MichaelD.CaldwellMDPhD, FACS

PubMed

• 119 citations
  Relative impact of covariates in prescribing warfarin according to CYP2C9 genotype.
  Michael A. Hillman, Russell A. Wilke, Michael D. Caldwell, Richard L. Berg, Ingrid Glurich
  Pharmacogenetics. 2004-08-01
• 65 citations
  Dose-Sparing H5N1 A/Indonesia/05/2005 Pre-pandemic Influenza Vaccine in Adults and Elderly Adults: A Phase III, Placebo-Controlled, Randomized Study
  Joanne M. Langley, George Risi, Michael Caldwell, Larry Gilderman, Bruce Berwald
  The Journal of Infectious Diseases. 2011-06-15
• 223 citations
  Disease Management Program for Chronic Obstructive Pulmonary Disease A Randomized Controlled Trial
  Kathryn L. Rice, Naresh Dewan, Hanna E. Bloomfield, Joseph Grill, Tamara M. Schult
  American Journal of Respiratory and Critical Care Medicine. 2010-10-01

Journal Articles

• A Pharmacogenetic versus a Clinical Algorithm for Warfarin Dosing  
  Kimmel SE, French B, Kasner SE, Johnson JA, Anderson JL, Gage BF,Rosenberg YD, Eby CS, Madigan RA, McBane RB, Abdel-Rahman SZ, Stevens SM, Yale S, Mohler ER III, Fang..., N Engl J Med, 12/12/2013
• Rationale and Design of the Clarification of Optimal Anticoagulation through Genetics (COAG) Trial  
  Kimmel SE, French B, Anderson J, Gage BF, Johnson JA, Rosenberg YD, Geller NL, Kasner S, Eby CS, Joo J, Caldwell MD, Goldhaber SZ, Hart RG, Cifelli D Madigan R, Brens..., American Heart Journal, 9/1/2013
• A Preliminary Investigation into Predictive Models for Adverse Drug Events  
  Davis J, Costa VS, Peissig P, Caldwell MD, Page D, Proceedings of the AAAI-13 Workshop on Expanding the Boundaries of Health Informatics Using AI, 1/1/2013
• Demand-Driven Clustering in Relational Domains for Predicting Adverse Drug Events.  
  Davis, J., Costa, V.S., Peissig, P., Caldwell, M., Berg, E., Page, D, Proceedings of the International Conference on Machine Leaning (ICML), 1/1/2012
• Identifying Adverse Drug Events by Relational Learning.  
  Page, D., Costa, V.S., Natarajan, S., Barnard, A., Peissig, P. Caldwell, M, Proceedings of AAAI, 1/1/2012
• Evaluation of a Mitochondrial DNA Mutation in Maternally Inherited and Sporadic Cases of Dupuytren Disease.  
  Anderson, E. R., Burmester, J. K., Caldwell, M. D., Clinical Medicine and Research., 1/1/2012
• Demand-Driven Clustering in Relational Domains for Predicting Adverse Drug Events  
  Davis J, Costa VS, Peissig P, Caldwell M, Berg E, Page D, Proceedings of the International Conference on Machine Leaning, 1/1/2012
• Identifying Adverse Drug Events by Relational Learning Identifying Adverse Drug Events by Relational Learning  
  Page D, Costa VS, Natarajan S, Barnard A, Peissig P Caldwell M, Proceedings of AAAI, 1/1/2012
• Evaluation of a Mitochondrial DNA Mutation in Maternally Inherited and Sporadic Cases of Dupuytren Disease  
  Anderson ER, Burmester JK, Caldwell MD, Clinical Medicine and Research, 1/1/2012
• Pharmacogenetic Warfarin Dose Refinements Remain Significantly Influenced by Genetic Factors After One Week of Therapy  
  Horne BD, Lenzini PA, Wadelius M, Jorgensen AL, Kimmel SE, Ridker PM, Eriksson N, Anderson JL, Pirmohamed M, Limdi NA, Pendleton RC, McMillin GA, Burmester JK, Kurnik ..., Thrombosis and Haemostasis, 12/21/2011
• Absence of Novel CYP4F2 and VKORC1 Coding Region DNA Variants in Patients Requiring High Warfarin Doses.  
