MichaelMGrunsteinMD PhD

PubMed

• 31 citations
  Effect of corticosteroids on bronchial responsiveness to methacholine in asthmatic children.
  Rajesh G. Bhagat, Michael M. Grunstein
  The American Review of Respiratory Disease. 2015-05-14
• 5 citations
  Constitutively Active Signaling by the G Protein βγ-Subunit Mediates Intrinsically Increased Phosphodiesterase-4 Activity in Human Asthmatic Airway Smooth Muscle Cells
  Aihua Hu, Barry L. Diener, Maureen B. Josephson, Michael M. Grunstein
  Plos One. 2015-03-05
• 4 citations
  Smooth Muscle Hypercontractility in Airway Hyperresponsiveness: Innate, Acquired, or Nonexistent?
  Ynuk Bossé, Eric Rousseau, Yassine Amrani, Michael M. Grunstein
  Journal of Allergy. 2013-06-17

Journal Articles

• Homeostatic glucocorticoid signaling in airway smooth muscle: A roadmap to asthma pathogenesis  
  Grunstein M.M., Frontiers in Endocrinology-Cellular, 1/4/2023
• Smooth Muscle Hypercontractility in Airway Hyperresponsiveness: Innate, Acquired, or Nonexistent?  
  Bosse, Y., Rousseau, E., Amrani, Y., and Grunstein, M.M., J. Allergy, 1/1/2013
• G protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma.  
  Nino G, Hu A, Grunstein J.S, McDonough J, Kreiger P.A, Josephson M.B, Choi J.K, G runstein M . M., PLoS One, 1/1/2012
• 7q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Ameri...  
  Flory JH, Sleiman PM, Christie JD, Annaiah K, Bradfield J, Kim CE, Glessner J, Imielinski M, Li H, Frackelton EC, Cuiping H, Otieno G, Thomas K, Smith R, Glaberson W, ..., J Allergy Clin Immunol, 1/1/2009
• Th2 cytokine-induced upregulation of 11{beta}-hydroxysteroid dehydrogenase-1 facilitates glucocorticoid suppression of proasthmatic airway smooth muscle function  
  Hu A, Fatma S, Cao J, Grunstein J.S, Nino G, Grumbach Y, G runstein M. M, Am J Physiol Lung Cell Mol Physiol, 1/1/2009
• Prolonged heterologous Beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction  
  Hu, A., G. Nino, J. S. Grunstein, S. Fatma, and M .M. G runstei n., Am J. Physiol. Lung Cell Mol Physiol., 1/1/2008
• Superantigen presentation by airway smooth muscle to CD4+ T lymphocytes elicits reciprocal pro-asthmatic changes in airway function  
  Veler, H., A. Hu, S. Fatma, J.S. Grunstein, C.M. DeStephan, D. Campbell, J.S. Orange, and M .M. G runstei n., J. Immunol., 1/1/2007
• Regulation of toll-like receptor 4-induced pro-asthmatic changes in airway smooth muscle function by opposing actions of ERK1/2 and p38 MAPK signaling  
  Shan, X., A. Hu, H. Veler, S. Fatma, J.S. Grunstein, S. Chuang, and M .M. Grunstein, Am. J. Physiol. Lung Cell. Mol. Physiol., 1/1/2006
• Pro-Asthmatic effects and mechanisms of action of the dust mite allergen, Der p 1, in airway smooth muscle  
  G runstein, M . M. , Veler, H., Shan, X., Larson, J., Grunstein, J. S., and S. Chuang, J. Allergy Clin. Immunol., 1/1/2005
• Role and regulation of IL-1 molecules in pro-asthmatic sensitized airway smooth muscle  
  Whelan, R., C. Kim, M. Chen, J. Leiter, M .M. G runstei n and H. Hakonarson, Eur. Respir. J., 1/1/2004
• Autocrine regulation of airway smooth muscle responsiveness  
  Hakonarson, H., and M .M. G runstei n, Respir. Physiol. Neurobiol., 1/1/2003
