MatthiasAngelosKarajannisMDMS

PubMed

• Phase 2 Trial of Veliparib, Local Irradiation and Temozolomide in Patients with Newly Diagnosed High-Grade Glioma: A Children's Oncology Group Study.
  Matthias A Karajannis, Arzu Onar-Thomas, Tong Lin, Patricia A Baxter, Daniel R Boué
  Neuro-Oncology. 2024-11-19
• Craniospinal irradiation and/or intraventricular radioimmunotherapy after high-dose chemotherapy and autologous stem cell rescue in patients with CNS retinoblastoma-Sa...
  Sameer Farouk Sait, Nancy A Kernan, Elizabeth Klein, Barbara Spitzer, Carolyn Fein Levy
  Pediatric Blood & Cancer. 2024-11-01
• Real-world experience with circulating tumor DNA in cerebrospinal fluid from patients with central nervous system tumors.
  Richard A Hickman, Alexandra M Miller, Bridget M Holle, Justin Jee, Si-Yang Liu
  Acta Neuropathologica Communications. 2024-09-17

Journal Articles

• Heterogeneity Within the PF-EPN-B Ependymoma Subgroup  
  Andrew Grossbach, Vijay Ramaswamy, Benjamin Lu, Mariarita Santi, Caterina Giannini, Linda M Liau, Terri S Armstrong, Sarah Leary, Matthias A Karajannis, Kenneth Aldape..., Acta Neuropathologica
• Clinical Response to Bevacizumab in Schwannomatosis  
  Blakeley J, Schreck KC, Evans DG, Korf BR, Zagzag D, Karajannis MA, Bergner AL, Belzberg AJ, Neurology, 10/22/2014
• Glioblastoma Multiforme: State of the Art and Future Therapeutics  
  Wilson T, Karajannis MA, Harter DH, Surgical Neurology International, 1/1/2014
• CRL4DCAF1-mediated Inhibition of Lats1/2 Promotes YAP-dependent Oncogenesis in NF2 Mutant Tumor Cells  
  Li W, Cooper J, Zhou L, Yang C, Erdjument-Bromage H, Zagzag D, Snuderl M, Ladanyi M, Hanemann CO, Zhou P, Karajannis MA, Giancotti FG, Cancer Cell, 1/1/2014
• Comprehensive Genomic Analysis of Diffuse Intrinsic Pontine Gliomas Unravels Three Molecular Subgroups and a Novel Cancer Driver ACVR1  
  Buczkowicz P, Hoeman C, Rakopoulos P, Pajovic S, Letourneau L, Dzamba M, Morrison A, Lewis P, Bouffet E, Bartels U, Zuccaro J, Agnihotri S, Ryall S, Barszczyk M, Chorn..., Nature Genetics, 1/1/2014
• Recurrent Ascites in a Pediatric Patient with Low-grade Astrocytoma and Ventriculo-peritoneal Shunt Treated with the Multi-kinase Inhibitor Sorafenib  
  Legault G, Kieran MW, Scott RM, Chordas C, Milla SS, Karajannis MA, Journal of Pediatric Hematology/Oncology, 1/1/2014
• Phase II Study of Everolimus in Children and Adults with Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas  
  Karajannis MA, Legault G, Hagiwara M, Giancotti FP, Filatov A, Derman A, Hochman T, Goldberg JD, Vega E, Wisoff JH, Golfinos JG, Merkelson A, Roland JT, Allen JC, Neuro-Oncology, 1/1/2014
• Recommendations for Imaging Tumor Response in Neurofibromatosis Clinical Trials  
  Dombi E, Ardern-Holmes SL, Babovic-Vuksanovic D, Barker FG, Connor S, Evans DG, Fisher MJ, Goutagny S, Harris GJ, Jaramillo D, Karajannis MA, Korf BR, Mautner V, Plotk..., Neurology, 1/1/2013
• Activation of MTORC1/mTORC2 Signaling in Pediatric Low Grade Glioma and Pilocytic Astrocytoma Reveals MTOR as a Therapeutic Target  
  Hutt-Cabezas M, Karajannis MA, Zagzag D, Shah S, Horkayne-Szakaly I, Rushing EJ, Cameron JD, Jain D, Eberhart CG, Raabe EH, Rodriguez FJ, Neuro-Oncology, 1/1/2013
• Recurrence Patterns across Medulloblastoma Subgroups- an Integrated Clinical and Molecular Analysis  
  Ramaswamy V, Remke M, Bouffet E, Farial CC, Perreault S, Cho YJ, Shih D, Luu B, Dubuc AM, Northcott PA, Schuller U, Gururangan S, McLendon R, Bigner D, Fouladi M, Ligo..., Lancet Oncology, 1/1/2013
• Recurrent Somatic Alterations of FGFR1 and NTRK2 in Pilocytic Astrocytoma  
