MichaelRDepietroMDFACP

Pulmonology • Wilmington, DE

Asthma & COPD, Critical Care Medicine, Clinical Pharmacology

Sr Medical Director inflammation and autoimmunity

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Office
1801 Augustine Cut Off Rd
Wilmington, DE 19803
Phone+1 484-981-2967

Summary

I am a very experienced pulmonary critical care medicine physician Interested in all aspects of pulmonary and critical care drug development as well as medical affairs support of assets in development, at launch and in market.

I have 9 years of industry experience in a variety of roles, Currently at Incyte, and previously at Airway Therapeutics, Teva and AstraZeneca. This experience covers late, and early stage clinical trial design and execution, RWE observational studies, and the full range of medical affairs activities, including medical affairs strategic support of a variety of drugs through the Pharmaceutical life cycle from pre launch, to launch and in market pharmaceutical support.

Before joining the pharmaceutical industry I had extensive clinical practice experience in pulmonary and critical care medicine. This included all aspects of critical care, including neurologic, cardiac and surgical critical care, as well as medical resident, medical student and critical care physician assistant education and supervision in multiple ICUs. In addition I have served as medical ICU director in a large tertiary care teaching hospital, and led a large number of clinical research and performance improvement projects involving multiple aspects of pulmonary critical care

Education & Training

George Washington UniversityFellowship, Pulmonary Disease and Critical Care Medicine, 1997 - 1999
National Institutes of Health Clinical CenterFellowship, Critical Care Medicine (Internal Medicine), 1996 - 1997
Johns Hopkins University School of Medicine1991 - 1993
MedStar Health/Georgetown University HospitalResidency, Neurology, 1988 - 1991
Drexel University College of Medicine/Hahnemann University HospitalResidency, Internal Medicine, 1987 - 1988
Mercy Catholic Medical CenterInternship, Transitional Year, 1986 - 1987
Drexel University College of MedicineClass of 1986
University of ScrantonBS, Biology, 1978 - 1982

Certifications & Licensure

MD State Medical License 1996 - 2026
DE State Medical License 1999 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Critical Care Medicine
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

US Medical Affairs Team excellence Award AstraZeneca, 2016
Presidents Award AstraZeneca, 2016
Christiana Care Focus on Excellence Award Christiana Care, 2013
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2011
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Clinical Trials

Ventilator-Associated Pneumonia/Hospital-Acquired Pneumonia Requiring Mechanical Ventilatory Support Start of enrollment: 2002 Jul 01
Completed
Phase 3
Tifacogin for the Treatment of Patients With Severe Community-Acquired Pneumonia Start of enrollment: 2004 May 01
Completed
Phase 3
Enteral Glutamine in Critical Illness Start of enrollment: 2006 May 01
Terminated
Phase 2, Phase 3
Phase 3 Safety and Efficacy Study of ART-123 in Subjects With Severe Sepsis and Coagulopathy Start of enrollment: 2012 Oct 29
Completed
Phase 3
Teva Asthma Predictive Analytics Study Start of enrollment: 2021 Jul 09
Active, not recruiting
Phase 4
A 24-Week Treatment Study to Compare Standard of Care Versus the eMDPI DS in Participants 13 Years or Older With Asthma Start of enrollment: 2021 Feb 16
Completed
Phase 4
Evaluate the Relationship Between Use of Albuterol Multidose Dry Powder Inhaler With an eModule (eMDPI) and Exacerbations in Participants With Chronic Obstructive Pulmonary Disease (COPD) Start of enrollment: 2017 Sep 28
Completed
Phase 3
A Clinical Safety Study on AT-100 in Treating Adults With Severe COVID-19 Infection or Severed Community Acquired Pneumonia Start of enrollment: 2021 Aug 17
Terminated
Phase 1
A Clinical Safety Study of AT-100 (rhSP-D) in Preterm Neonates at High Risk for Bronchopulmonary Dysplasia (BPD) Start of enrollment: 2021 Sep 01
Active, not recruiting
Phase 1
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Publications & Presentations

PubMed

Uncovering patterns of inhaler technique and reliever use: the value of objective, personalized data from a digital inhaler.
Mark L Levy, Janwillem W H Kocks, Sinthia Bosnic-Anticevich, Guilherme Safioti, Michael Reich
NPJ Primary Care Respiratory Medicine. 2024-08-20
7 citations
Effectiveness of a Maintenance and Reliever Digihaler System in Asthma: 24-Week Randomized Study (CONNECT2).
Giselle S Mosnaim, Flavia C L Hoyte, Guilherme Safioti, Randall Brown, Tanisha D Hill
The Journal of Allergy and Clinical Immunology. in Practice. 2024-02-01
15 citations
Effectiveness of a Digital Inhaler System for Patients With Asthma: A 12-Week, Open-Label, Randomized Study (CONNECT1).
Flavia C L Hoyte, Giselle S Mosnaim, Linda Rogers, Guilherme Safioti, Randall Brown
The Journal of Allergy and Clinical Immunology. in Practice. 2022-10-01

Journal Articles

Induced Hypothermia for Cardiac Arrest Paper Report.
DePietro M, Critical Care
Therapeutic Hypothermia for Cardiac Arrest Paper Report.
DePietro M, Critical Care
Immunonutrition in the Critically Ill Paper Report.
DePietro M, Critical Care
Effects of Increasing MAP on Tissue Perfusion.
DePietro M, Critical Care
Sepsis Trials, What have we learned?
DePietro MR, Natanson C, Clinical Pulmonary Medicine
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Books/Book Chapters

