Michael J.AckermanMDPhD

PubMed

• 99 citations
  Identification of a common genetic substrate underlying postpartum cardiac events in congenital long QT syndrome.
  Anant Khositseth, David J. Tester, Melissa L. Will, Carla M Bell, Michael J. Ackerman
  Heart Rhythm. 2004-05-01
• 213 citations
  Long QT Syndrome and Pregnancy
  Rahul Seth, Arthur J. Moss, Scott McNitt, Wojciech Zareba, Mark L. Andrews
  Journal of the American College of Cardiology. 2007-03-13
• 157 citations
  2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary
  Sana M. Al-Khatib, William G. Stevenson, Michael J. Ackerman, William J. Bryant, David J. Callans
  Circulation. 2017-10-01

Journal Articles

• Electromechanical Window Negativity in Genotyped Long-QT Syndrome Patients: Relation to Arrhythmia Risk  
  Ter Bekke RM, Haugaa KH, van den Wijngaard A, Bos JM, Ackerman MJ, Edvardsen T, Volders PG, Eur Heart Journal, 9/8/2014
• Reduced Junctional Na/Ca2+-exchanger Activity Contributes to Sarcoplasmic Reticulum Ca2+ Leak in Junctophilin-2 Deficient Mice  
  Wang W, Landstrom AP, Wang Q, Munro ML, Beavers D, Ackerman MJ, Soeller C, Wehrens XH, Am J Physiol Heart Circ Physiol, 9/5/2014
• Compound Heterozygous Mutations in the SCN5A-Encoded Nav15 Cardiac Sodium Channel Resulting in Atrial Standstill and His-Purkinje System Disease  
  Baskar S, Ackerman MJ, Clements D, Mayuga KA, Aziz PF, J Pediatr, 8/27/2014
• Epilepsy Misdiagnosed as Long QT Syndrome: It Can Go Both Ways  
  Medford BA, Bos JM, Ackerman MJ, Congenit Heart Dis, 1/1/2014
• A KCNQ1 Mutation Contributes to the Concealed Type 1 Long QT Phenotype by Limiting the Kv71 Channel Conformational Changes Associated with Protein Kinase a Phosphoryla...  
  Bartos DC, Giudicessi JR, Tester DJ, Ackerman MJ, Ohno S, Horie M, Gollob MH, Burgess DE, Delisle BP, Heart Rhythm, 1/1/2014
• Confirmation of Cause and Manner of Death via a Comprehensive Cardiac Autopsy Including Whole Exome Next-Generation Sequencing  
  Loporcaro CG, Tester DJ, Maleszewski JJ, Kruisselbrink T, Ackerman MJ, Arch Pathol Lab Med, 1/1/2014
• Sympathetic Nerve Activity and Simulated Diving in Healthy Humans  
  Shamsuzzaman A, Ackerman MJ, Kuniyoshi FS, Accurso V, Davison D, Amin RS, Somers VK, Autonomic Neuroscience, 1/1/2014
• Surgical Myectomy Improves Pulmonary Hypertension in Obstructive Hypertrophic Cardiomyopathy  
  Geske JB, Konecny T, Ommen SR, Nishimura RA, Sorajja P, Schaff HV, Ackerman MJ, Gersh BJ, Eur Heart Journal, 1/1/2014
• Is Sudden Unexplained Nocturnal Death Syndrome in Southern China a Cardiac Sodium Channel Dysfunction Disorder?  
  Liu C, Tester DJ, Hou Y, Wang W, Lv G, Ackerman MJ, Makielski JC, Cheng J, Forensic Sci Int, 1/1/2014
• Pathogeneses of Sudden Cardiac Death in National Collegiate Athletic Association Athletes  
  Harmon KG, Drezner JA, Maleszewski JJ, Lopez-Anderson M, Owens D, Prutkin JM, Asif IM, Klossner D, Ackerman MJ, Circ Arrhythm Electrophysiol, 1/1/2014
• Association of Common Variants in NOS1AP Gene with Sudden Unexplained Nocturnal Death Syndrome in the Southern Chinese Han Population  
  Huang L, Yu Y, Chen Y, Tester DJ, Tang S, Ackerman MJ, Yuan Z, Cheng J, Int J Legal Med, 1/1/2014
• Characterization of a Phenotype-Based Genetic Test Prediction Score for Unrelated Patients with Hypertrophic Cardiomyopathy  
  Bos JM, Will ML, Gersh BJ, Kruisselbrink TM, Ommen SR, Ackerman MJ, Mayo Clin Proc, 1/1/2014
• Response to Letters regarding Article, "Stroke or Transient Ischemic Attack in Patients with Transvenous Pacemaker or Defibrillator and Echocardiographically Detected ...  