  Jones DTW, Hutter B, Jager N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Khuong Quang DA, Fontebasso A, Stutz AM, Hutter S, Zuckermann M, Sturm..., Nature Genetics, 1/1/2013
• Phase II Clinical Trial of Lapatinib in Adult and Pediatric Patients with Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas  
  Karajannis MA, Legault G, Hagiwara M, Ballas MS, Brown K, Nusbaum AO, Hochman T, Goldberg JD, Koch KM, Golfinos JG, Roland JT, Allen JC, Neuro-Oncology, 1/1/2012
• Merlin: A Tumor Suppressor with Functions at the Cell Cortex and in the Nucleus  
  Li W, Cooper J, Karajannis, MA, Giancotti FG, EMBO Reports, 1/1/2012
• MicroRNA Profiling in Pediatric Pilocytic Astrocytoma Reveals Biologically Relevant Targets including PBX3, NFIB, and METAP2  
  Ho CY, Bar E, Giannini C, Karajannis MA, Zagzag D, Eberhart CG, Rodriguez FJ, Neuro-Oncology, 1/1/2012
• BRAF Alterations in Primary Glial and Glioneuronal Neoplasms of the Central Nervous System with Identification of Two Novel KIAA1549:BRAF Fusion Variants  
  Lin A, Rodriguez FJ, Karajannis MA, Williams SC, Legault G, Zagzag D, Burger PC, Allen JC, Eberhart CG, Bar E, Journal of Neuropathology and Experimental Neurology, 1/1/2012
• Consensus Recommendations for Current Treatments and Accelerating Clinical Trials for Patients with Neurofibromatosis Type 2  
  Blakeley JO, Evans DG, Adler J, Brackmann D, Chen R, Ferner RE, Hanemann CO, Harris G, Huson SM, Jacob A, Kalamarides M, Karajannis MA, Korf BR, Mautner VF, McClatchey..., American Journal of Medical Genetics, 1/1/2012
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  Williams SC, Karajannis MA, Chiriboga L, Golfinos JG, von Deimling A, Zagzag D, Acta Neuropathologica, 1/1/2010
• Prospective Neuraxis MRI Surveillance Reveals a High Risk of Leptomeningeal Dissemination in Diffuse Intrinsic Pontine Glioma  
  Sethi R, Allen J, Donahue B, Karajannis M, Gardner S, Wisoff J, Kunnakkat S, Mathew J, Zagzag D, Newman K, Narayana A, Journal of Neuro-Oncology, 1/1/2010
• Bevacizumab in Recurrent High-grade Pediatric Gliomas  
  Narayana A, Kunnakkat S, Chacko-Mathew J, Gardner S, Karajannis M, Raza S, Wisoff J, Weiner H, Harter D, Allen J, Neuro-Oncology, 1/1/2010
• Overexpression and Activation of Epidermal Growth Factor Receptor in Hemangioblastomas  
  Chen GJ, Karajannis MA, Newcomb EW, Zagzag D, Journal of Neuro-Oncology, 1/1/2010
• ErbB/HER Receptor Activation and Preclinical Efficacy of Lapatinib in Vestibular Schwannoma  
  Ammoun S, Cunliffe CH, Allen JC, Chiriboga L, Giancotti FG, Zagzag D, Hanemann CO, Karajannis MA, Neuro-Oncology, 1/1/2010
• Consensus Recommendations to Accelerate Clinical Trials for Neurofibromatosis Type 2  
  Evans DG, Kalamarides M, Hunter-Schaedle K, Blakeley J, Allen J, Babovic-Vuskanovic D, Belzberg A, Bollag G, Chen R, Ditomaso E, Golfinos J, Harris G, Jacob A, Kalpana..., Clinical Cancer Research, 1/1/2009
• Synchronous Mixed Germ Cell Tumor of the Pineal Gland and Suprasellar Region with a Predominant Angiomatous Component: A Diagnostic Challenge  
  Cunliffe CH, Fischer I, Karajannis M, Monoky D, Allen J, Wisoff J, Zagzag D, Journal of Neuro-Oncology, 1/1/2009
• The Microtubule Targeting Agent, CA4P, Regresses Leukemic Xenografts by Disrupting Interaction with Vascular Cells and Mitochondrial-dependent Cell Death  
  Petit I, Karajannis MA, Vincent L, Young LM, Butler J, Hooper AT, Shido K, Steller H, Chaplin DJ, Feldman E, Rafii S, Blood, 1/1/2008
• Treatment of Pediatric Brain Tumors  
  Karajannis M, Allen JC, Newcomb EW, Journal of Cellular Physiology, 1/1/2008
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Books/Book Chapters

