Matthew Old MD

PubMed

• Impact of circulating tumor human papillomavirus DNA kinetics on disease outcomes in HPV-associated oropharyngeal cancer.
  Sachin R Jhawar, Catherine Haring, Xueliang Pan, Jianing Ma, Priyanka Bhateja
  International Journal of Cancer. 2025-04-15
• Patient Characteristics and Treatment Outcomes of Nasopharyngeal Carcinoma in Nonendemic Regions.
  Mohammad Bilal Alsavaf, Matthew Marquardt, Moataz D Abouammo, Menglin Xu, Ahmed Elguindy
  JAMA Network Open. 2025-03-03
• Response-Adaptive Surgical Timing in Neoadjuvant Immunotherapy Demonstrates Enhanced Pathologic Treatment Response in Head and Neck Squamous Cell Carcinoma.
  Eric V Mastrolonardo, Kathryn L Nunes, Pablo Llerena, Anastasia Nikitina, Anastasia Sobol
  Clinical Cancer Research. 2025-02-03

Journal Articles

• Predictors of Gastrostomy Tube Dependence in Surgically Managed Oropharyngeal Squamous Cell Carcinoma  
  Stephen Y Kang, James W Rocco, Michael J Cipolla, Amit Agrawal, David E Schuller, Peter T Dziegielewski, Ricardo L Carrau, Matthew O Old, Enver Ozer, Vivek R Varma, Th..., The Laryngoscope
• Nuclear PRMT5, cyclin D1 and IL-6 are associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with p16-status  
  Kumar B, Yadav A, Brown NV, Zhao S, Cipolla MJ, Wakely PE, Schmitt AC, Baiocchi RA, Teknos TN, Old MO, Kumar P, Oncotarget, 1/17/2017
• Notch1 Overexpression Correlates to Improved Survival in Cancer of the Oropharynx  
  Kaka A, Zhao S, Old M, Agrawal A, Ozer E, Carrau R, Schuller d, Kumar P, Teknos T, Nowacki N, Otolaryngology - Head and Neck Surgery, 1/1/2017
• BAI1 Orchestrates Macrophage Inflammatory Response to HSV Infection-Implications for Oncolytic Viral Therapy  
  Bolyard C, Meisen WH, Banasavadi-Siddegowda Y, Hardcastle J, Yoo JY, Wohleb ES, Wojton J, Yu JG, Dubin S, Khosla M, Xu B, Smith J, Alvarez-Breckenridge C, Pow-Anpongku..., Clinical Cancer Research, 1/1/2017
• Reconstruction Special Edition, Issue 2  
  Old M, Oral Oncol, 1/1/2017
• Lateral Arm Free Tissue Transfer for Parotid Reconstruction: A Pictorial Essay  
  Kang SY, Old MO, Teknos TN, Head & Neck, 1/1/2017
• NUT Midline Carcinoma of the Sublingual Gland: Clinical Presentation and Review  
  Seim NB, Philips RH, Schoenfield L, Teknos TN, Rocco JW, Agrawal A, Ozer E, Carrau RL, Kang SY, Old MO, Head and Neck Pathology, 1/1/2017
• RNA nanoparticle based targeted therapy for glioblastoma through inhibition of oncogenic miR-21  
  Lee TJ, Yoo JY, Shu D, Li H, Zhang J, Yu JG, Jaime-Ramirez AC, Acunzo M, Romano G, Cui R, Sun HL, Luo Z, Old M, Kaur B, Guo P, Croce CM, Molecular Therapy, 1/1/2017
• Primary Lingual Colonic-Type Adenocarcinoma: A Rare and Emerging Distinct Entity!  
  Smith SM, Old M, Iwenofu OH, Head Neck Pathol, 1/1/2017
• Reolysin and Histone Deacetylase Inhibition in the Treatment of Head and Neck Squamous Cell Carcinoma  
  Jaime-Ramirez AC, Yu J, Caserta E, Yoo JY, Zhang J, Lee TJ, Hofmeister C, Lee JH, Kumar B, Pan Q, Kumar P, Baiocchi R, Teknos TN, Pichiorri F, Kaur B, Old MO, Mol Ther Onc, 1/1/2017
• Reduction of severe oropharyngeal hemorrhage following transoral robotic surgery  
  Old MO, Oral Oncology, 1/1/2017
• Reolysin and Histone Deacetylase Inhibition in the Treatment of Head and Neck Squamous Cell Carcinoma  
  Jaime-Ramirez AC, Yu JG, Caserta E, Yoo JY, Zhang J, Lee TJ, Hofmeister C, Lee JH, Kumar B, Pan Q, Kumar P, Baiocchi R, Teknos T, Pichiorri F, Kaur B, Old M, Mol Ther Oncolytics, 1/1/2017
• Reconstruction Special Edition, Issue 1  
  Old M, Oral Oncol, 1/1/2017
• Advances in midface reconstruction: beyond the reconstructive ladder  
  Eskander A, Kang SY, Teknos TN, Old MO, Curr Opin Otolaryngol Head Neck Surg, 1/1/2017
• Appraisal of the AJCC 8th edition pathologic staging modifications for HPV-positive oropharyngeal cancer, a study of the National Cancer Data Base  
  Zhan KY, Eskander A, Kang SY, Old MO, Ozer E, Agrawal AA, Carrau RL, Rocco JW, Teknos TN., Oral Oncol, 1/1/2017
• One-year quality of life and functional outcomes of transoral robotic surgery for carcinoma of unknown primary  
  Ozbay I, Yumusakhuylu AC, Sethia R, Wei L, Old MO, Agrawal A, Teknos TN, Ozer E, Head and Neck, 1/1/2017
• RNA Nanoparticle-Based Targeted Therapy for Glioblastoma through Inhibition of Oncogenic miR-21  
  Lee TJ, Yoo JY, Shu D, Li H, Zhang J, Yu JG, Jaime-Ramirez AC, Acunzo M, Romano G, Cui R, Sun HL, Luo Z, Old M, Kaur B, Guo P, Croce CM, Mol Ther, 1/1/2017
• Primary Lingual Colonic-Type Adenocarcinoma: A Rare and Emerging Distinct Entity  
  Smith SM, Old M, Iwenofu OH, Head Neck Pathol, 1/29/2016
• Histone Deacetylase Inhibitors Enhance the Therapeutic Potential of Reovirus in Multiple Myeloma  
  Stiff A, Caserta E, Sborov DW, Nuovo GJ, Mo X, Schlotter SY, Canella A, Smith E, Badway J, Old M, Jaime-Ramirez AC, Yan P, Benson DM Jr, Byrd JC, Baiocchi R, Kaur B, H..., Mol Cancer Ther, 1/25/2016
• The current status of oncolytic viral therapy for head and neck cancer  
  Old MO, Wise-Draper T, Wright CL, Kaur B, Teknos TN, WJORL, 1/1/2016
• Surgical management of oropharyngeal squamous cell carcinoma: Survival and functional outcomes  
  Kumar B, Old M, Ozer E, Agrawal A, Carrau R, Schuller D, Pan Q, Kumar P, Teknos T, Head and Neck, 1/1/2016
• Tridandapani S, Muthusamy N, Caligiuri M, Byrd JC, Carson WE 3rd Myeloid-derived suppressor cells express Bruton's tyrosine kinase and can be depleted in tumor bearing...  
  Stiff A, Trikha P, Wesolowski R, Kendra K, Hsu V, Uppati S, McMichael EL, Duggan M, Campbell A, Keller K, Landi I, Zhong Y, Dubovsky J, Howard JH, Yu L, Harrington B, ..., Cancer Res, 1/1/2016
• Survival Is Independent of Radiation Therapy Treatment Center Experience After Surgical Therapy  
  Martin D, Kumar B, Brown N, Agrawal A, Ozer E, Kang S, Rocco JW, Carrau R, Schuller D, Grecula JC, Bhatt AD, Blakaj D, Teknos T, Diavolitsis VM, Old M, International journal of radiation oncology, biology, physics, 1/1/2016
• High expression of myoferlin is associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with HPV-status  
  Kumar B, Brown N, Swanson B, Schmitt A, Old M, Ozer E, Agrawal A, Schuller D, Teknos T, Kumar P, Oncotarget, 1/1/2016
• Contour an osteotomy of free fibula transplant using a ruler template  
  Kang SY, Old MO, Teknos TN, Laryngoscope, 1/1/2016
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Books/Book Chapters

