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Office
4202 Babcock Avenue
Studio City, CA 91604Phone+1 610-909-6235Fax+1 888-431-8921
Summary
- Michael Grunstein, MD, PhD is a specialist in pediatric pulmonology. He completed his PhD and medical degrees at McGill University Faculty of Medicine, followed by a residency in Pediatrics at the University of Colorado, and a fellowship in Pulmonary Disease at the University of California, San Francisco. Dr. Grunstein has held faculty positions including Professor of Pediatrics at the University of Pennsylvania School of Medicine and Chief of Pulmonary Medicine at Children's Hospital of Philadelphia. He has published extensively on research in asthma pathogenesis, with emphasis on signaling mechanisms in airway smooth muscle, contributing significantly to the field. He received the Richard Farr Award for his contributions to the application of basic science to allergic diseases and has been an invited speaker widely on related topics in pulmonary medicine and pathobiology. He is currently Professor Emeritus at the Perelman School of Medicine at University of Pennsylvania, and lives in Studio City, CA.
Education & Training
- University of PennsylvaniaM.A.(Hon), 1987
- University of California (San Francisco)Fellowship, Pulmonary Disease and Critical Care Medicine, 1979 - 1980
- University of ColoradoResidency, Pediatrics, 1977 - 1979
- McGill University Faculty of MedicineClass of 1977, MDCM
- McGill UniversityPh.D., Pulmonary Physiology, 1974
- McGill UniversityM.Sc., Pulmonary Physiology, 1972
- Sir George Williams UniversityB.Sc., 1970
Certifications & Licensure
- CA State Medical License 1978 - 2026
- PA State Medical License 1987 - 2014
- CO State Medical License 1978 - 1989
- American Board of Pediatrics Pediatrics
Awards, Honors, & Recognition
- Invited Speaker: “Mechanisms of induction of the proasthmatic phenotype in airway smooth muscle." Merck Pharmaceutical Co., 2002
- Richard Farr Award - For outstanding contributions in the application of basic science to allergic diseases Colorado Allergy Society, 2002
- Invited Speaker: “How Do Infammation and Infections Affect Airway Smooth Muscle Function” American Academy of Allergy, Asthma, and Immunology, 2002
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Publications & Presentations
PubMed
- 31 citationsEffect of corticosteroids on bronchial responsiveness to methacholine in asthmatic children.Rajesh G. Bhagat, Michael M. Grunstein
The American Review of Respiratory Disease. 2015-05-14 - 5 citationsConstitutively Active Signaling by the G Protein βγ-Subunit Mediates Intrinsically Increased Phosphodiesterase-4 Activity in Human Asthmatic Airway Smooth Muscle CellsAihua Hu, Barry L. Diener, Maureen B. Josephson, Michael M. Grunstein
Plos One. 2015-03-05 - 4 citationsSmooth Muscle Hypercontractility in Airway Hyperresponsiveness: Innate, Acquired, or Nonexistent?Ynuk Bossé, Eric Rousseau, Yassine Amrani, Michael M. Grunstein
Journal of Allergy. 2013-06-17
Journal Articles
- Homeostatic glucocorticoid signaling in airway smooth muscle: A roadmap to asthma pathogenesisGrunstein M.M., Frontiers in Endocrinology-Cellular, 1/4/2023
- Smooth Muscle Hypercontractility in Airway Hyperresponsiveness: Innate, Acquired, or Nonexistent?Bosse, Y., Rousseau, E., Amrani, Y., and Grunstein, M.M., J. Allergy, 1/1/2013
- G protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma.Nino G, Hu A, Grunstein J.S, McDonough J, Kreiger P.A, Josephson M.B, Choi J.K, G runstein M . M., PLoS One, 1/1/2012
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Books/Book Chapters
Abstracts/Posters
- Differential Effects Of IL- 13 On Serine Site-Specific Glucocorticoid Receptor (GR) Phosphorylation In Human Airway Smooth Muscle (HASM) CellsDiener, BL, A. Hu, M.B. Josephson, M.M. Grunstein, Am. Thoracic Soc. Am J Respir Crit Care Med, 1/1/2013
- Pro-asthmatic Signaling via the G protein BetaGamma-subunit is Intrinsically Activated in Cultured Human Asthmatic Airway Smooth Muscle CellsHu, A, B. L. Diener, M. B. Josephson, and M. M. Grunstein, Am. Thoracic Soc. Am J Respir Crit Care Med, 1/1/2013
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Other
- Regulation of the Frequency and Depth of Breathing (Ph.D. Thesis)Grunstein, M.M., McGill University
Montreal, Canada - 1/1/1974 - A Quantitative Analysis of the Effect of Body Temperature on Tidal Volume and Respiratory Frequency in Anesthetized Cats (M.Sc. Thesis)Grunstein, M.M., McGill University
Montreal, Canada - 1/1/1972
Grant Support
- Regulation Of Pro-Asthmatic And Glucocorticoid Signaling By Airway Smooth MuscleNational Heart, Lung, And Blood Institute2009–2011
- Virus-Induced Mechanics Of Altered Airway ResponsivenessNational Heart, Lung, And Blood Institute2004–2008
- Maturation Of Non-Specific Airways ReactivityNational Heart, Lung, And Blood Institute2004–2007
- Virus-Induced Mechs Of Altered Airway ResponsivenessNational Heart, Lung, And Blood Institute2005–2006
- Virus Induced Mechanisms Of Altered Airway ResponsivenesNational Heart, Lung, And Blood Institute1999–2002
- Signal Transduction In Sensitized Airway Smooth MuscleNational Heart, Lung, And Blood Institute1998–2002
- Maturation Of Nonspecific Airways ReactivityNational Heart, Lung, And Blood Institute1998–2001
- Maturation Of Nonspecific Airway ReactivityNational Heart, Lung, And Blood Institute1993–1997
- Mediators, Airway Smooth Muscle Growth And ContractilityNational Heart, Lung, And Blood Institute1990–1992
- Maturation Of Non-Specific Airway ReactivityNational Heart, Lung, And Blood Institute1988–1992
- Maturation Of Nonspecific Airway ReactivityNational Heart, Lung, And Blood Institute1985–1986
Professional Memberships
- Member
- American Pediatric SocietyMember
- American Society for Clinical InvestigationMember
- American Physiological SocietyMember
- American Association of ImmunologistsMember
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