• Neurofibromatosis Type 1: Symptoms, Treatment and Prognosis 
  Editors: Karajannis MA and Allen JC.Nova Science Publishers, New York2013
• Bradley's Neurology in Clinical Practice 
  Chapter: Management of Primary Nervous System Tumors in Infants and Children 
  Karajannis MA, Gardner SL, Allen JCEditors: Daroff RB et al.Elsevier Science, PhiladelphiaEdition 6th,2012
• Genome and Proteome in Oncology 
  Chapter: Epstein-Barr Virus Infection and Viral Gene Expression in Pediatric Non-Hodgkin Lymphomas 
  Karajannis MA, Hummel M, Oschlies I, Anagnostopoulos I, Zimmermann M, Parwaresch R, Reiter, AEditors: Stathopoulou FT.Nova Science Publishers, New York2005

Abstracts/Posters

• Her2 Amplification or Polysomy Chromosome 17 (PCH17) in Pilocytic Astrocytoma
  Michael Deel M, McLendon R, Becher O, Karajannis M, Wisoff J, Muh C, Schroeder K, Gururangan S, 16th International Symposium on Pediatric Neuro-Oncology, Singapore, 6/1/2014
• DNA Methylation Profiling identifies New Tumor Subgroups and Aids Diagnostic Accuracy in a Clinical Neuropathology Setting
  Jones DTW, Capper D, Sill M, Hovestadt V, Schweizer L, Lichter P, Zagzag D, Karajannis MA, Aldape KD, Korshunov A, von Deimling A, Pfister S, 16th International Symposium on Pediatric Neuro-Oncology, Singapore, 6/1/2014
• Molecular Subgroups of Paediatric Ependymoma
  Witt H, Mack S, Jones DTW, Jager N, Bender S, Ryzhova M, Northcott PA, Remke M, Pfaff E, Tzaridis T, Sill M, Benner A, Isserlin R, Milde T, Gupta N, Karajannis M, Fult..., 44th Congress of the International Society of Paediatric Oncology (SIOP), London, UK, 10/1/2012
• Intratumoral Concentration and Molecular Pharmacodynamics of Lapatinib in vivo in Sporadic and NF2-related Vestibular Schwannomas
  Karajannis MA, Bergner A, Giovannini A, Welling DB, Niparko J, Slattery W, Roland JT, Golfinos J, Allen J, Blakeley J, 15th International Symposium on Pediatric Neuro-Oncology, Toronto, Canada, 6/1/2012
• The Genetic Heterogeneity of Posterior Fossa Ependymoma
  Witt H, Mack S, Jager N, Jones DT, Bender S, Stutz A, Milde T, Northcott PA, Fults DW, Gupta N, Karajannis M, Kulozik AE, Deimling AV, Witt O, Rutka JT, Lichter P, Kor..., 15th International Symposium on Pediatric Neuro-Oncology, Toronto, Canada, 6/1/2012
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Lectures