• T lymphyocyte-mediated changes in airway smooth muscle responsiveness are attributed to induced autocrine release and actions of interleukin (IL)-5 and IL-1Beta  
  Hakonarson, H., R. Whelan, J. Leiter, C. Kim, M. Chen, D. Campbell, and M .M. Grunstein, J. Allergy Clin. Immunol., 1/1/2002
• IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle  
  Hakonarson, H., R. Whelan, J. Leiter, C. Kim, M. Chen, D. Campbell, and M .M., Am. J. Physiol. Lung Cell. Mol. Physiol., 1/1/2002
• Association between IL-1Beta/TNF-alpha-induced glucocorticoid-sensitive changes in multiple gene expression and altered responsiveness in airway smooth muscle  
  Hakonarson, H., E. Halapi, R. Whelan, J. Gulcher, K. Stefansson, and M .M. Grunstein, Am. J. Respir. Cell Mol. Biol., 1/1/2001
• Rhinovirus elicits pro-asthmatic changes in airway responsiveness independently of viral infection  
  G runstein, M .M ., H. Hakonarson, R. Whelan, Z. Yu, J.S. Grunstein, and S. Chuang., J. Allergy Clin. Immunol., 1/1/2001
• Autocrine signaling by IL-10 mediates altered responsiveness of atopic sensitized airway smooth muscle  
  G runstein, M .M ., H. Hakonarson, J. Leiter, M. Chen, R. Whelan, J.S. Grunstein, and S. Chuang., Am. J. Physiol. Lung Cell. Mol. Physiol., 1/1/2001
• Bi-directional activation between human airway smooth muscle cells and T lymphocytes: Role in induction of altered airway responsiveness  
  Hakonarson, H., C. Kim, R. Whelan, D. Campbell, and M .M. G runstei n, J. Immunol., 1/1/2001
• Mechanism of cooperative effects of rhinovirus and atopic sensitzation on airway responsiveness  
  G runstein, M .M ., H. Hakonarson, R.L. Hodinka, N. Maskeri, C. Kim, and S. Chuang., Am. J. Physiol. Lung Cell. Mol. Physiol., 1/1/2001
• Methacholine induced temporal changes in airway geometry and lung density by CT  
  Amirav, I., S.S. Kramer, M .M. G runstei n, and E.A. Hoffman., Chest, 1/1/2001
• Autocrine cytokine signaling mediates effects of rhinovirous on airway responsiveness  
  G runstein, M .M ., H. Hakonarson, N. Maskeri, and S. Chuang., Am. J. Physiol. Lung Cell. Mol. Physiol., 1/1/2000
• Intrinsic ICAM-1/LFA-1 activation mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle  
  G runstein, M .M ., H. Hakonarson, N. Maskeri, C. Kim, and S. Chuang., Am. J. Physiol. Lung Cell. Mol. Physiol., 1/1/2000
• Autocrine interaction between interleukin (IL)-5 and IL-1ß mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle  
  Hakonaron, H., N. Maskeri, C. Carter, S. Chuang, and M .M. G runstei n., J. Clin. Invest., 1/1/1999
• Altered expression and action of the low-affinity IgE receptor, FceRII (CD23), in asthmatic airway smooth muscle  
  Hakonarson, H., C. Carter, C. Kim, and M .M. G r unstei n, J. Allergy Clin. Immunol., 1/1/1999
• Regulation of TH1- and TH2-type cytokine expression and action in atopic asthmatic sensitized airway smooth muscle  
  Hakonarson, H., N. Maskeri, C. Carter, and M .M. G runstei n., J. Clin. Invest., 1/1/1999
• Rhinovirus-mediated changes in airway smooth muscle responsiveness: Induced autocrine role of interleukin-1Beta  
  Hakonarson, H., C. Carter, N. Maskeri, R. Hodinka, and M .M. G runstei n., Am. J. Physiol. (Lung Cell. Mol. Physiol.), 1/1/1999
