Michael M Grunstein MD PhD

Pediatric Pulmonology•Studio City, CA

Professor Emeritus, University of Pennsylvania Perelman School of Medicine

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4202 Babcock AvenueStudio City, CA 91604
Phone+1 610-909-6235
Fax+1 888-431-8921

Summary

Michael Grunstein, MD, PhD is a specialist in pediatric pulmonology. He completed his PhD and medical degrees at McGill University Faculty of Medicine, followed by a residency in Pediatrics at the University of Colorado, and a fellowship in Pulmonary Disease at the University of California, San Francisco. Dr. Grunstein has held faculty positions including Professor of Pediatrics at the University of Pennsylvania School of Medicine and Chief of Pulmonary Medicine at Children's Hospital of Philadelphia. He has published extensively on research in asthma pathogenesis, with emphasis on signaling mechanisms in airway smooth muscle, contributing significantly to the field. He received the Richard Farr Award for his contributions to the application of basic science to allergic diseases and has been an invited speaker widely on related topics in pulmonary medicine and pathobiology. He is currently Professor Emeritus at the Perelman School of Medicine at University of Pennsylvania, and lives in Studio City, CA.

Education & Training

University of PennsylvaniaM.A.(Hon), 1987
University of California (San Francisco)Fellowship, Pulmonary Disease and Critical Care Medicine, 1979 - 1980
University of ColoradoResidency, Pediatrics, 1977 - 1979
McGill University Faculty of MedicineClass of 1977, MDCM
McGill UniversityPh.D., Pulmonary Physiology, 1974
McGill UniversityM.Sc., Pulmonary Physiology, 1972
Sir George Williams UniversityB.Sc., 1970

Certifications & Licensure

CA State Medical License 1978 - 2026
PA State Medical License 1987 - 2014
CO State Medical License 1978 - 1989
American Board of Pediatrics Pediatrics

Awards, Honors, & Recognition

Invited Speaker: “Mechanisms of induction of the proasthmatic phenotype in airway smooth muscle." Merck Pharmaceutical Co., 2002
Richard Farr Award - For outstanding contributions in the application of basic science to allergic diseases Colorado Allergy Society, 2002
Invited Speaker: “How Do Infammation and Infections Affect Airway Smooth Muscle Function” American Academy of Allergy, Asthma, and Immunology, 2002
Invited Speaker: “Effect of Respiratory Infections on Airway Smooth Muscle Function” American Academy of Allergy, Asthma, and Immunology, 2001
Invited Speaker: "Autocrine Signaling in Airway Smooth Muscle" American Thoracic Society, 1999
Chair and Invited Speaker: "New Concepts on the Pathogenesis of Asthma: State-of-the-Art" American Pediatric Society and Society for Pediatric Research, 1998
Invited Keynote Speaker: International Symposium on Asthma. "New Concepts on the Pathogenesis of Asthma" 1998
Invited Speaker: Transatlantic Airway Conference "Regulation of Second Messengers Associated with Airway Smooth Muscle Contraction and Relaxation" 1997
Member Program Committee of Pediatric Academic Societies, 1997
The Best Doctors in America 1996
Co-Director, Medical Program American Austrian Foundation, 1995
Elected Member The American Society for Clinical Investigation, 1991
Invited Keynote Speaker: "Regulation of Airway Smooth Muscle Responses: Signal Transduction and Second Messengers. State of the Art." American Physiological and American Thoracic Societies, 1989
Individual Fellowship Award NIH, 1979
Quebec Research Award Medical Research Council of Canada, 1975
Medical Scientist Fellowship Award Canadian Heart Foundation, 1973
Dean's Honor List McGill University, 1972
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Publications & Presentations

