Melissa Lynne Johnson MD

Thoracic Cancer

Director, Lung Cancer Research Associate Director, Drug Development Unit-Nashville Sarah Cannon Research Institute Tennessee Oncology, PLLC

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250 25th Ave., NSuite 200Nashville, TN 37203
Phone+1 615-320-5090

Summary

Dr. Melissa Johnson is the Director of the Lung Cancer Research Program at Sarah Cannon Research Institute and the Associate Director of the Drug Development Unit in Nashville. She is also a partner in Tennessee Oncology, PLLC. She is a medical oncologist affiliated with TriStar Centennial Medical Center. She received her medical degree from Perelman School of Medicine at the University of Pennsylvania and has been in practice 13 years. She specializes in thoracic oncology and clinical trial investigation.

Education & Training

Memorial Sloan Kettering Cancer CenterFellowship, Hematology and Medical Oncology, 2007 - 2010
New York Presbyterian Hospital (Cornell Campus)Residency, Internal Medicine, 2004 - 2007
Perelman School of Medicine at the University of PennsylvaniaClass of 2004

Certifications & Licensure

FL State Medical License 2020 - Present
TN State Medical License 2021 - 2025
LA State Medical License 2020 - 2022
AL State Medical License 2020 - 2020
IL State Medical License 2010 - 2017
NY State Medical License 2006 - 2011
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2011

Clinical Trials

Bevacizumab or Pemetrexed Disodium Alone or In Combination After Induction Therapy in Treating Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer Start of enrollment: 2010 Oct 25
Completed
Phase 3
LDE225 for Patients With PTCH1 or SMO Mutated Tumors Start of enrollment: 2014 Feb 01
Terminated
Phase 2
A Study to Evaluate Immunotherapy Combinations in Participants With Lung Cancer Start of enrollment: 2019 Apr 01
COMPLETED
PHASE1
SL-279252 (PD1-Fc-OX40L) in Subjects With Advanced Solid Tumors or Lymphomas Start of enrollment: 2019 Mar 26
COMPLETED
PHASE1
A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2) Start of enrollment: 2019 Sep 19
ACTIVE_NOT_RECRUITING
PHASE2
A Study to Test Different Doses of BI 1701963 Alone and Combined With Trametinib in Patients With Different Types of Advanced Cancer (Solid Tumours With KRAS Mutation) Start of enrollment: 2019 Nov 04
ACTIVE_NOT_RECRUITING
PHASE1
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors Start of enrollment: 2020 Dec 13
RECRUITING
PHASE1, PHASE2
RBN-2397 in Combination With Pembrolizumab in Patients With SCCL Start of enrollment: 2022 Mar 15
Active, not recruiting
Phase 1, Phase 2
Roles: Principal Investigator
Phase 3 Study of Pyrotinib Versus Docetaxel in Patients With Advanced Non-squamous NSCLC Harboring a HER2 Exon 20 Mutation Who Failed Platinum Based Chemotherapy Start of enrollment: 2020 Sep 11
Active, not recruiting
Phase 3
Roles: Contact
NT-I7 in Combination With Atezolizumab in Previously Untreated, PD-L1-expressing, Locally Advanced or Metastatic NSCLC Start of enrollment: 2021 Nov 03
Active, not recruiting
Phase 2
Roles: Contact, Principal Investigator
Study of RET Inhibitor TAS0953/HM06 in Patients with Advanced Solid Tumors with RET Gene Abnormalities Start of enrollment: 2020 Dec 16
RECRUITING
PHASE1, PHASE2
Roles: Contact
TAK-788 as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations Start of enrollment: 2020 Jan 10
ACTIVE_NOT_RECRUITING
PHASE3
Roles: Principal Investigator
Phase 1 Study of RBN-2397, an Oral PARP7 Inhibitor, in Patients With Solid Tumors Start of enrollment: 2019 Aug 01
Recruiting
Phase 1
Roles: Contact, Principal Investigator
Phase 1/2 Study of BDTX-1535 in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations Start of enrollment: 2022 Mar 31
RECRUITING
PHASE1, PHASE2
Roles: Contact
A Study of NM21-1480 in Adult Patients With Advanced Solid Tumors Start of enrollment: 2020 Aug 19
Terminated
Phase 1, Phase 2
Roles: Contact
A Study of TAS3351 in NSCLC Patients With EGFRmt Start of enrollment: 2023 May 25
RECRUITING
PHASE1, PHASE2
Roles: Principal Investigator
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Publications & Presentations

PubMed

Patient-Reported Outcomes for Patients with Previously Treated Small Cell Lung Cancer Receiving Tarlatamab: Results from the DeLLphi-301 Phase 2 Trial.
Horst-Dieter Hummel, Myung-Ju Ahn, Fiona Blackhall, Martin Reck, Hiroaki Akamatsu
Advances in Therapy. 2025-04-01
Sotorasib versus docetaxel for previously treated KRAS G12C-mutated non-small-cell lung cancer: a plain language summary.
Adrianus Johannes de Langen, Melissa L Johnson, Julien Mazieres, Anne-Marie C Dingemans, Giannis Mountzios
Future Oncology. 2025-03-24
A phase 1b study of cofetuzumab pelidotin monotherapy in patients with PTK7-expressing recurrent non-small cell lung cancer.
Byoung Chul Cho, Melissa Johnson, Jair Bar, Eric Schaefer, Kiyotaka Yoh
Lung Cancer. 2025-03-10

Lectures

A phase I, open label, multicenter dose escalation study of AZD2811 nanoparticle in patients with advanced solid tumors.
ASCO Annual Meeting 2019 - Chicago, IL - 6/1/2019
A phase I, open-label, multicenter dose escalation study to assess the safety, tolerability, and pharmacokinetics of AZD2811 nanoparticle in patients with advanced sol...
2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018
First in human phase 1/2a study of PEN-221 somatostatin analog (SSA)-DM1 conjugate for patients (PTS) with advanced neuroendocrine tumor (NET) or small cell lung cance...
2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018
Combination Chemotherapy Strategies in Frontline Therapy
2018 ASCO Annual Meeting - Chicago, Illinois - 06/1/2018
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Press Mentions

Arcus Biosciences Announces That Domvanalimab plus Zimberelimab Improved Overall Survival in ARC-10, a Randomized Study in Patients with PD-L1-High Non-Small Cell Lung CancerNovember 5th, 2024
Immunitas Therapeutics Announces First Patient Dosed in Phase 1/2a Study of IMT-009January 4th, 2023
Domvanalimab-Containing Regimens Show Activity in PD-L1-High NSCLCDecember 28th, 2022
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