  DeSimone CV, Friedman PA, Noheria A, Ackerman MJ, Asirvatham SJ, DeSimone DC, Aakre CA, Vaidya VR, Noheria A, Patel NA, Bdeir S, Slusser JP, Hodge DO, Rabinstein AA, Circulation, 1/1/2014
• Characterization of SEMA3A-encoded Semaphorin as a Naturally Occurring Kv43 Protein Inhibitor and Its Contribution to Brugada Syndrome  
  Boczek NJ, Ye D, Johnson EK, Wang W, Crotti L, Tester DJ, Dagradi F, Mizusawa Y, Torchio M, Alders M, Giudicessi JR, Wilde AA, Schwartz PJ, Nerbonne JM, Ackerman MJ, Circ Res, 1/1/2014
• Congenital Long QT Syndrome and Concomitant Early Repolarization Pattern: A Benign Association or an ICD-worthy One?  
  DeSimone CV, Ackerman MJ, Heart Rhythm, 1/1/2014
• Beta-Blockers in the Treatment of Congenital Long QT Syndrome: Is One Beta-Blocker Superior to Another?  
  Wilde AA, Ackerman MJ, J Am Coll Cardiol, 1/1/2014
• Unctophilin-2 Is Necessary for T-tubule Maturation during Mouse Heart Development  
  Reynolds JO, Chiang DY, Wang W, Beavers DL, Dixit SS, Skapura DG, Landstrom AP, Song LS, Ackerman MJ, Wehrens XH, Cardiovasc Res, 7/1/2013
• Left Cardiac Sympathetic Denervation in Long QT Syndrome: Analysis of Therapeutic Non-Responders  
  Bos JM, Bos KM, Johnson JN, Moir C, Ackerman MJ, Circ Arrhythm Electrophysiol, 5/31/2013
• Exome Sequencing and Systems Biology Converge to Identify Novel Mutations in the L-Type Calcium Channel, CACNA1C, Linked to Autosomal Dominant Long QT Syndrome  
  Boczek NJ, Best JM, Tester DJ, Giudicessi JR, Middha S, Evans JM, Kamp TJ, Ackerman MJ, Circ Cardiovasc Genet, 5/15/2013
• Sudden Cardiac Arrest in a Young Patient with Hypertrophic Cardiomyopathy and Zero Canonical Risk Factors: The Inherent Limitations of Risk Stratification in Hypertrop...  
