for Stereotactic and Functional NeurosurgeryMember
Insurance Accepted
- Aetna Choice POS II
Aetna HMO
BCBS Blue Card PPO
CIGNA HMO
CIGNA Open Access
CIGNA PPO
Empire BCBS HMO
Empire BCBS PPO
GHI PPOGreat West PPO
HIP of New York - Select PPO
Humana ChoiceCare Network PPO
MagnaCare PPO
MVP Healthcare PPO
Oxford Health Freedom
Oxford Health Liberty
United Healthcare - Direct Choice Plus POS
United Healthcare - Direct Options PPO - Please verify your coverage with the provider's office directly when scheduling an appointment
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