  Burmester, JK, Berg, RL, Glurich, I, Yale, SH, Schmelzer, JR, Caldwell, MD., Clinical Medicine and Research, 11/1/2011
• A Randomized-Controlled Trial of Genotype-Based Coumadin Initiation.  
  Burmester, JK, Berg, RL, Yale, SH, Rottscheit, CM, Glurich, IE, Schmelzer, JR, Caldwell, MD, Genetics in Medicine, 6/1/2011
• International Warfarin Pharmacogenetics Consortium Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups  
  Limdi NA, Wadelius M, Cavallari L, Eriksson N, Crawford DC, Lee MT, Chen CH, Motsinger-Reif A, Sagreiya H, Liu N, Wu AH, Gage BF, Jorgensen A, Pirmohamed M, Shin JG, S..., Blood, 5/6/2010
• Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups.  
  Limdi NA, Wadelius M, Cavallari L, Eriksson N, Crawford DC, Lee MT, Chen CH, Motsinger-Reif A, Sagreiya H, Liu N, Wu AH, Gage BF, Jorgensen A, Pirmohamed M, Shin JG, S..., Blood, 5/1/2010
• Understanding The Pharmacogenetic Approach To Warfarin Dosing  
  Glurich, I., Burmester, J., Caldwell, M.D, Heart Failure Reviews, 1/1/2010
• Integration of Genetic, Clinical, and INR Data to Refine Warfarin Dosing.  
  P Lenzini1, M Wadelius, S Kimmel, JL Anderson, AL Jorgensen, M Pirmohamed, MD Caldwell, N Limdi, JK Burmester, MB Dowd, P Angchaisuksiri, AR Bass, J Chen, N Er..., Clinical Pharmacology and Therapeutics, 1/1/2010
• New Adjuvants to Enhance Anticoagulant Activity of Warfarin.  
  Stromich, J.J., Weber, A.K., Mirzaei, Y.R., Caldwell, M.D., Lewis, D.E, Bioorganic & Medicinal Chemistry Letters, 1/1/2010
• Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data.  
  The International Warfarin Pharmacogenetic Consortium. Caldwell, M. D. (Member of the Consortium and of the Writing Committee, among other committees), New England Journal of Medicine, 1/1/2009
• Perioperative Genomic Profiles Using Structure-Specific Oligonucleotide Probes  
  Hogan, K.J., Burmester, J.K., Caldwell, M.D., Hogan, Q.H., Coursin, D.B., Green, D.N., Selzer, R.M.R., Broderick, T.P., Rusy, D.A., Poroli, M., Lutz, A.L., Sanders, A...., Clin. Med. Res., 1/1/2009
• The Marshfield Clinic Personalized Medicine Research Project: 2008 scientific update and lessons learned in the first 6 years  
  McCarty, C.A., Peissig, P., Caldwell, M.D., Wilke, R.A, Personalized Medicine, 1/1/2008
• CYP4F2 genetic variant alters required warfarin dose.  
  Caldwell, M.D., Awad, T., Johnson, J.A., Gage, B.F., Falkowski, M., Gardina, P., Hubbard, J., Turpaz, Y., Langaee, T.Y., Eby, C., King, C., Brower, A., Schmelzer, J.R...., Blood, 1/1/2008
• Machine Learning for Personalized Medicine: Will This Drug Give Me a Heart Attack?, In the Proceedings of Machine Learning in Health Care Applications Workshop In conj...  
  Davis J, Lantz E, Page D, Struyf J, Peissig P, Vidailet H, Caldwell MD, Health Workshop, 1/1/2008
• Necrotizing fasciitis due to a methicillin-sensitive Staphylococcus aureus harboring an enterotoxin gene cluster.  
  Morgan, W., Caldwell, M.D., Brady, J.M., Stemper, M.E., Reed, K.D., Shukla, S.K., Journal Clinical Microbiology, 1/1/2007
• Evaluation of genetic factors for warfarin dose prediction.  