• Miracles We Have Seen: America's Leading Physicians Share Stories They Can't Forget. 
  Chapter: Right Where She Needed to Be. 
  Old, MOHealth Communications, INC., Deerfield2016
• ENT Secrets 
  Chapter: Vascular Tumors of the Head and Neck. Ch 17 
  Old, MOEditors: Scholes, M. Ramakrishnan, V.ElsevierEdition 4th,2015
• Reconstruction of the Head and Neck: A Defect-Oriented Approach. 
  Chapter: Pharynx, Cervical Esophagus, and Hypopharynx Reconstruction. 
  Old, MO; Teknos, TheodorosEditors: Genden, E.Thieme, New York, NY2012
• Head and Neck Cancer Multimodality Management 
  Chapter: Benign Salivary Gland Neoplasms. 
  Arshad H, Old M, Teknos TEditors: Bernier, J.Springer-Verlag, New York, NYEdition 2nd,2011
• Head and Neck Cancer Multimodality Management 
  Chapter: Head and Neck Paragangliomas. 
  Old M, Netterville JLEditors: Bernier, J.Springer-Verlag, New York, NYEdition 2nd,2011
• Head and Neck Cancer Multimodality Management 
  Chapter: Paragangliomas of the Head and Neck 
  Old, MOEditors: Bernier, J.Springer-Verlag, New York, NYEdition 2nd,2011
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Abstracts/Posters