• Genomics, Personalized Medicine and Acoustic Neuroma 
  Berkeley Heights, NJ - 10/28/2014
• Everolimus for Vestibular Schwannomas and Meningiomas: Updates from the Phase 2 and Phase 0 Trials 
  Washington, DC - 6/8/2014
• Chemotherapy 
  Boston, MA - 6/5/2014
• Exploring the Clinical and Molecular Activity of Everolimus in Vestibular Schwannomas and Meningiomas: Updates from the Phase 2 and Phase 0 Studies 
  Boston, MA - 6/5/2014
• Neurofibromatosis Type 2: Clinical Management, Molecular Pathways and Novel Therapies 
  Nationwide Children's Hospital, Columbus, OH - 1/16/2014
• Non-surgical Therapies for NF2-related Tumors 
  NYU Langone Medical Center, New York, NY - 6/21/2013
• Phase II Study of Everolimus in Children and Adults with Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas 
  Monterey, CA - 6/9/2013
• Radiation Therapy and Chemotherapy for Vestibular Schwannomas 
  Monterey, CA - 6/8/2013
• Neurofibromatosis Type 2: Genes, Pathways and Novel Therapies 
  University of Texas Southwestern, Dallas, TX - 3/19/2013
• NF2 Medical Therapies and Clinical Trials 
  New York, NY - 10/27/2012
• Study Concept for the New COG High-Grade Glioma Study 
  Atlanta, GA - 9/13/2012
• Exploring New Agents for Pediatric Low-Grade Gliomas: Sorafenib Phase II Study 
  Atlanta, GA - 9/12/2012
• Intratumoral Concentration and Molecular Pharmacodynamics of Lapatinib in vivo in Sporadic and NF2-related Vestibular Schwannomas 
  Toronto, Canada - 6/27/2012
• NF2 Clinical Trials NF2 Clinical Trials with Molecular Targeted Agents 
  New Orleans, LA - 6/11/2012
• Use of EGFR/ErbB2 Inhibitors in NF2 and Results from the Lapatinib Phase II Clinical Trial 
  Manchester, UK - 5/21/2012
• The Comprehensive NF Center at NYU: Clinical Management of NF2 and Development of Novel Therapies 
  SUNY Downstate Medical Center, Brooklyn, NY - 4/13/2012
• Pediatric Low-Grade Gliomas 
  Woodhull Medical Center, Brooklyn, NY - 12/10/2011
• Developing Molecular Targeted Therapies for Neurofibromatosis Type 2-related Tumors 
  Memorial Sloan-Kettering Cancer Center, New York, NY - 11/6/2011
• Intratumoral Concentration and Molecular Pharmacodynamics of Lapatinib in Sporadic and NF2-related Vestibular Schwannomas 
  New York Academy of Medicine, New York, NY - 10/28/2011
• Neurofibromatosis Type 2 at the NYU Comprehensive NF Center: Clinical Management and Development of Molecular Targeted Therapies 
  German Cancer Research Center, Heidelberg, Germany - 8/30/2011
• Of Mice and Men: Mouse Models in the Development of Molecular Targeted Therapies for Human Cancer 
  Jackson Hole, WY - 6/13/2011
• Neurofibromatosis Type 2: Diagnosis, Clinical Management and Novel Therapies 
  NYU Langone Medical Center, New York, NY - 1/15/2011
• Neurofibromatosis Type 2: Clinical Features, Genetics, Biology and Novel Therapies 
  Woodhull Medical Center, Brooklyn, NY - 12/10/2010
• Phase II Clinical Trial of Lapatinib in Children and Adults with NF2 and Progressive Vestibular Schwannomas 
  New York Academy of Medicine, New York, NY - 10/22/2010
• A Comprehensive Clinic Model for Neurofibromatosis Type 2: Patient Care Delivery at the NYU NF Center 
  Chicago, IL - 10/16/2010
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Other

• Tumours of the Central Nervous System: Hemangioblastoma 
  Zagzag D, Weiner H, Karajannis M, Milla S, PubCan: A Public Database of Human Cancers
  http://www.pubcan.org
  1/1/2010