PubMed

31 citations
Effect of corticosteroids on bronchial responsiveness to methacholine in asthmatic children.
Rajesh G. Bhagat, Michael M. Grunstein
The American Review of Respiratory Disease. 2015-05-14
5 citations
Constitutively Active Signaling by the G Protein βγ-Subunit Mediates Intrinsically Increased Phosphodiesterase-4 Activity in Human Asthmatic Airway Smooth Muscle Cells
Aihua Hu, Barry L. Diener, Maureen B. Josephson, Michael M. Grunstein
Plos One. 2015-03-05
4 citations
Smooth Muscle Hypercontractility in Airway Hyperresponsiveness: Innate, Acquired, or Nonexistent?
Ynuk Bossé, Eric Rousseau, Yassine Amrani, Michael M. Grunstein
Journal of Allergy. 2013-06-17

Journal Articles

Homeostatic glucocorticoid signaling in airway smooth muscle: A roadmap to asthma pathogenesis
Grunstein M.M., Frontiers in Endocrinology-Cellular, 1/4/2023
Smooth Muscle Hypercontractility in Airway Hyperresponsiveness: Innate, Acquired, or Nonexistent?
Bosse, Y., Rousseau, E., Amrani, Y., and Grunstein, M.M., J. Allergy, 1/1/2013
G protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma.
Nino G, Hu A, Grunstein J.S, McDonough J, Kreiger P.A, Josephson M.B, Choi J.K, G runstein M . M., PLoS One, 1/1/2012
7q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Ameri...
Flory JH, Sleiman PM, Christie JD, Annaiah K, Bradfield J, Kim CE, Glessner J, Imielinski M, Li H, Frackelton EC, Cuiping H, Otieno G, Thomas K, Smith R, Glaberson W, ..., J Allergy Clin Immunol, 1/1/2009
Th2 cytokine-induced upregulation of 11{beta}-hydroxysteroid dehydrogenase-1 facilitates glucocorticoid suppression of proasthmatic airway smooth muscle function
Hu A, Fatma S, Cao J, Grunstein J.S, Nino G, Grumbach Y, G runstein M. M, Am J Physiol Lung Cell Mol Physiol, 1/1/2009
Prolonged heterologous Beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction
Hu, A., G. Nino, J. S. Grunstein, S. Fatma, and M .M. G runstei n., Am J. Physiol. Lung Cell Mol Physiol., 1/1/2008
Superantigen presentation by airway smooth muscle to CD4+ T lymphocytes elicits reciprocal pro-asthmatic changes in airway function
Veler, H., A. Hu, S. Fatma, J.S. Grunstein, C.M. DeStephan, D. Campbell, J.S. Orange, and M .M. G runstei n., J. Immunol., 1/1/2007
Regulation of toll-like receptor 4-induced pro-asthmatic changes in airway smooth muscle function by opposing actions of ERK1/2 and p38 MAPK signaling
Shan, X., A. Hu, H. Veler, S. Fatma, J.S. Grunstein, S. Chuang, and M .M. Grunstein, Am. J. Physiol. Lung Cell. Mol. Physiol., 1/1/2006
Pro-Asthmatic effects and mechanisms of action of the dust mite allergen, Der p 1, in airway smooth muscle
G runstein, M . M. , Veler, H., Shan, X., Larson, J., Grunstein, J. S., and S. Chuang, J. Allergy Clin. Immunol., 1/1/2005
Role and regulation of IL-1 molecules in pro-asthmatic sensitized airway smooth muscle
Whelan, R., C. Kim, M. Chen, J. Leiter, M .M. G runstei n and H. Hakonarson, Eur. Respir. J., 1/1/2004
Autocrine regulation of airway smooth muscle responsiveness
Hakonarson, H., and M .M. G runstei n, Respir. Physiol. Neurobiol., 1/1/2003
T lymphyocyte-mediated changes in airway smooth muscle responsiveness are attributed to induced autocrine release and actions of interleukin (IL)-5 and IL-1Beta
Hakonarson, H., R. Whelan, J. Leiter, C. Kim, M. Chen, D. Campbell, and M .M. Grunstein, J. Allergy Clin. Immunol., 1/1/2002
IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle
Hakonarson, H., R. Whelan, J. Leiter, C. Kim, M. Chen, D. Campbell, and M .M., Am. J. Physiol. Lung Cell. Mol. Physiol., 1/1/2002
Association between IL-1Beta/TNF-alpha-induced glucocorticoid-sensitive changes in multiple gene expression and altered responsiveness in airway smooth muscle
Hakonarson, H., E. Halapi, R. Whelan, J. Gulcher, K. Stefansson, and M .M. Grunstein, Am. J. Respir. Cell Mol. Biol., 1/1/2001
Rhinovirus elicits pro-asthmatic changes in airway responsiveness independently of viral infection
G runstein, M .M ., H. Hakonarson, R. Whelan, Z. Yu, J.S. Grunstein, and S. Chuang., J. Allergy Clin. Immunol., 1/1/2001
Autocrine signaling by IL-10 mediates altered responsiveness of atopic sensitized airway smooth muscle
G runstein, M .M ., H. Hakonarson, J. Leiter, M. Chen, R. Whelan, J.S. Grunstein, and S. Chuang., Am. J. Physiol. Lung Cell. Mol. Physiol., 1/1/2001
Bi-directional activation between human airway smooth muscle cells and T lymphocytes: Role in induction of altered airway responsiveness
Hakonarson, H., C. Kim, R. Whelan, D. Campbell, and M .M. G runstei n, J. Immunol., 1/1/2001
Mechanism of cooperative effects of rhinovirus and atopic sensitzation on airway responsiveness
G runstein, M .M ., H. Hakonarson, R.L. Hodinka, N. Maskeri, C. Kim, and S. Chuang., Am. J. Physiol. Lung Cell. Mol. Physiol., 1/1/2001
Methacholine induced temporal changes in airway geometry and lung density by CT
Amirav, I., S.S. Kramer, M .M. G runstei n, and E.A. Hoffman., Chest, 1/1/2001
Autocrine cytokine signaling mediates effects of rhinovirous on airway responsiveness
G runstein, M .M ., H. Hakonarson, N. Maskeri, and S. Chuang., Am. J. Physiol. Lung Cell. Mol. Physiol., 1/1/2000
Intrinsic ICAM-1/LFA-1 activation mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle
G runstein, M .M ., H. Hakonarson, N. Maskeri, C. Kim, and S. Chuang., Am. J. Physiol. Lung Cell. Mol. Physiol., 1/1/2000
Autocrine interaction between interleukin (IL)-5 and IL-1ß mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle
Hakonaron, H., N. Maskeri, C. Carter, S. Chuang, and M .M. G runstei n., J. Clin. Invest., 1/1/1999
Altered expression and action of the low-affinity IgE receptor, FceRII (CD23), in asthmatic airway smooth muscle
Hakonarson, H., C. Carter, C. Kim, and M .M. G r unstei n, J. Allergy Clin. Immunol., 1/1/1999
Regulation of TH1- and TH2-type cytokine expression and action in atopic asthmatic sensitized airway smooth muscle
Hakonarson, H., N. Maskeri, C. Carter, and M .M. G runstei n., J. Clin. Invest., 1/1/1999
Rhinovirus-mediated changes in airway smooth muscle responsiveness: Induced autocrine role of interleukin-1Beta
Hakonarson, H., C. Carter, N. Maskeri, R. Hodinka, and M .M. G runstei n., Am. J. Physiol. (Lung Cell. Mol. Physiol.), 1/1/1999
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Books/Book Chapters

