MichaelCharlesDavisMDPhD

Psychiatry • Fitchburg, WI

Psychopharmacology

Chief Medical Officer

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Office
The Usona Institute
2780 Woods Hollow Rd
Fitchburg, WI 53711
Phone+1 608-277-2514

Fax+1 888-202-1492

Summary

I am a board-certified psychiatrist who completed the Medical Scientist Training Program (M.D./Ph.D.) at Case Western Reserve University, receiving a Ph.D. in Pharmacology. I completed residency training in Psychiatry at the UCLA Semel Institute of Neuroscience and Human Behavior, where I was chief resident from 2011-2012. I then completed the Advanced Fellowship Program in Mental Illness Research and Treatment at the West Los Angeles VA Medical Center; as part of this fellowship, I designed and conducted clinical and translational research on novel therapeutics for schizophrenia. After 1-2 years as junior faculty at Baylor College of Medicine and the Michael E. DeBakey VA Medical Center, I transitioned to the Division of Psychiatry at the Food and Drug Administration, where I was a primary clinical reviewer and then a clinical team leader. After ~6.5 years at the FDA, I left the Agency to accept a Chief Medical Officer position at the Usona Institute, where I currently work on developing psychedelic drugs for the treatment of major depressive disorder.

Education & Training

Greater Los Angeles HCSPost-Doctoral Fellowship, 2012 - 2014
UCLA David Geffen School of Medicine/UCLA Medical CenterChief Residency, Psychiatry, 2011 - 2012
UCLA David Geffen School of Medicine/UCLA Medical CenterResidency, Psychiatry, 2008 - 2012
Case Western Reserve University School of MedicineClass of 2008, M.D.
Case Western Reserve UniversityPh.D., Pharmacology, 2002 - 2006
Iowa State UniversityB.S., Biochemistry, 1999

Certifications & Licensure

MD State Medical License 2016 - 2026
CA State Medical License 2009 - 2025
NY State Medical License 2021 - 2023
American Board of Psychiatry and Neurology Psychiatry

Awards, Honors, & Recognition

Friends Travel Grant The Friends of the Semel Institute for Neuroscience and Human Behavior at UCLA, 2014
New Investigator Award American Society of Clinical Psychopharmacology, 2014
Schizophrenia Research Fellowship Award American Psychiatric Foundation, 2013
Selected Participant Research Career Development Institute in Psychiatry, 2012
Travel Award Junior Investigator Research Colloquium, American Psychiatric Association, 2012
Travel Award American Psychiatric Association Leadership Conference, 2011
Travel Award American Society of Clinical Psychopharmacology Workshop On Clinical Trials in Psychopharmacology, New York, NY, 2010
Minerva and Carl Wiggers Prize in Physiology Case Western Reserve University, 2008
Mentoring Award Case Western Reserve University, 2005
Best Oral Presentation Award Case Western Reserve University, 2005
AOA Award Winner Irwin H. Lepow Research Day, Case Western Reserve University, 2005
Dexter French Biochemistry Scholarship Iowa State University, 1999
High Scholarship Student Award Iowa State University, 1998
Hayward-Goodspeed Biochemistry Scholarship Iowa State University 1997, 1998
Phi Beta Kappa Iowa State University, 1998
National Merit Scholar National Merit Scholarship Corporation, Iowa State University, 1996
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Clinical Trials

Does Acute Oxytocin Administration Enhance Social Cognition in Individuals With Schizophrenia? Start of enrollment: 2011 Apr 01
Completed
Not Applicable
Pharmacological Approach to Improve the Outcome of Social Cognition Training Start of enrollment: 2012 Jan 01
Completed
Phase 1
N-acetylcysteine (NAC) for Improving Cognitive Dysfunction in Schizophrenia Start of enrollment: 2013 Jun 01
Completed
Phase 1
Curcumin as a Novel Treatment to Improve Cognitive Dysfunction in Schizophrenia Start of enrollment: 2014 Jul 01
Completed
Phase 1, Phase 2
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Publications & Presentations

PubMed

44 citations
Psychopharmacology of the negative symptoms: current status and prospects for progress.
Michael C. Davis, William P. Horan, Stephen R. Marder
European Neuropsychopharmacology. 2014-05-01
95 citations
Oxytocin-augmented social cognitive skills training in schizophrenia.
Michael C. Davis, Michael F. Green, Junghee Lee, William P. Horan, Damla Şentürk
Neuropsychopharmacology. 2014-03-18
127 citations
Impulsivity and risk taking in bipolar disorder and schizophrenia.
L. Felice Reddy, Junghee Lee, Michael C. Davis, Lori L. Altshuler, David C. Glahn
Neuropsychopharmacology. 2014-01-01