  Kohorst JJ, Bos JM, Hagler DJ, Ackerman MJ, Congenit Heart Dis, 5/7/2013
• The Long QT Syndrome: A Transatlantic Clinical Approach to Diagnosis and Therapy  
  Schwartz PJ, Ackerman MJ, Eur Heart J, 3/18/2013
• A KCNQ1 Mutation Causes a High Penetrance for Familial Atrial Fibrillation  
  Bartos DC, Anderson JB, Bastiaenen R, Johnson JN, Gollob MH, Tester DJ, Burgess DE, Homfray T, Behr ER, Ackerman MJ, Guicheney P, Delisle BP, JCE, 1/1/2013
• Institution-Wide QT Alert System Identifies Patients With a High Risk of Mortality  
  Haugaa KH, Bos JM, Tarrell RF, Morlan BW, Caraballo PJ, Ackerman MJ, Mayo Clin Proc, 1/1/2013
• Prevention of Sudden Cardiac Death with Implantable Cardioverter-defibrillators in Children and Adolescents with Hypertrophic Cardiomyopathy  
  Maron BJ, Spirito P, Ackerman MJ, Casey SA, Semsarian C, Estes NA 3rd, Shannon KM, Ashley EA, Day SM, Pacileo G, Formisano F, Devoto E, Anastasakis A, Bos JM, Woo A, A..., J Am Coll Cardiol, 1/1/2013
• Personalized Medicine: Genetic Diagnosis for Inherited Cardiomyopathies/Channelopathies  
  Ackerman MJ, Marcou CA, Tester DJ, Rev Esp Cardiol, 1/1/2013
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Books/Book Chapters

• Forensic Pathology of Infancy and Childhood 
  Chapter: Chaper 31 Cardiac Channelopathies and the Molecular Autopsy 
  Page 899 - 942Tester DJ, Ackerman MJSpringer Publishing, New York, NY2014
• Management of Cardiac Arrhythmias 
  Chapter: Chapter 19, Long QT Syndrome 
  Page 419 - 440Johnson JN, Ackerman MJSpringer Publishing, New York, NYEdition 2nd,2010
• Electrical Diseases of the Heart; Genetics, Mechanisms, Treatment, Prevention 
  Chapter: Chapter 62. Sudden Cardiac Death in Infancy: Focus on Prolonged Repolarization 
  Page 924 - 933Schwartz PJ, Stramba-Badiale M, Crotti L, Ackerman MJSpringer Publishing, New York, NY2008
• Electrical Diseases of the Heart; Genetics, Mechanisms, Treatment, Prevention 
  Chapter: Chapter 40. Arrhythmogenic Malignancies in Hypertrophic Cardiomyopathy 
  Page 610 - 626Menon SC, Bos, JM, Ommen SR, Ackerman MJSpringer Publishing, New York, NY2008
• Electrical Diseases of the Heart; Genetics, Mechanisms, Treatment, Prevention 
  Chapter: Chapter 31. Congenital Long QT Syndrome 
  Page 462 - 482Ackerman MJ, Khositseth A, Tester DJ, Schwartz PJSpringer Publishing, New York, NY2008
• Electrical Diseases of the Heart; Genetics, Mechanisms, Treatment, Prevention 
  Chapter: Chapter 30: Genetic Testing 
  Page 444 - 458Tester DJ and Ackerman MJSpringer Publishing, New York, NY2008
• Electrical Diseases of the Heart; Genetics, Mechanisms, Treatment, Prevention 
  Chapter: Chapter 28: Provocative testing in Inherited Arrhythmias 
  Page 424 - 433Shimizu W and Ackerman MJSpringer Publishing, New York, NY2008
• Electrical Diseases of the Heart; Genetics, Mechanisms, Treatment, Prevention 
  Gussak I, Antzelevitch C, Ackerman MJ, Friedman PA, Shen WKSpringer Publishing, New York, NY2008
• Mayo Clinic Cardiology: Concise Textbook 
  Chapter: Cardiac Channelopathies 
  Page 335 - 344Bunch TJ and Ackerman MJMayo Clinic Scientific Press: Informa Healthcare, Rochester, MNEdition 3rd,2007
• Mayo Clinic Cardiology: Concise Textbook 
  Chapter: Heritable Cardiomyopathyies 