  Caldwell, M.D., Berg, R.L., Zhang,K.Q., Glurich, I.E., Schmelzer, J.R., Yale, S.H., Vidaillet, H.J., Burmester, J.K., Clinical Medicine and Research, 1/1/2007
• Mactinin treatment promotes wou nd healing associated inflammation in urokinase knockout mice.  
  Luikart, S.D., Levay-Young, B., Hinkel, T., Shearer, J.D., Mills, C., Caldwell, M.D., Gyetko, M.R., Oegema, T.R, Wound Repair and Regeneration, 1/1/2006
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Books/Book Chapters

• Principles of Pharmacogenetics and Pharmacogenomics 
  Chapter: Introduction to Population Diversity and Genetic Testing 
  Page 3 - 11Caldwell MD, Glurich I, Pillsbury K, Burmester JKEditors: Altman RB, Flockhart D and Goldstein DB.Cambridge University Press2012
• Principles of Pharmacogenetics and Pharmacogenomics. 
  Chapter: Introduction to Population Diversity and Genetic Testing. 
  Page 3 - 11Caldwell, MD, Glurich, I, Pillsbury, K, Burmester, JKEditors: Altman, R.B., Flockhart, D., and Goldstein, D.B..Cambridge University Press2012
• Surgical Clinics of North America Series 
  Chapter: Wounds and Wound Management 
  Page 1125 - 1132Caldwell, MDEditors: Caldwell, MD (Guest Ed); RF Martin, Consulting Editor..W.B. Saunders, Co., W.B. Saunders, Co.2010
• Wounds and Wound Management : Surgical Clinics of North America Series 
  Chapter: Wound Surgery 
  Page 1125 - 1132Caldwell MDEditors: Caldwell MD (Guest Ed.), Martin RF (Consulting Editor).W.B. Saunders, Co., Philadelphia, PA2010
• Wounds and Wound Management : Surgical Clinics of North America Series 
  Editors: Caldwell, MD (Guest Ed.), Martin, RF (Consulting Editor).W.B. Saunders, Co., Philadelphia, PA2010
• Cardiovascular Genetics and Genomics. AHA Publication 
  Chapter: Case Study: Warfarin Pharmacogenetics from Single to Multiple Genes 
  Caldwell MD, Berg REditors: Roden D.2009
• Cardiovascular Genetics and Genomics 
  Chapter: Case Study: Warfarin Pharmacogenetics from Single to Multiple Genes. 
  Caldwell, MD, Berg, REditors: Roden, D.AHA Publication2009
• Modern Surgical Care: Physiologic Foundations & Clinical Applications, 
  Chapter: The metabolic response to starvation, stress and sepsis 
  Page 1 - 36Amaral JR, Caldwell MDEditors: Miller TA.Quality Medical Publishing, Inc., St. LouisEdition 2nd ,1998
• Modern Surgical Care: Physiologic Foundations & Clinical Applications 
  Chapter: The metabolic response to starvation, stress and sepsis 
  Page 1 - 36Amaral JR, Caldwell MDEditors: Miller TA.Quality Medical Publishing, Inc., St. Louis, MOEdition 2nd,1998
• Growth Factors and Wound Healing. 
  Chapter: Steroid impaired wound healing: mechanisms for the beneficial effects of retinoic acid 
  Page 92 - 103Ulland AE, Shearer JD, Caldwell MDEditors: Ziegler TR, Pierce GF, Herndon DN.Springer Verlag, New York1997
• Growth Factors and Wound Healing 
  Chapter: Steroid impaired wound healing: mechanisms for the beneficial effects of retinoic acid 
  Page 92 - 103Ulland AE, Shearer JD, Caldwell MDEditors: Ziegler TR, Pierce GF, Herndon DN.Springer Verlag, NY1997
• Growth Factors and Wound Healing. 