Journal Articles

Discontinuation of clozapine: a 15-year naturalistic retrospective study of 320 patients
Davis MC, Fuller MA, Strauss ME, Konicki PE, Jaskiw GE, Acta Psychiatrica Scandinavica, 1/1/2014
Psychopharmacology of the Negative Symptoms: Current Status and Prospects for Progress
Davis MC, Horan WP, Marder SR, European Neuropsychopharmacology, 1/1/2014
New-onset extrapyramidal symptoms following oxcarbazepine discontinuation in a child receiving risperidone
Kruse JL & Davis MC, Journal of Child and Adolescent Psychopharmacology, 1/1/2014
Anti-NMDA Receptor Encephalitis: Two Case Reports and a Review of Psychiatric Manifestations and Management
Kruse JL, Jeffrey JK, Davis MC, Dearlove J, IsHak WW, Brooks JO, Annals of Clinical Psychiatry, 1/1/2014
Impulsivity and Risk-taking in Bipolar Disorder and Schizophrenia
Reddy LF, Lee J, Davis MC, Altshuler LL, Glahn DC, Miklowitz DJ, Green MF, Neuropsychopharmacology, 1/1/2014
Effects of single dose intranasal oxytocin on social cognition in schizophrenia
Davis MC, Lee J, Horan WP, Clarke AD, McGee MR, Green MF, Marder SR, Schizophrenia Research, 1/1/2013
Hydroxyzine: Rational choice for inpatients with insomnia
Schiffman J*, Davis M*, Pierre J, Saunders CS, Current Psychiatry, 1/1/2011
Disorders of Orgasm in Women: A Literature Review of Etiology and Current Treatments
IsHak WW, Bokarius A, Jeffrey JK, Davis MC, Bakhta Y, Journal of Sexual Medicine, 1/1/2010
The role of dopaminergic agents in improving quality of life in major depressive disorder
IsHak WW, Davis M, Jeffrey J, Balayan K, Pechnick RN, Bagot K, Rapaport MH, Current Psychiatry Reports, 1/1/2009
Dexamethasone-induced inositol-1,4,5-trisphosphate receptor elevation in murine lymphoma cells is not required for dexamethasone-mediated calcium elevation and apoptosis
Davis MC, McColl KS, Zhong F, Wang Z, Malone MH, Distelhorst CW, Journal of Biological Chemistry, 1/1/2008
Live Free or Die - An Immature T cell decision encoded in distinct Bcl-2 sensitive and insensitive Ca2+ signals
Davis MC, Distelhorst CW, Cell Cycle, 1/1/2006
Bcl-2 differentially regulates calcium signals according to the strength of T-cell receptor activation
Zhong F*, Davis MC*, McColl KS, Distelhorst CW, Journal of Cell Biology, 1/1/2006
Bcl-2 differentially regulates calcium signals according to the strength of T-cell receptor activation.
Zhong F*, Davis MC*, McColl KS, Distelhorst CW, Journal of Cell Biology 172(1): 127-137 (2006)
Hydroxyzine: Rational choice for inpatients with insomnia.
Schiffman J, Davis M, Pierre J, Saunders CS, Current Psychiatry 10(3):88 (2011)
Disorders of orgasm in women: A literature review of etiology and current treatments.
IsHak WW, Bokarius A, Jeffrey JK, Davis MC, Bakhta Y, Journal of Sexual Medicine 7(10): 3254-3268 (2010)
The role of dopaminergic agents in improving quality of life in major depressive disorder.
IsHak WW, Davis M, Jeffrey J, Balayan K, Pechnick RN, Bagot K, Rapaport MH, Current Psychiatry Reports 11(6): 503-508 (2009)
Dexamethasone-induced inositol-1,4,5-trisphosphate receptor elevation in murine lymphoma cells is not required for dexamethasone-mediated calcium elevation and apoptosis.
Davis MC, McColl KS, Zhong F, Wang Z, Malone MH, Distelhorst CW, Journal of Biological Chemistry 283(16): 10357-10365 (2008)
Live free or die – An immature T cell decision encoded in distinct Bcl-2 sensitive and insensitive Ca2+ signals.
Davis MC, Distelhorst CW, Cell Cycle
Thioredoxin-interacting protein (txnip) is a glucocorticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis.
Wang Z, Rong YP, Malone MH, Davis MC, Distelhorst CW, Oncogene
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Books/Book Chapters

How to Succeed in Psychiatry: A Guide to Training and Practice.
Chapter: The psychiatrist in the digital era: new opportunities and new challenges for early career psychiatrists.
Page 98 - 121Volpe U, Davis M, & Mucic DEditors: A. Fiorillo, I. Calliess, & H. Sass.Wiley, Hoboken, NJ2012
Pharmacological Treatments in Schizophrenia.
Chapter: Novel approaches for treating schizophrenia.
Page 40 - 48Davis MC, & Marder SREditors: M.S. Keshavan.Future Medicine Ltd., London, England2012