  Page 425 - 442Menon SC, Ommen SR, Ackerman MJMayo Clinic Scientific Press: Informa Healthcare, Rochester, MNEdition 3rd,2007
• Molecular Pathology in Clinical Practice 
  Chapter: Chapter 14: Cardiovascular Disease 
  Page 161 - 177Khositseth A and Ackerman MJSpringer Publishing, New York, NY2007
• Cardiovascular Disease: Methods and Protocols 
  Chapter: Chapter 13: Mutation Detection in Congenital Long QT Syndrome 
  Page 181 - 207Tester DJ, Will ML, Ackerman MJEditors: Wang QK.Humana Press Inc., Totowa, New Jersey2006
• Cardiac Electrophysiology: From Cell to Bedside 
  Chapter: Chapter 4. Intracellular Signaling and Regulation of Cardiac Ion Channels 
  Page 33 - 41Khositseth A, Clapham DE, and Ackerman MJEditors: Zipes DP, Jalife J.W.B. Saunders, Philadelphia2004
• Molecular Basis of Cardiovascular Disease: A Companion to Braunwald's Heart Disease 
  Chapter: Excitability and Conduction 
  Page 311 - 335Ackerman MJ and Clapham DEEditors: Kenneth R. Chien.W.B. Saunders, PhiladelphiaEdition Seco,2004
• Cardiac Repolarization: Bridging Basic and Clinical Science 
  Chapter: Clinical Evaluation, Risk Stratification, and Management of Congenital Long QT Syndrome 
  Page 447 - 480Khositseth A and Ackerman MJEditors: Gussak I and Antzelevitch C.Humana Press, Totowa NJ2003
• Cardiac Electrophysiology: From Cell to Bedside 
  Chapter: G Proteins and Ion Channels 
  Page 112 - 118Ackerman MJ and Clapham DEEditors: Zipes DP, Jalife J.W.B. Saunders, Philadelphia2000
• Molecular Basis of Cardiovascular Disease: A Companion to Braunwald's Heart Disease 
  Chapter: Normal Cardiac Electrophysiology. Understanding the Action Potential in the Human Heart 
  Page 281 - 301Ackerman MJ and Clapham DEEditors: Chien KR and Braunwald E.W.B. Saunders, Philadelphia1999
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Abstracts/Posters

• Automatic External Defibrillator Rescues Among Children with Diagnosed and Treated Long QT Syndrome
  Pundi KN, Bos JM, Cannon BC, Ackerman MJ, Heart Rhythm, 1/1/2014
• Minimally Invasive Epicardial ICD Placement: An Effective Alternative to the Transvenous Approach
  Schneider A, Burkhard H, Ackerman MJ, Dearani JA, Cannon BC, Heart Rhythm, 1/1/2014
• Personal Wearable Defibrillators for Adults with Long QT Syndrome
  Owen HJ, Bos JM, Ackerman MJ, Heart Rhythm, 1/1/2014
• Short and Long-Term ECG Changes After Left Cardiac Sympathetic Denervation in Patients with Long QT Syndrome
  DeSimone CV, Bos JM, Patel N, Liang J, Hodge D, Noheria A, Asirvatham SJ, Ackerman MJ, Heart Rhythm, 1/1/2014
• Functional Characterization of a Novel Long QT Syndrome-Susceptibility Mutation, E141G, in CALM1-Encoded Calmodulin
  Boczek NJ, Ye D, Will M, Tester D, Shah MJ, Ackerman MJ, Heart Rhythm, 1/1/2014
• LMNA-Mediated Arrhythmogenic Right Ventricular Cardiomyopathy and Charcot-Marie Tooth Type 2B1: A Patient Discovered Unifying Diagnosis
  Liang JJ, Goodsell K, Grogan M, Ackerman MJ, Heart Rhythm, 1/1/2014
• Left Cardiac Sympathetic Denervation for CPVT
  Dusi, Veronica, De Ferrari GM, Bos JM, Moir C, Shkolnikova MA, Abrams DJ, Crotti L, Wilde AAM, Ackerman MJ, Schwartz PJ, Heart Rhythm, 1/1/2014
• Sudden Cardiac Arrest During Sex in Patients with either CPVT or LQTS: A Rare but Shocking Experience
