MichaelYoungjunChoiMD

Hematology • La Jolla, CA

Hematologic Oncology

Associate Professor, Medicine, UC San Diego Sch. of Medicine

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Office
3855 Health Sciences Dr
La Jolla, CA 92093
Phone+1 858-822-0863

Fax+1 858-246-1847

Education & Training

University of California (San Diego) Medical CenterFellowship, Hematology and Medical Oncology, 2009 - 2012
University of California (San Diego) Medical CenterResidency, Internal Medicine, 2005 - 2008
Keck School of Medicine of the University of Southern CaliforniaClass of 2005

Certifications & Licensure

CA State Medical License 2007 - 2026
American Board of Internal Medicine Hematology

Awards, Honors, & Recognition

Young Investigator Award Tower Cancer Research Foundation, 2012

Clinical Trials

UC-961 (Cirmtuzumab) in Relapsed or Refractory Chronic Lymphocytic Leukemia Start of enrollment: 2014 Aug 08
Completed
Phase 1
Dimethylfumarate (DMF) in Relapsed/Refractory CLL/SLL Start of enrollment: 2016 Jun 01
Terminated
Phase 1
Obinutuzumab, High Dose Methylprednisolone (HDMP), and Lenalidomide for the Treatment of Patients With Richter's Syndrome Start of enrollment: 2017 Dec 20
Completed
Phase 1
Venetoclax With High-dose Ibrutinib for CLL Progressing on Single Agent Ibrutinib Start of enrollment: 2018 May 01
Active, not recruiting
Phase 1
Rituximab + High-Dose Methylprednisolone Debulking Prior to Venetoclax for CLL & SLL Patients Start of enrollment: 2021 Sep 02
Active, not recruiting
Phase 1
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

4 citations
Mutation in Bruton Tyrosine Kinase (BTK) A428D confers resistance To BTK-degrader therapy in chronic lymphocytic leukemia.
Richard L Wong, Michael Y Choi, Huan-You Wang, Thomas J Kipps
Leukemia. 2024-08-01
Aberrant spliceosome activity via elevated intron retention and upregulation and phosphorylation of SF3B1 in chronic lymphocytic leukemia.
Manoj Kumar Kashyap, Hiren Karathia, Deepak Kumar, Roberto Vera Alvarez, Jose Vicente Forero-Forero
Molecular Therapy. Nucleic Acids. 2024-06-11
6 citations
Metastatic gastric cancer target lesion complete response with Claudin18.2-CAR T cells.
Gregory P Botta, Joseph Chao, Hong Ma, Michael Hahn, Gloria Sierra
Journal for Immunotherapy of Cancer. 2024-02-05

Abstracts/Posters

The Chronic Lymphocytic Leukemia Comorbidity Index (CLL-CI): A Novel Comorbidity Score Derived from a Large Multicenter Retrospective Cohort Study of Patients Treated ...
Michael Y. Choi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Cirmtuzumab, a ROR1 Targeted Mab, Reverses Cancer Stemness, and Its Combination with Ibrutinib Is Safe and Effective: Planned Analysis of the Cirll Phase 1/2 Trial for...
Michael Y. Choi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Efficacy of Therapies Following Venetoclax Discontinuation in CLL: Focus on B-Cell Receptor Signal Transduction Inhibitors and Cellular Therapies
Michael Y. Choi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Fostamatinib, a Spleen Tyrosine Kinase (SYK) Inhibitor, for the Treatment of Warm Antibody Autoimmune Hemolytic Anemia (wAIHA): Final Results of the Phase 2, Multicent...
Michael Y. Choi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
High-Level ROR1 and BCL2, Cancer-Stemness, and BCL2 Mutations Associate with Venetoclax Resistance in Chronic Lymphocytic Leukemia
Michael Y. Choi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Ongoing Results of a Phase 1B/2 Dose-Escalation and Cohort-Expansion Study of the Selective, Noncovalent, Reversible BrutonÍS Tyrosine Kinase Inhibitor, Vecabrutinib, ...
Michael Y. Choi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
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Lectures

Cirmtuzumab, a ROR1 Targeted Mab, Reverses Cancer Stemness, and Its Combination with Ibrutinib Is Safe and Effective: Planned Analysis of the Cirll Phase 1/2 Trial for...
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
Phase 1/2 trial of cirmtuzumab and ibrutinib: Planned analysis of phase 1 CLL cohorts.
2019 ASCO Annual Meeting - 6/1/2019

Press Mentions

Acalabrutinib Plus Venetoclax Improves PFS in First-of-Its-Kind CLL TrialDecember 9th, 2024
Community Cancer Practices Implement Venetoclax Protocols for CLL, but Gaps RemainDecember 8th, 2024
Oncternal Therapeutics Announces Presentation of Clinical Data Update on Cirmtuzumab in Combination with Ibrutinib at 2019 ASH Annual MeetingDecember 9th, 2019
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