Abstracts/Posters

Can Oxytocin Enhance Learning During Social Cognitive Skills Training in Schizophrenia?
Davis MC, Green MF, Lee J, Horan WP, Wynn JK, Marder SR, Society of Biological Psychiatry Annual Meeting, Biological Psychiatry, 5/8/2014
Can Oxytocin Enhance Learning During Social Cognitive Skills Training in Schizophrenia?
Davis MC, Green MF, Lee J, Horan WP, Wynn JK, Marder SR, American College of Neuropsychopharmacology Annual Meeting, 12/8/2013
Psychiatric Manifestations and Management of Anti-NMDA Receptor Encephalitis.
Kruse JL, Jeffrey JK, Davis MC, Brooks JO III, Academy of Psychosomatic Medicine Annual Meeting, 11/15/2013
A Pilot Study on the Effects of Single Dose Intranasal Oxytocin in Schizophrenia.
Davis MC, Lee J, Horan WP, Green MF, Marder SR, Schizophrenia Bulletin, 1/1/2013
A Pilot Study on the Effects of Single Dose Intranasal Oxytocin in Schizophrenia.
Davis MC, Lee J, Horan WP, Green MF, Marder SR, American College of Neuropsychopharmacology Annual Meeting, 12/2/2012
Does oxytocin administration enhance social cognition in individuals with schizophrenia?
Davis MC, Lee J, Green MF, Marder SR, American College of Neuropsychopharmacology Annual Meeting, Waikaloa, HI
Glucocorticoid reversal of vinblastine resistance in cultured human leukemic cells.
Davis MC, Hines HM, Schmidt TJ, American Association for Cancer Research Annual Meeting, San Francisco, CA
Bcl-2 selectively inhibits pro-apoptotic calcium signals induced by strong TCR activation but not pro-survival calcium signals induced by weak TCR activation.
Distelhorst CW, Zhong F, Davis MC, Cold Spring Harbor Laboratory Meeting: Programmed Cell Death, Cold Spring Harbor, New York
A pilot study on the effects of single dose intranasal oxytocin in schizophrenia
Davis, M.C., Lee, J., Horan, W.P., Green, M.F., Marder, S.R., American College of Neuropsychopharmacology Annual Meeting, Hollywood, FL
Does oxytocin administration enhance social cognition in individuals with schizophrenia?
Davis M.C., Lee J., Green M.F., Marder S.R., American Psychiatric Association Junior Investigator Research Colloquium, Philadelphia, PA
Dexamethasone induces expression of the inositol-1,4,5-trisphosphate receptor, thereby elevating cytosolic calcium and inducing apoptosis
Davis MC, McColl KS, Zhong F, Distelhorst CW, Cold Spring Harbor Laboratory Meeting: Programmed Cell Death, Cold Spring Harbor, NY
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Lectures

Effects of single dose intranasal oxytocin on social cognition in schizophrenia.
San Francisco, CA - 1/1/2013
N-Acetylcysteine in Psychiatry
UCLA Semel Institute of Neuroscience and Human Behavior
Oxytocin and Social Cognition in Schizophrenia
West Los Angeles VA Medical Center
Live Free or Die: An Immature T Cell Decision Encoded in Distinct Bcl-2 Sensitive and Insensitive Calcium Signals
Case Western Reserve University
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Press Mentions

Review the Article, “Facing Our Fears.”January 3rd, 2021

Grant Support

Advanced Fellowship in Mental Illness Research and TreatmentVA Mental Illness Research, Education, and Clinical Center2012–2014
Pala Pilot GrantVISN 22 Mental Illness Research, Education, and Clinical Center2011–2012
Medical Scientist Training ProgramNIH2000–2008
Hematology Training GrantNIH2004–2006
Howard Hughes Medical Institute Research AssistantshipHHMI1998–1999
Signal Transduction Training Group InternshipNSF1998–1999

Committees

Resident representative, Outpatient Practice Council 2011 - 2012
Psychiatry resident representative, Graduate Medical Education Committee 2011 - 2012
Cutting Edge Journal Club Coordinator; Recruitment Committee Member; Resident Handbook Chairman; Resident Website Administrator; President, Psychiatry Residency Council 2009 - 2012
Resident representative, Psychiatry Residency Oversight Committee 2008 - 2012
Monthly meeting chairperson, Medical Scientist Training Program 2004 - 2005
Graduate Student Senate representative; Summer Undergraduate Research Program chairperson; Social chairperson; discussion group steering committee, Department of Pharmacology Graduate Student Organization 2003 - 2006
Student representative, Student Health Advisory Committee 1998 - 1999

Research History

Research FellowDevelopment of novel therapeutics for treatment-resistant symptoms of schizophrenia2012 - 2014
Psychiatry Residency Research TrackPharmacological enhancement of social cognition in individuals with schizophrenia2008 - 2012
Medical student research`Analysis of the frequency, causes, and outcomes of clozapine discontinuation2007 - 2007
Ph.D. thesis researchGeneration and regulation of pro-apoptotic calcium signals in T cells2002 - 2006
Research assistantRegulation of calcitonin gene-related peptide during migraines2000 - 2000
Undergraduate research; Research assistantRole of glucocorticoids in multi-drug resistance of human leukemic lymphocytes1999 - 2000
Undergraduate researchAnalysis of glutamate release from astrocytes using fluorescence microscopy and fiber optics/laser instrumentation1998 - 1998
Undergraduate researchInvestigation of the role of phospholipase A2 in neurotransmitter-induced release of calcium from astrocytes1998 - 1998
Undergraduate researchLipid analysis of pork samples for National Pork Producers Council-sponsored project1997 - 1997
Undergraduate researchDeveloped PERL scripts and web-based interface for genetics bioinformatics tools1997 - 1997