  Chapter: Endogenous growth factors and nutrients in the healing wound 
  Page 186 - 205Arlein W, Caldwell MDEditors: Ziegler TR, Pierce GF, Herndon DN.Springer Verlag, New York1997
• Growth Factors and Wound Healing 
  Chapter: Endogenous growth factors and nutrients in the healing wound 
  Page 186 - 205Arlein W, Caldwell MDEditors: Ziegler TR, Pierce GF, Herndon DN.Springer Verlag, NY1997
• Nutrition for the Hospitalized Patient: Basic Science and Principles of Practice 
  Chapter: Lipid metablism 
  Page 37 - 55Ulland AE, Caldwell MDEditors: Torosian MH.Marcel Dekker, Inc., NY1995
• Nutrition for the Hospitalized Patient: Basic Science and Principles of Practice. 
  Chapter: Lipid metablism 
  Page 37 - 55Ulland AE, Caldwell MDEditors: Torosian, MH.Marcel Dekker, Inc., New York1995
• Clinical Nutrition II: Parenteral Nutrition 
  Editors: Rombeau J, Caldwell MD.W.B. Saunders, Co., Philadelphia, PAEdition 2nd,1993
• Biology of Nitric Oxide 
  Chapter: Macrophage arginine metabolism via synthase or arginase equates with immunosurveillance or immunostimulation of cancer 
  Page 228 - 234Mills CD, Shearer J, Caldwell MDEditors: Monkadas M, Marletta MA, Hibbs JB.Portland Press, London1993
• Clinical Nutrition 11: Parenteral Nutrition. 
  Chapter: Nutrition and Molecular Biology 
  Page 203 - 208Gartner MH, Caldwell MDEditors: Rombeau JL, Caldwell MD.W.B. Saunders Company, PhiladelphiaEdition Seco,1993
• Fetal Wound Healing 
  Chapter: Metabolic aspects of fetal wound healing 
  Page 241 - 253Ahrendt MN, Caldwell MDEditors: Adzick NS, Longacker M.Elsevier, New York1992
• Current Surgical Therapy 
  Chapter: Nutritional support in the surgical patient 
  Page 946 - 950Caldwell MDEditors: Cameron JL.Mosby Year Book, St. LouisEdition 4th ,1992
• Clinical and Experimental Approaches to Dermal & Epidermal Repair: Normal and Chronic Wounds 
  Editors: Barbul A, Pines E, Caldwell M, Hunt T, Eaglstein W.Wiley Liss, Inc., NY1991
• Clinical and Experimental Approaches to Dermal and Experimental Repair: Normal and Chronic Wounds 
  Chapter: Concomitant macrophage activation and fibroblast/lymphocyte inhibition by wound fluid: The "arginine deficiency of inflammation" is a partial explanation 
  Page 193 - 203Mills CD, Pricolo VE, Caldwell MDEditors: Barbul AA, Pine E, Caldwell MD, Eaglestein W.Wiley Liss, Inc.1991
• Clinical and Experimental Approaches to Dermal & Epidermal Repair: Normal and Chronic Wounds 
  Chapter: The temporal changes in amino acid concentration within wound fluid: A putative rationale 
  Page 205 - 222Caldwell MD, Mastrofrancesco B, Shearer JD, Bereiter DFEditors: Barbul A, Pines E, Caldwell M, Hunt T, Eaglstein W.Wiley Liss, Inc., New York1991
• Clinical Nutrition I: Enteral and Tube Feeding. 
  Chapter: Pediatric enteral nutrition 
  Page 434 - 479Kennedy Caldwell C, Caldwell MDW.B. Saunders, PhiladelphiaEdition Seco,1990
• Clinical Nutrition I: Enteral and Tube Feeding 
  Editors: Rombeau J, Caldwell MD.W.B. Saunders, Co., Philadelphia, PAEdition 2nd,1990
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Abstracts/Posters

• Treadmill exercise assessment of limb venous functional responses.