Institute of Medicine
Chapter: "Clearing the Air: Asthma and Indoor Air Exposure
National Academy of Sciences; National Academy Press, Washington, DC2000
Asthma
Chapter: Two-Volume Textbook
Editors: P.J. Barnes, M.M. Grunstein, A.R. Leff, A. Woolcock.Lippincott-Raven Publishers, Philadelphia/New York1997
ASTHMA
Grunstein, M.M.Editors: P.J. Barnes, M.M. Grunstein, A.R. Leff, A. Woolcock.Lippincott-Raven Publishers1997
ASTHMA
Chapter: Receptor Mechanisms
Barnes, P.J., and M.M. GrunsteinEditors: P.J. Barnes, M.M. Grunstein, A.R. Leff, A. Woolcock.Lippincott-Raven Publishers, Philadelphia, New York1997
ASTHMA
Chapter: Airway smooth muscle hyperplasia and hypertrophy
Panettieri, R.A., Jr., and M.M. GrunsteinEditors: P.J. Barnes, M.M. Grunstein, A.R. Leff, A. Woolcock.Lippincott-Raven Publishers, Philadelphia, New York1997
ASTHMA
Chapter: Management of childhood asthma
Hakonarson, H., and M.M. GrunsteinEditors: P.J. Barnes, M.M. Grunstein, A.R. Leff, A. Woolcock.Lippincott-Raven Publishers, Philadelphia, New York1997
Pulmonary and Critical Care Pharmacology and Therapeutics
Chapter: G Protein-Linked Receptors
Page 3 - 15Grunstein, M.M., and C.M. SchrammEditors: A.R. Leff.McGraw-Hill Publishers, New York1996
Pulmonary and Critical Care Pharmacology and Therapeutics
Chapter: Enzyme-Linked Receptors
Page 17 - 38Schramm, C.M., and M.M. GrunsteinEditors: A.R. Leff.McGraw-Hill Publishers, New York1996
Pulmonary Critical Care Pharmacology and Therapeutics
Chapter: Nuclear Hormone Receptors
Page 39 - 52Schramm, C.M., and M.M. Grunstein.Editors: A.R. Leff.McGraw-Hill Publishers, New York1996
Pulmonary Critical Care Pharmacology and Therapeutics
Chapter: Pulmonary Function Tests In Infants
Page 175 - 196Schramm, C.M., and M.M. GrunsteinEditors: A.R. Leff.McGraw-Hill Publishers, New York1996
Kendig's Disorders of the Respiratory Tract in Children
Chapter: Infant Pulmonary Function Testing
Page 127 - 147Schramm, C.M., Grunstein, M.M.Editors: Chernick, V.W.B. Saunders Co., Philadelphia1990
Bronchopulmonary Dysplasia
Chapter: Infant Pulmonary Function Testing: State of the Art
Schramm, C.M., and M.M. GrunsteinEditors: J.T. Stocker and E. Bancalari.1988
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Abstracts/Posters