  Loar R, Bos JM, Cannon BC, Ackerman MJ, Heart Rhythm, 1/1/2014
• Sudden Arrhythmic Death Syndrome and the Impact on Insurability: A North American Survey
  Mohammed S, Lim Z, Potts JE, Etheridge SP, Lara A, Husband PR, Sherwin ED, Ackerman MJ, Sanatani S, Heart Rhythm, 1/1/2014
• In-Silico Tools Including the Probability of Pathogenicity Calculator and the Identification of SCN5A Variants with Aberrant Functional Properties
  Kapplinger JD, Ye D, Giudicessi JR, Tester DJ, Valdivia CR, Makielski JC, Wilde AAM, Ackerman MJ, Heart Rhythm, 1/1/2014
• Whole Exome Sequencing Coverage Analysis of Genes Associated with Life-threatening Metabolic Disorders, Cardiac Channelopathies, and Cardiomyopathies
  Middha S, Tester DJ, Kapplinger JD, Boczek NJ, Ackerman MJ., Heart Rhythm, 1/1/2014
• Outcome of Left Cardiac Sympathetic Denervation (LCSD) as Monotherapy in Patients with Long QT Syndrome
  Bos JM, Owen H, Moir C, Ackerman MJ, Heart Rhythm, 1/1/2014
• Breath Holding Spells in Children with Long QT Syndrome
  Robinson JA, Bos JM, Etheridge SP, Ackerman MJ, Heart Rhythm, 1/1/2014
• Characterization of SEMA3A-Encoded Semaphorin as a Naturally Occurring KV4.3 Protein Inhibitor and its Contribution to Brugada Syndrome
  Boczek NJ, Ye D, Wang D, Crotti L, Tester D, Nerbonne JM, Schwartz PJ, Ackerman MJ, Heart Rhythm, 1/1/2014
• Spectrum and Prevalence of Mutations Involving BRS1-12-Susceptibility Genes in a Cohort of Unrelated Patients Referred for Brugada Syndrome Genetic Testing
  Kellen CA, Crotti L, Tester DJ, Castelletti S, Giudicessi JR, Torchio M, Medeiros-Domingo A, Will ML, Dagradi F, Schwartz PJ, Ackerman MJ, Heart Rhythm, 1/1/2012
• Comparison of Rare Genetic Variation in Cases and Controls in Minor Long QT Syndrome (LQTS)-Susceptibility Genes Reveals a Low Signal-to-Noise Ratio
  Callis TE, Pollevik GD, Tester DJ, Ackerman MJ, Salisbury BA, Heart Rhythm, 1/1/2012
• Videoscopic Left Cardiac Sympathetic Denervation for Patients with Recurrent Ventricular Fibrillation of Malignant Ventricular Arrhythmia Syndromes Besides Autosomal D...
  Coleman M, Johnson JN, Bos JM, Owen HJ, Deschamps C, Moir C, Ackerman MJ, Heart Rhythm, 1/1/2012
• Competitive Sports Participation in Athletes with Congenital Long QT Syndrome and an Implantable Cardioverter Defibrillator
  Johnson JN, Cannon BC, Ackerman MJ, Heart Rhythm, 1/1/2012
• Electrophysiological Mechanisms by Which Quinidine Reduces the Genetic Enhancement of the Transient Outward KV4.3 Current in KCND3-Mediated Brugada Syndrome
  Ye D, Giudicessi JR, Tester DJ, Ackerman MJ, Heart Rhythm, 1/1/2012
• Assessment of Variants Identified in ARVC-Associated Genes in Samples From the 1000 Genome Project and the Exome Chip Design Project
  Kapplinger JD, Salisbury BA, Tester DJ, Callis TE, Pollevik GD, van Tintelen P, Calkins, H, Judge DP, Wilde AAM, Ackerman MJ, Heart Rhythm, 1/1/2012
• RYR2-Mediated Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) in Patients with Hypertrophic Cardiomyopathy
  Kellen CA, Bos JM, Will ML, Medeiros-Domingo A, Gersh BJ, Ommen SR, Ackerman MJ, Heart Rhythm, 1/1/2012
• Conservation Analysis of the C-Terminal Region of KCNQ1-Encoded KV7.1 Potassium Channel Identifies Regions of High and Low Probability of Pathogenicity for Type 1 Long...