• Cancer- Oncolytic Viruses I
  Old M, ASGCT, Washington, DC, 1/1/2016
• Efficacy of RAMBO for Sarcoma Therapy.
  Bolyard C, Khosla M, Yu J, Zhang J, Lopez G, Pollock R, Cripe T, Kaur B, Old M, ASGCT, Washington, DC, 1/1/2016
• High Expression Of PRMT5 And Cyclin D1 Is Associated With Poor Outcome In Oropharyngeal Squamous Cell Carcinoma (OPSCC) Patients And Is Inversely Associated With p16 S...
  B. Kumar, M. J. Cipolla, N. Arradaza, P. E. Wakely, F. Yan, A. Schmitt, P. Kumar, R. A. Baiocchi, T. N. Teknos, M. Old, Multidisciplinary Head and Neck Cancer Symposium JW Marriott Camelback Inn Resort and Spa, Scottsdale, AZ, 1/1/2014
• Predictors of Perioperative Outcomes and Complications in Oral Cavity Squamous Cell Carcinoma.
  Schord J, Ali S, Martin D, Brown N, Agrawal A, Ozer O, Carrau R, Schuller D, Kumar B, Teknos T, Old M, OSUCCC Annual Scientific Conference, 1/1/2014
• Predictors and outcomes of overall survival in oral cavity squamous cell carcinoma.
  Martin D, Schord, J, Ali S, Brown N, Agrawal A, Ozer O, Carrau R, Schuller D, Kumar B, Teknos T, Old M, OSUCCC Annual Scientific Conference, 1/1/2014
• A retrospective case-control cohort evaluation of the effectiveness of hyperbaric oxygen therapy (HBOT) for the prevention of post-operative complications in patients ...
  Marcinow A, Teknos T, Agrawal A, Ozer E, Carrau R, Schuller D, Old M, Multidisciplinary Head and Neck Cancer Symposium JW Marriott Camelback Inn Resort and Spa, Scottsdale, AZ, 1/1/2014
• Tumor- associated Endothelial Cells Promote Tumor Metastasis by Chaperoning Circulating Tumor Cells and Protecting Them from Anoikis.
  Yadav A, Kumar B, Yu J, Old M, Teknos T, Kumar P, COSM, JW Marriott Grande Lakes, Orlando, FL, 1/1/2013
• Enhancement of Antitumor Activity of OHSV (34.5ENVE) for Head and Neck Squamous Cell Carcinoma by Bortezomib.
  Old MO, Yu J, Yoo J, Hurhuiz B, Boyard C, Pan Q, Kumar P, et al, COSM, JW Marriott Grande Lakes, Orlando, FL, 1/1/2013
• Squamous Cell Carcinoma of the Head and Neck of Unknown Primary: A Fifteen Year Single Institution Experience.
  Kim L, Waltonen J, Schuller D, Ozer E, Teknos T, Old M, COSM, JW Marriott Grande Lakes, Orlando, FL, 1/1/2013
• Highly Aggressive HPV-Related Oropharyngeal Cancer: Clinical, Radiologic, and Pathologic Characteristics.
  Kaka A, Kumar B, Kumar P, Wakely P, Kirsch C, Old M, Agrawal A, et al, COSM, JW Marriott Grande Lakes, Orlando, FL, 1/1/2013
• A Phase I Trial of Vorinostat in Combination with Standard Chemoradiation Therapy in Advanced Oropharyngeal Squamous Cell Carcinoma: Preliminary Results.
  Teknos TN, Old, MO, Ozer E, Agrawal A, Carrau R, Savvides P, Chao B, et al, 18th NCCN Annual Conference: Advancing the Standard of Cancer Care, Peers within Field, Westin Dilpomat, Hollywood, FL, 1/1/2013
• Inhibition of Protein Arginine Methyltransferase-5 (PRMT-5) Decreases Cell Growth, Division and Migration in Head and Neck Squamous Cell Carcinoma.
  Boyce B, Old M, Teknos T, Baiocchi R, Zhang M, Pan Q, COSM, JW Marriott Grande Lakes, Orlando, FL, 1/1/2013
• Surgical Management of Oropharyngeal Squamous Cell Carcinoma: Survival & Functional Outcomes.
  Bhavna Kumar, Michael Cipolla, Nicole Arradaz, Peter Dziegielewski, Kasim Durmus, Enver Ozer, et al, COSM, JW Marriott Grande Lakes, Orlando, FL, 1/1/2013
• Anterolateral Thigh Butterfly Free Flap Reconstruction For Peristomal Recurrence Following Laryngectomy.
  Durmus K, Kakarala K, Old MO, Teknos TN, Ozer E, American College of Surgeons 98th Annual Clinical Congress, Peers within Field, Chicago, IL, 1/1/2012
• Rescue and enhancement of oncolytic HSV therapy via copper chelation with ATN-224 in head and neck squamous cell carcinoma.
  Old M, Yu JG, Yoo JY, Kaka A, Pan Q, Kumar P, Kumar B, Mazar A, Teknos TN, Kaur B, 8th International Conference on Head & Neck Cancer, 1/1/2012
• ATN 224 Enhances Oncolytic HSV Therapy in Squamous Cell Carcinomas.
  Old MO, Yu JG, Kaka A, Yoo JY, Teknos N, Kaur B., CCTS Annual Meeting, Ohio State University, 1/1/2011
• Novel Oncolytic HSV Therapy in Squamous Cell Carcinoma.
  Old M, Yu JG, Kaka A, Yoo JY, Teknos N, Kaur B, OSU CCTS Pilot Studies Colloquium, 1/1/2010
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Lectures