Differential Effects Of IL- 13 On Serine Site-Specific Glucocorticoid Receptor (GR) Phosphorylation In Human Airway Smooth Muscle (HASM) Cells
Diener, BL, A. Hu, M.B. Josephson, M.M. Grunstein, Am. Thoracic Soc. Am J Respir Crit Care Med, 1/1/2013
Josephson, N.B, A. Hu, B.L. Diener, M.M. Grunstein, Am. Thoracic Soc. Am J Respir Crit Care Med, 1/1/2013
Pro-asthmatic Signaling via the G protein BetaGamma-subunit is Intrinsically Activated in Cultured Human Asthmatic Airway Smooth Muscle Cells
Hu, A, B. L. Diener, M. B. Josephson, and M. M. Grunstein, Am. Thoracic Soc. Am J Respir Crit Care Med, 1/1/2013
Expression And Activity Of The Endogenous Glucocorticoid (GC)-Activating Enzyme, 11_-Hydroxysteroid Dehydrogenase-1 (HSD-1), Are Suppressed In Asthmatic Airway Smooth ...
Josephson, M.B., S. Xu, G. Nino, A. Hu, J.S. Grunstein, M.M. Grunstein, Am. Thoracic Soc. Am J Respir Crit Care Med, 1/1/2012
Regulation Of Glucocorticoid Receptor (GR) Phosphorylation And Transcriptional Signaling By IL-13 In Human Airway Smooth Muscle (HASM) Cells
Hu,A., M.B. Josephson, S. Xu, G. Nino, J.S. Grunstein, M.M. Grunstein, Am. Thoracic Soc. Am J Respir Crit Care Med, 1/1/2012
Glucocorticosteroids Prevent The Pro-Asthmatic Effects Of IgE On Airway Smooth Muscle (ASM) Function By Inhibiting Phosphodiesterase 4 (PDE4) Activity
Nino, G., A. Hu, J.S. Grunstein, M.B. Josephson, C.S. Parenjape, M.M. Grunstein, Am. Thoracic Soc. Am J Respir Crit Care Med, 1/1/2012
Activation Of The BetaGamma-Subunits Of Gi Protein Mediates The Pro-Asthmatic Effects Of IgE Immune Complexes On Airway Smooth Muscle (ASM) Responsiveness
Nino, G, K. Koul, A. Hu, J.S. Grunstein, C.S. Parenjape, B. Joseph, M.M. Grunstein, Am. Thoracic Soc., 1/1/2011
Mechanism Of Upregulation Of Glucocorticoid Receptor (GR) Signaling By IL-13 In Human Airway Smooth Muscle (HASM) Cells
Hu, A, G. Nino, J.S. Grunstein, C.S. Parenjape, M.M. Grunstein, Am. Thoracic Soc., 1/1/2011
Inhibition Of G Protein Beta-Gamma-Subunits Prevents Il-13-Induced Pro- Asthmatic Changes In Airway Smooth Muscle (ASM) Responsiveness
Joseph, A, C.S. Parenjape, J.S. Grunstein, A. Hu, G. Nino, M.M. Grunstein, Am. Thoracic Soc., 1/1/2011
IL-13-Induced 11beta-hydroxysteroid dehydrogenase Type 2 (HSD2) Activity In Airway Epithelial Cells Suppresses Bronchoprotective Action Of Cortisol In Airway Smooth Mu...
Josephson, M.B., J. Jiao2, C.S. Parenjape2, J.S. Grunstein1, B. Joseph1, A. Hu, G. Nino1, M.M. Grunstein, Am. Thoracic Soc., 1/1/2011
G protein BeatGamma subunit-dependent signaling mediates airway hyperreactivity and allergic airway inflammation
Nino G, A. Hu, S. J. S. Grunstein, J. McDonough, P. A. Kreiger and M. M. Grunstein, Am. Thoracic Soc., 1/1/2010
IL-13 Differentially Modulates Expression of the 11Beta-Hydroxysteroid Dehydrogenase (HSD) Enzymes in Human Airway Smooth Muscle and Airway Epithelial Cells
Jiao, J, A. Hu, J. Grunstein, G. Nino, and M.M. Grunstein, Am. Thoracic Soc., 1/1/2010