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Books/Book Chapters

• Institute of Medicine 
  Chapter: "Clearing the Air: Asthma and Indoor Air Exposure 
  National Academy of Sciences; National Academy Press, Washington, DC2000
• Asthma 
  Chapter: Two-Volume Textbook 
  Editors: P.J. Barnes, M.M. Grunstein, A.R. Leff, A. Woolcock.Lippincott-Raven Publishers, Philadelphia/New York1997
• ASTHMA 
  Grunstein, M.M.Editors: P.J. Barnes, M.M. Grunstein, A.R. Leff, A. Woolcock.Lippincott-Raven Publishers1997
• ASTHMA 
  Chapter: Receptor Mechanisms 
  Barnes, P.J., and M.M. GrunsteinEditors: P.J. Barnes, M.M. Grunstein, A.R. Leff, A. Woolcock.Lippincott-Raven Publishers, Philadelphia, New York1997
• ASTHMA 
  Chapter: Airway smooth muscle hyperplasia and hypertrophy 
  Panettieri, R.A., Jr., and M.M. GrunsteinEditors: P.J. Barnes, M.M. Grunstein, A.R. Leff, A. Woolcock.Lippincott-Raven Publishers, Philadelphia, New York1997
• ASTHMA 
  Chapter: Management of childhood asthma 
  Hakonarson, H., and M.M. GrunsteinEditors: P.J. Barnes, M.M. Grunstein, A.R. Leff, A. Woolcock.Lippincott-Raven Publishers, Philadelphia, New York1997
• Pulmonary and Critical Care Pharmacology and Therapeutics 
  Chapter: G Protein-Linked Receptors 
  Page 3 - 15Grunstein, M.M., and C.M. SchrammEditors: A.R. Leff.McGraw-Hill Publishers, New York1996
• Pulmonary and Critical Care Pharmacology and Therapeutics 
  Chapter: Enzyme-Linked Receptors 
  Page 17 - 38Schramm, C.M., and M.M. GrunsteinEditors: A.R. Leff.McGraw-Hill Publishers, New York1996
• Pulmonary Critical Care Pharmacology and Therapeutics 
  Chapter: Nuclear Hormone Receptors 
  Page 39 - 52Schramm, C.M., and M.M. Grunstein.Editors: A.R. Leff.McGraw-Hill Publishers, New York1996
• Pulmonary Critical Care Pharmacology and Therapeutics 
  Chapter: Pulmonary Function Tests In Infants 
  Page 175 - 196Schramm, C.M., and M.M. GrunsteinEditors: A.R. Leff.McGraw-Hill Publishers, New York1996
• Kendig's Disorders of the Respiratory Tract in Children 
  Chapter: Infant Pulmonary Function Testing 
  Page 127 - 147Schramm, C.M., Grunstein, M.M.Editors: Chernick, V.W.B. Saunders Co., Philadelphia1990
• Bronchopulmonary Dysplasia 
  Chapter: Infant Pulmonary Function Testing: State of the Art 
  Schramm, C.M., and M.M. GrunsteinEditors: J.T. Stocker and E. Bancalari.1988
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Abstracts/Posters

• Differential Effects Of IL- 13 On Serine Site-Specific Glucocorticoid Receptor (GR) Phosphorylation In Human Airway Smooth Muscle (HASM) Cells
  Diener, BL, A. Hu, M.B. Josephson, M.M. Grunstein, Am. Thoracic Soc. Am J Respir Crit Care Med, 1/1/2013
• Josephson, N.B, A. Hu, B.L. Diener, M.M. Grunstein, Am. Thoracic Soc. Am J Respir Crit Care Med, 1/1/2013
• Pro-asthmatic Signaling via the G protein BetaGamma-subunit is Intrinsically Activated in Cultured Human Asthmatic Airway Smooth Muscle Cells
  Hu, A, B. L. Diener, M. B. Josephson, and M. M. Grunstein, Am. Thoracic Soc. Am J Respir Crit Care Med, 1/1/2013
• Expression And Activity Of The Endogenous Glucocorticoid (GC)-Activating Enzyme, 11_-Hydroxysteroid Dehydrogenase-1 (HSD-1), Are Suppressed In Asthmatic Airway Smooth ...