• Total Laryngectomy using Automatic Stapling Device. 
  Paris, France - 1/24/2017
• Pharyngocutaneous Fistulization Rate following Salvage Total Laryngectomy. 
  Eilat, Israel - 1/1/2017
• Tumor Board: Case presentations and review of recent literature driving treatment methods 
  Vail, CO - 1/1/2017
• Radioencrosis and Other Radiation Complications 
  Chicago, IL - 1/1/2016
• Lateral Arm Free Flap Harvest. 
  Dayton, OH - 1/1/2016
• Quality of Life and Functional Outcomes of TORS without Adjuvant Radiation Therapy for Oropharyngeal Cancer 
  Miami, FL - 1/1/2016
• Case discussion panel: Decision making in infratemporal fossa/anterior skull base neoplasms 
  Nashville, TN - 1/1/2016
• Reconstruction of major skull base defects 
  Nashville, TN - 1/1/2016
• Post-Operative Controversies - ICU vs Non ICU 
  Nashville, TN - 1/1/2016
• Clinical Trials: definition, controls, evaluation, pitfalls. 
  Ohio State University - 1/1/2016
• Long term survival outcomes and p16 tissue analysis for multimodal intensification protocols for stage III-IV head/neck squamous cell carcinomas 
  Scottsdale, AZ - 1/1/2016
• High expression of myoferlin is associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with HPV-status 
  Seattle, WA - 1/1/2016
• The Potency of a Histone Deacetylase Inhibitor and Reovirus in Head and Neck Squamous Cell Carcinoma 
  Seattle, WA - 1/1/2016
• Long-Term Quality of Life and Functional Outcomes of Transoral Robotic Surgery for Carcinoma of Unknown Primary 
  Seattle, WA - 1/1/2016
• Report of an Exceptionally Aggressive Undifferentiated Carcinoma of the Sublingual Gland in a Young Patient - Case Report and Literature Review 
  Seattle, WA - 1/1/2016
• The High Stakes of Head and Neck Surgery Following Radiation and Chemotherapy - An Approach to Predicting Surgical Complications 
  Seattle, WA - 1/1/2016
• Predictors of Gastrostomy Tube Dependence in Surgically Managed Oropharyngeal Cancer 
  Seattle, WA - 1/1/2016
• Functional and Quality of Life Outcomes of Surgical and Nonsurgical Therapy in Oropharyngeal Cancer 
  Seattle, WA - 1/1/2016
• Cancer-Targeted Gene and Cell Therapy. 
  Washington, DC - 1/1/2016
• Personalized Reconstruction. 
  1/1/2016
• State of the Art in Mandibular and Maxillary Reconstruction - Maxillary Reconstruction 
  1/1/2016
• Head and Neck Panel: Oropharynx Cancer in the HPV Era: Case Based Discussion 
  1/1/2016
• A Phase 1 Trial of Vorinostat in Combination with Concurrent Chemoradiation Therapy in the Treatment of Advanced Staged Head and Neck Squamous Cell Carcinoma. 
  1/1/2016
• Prognostic Factors of Recurrent Oral Cavity Squamous Cell Carcinoma Associated with Survival in the Salvage Patient Population. 
  Boston, MA - 1/1/2015
• Squamous Cell Carcinoma of the Head and Neck of Unknown Primary: A Fifteen-Year Single Institution Experience. 
  Boston, MA - 1/1/2015
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Other

• Getting a job saved this 19-year-old's life. Worldwide Published News Article 
  Old, MO, CNN
  1/1/2015
• Getting a job at Ohio State’s James Cancer Hospital saved this 19-year- old’s life. Regionally Published News Article and Interview 
  Old, MO, Fox 8
  Cleveland, OH - 1/1/2015