Mechanism of IL-13- Induced Upregulation of Glucocorticoid Receptor Activation in Human Airway Smooth Muscle Cells
Hu A, G. Nino, J. Grunstein, J. Jiao, M.M. Grunstein, Am. Thoracic Soc., 1/1/2010
Regulation of Glucocorticoid Receptor (GR) Signaling by IL-13 in Cultured Human Airway Smooth Muscle (HASM) Cells
Hu A, G. Nino,J.S. Grunstein, Y. Grumbach, L. Gober, and M.M. Grunstein, Am. Thoracic Soc, 1/1/2009
Glucocorticosteroids Prevent the Pro-Asthmatic Effects of Prolonged Homologous Beta2-Adrenergic Receptor Desensitization in Airway Smooth Muscle by Inhibiting Phosphod...
Nino G, A. Hu, J.S. Grunstein, S.J. Kim, and M.M. Grunstein, Am. Thoracic Soc., 1/1/2009
Regulation of 11Beta-Hydroxysteroid Dehydrogenase Type 1 (11Beta-HSD1) Expression in Human Airway Smooth Muscle (HASM) Cells
Grumbach Y, A. Hu, J.S. Grunstein, G. Nino, L. Gober, and M.M. Grunstein, Am. Thoracic Soc., 1/1/2009
Altered Responsiveness of Beta2-Adrenergic Receptor (beta2AR)-Desensitized Airway Smooth Muscle (ASM) Is Mediated by Upregulated Phosphodiesterase (PDE)-4 Expression I...
Hu A, G. Nino, J.S. Grunstein, M.M. Grunstein, Am. Thoracic Soc., 1/1/2008
Phosphodiesterase 4 (PDE4) Mediates Pro-Asthmatic-Like Changes in Airway Smooth Muscle (ASM) Responsiveness Induced by Prolonged Exposure to a Long-Acting Beta2- Adren...
Nino G, A. Hu, J. S. Grunstein, M. M. Grunstein, Am. Thoracic Soc., 1/1/2008
Interleukin-13 (IL-13) Induces Homeostatic Upregulation of Glucocorticoid Receptor (GR) Signaling in Human Airway Smooth Muscle (HASM) Cells
Cao J, S. Fatma, A. Hu, J. S. Grunstein, G. Nino, M.D., M. M. Grunstein, Am. Thoracic Soc., 1/1/2008
Role of ERK1/2 in mediating altered agonist responsiveness of airway smooth muscle (ASM) desensitized to Beta2-adrenergic stimulation
Hu, A., S. Fatma, J. S. Grunstein, G. Nino, and M. M. Grunstein, Am. Thoracic Soc., 1/1/2007
Regulation of 11Beta-hydroxysteroid dehydrogenase type 1 (HSD-1) expression and action by proinflammatory cytokines in airway smooth muscle (ASM)
Fatma, S., A. Hu, H. Veler, J. S. Grunstein, J. Lee, A. Richardson, G. Nino, and M. M. Grunstein, Am. Thoracic Soc., 1/1/2007
Superantigen presentation by airway smooth muscle (ASM) to CD4+ T lymphocytes elicits reciprocal changes in ASM responsiveness
Veler, H., J. S. Grunstein, S. Chuang, D. Campbell, and M. M. Grunstein, Am. Thoracic Soc., 1/1/2006
Mechanism of Toll-Like receptor (TLR) 4-induced changes in airway smooth muscle function
Hu, A., H. Veler, M.D., J.S. Grunstein, S. Chuang, and M.M. Grunstein, Am. Thoracic Soc., 1/1/2006
Expression and effects of activation of toll-like receptors in cultured human airway smooth muscle cells
Shan, X., h. Veler, and M. M. Grunstein, Am. Thoracic Soc., 1/1/2005
Role of airway smooth muscle as an antigen-presenting cell to CD4+ T lymphocytes
Veler, H. X. Shan, D. Campbell, and M. M. Grunstein, Am. Thoracic Soc., 1/1/2005
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Other