  Hirsch AT, Lunzer MM, Serfass RC, Caldwell MD, Dietz CA, 10th Annual Meeting of the American Venous Forum, Lake Buena Vista, FL, 2/19/1998
• Treadmill exercise assessment of limb venous functional responses
  Hirsch AT, Lunzer MM, Serfass RC, Caldwell MD, Dietz CA, 10th Annual Meeting of the American Venous Forum, Lake Buena Vista, FL, 2/19/1998
• Differential degradation of insulin and insulin-like growth factor I in wound fluid.
  Shearer JD, Glanzer T, Coulter CF, Caldwell MD, Faseb, 1/1/1998
• Differential degradation of insulin and insulin-like growth factor I in wound fluid
  Shearer JD, Glanzer T, Coulter CF, Caldwell MD, Faseb J, 1/1/1998
• An absence of wound insulin degradation parallels impaired wound healing in CM INH treated, steroid treated and diabetic rats.
  Coulter CF, Shearer JD, Caldwell MD, J of Minn Acad Sci, 1/1/1997
• An absence of wound insulin degradation parallels impaired wound healing in CM INH treated, steroid treated and diabetic rats
  Coulter CF, Shearer JD, Caldwell MD, J of Minn Acad Sci, 1/1/1997
• Insulin degrading activity in normal diabetic and insulin treated diabetic rats.
  Shearer JD, Coulter CF, Caldwell MD, Wound Repair and Regeneration, 1/1/1996
• Characterization of insulin degrading activity in normal healing wounds.
  Coulter CF, Shearer JD, Caldwell MD, Faseb, 1/1/1996
• Differential degradation of peptide hormones and growth factors in wounds.
  Shearer JD, Coulter CF, Caldwell MD, Faseb, 1/1/1996
• Stimulatory and inhibitory effects of wound fluid (WF) on fibroblast proliferation.
  Wotus C, Shearer JD, Caldwell MD, Faseb, 1/1/1996
• Insulin degrading activity in normal diabetic and insulin treated diabetic rats
  Shearer JD, Coulter CF, Caldwell MD, Wound Repair and Regeneration, 1/1/1996
• Characterization of insulin degrading activity in normal healing wounds
  Coulter CF, Shearer JD, Caldwell MD, Faseb J, 1/1/1996
• Differential degradation of peptide hormones and growth factors in wounds
  Shearer JD, Coulter CF, Caldwell MD, Faseb J, 1/1/1996
• Stimulatory and inhibitory effects of wound fluid (WF) on fibroblast proliferation
  Wotus C, Shearer JD, Caldwell MD, Faseb J, 1/1/1996
• Investigation of rat fibroblast replication using PKE 2, a fluorescent label.
  Arlein WJ, Shearer JD, Caldwell MD, Wound Repair and Regeneration, 1/1/1995
• Flow cytometric analysis of wound cell replication.
  Shearer JD, Aberle LA, Richards JR, Caldwell MD, Wound Repair and Regeneration, 1/1/1995
• Retinoic acid reverses steroid impaired arginase activity in rat wounds.
  Ulland AE, Shearer JD, Caldwell MD, Wound Repair and Regeneration, 1/1/1995
• Investigation of rat fibroblast replication using PKE 2, a fluorescent label
  Arlein WJ, Shearer JD, Caldwell MD, Wound Repair and Regeneration, 1/1/1995
• Flow cytometric analysis of wound cell replication
  Shearer JD, Aberle LA, Richards JR, Caldwell MD, Wound Repair and Regeneration, 1/1/1995
• Retinoic acid reverses steroid impaired arginase activity in rat wounds
  Ulland AE, Shearer JD, Caldwell MD, Wound Repair and Regeneration, 1/1/1995
• The role of 15 deoxyspergualin (DSG) in the prevention of diabetes in the BBIW rat.
  Lokeh A, Stevens RB, Ansite JD, Benson J, Tepper M, Caldwell MD, Brayman KL, Sutherland DER, Transplant Proceedings, 4/1/1994
• The role of nitric oxide (NO) in the pathogenesis of early pancreatic islet (lx) dysfunction during rat and human intraportal (IP) islet transplantation (Tx).