  Josephson, M.B., S. Xu, G. Nino, A. Hu, J.S. Grunstein, M.M. Grunstein, Am. Thoracic Soc. Am J Respir Crit Care Med, 1/1/2012
• Regulation Of Glucocorticoid Receptor (GR) Phosphorylation And Transcriptional Signaling By IL-13 In Human Airway Smooth Muscle (HASM) Cells
  Hu,A., M.B. Josephson, S. Xu, G. Nino, J.S. Grunstein, M.M. Grunstein, Am. Thoracic Soc. Am J Respir Crit Care Med, 1/1/2012
• Glucocorticosteroids Prevent The Pro-Asthmatic Effects Of IgE On Airway Smooth Muscle (ASM) Function By Inhibiting Phosphodiesterase 4 (PDE4) Activity
  Nino, G., A. Hu, J.S. Grunstein, M.B. Josephson, C.S. Parenjape, M.M. Grunstein, Am. Thoracic Soc. Am J Respir Crit Care Med, 1/1/2012
• Activation Of The BetaGamma-Subunits Of Gi Protein Mediates The Pro-Asthmatic Effects Of IgE Immune Complexes On Airway Smooth Muscle (ASM) Responsiveness
  Nino, G, K. Koul, A. Hu, J.S. Grunstein, C.S. Parenjape, B. Joseph, M.M. Grunstein, Am. Thoracic Soc., 1/1/2011
• Mechanism Of Upregulation Of Glucocorticoid Receptor (GR) Signaling By IL-13 In Human Airway Smooth Muscle (HASM) Cells
  Hu, A, G. Nino, J.S. Grunstein, C.S. Parenjape, M.M. Grunstein, Am. Thoracic Soc., 1/1/2011
• Inhibition Of G Protein Beta-Gamma-Subunits Prevents Il-13-Induced Pro- Asthmatic Changes In Airway Smooth Muscle (ASM) Responsiveness
  Joseph, A, C.S. Parenjape, J.S. Grunstein, A. Hu, G. Nino, M.M. Grunstein, Am. Thoracic Soc., 1/1/2011
• IL-13-Induced 11beta-hydroxysteroid dehydrogenase Type 2 (HSD2) Activity In Airway Epithelial Cells Suppresses Bronchoprotective Action Of Cortisol In Airway Smooth Mu...
  Josephson, M.B., J. Jiao2, C.S. Parenjape2, J.S. Grunstein1, B. Joseph1, A. Hu, G. Nino1, M.M. Grunstein, Am. Thoracic Soc., 1/1/2011
• G protein BeatGamma subunit-dependent signaling mediates airway hyperreactivity and allergic airway inflammation
  Nino G, A. Hu, S. J. S. Grunstein, J. McDonough, P. A. Kreiger and M. M. Grunstein, Am. Thoracic Soc., 1/1/2010
• IL-13 Differentially Modulates Expression of the 11Beta-Hydroxysteroid Dehydrogenase (HSD) Enzymes in Human Airway Smooth Muscle and Airway Epithelial Cells
  Jiao, J, A. Hu, J. Grunstein, G. Nino, and M.M. Grunstein, Am. Thoracic Soc., 1/1/2010
• Mechanism of IL-13- Induced Upregulation of Glucocorticoid Receptor Activation in Human Airway Smooth Muscle Cells
  Hu A, G. Nino, J. Grunstein, J. Jiao, M.M. Grunstein, Am. Thoracic Soc., 1/1/2010
• Regulation of Glucocorticoid Receptor (GR) Signaling by IL-13 in Cultured Human Airway Smooth Muscle (HASM) Cells
  Hu A, G. Nino,J.S. Grunstein, Y. Grumbach, L. Gober, and M.M. Grunstein, Am. Thoracic Soc, 1/1/2009
• Glucocorticosteroids Prevent the Pro-Asthmatic Effects of Prolonged Homologous Beta2-Adrenergic Receptor Desensitization in Airway Smooth Muscle by Inhibiting Phosphod...