Regulation of the Frequency and Depth of Breathing (Ph.D. Thesis)
Grunstein, M.M., McGill University
Montreal, Canada - 1/1/1974
A Quantitative Analysis of the Effect of Body Temperature on Tidal Volume and Respiratory Frequency in Anesthetized Cats (M.Sc. Thesis)
Grunstein, M.M., McGill University
Montreal, Canada - 1/1/1972

Grant Support

Regulation Of Pro-Asthmatic And Glucocorticoid Signaling By Airway Smooth MuscleNational Heart, Lung, And Blood Institute2009–2011
Virus-Induced Mechanics Of Altered Airway ResponsivenessNational Heart, Lung, And Blood Institute2004–2008
Maturation Of Non-Specific Airways ReactivityNational Heart, Lung, And Blood Institute2004–2007
Virus-Induced Mechs Of Altered Airway ResponsivenessNational Heart, Lung, And Blood Institute2005–2006
Virus Induced Mechanisms Of Altered Airway ResponsivenesNational Heart, Lung, And Blood Institute1999–2002
Signal Transduction In Sensitized Airway Smooth MuscleNational Heart, Lung, And Blood Institute1998–2002
Maturation Of Nonspecific Airways ReactivityNational Heart, Lung, And Blood Institute1998–2001
Maturation Of Nonspecific Airway ReactivityNational Heart, Lung, And Blood Institute1993–1997
Mediators, Airway Smooth Muscle Growth And ContractilityNational Heart, Lung, And Blood Institute1990–1992
Maturation Of Non-Specific Airway ReactivityNational Heart, Lung, And Blood Institute1988–1992
Maturation Of Nonspecific Airway ReactivityNational Heart, Lung, And Blood Institute1985–1986