  Stevens RB, Ansite JD, Lokeh A, Benson J, Field MJ, Caldwell MD, Gores PF, Sutherland DER, Transplant Proceedings, 4/1/1994
• The role of 15 deoxyspergualin (DSG) in the prevention of diabetes in the BBIW rat
  Lokeh A, Stevens RB, Ansite JD, Benson J, Tepper M, Caldwell MD, Brayman KL, Sutherland DER, Transplant Proceedings, 4/1/1994
• The role of nitric oxide (NO) in the pathogenesis of early pancreatic islet (lx) dysfunction during rat and human intraportal (IP) islet transplantation (Tx)
  Stevens RB, Ansite JD, Lokeh A, Benson J, Field MJ, Caldwell MD, Gores PF, Sutherland DER, Transplant Proceedings, 4/1/1994
• Altered arginine metabolism in diabetic wounds.
  Shearer JD, Caldwell MD, Wound Repair and Regeneration, 1/1/1994
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Lectures

• Mediators of Inflammation from Physiologic Basis of Surgery by O'Leary 
  Marshfield, WI - 2/24/2012
• Surgical Infection from Physiologic Basis of Surgery by O'Leary. 
  Marshfield, WI - 1/17/2012
• Surgical Infection from Physiologic Basis of Surgery by O'Leary 
  Marshfield, WI - 1/17/2012
• Wound Healing 
  St. Joseph’s Hospital, Marshfield, WI - 3/15/2011
• Wound Healing from Physiologic Basis of Surgery by O'Leary. 
  Marshfield, WI - 3/15/2011
• Wound Healing, Surgical Residents Basic Science Lectures 
  Marshfield, WI - 3/15/2011
• Wound Healing from Physiologic Basis of Surgery by O'Leary 
  Marshfield, WI - 3/15/2011
• Pharmacogenetic Approaches to Warfarin Dosing 
  Washington, DC - 1/6/2011
• Cows, and Enzymes, and Rats ! Oh My ! 
  Marshfield Clinic, Marshfield, WI - 5/18/2010
• Cows, and Enzymes, and Rats! Oh My! 
  Marshfield, WI - 5/18/2010
• Pharmacogenetics of Warfarin 
  Chicago, IL - 7/22/2009
• Warfarin Pharmacogenetics 
  Appleton, WI - 4/28/2009
• Warfarin Pharmacogenetics Wisconsin 
  Appleton, WI - 4/28/2009
• Candidate Gene Approach to Warfarin Dosing. 
  Rockville, MD - 11/4/2008
• Candidate Gene Approach to Warfarin Dosing 
  Rockville, MD - 11/4/2008
• The Marshfield Clinic Prospective Genotyping for Warfarin Dosing Experience. 
  FDA Bethesda, MD - 11/3/2008
• Novel Genotypes Associated with Warfarin Stable Therapeutic Dose and the IWPC 
  FDA Bethesda, MD - 11/3/2008
• The Marshfield Clinic Prospective Genotyping for Warfarin Dosing Experience 
  Bethesda, MD - 11/3/2008
• Genetic Loci Responsible for Interindividual Differences in Response to Warfarin 
  American Regional ISSX Meeting - 10/15/2008
• Using Warfarin Pharmacogenetics to Design New Anticoagulants 
  UW-Stout, Menomonie, WI - 7/18/2008
• Genotyping for Warfarin Dosing (Invited Presentation ) 
  Philadelphia, PA - 9/17/2007
• Genotyping for Warfarin Dosing (Invited Presentation) 
  Philadelphia, PA - 9/17/2007
• Making Personalized Predictive Medicine A Bedside Reality (Invited Presentation) 
  Washington, DC - 9/11/2007
• Recent Developments in Warfarin Pharmacogenetics (Invited Seminar) 
  Stanford University, Palo Alto, CA - 6/7/2007
• Recent Developments in Warfarin Pharmacogenetics (Invited Seminar) 
  Palo Alto, CA - 6/7/2007
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Other

• Nutrition Care Delivery: Dynamics and Economics 
  Caldwell MD, National Video Teleconference
  Providence, RI - 10/26/1983