  Nino G, A. Hu, J.S. Grunstein, S.J. Kim, and M.M. Grunstein, Am. Thoracic Soc., 1/1/2009
• Regulation of 11Beta-Hydroxysteroid Dehydrogenase Type 1 (11Beta-HSD1) Expression in Human Airway Smooth Muscle (HASM) Cells
  Grumbach Y, A. Hu, J.S. Grunstein, G. Nino, L. Gober, and M.M. Grunstein, Am. Thoracic Soc., 1/1/2009
• Altered Responsiveness of Beta2-Adrenergic Receptor (beta2AR)-Desensitized Airway Smooth Muscle (ASM) Is Mediated by Upregulated Phosphodiesterase (PDE)-4 Expression I...
  Hu A, G. Nino, J.S. Grunstein, M.M. Grunstein, Am. Thoracic Soc., 1/1/2008
• Phosphodiesterase 4 (PDE4) Mediates Pro-Asthmatic-Like Changes in Airway Smooth Muscle (ASM) Responsiveness Induced by Prolonged Exposure to a Long-Acting Beta2- Adren...
  Nino G, A. Hu, J. S. Grunstein, M. M. Grunstein, Am. Thoracic Soc., 1/1/2008
• Interleukin-13 (IL-13) Induces Homeostatic Upregulation of Glucocorticoid Receptor (GR) Signaling in Human Airway Smooth Muscle (HASM) Cells
  Cao J, S. Fatma, A. Hu, J. S. Grunstein, G. Nino, M.D., M. M. Grunstein, Am. Thoracic Soc., 1/1/2008
• Role of ERK1/2 in mediating altered agonist responsiveness of airway smooth muscle (ASM) desensitized to Beta2-adrenergic stimulation
  Hu, A., S. Fatma, J. S. Grunstein, G. Nino, and M. M. Grunstein, Am. Thoracic Soc., 1/1/2007
• Regulation of 11Beta-hydroxysteroid dehydrogenase type 1 (HSD-1) expression and action by proinflammatory cytokines in airway smooth muscle (ASM)
  Fatma, S., A. Hu, H. Veler, J. S. Grunstein, J. Lee, A. Richardson, G. Nino, and M. M. Grunstein, Am. Thoracic Soc., 1/1/2007
• Superantigen presentation by airway smooth muscle (ASM) to CD4+ T lymphocytes elicits reciprocal changes in ASM responsiveness
  Veler, H., J. S. Grunstein, S. Chuang, D. Campbell, and M. M. Grunstein, Am. Thoracic Soc., 1/1/2006
• Mechanism of Toll-Like receptor (TLR) 4-induced changes in airway smooth muscle function
  Hu, A., H. Veler, M.D., J.S. Grunstein, S. Chuang, and M.M. Grunstein, Am. Thoracic Soc., 1/1/2006
• Expression and effects of activation of toll-like receptors in cultured human airway smooth muscle cells
  Shan, X., h. Veler, and M. M. Grunstein, Am. Thoracic Soc., 1/1/2005
• Role of airway smooth muscle as an antigen-presenting cell to CD4+ T lymphocytes
  Veler, H. X. Shan, D. Campbell, and M. M. Grunstein, Am. Thoracic Soc., 1/1/2005
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Other

• Regulation of the Frequency and Depth of Breathing (Ph.D. Thesis) 
  Grunstein, M.M., McGill University
  Montreal, Canada - 1/1/1974
• A Quantitative Analysis of the Effect of Body Temperature on Tidal Volume and Respiratory Frequency in Anesthetized Cats (M.Sc. Thesis) 
  Grunstein, M.M., McGill University
  Montreal, Canada - 1/1/1972