Principles and Practice of Critical Care Monitoring.
Chapter: Complications of Pulmonary Artery Catherization
DePietro MR, Esposito C., Eichacker PQEditors: Tobin, Martin.McGraw Hill Pub

Abstracts/Posters

Occurrence of Severe Asthma Events and Exacerbations by Level of Controller Therapy in Patients with asthma in the United States
Durden E, Fox K, Brouillete M, Davis J, DePietro M, ATS International Conference 2016,, San Francisco, California., 5/13/2016
Prevalence of age adjusted comorbid diseases and implications for survival in a COPD population in a primary care Accountable Care Organization
Kleppinger A, Lynch J, Fox K, Davis J, DePietro M, ATS International Conference 2016,, San Francisco, California., 5/13/2016
COPD Population Health Management: Incidence, Prevalence, and Mortality in a Primary Care Accountable Care Organization: 1
: Lynch J, Fox K, Davis J, Cobden D, DePietro M, CHEST 2015,, Montreal, Canada
Effect of Fixed Airflow Obstruction Status on Peak Expiratory Flow and Rescue Medication Use in Response to Budesonide/Formoterol Treatment in Patients With Mode...
Chipps B, Tahskin D, DePietro M, Trudo F, American College of Allergy, Asthma and Immunology meeting, Atlanta Georgia
Rates and Predictors of Hospital Readmission among Patients with Chronic Obstructive Pulmonary Disease (COPD) in the Department of Veterans Affairs:
Duvall SL, Davis J, Nici L, Rochester CL, Nechodom P, Fox KM, Chun DS, Viernes B, DePietro M, CHEST 2015,, Montreal, Canada, 10/24/2015
Effect of sedation tapering as part of a multidisciplinary agitation and delirium program on ICU outcomes.
Hassan E, DePietro M, Zubrow M, Farraj M, Witzke A, Badawi O, ASHP Meeting, Denver, Colorado
MICU Alert Team, a novel intervention to improve door to MICU time.
Dressler R, Kerr H, Coletti C, DePietro M, Michalec B, Reinhold N, Eliott D, AAMC COTH Meeting, Chicago, Illinois
Effects of Budesonide/Formoterol on Fixed Airflow Obstruction Status and Early Study Withdrawal due to Predefined Asthma Events in Patients With Moderate to Severe Asthma
Chipps B, Tashkin D DePietro M, Trudo F., American College of Allergy, Asthma and Immunology meeting, Atlanta Georgia, 11/6/2014
Effectiveness of an integrated multidisciplinary tele-icu and bedside delirium assessment program.
DePietro M, Hassan E, Mubrow M, Farraj M, Witzke A, Badawi O, Seckel M, French R, 42nd Critical Care Congress, San Juan, Puerto Rico
Effects of Doubling the Highest Indicated Dose of Budesonide/Formoterol (BUD/FM) on Lung function And Symptoms in Moderate-to-Severe Asthma with Fixed Airflow...
DePietro M,Chipps B, Trudo F, Tashkin D, American College of Allergy, Asthma and Immunology meeting, Houston Texas, 2/20/2014
Effect of Fixed Airflow Obstruction (FAO) Status on Lung Function, Asthma Control Days (ACD), and Asthma symptom score, Responses to Budesonide/Formoterol (BUD...
Tashkin D, Trudo F, DePietro M, Chipps B;, American Academy of Allergy, Asthma and Immunology meeting,, Houston, Texas, 2/20/2014
Telemedicine collaboration with the bedside team improves outcomes of ICU patients in the Management of sedation and delirium
DePietro M, Hassan E, Zubrow M, Farraj M, Witzke A, Badawi O, Seckel M, French R, 43rd Critical Care Congress,SCCM, San Francisco, California, 1/9/2014
TGF-beta alters survival rates and lung injury dependent on the mortality of E.coli challenge in a rat pneumonia model.
Depietro M, Correa R, Zeni F, Vodovotz Y, Natanson C, et al, ALA/ATS International Conference, San Diego California
Doppler ultrasound as a non-invasive means to determine stroke volume and cardiac output.
Siegle J, DePietro M, Fontinilla L, et al, SAEM Conference, Boston MA
Clinical use of Non Bronchoscopic BAL Catheter in Mechanically Ventilated Patients.
Emberger J, Donnelly R, Montee A, DePietro M, AARC International Conference, Anaheim California
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Lectures

Cerebral Edema and ICP Monitoring In Fulminate Hepatic Failure.
University of Tennessee Hospital, Memphis TN
Cerebral Edema in Acute Hepatic Failure.
Beth Israel Hospital, Boston MA
ICP Monitoring in Acute Hepatic Failure.
Ohio State University Hospital, Columbus, Ohio
Neuromuscular Weakness in the ICU.
Christiana Care Medical Grand Rounds, Christiana Care Health System Newark, DE
ARDS an Overview.
ALA of Delaware/Delaware Thoracic Society, Perspectives in Pulmonary Care 2001, Wilmington, DE
Mechanical Ventilation.
Fundamentals of Critical Care Support Course :Christiana Hospital, Newark DE
Nosocomial Pneumonia.
Medical Resident Core Lectures , Christiana Care Health System
Venous Thromboembolic Disease.
Medical Resident Core Lectures: Christiana Care Health System
Diagnosis and Treatment of Pulmonary Emboli and DVT.
Christiana Care Health Systems Grand rounds, Clinical Pearls
Venous Thromboembolic Disease Update.
Medical Resident Core Lectures, Christiana Care Health Systems
Concepts in ICP Management.
Status Epilepticus in Children.
1996, 1997, 1998
Clinical Determination of Brain Death.
Kids Concepts.
National Naval Medical Center
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