  Salisbury B, Callis TE, Susswein L, Pollevik GD, Kapplinger JD, Tester DJ, Alders M, Wilde AAM, Ackerman MJ, Heart Rhythm, 1/1/2012
• Identification of Putative Sudden Death Predisposing Mutations in Antepartum Intrauterine Detal Demise: A Cardiac Channel Molecular Autopsy of 98 Stillbirths
  Tester DJ, Crotti L, White WM, Bartos DC, Will ML, Velasco EJ, Bair JJ, Insolia R, Ghidoni A, Facchinetti F, Cetin I, Pfeufer A, Van Dyke DL, Wick MJ, Brost BC, Delisl..., Heart Rhythm, 1/1/2012
• Maternal Mosaicism Confounds the Neonatal Diagnosis of Type 1 Timothy Syndrome
  Dufendach KA, Giudicessi JR, Boczek NJ, Tester DJ, Ackerman MJ, Heart Rhythm, 1/1/2012
• The KCNQ1 Variant R231H Confers a High Risk for Early Onset Atrial Fibrillation
  Bartos DC, Anderson JB, Burgess DE, Johnson JN, Tester DJ, Bastiaenen R, Behr ER, Ackerman MJ, Guicheney P, Delisle BP, Heart Rhythm, 1/1/2012
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Lectures

• The Cardiac Channelopathies 
  Moscow, Russia - 6/12/2014
• The Molecular Autopsy for Sudden Unexplained Death in the Young 
  Moscow, Russia - 6/12/2014
• Latest Diagnostic and Treatment Strategies for the Congenital Long QT Syndromes 
  MA General Hospital for Children, Boston, MA - 5/15/2014
• Videoscopic Left Cardiac Sympathetic Denervation for LQTS and CPVT 
  San Francisco, CA - 5/9/2014
• Presention Title: Getting out of Genetic Purgatory: Resolving the VUS Issue 
  San Francisco, CA - 5/8/2014
• State of the Art: The Cardiac Channelopathies 
  Manhattan, NY - 4/11/2014
• State of Postmortem Genetic Testing for Autopsy Negative Sudden Unexplained Death (aka, The Molecular Autopsy 
  Lancaster General, Lancaster, Philadelphia, PA - 3/27/2014
• The Cardiac Channelopathies: Who needs an ICD? 
  Salt Lake City, UT - 3/7/2014
• Update on Management of Long QT Syndrome and Brugada Syndrome: Role of ICD, Pharmacologic Therapy, and Genetic Testing 
  Cancun, Mexico - 2/28/2014
• ECGS for Experts I 
  Cancun, Mexico - 2/28/2014
• The Cardiac Channelopathies: Who Needs and ICD? 
  Kauai, HI - 1/28/2014
• Arrhythmias in Athletes: When are Sports Not Worth the Risk? 
  Kauai, HI - 1/28/2014
• Denervation Therapy for VF Syndromes 
  Kauai, HI - 1/28/2014
• Update on Management of Long QT Syndrome and Brugada Syndrome: Role of ICD, Pharmacologic Therapy, and Genetic Testing 
  Nanjing, China - 1/8/2014
• Electrophysiology Review for Boards and Recertification 
  Mayo School of Continuous Professional Development, Rochester, Minnesota - 8/23/2013
• MMVR20 / NextMed (Medicine Meets Virtual Reality) 2013 
  Aligned Management Associates, Inc., San Diego, California - 2/20/2013
• Hypertrophic Cardiomyopathy Diagnosis and Treatment 
  Tulsa, OK - 2/8/2013
• Is Genetic Testing for Cardiomyopathies/Channelopathies Ready for the Big Screen? 
  Tulsa, OK - 2/8/2013
• Cardiac Channelopathies for the Boards 
  Rochester, MN - 2/7/2013
• Videoscopic Left Cardiac Sympathetic Denervation for Potentially Lethal VF Syndromes 
  Minneapolis, MN - 12/3/2012
• Athletes with Heart Diseases: The ESC Guidelines Are Too Strict 
  Los Angeles - 11/4/2012
• What Explains the Rest of Congenital LQTS?, Grand Rounds 
  UCLA, Los Angeles, CA - 11/2/2012
• The Latest Treatment Strategies for Channelopathies,Grand Rounds 
  CHOC Children's Hospital, Orange, CA - 11/2/2012
• From Detassling Corn to Decoding Sudden Death - Who/What Should I Be/Do When I Grow Up? 
  Rochester, MN - 10/16/2012
• Latest Treatment Strategies for SADS Conditions 
  Salt Lake City, UT - 10/13/2012
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Other

• Medical Edge 
• WCCO Lifeline: SUDs 
• Lifeline: Discovery Health 
• Medical Mysteries: ABC Primetime 
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