MatthewJEllisMDPhD FRCP

Breast Cancer, Hematologic Oncology

Director, Lester and Sue Smith Breast Center Baylor College of Medicine, Professor of Medicine and Molecular Cell Biology, associate director, translational research Dan L Duncan Comprehensive Cancer Center

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Office
6620 Main St
Houston, TX 77030
Phone+1 713-798-1999

Fax+1 713-798-1990

Education & Training

MedStart Georgetown University HospitalFellowship, Medical Oncology, 1992 - 1994
School of Clinical Medicine, University of CambridgeClass of 1983

Certifications & Licensure

TX State Medical License 2014 - 2022
MO State Medical License 2003 - 2015
NC State Medical License 2001 - 2005
DC State Medical License 1996 - 2004
MD State Medical License 1995 - 1996

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012

Clinical Trials

Letrozole, Herceptin in Her2neu +, Estrogen Receptor [ER] and/or Progesterone Receptor [PR] Positive, MBC Start of enrollment: 2000 Jan 01
Completed
Phase 2
Study of Physiological and High Dose Estradiol in the Treatment of Hormone Receptor Positive Metastatic Breast Cancer Start of enrollment: 2004 Aug 01
Completed
Phase 2
Effect of Neoadjuvant or Adjuvant Systemic Therapy on Breast Cancers, Bone Marrow Cancer Cells, and Circulating Cancer Cells Start of enrollment: 2005 Sep 14
RECRUITING
Combination Chemotherapy and Paclitaxel Plus Trastuzumab in Treating Women With Palpable Breast Cancer That Can Be Removed by Surgery Start of enrollment: 2007 Jul 01
Completed
Phase 3
Azacitidine and Entinostat in Treating Patients With Advanced Breast Cancer Start of enrollment: 2011 Apr 21
ACTIVE_NOT_RECRUITING
PHASE2
Combining MLN8237 With Nab-Paclitaxel in Patients With Advanced Solid Malignancies Start of enrollment: 2013 May 07
Completed
Phase 1
PD 0332991 and Anastrozole for Stage 2 or 3 Estrogen Receptor Positive and HER2 Negative Breast Cancer Start of enrollment: 2013 Apr 10
ACTIVE_NOT_RECRUITING
PHASE2
LDE225 in Treating Patients With Stage II-III Estrogen Receptor- and HER2-Negative Breast Cancer Start of enrollment: 2014 Apr 01
Withdrawn
Phase 2
Effect of Trastuzumab on Disease Free Survival in Early Stage HER2-Negative Breast Cancer Patients With ERBB2 Expressing Disseminated Tumor Cells Start of enrollment: 2013 Dec 19
Terminated
Phase 2
VEGFR/PDGFR Dual Kinase Inhibitor X-82 and Everolimus for Treating Patients With Pancreatic Neuroendocrine Tumors Start of enrollment: 2013 May 03
Terminated
Phase 1, Phase 2
Neoadjuvant Treatment of Triple Negative Breast Cancer Patients With Docetaxel and Carboplatin to Assess Anti-tumor Activity Start of enrollment: 2014 Jul 07
Terminated
Phase 2
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Publications & Presentations

PubMed

Increased Synthetic Cytotoxicity of Combinatorial Chemoradiation Therapy in Homologous Recombination Deficient Tumors.
Jennifer Ma, Rachna Shah, Andrew C Bell, Niamh McDermott, Xin Pei
International Journal of Radiation Oncology, Biology, Physics. 2025-03-01
1 citations
Patient-Derived Xenografts of Triple-Negative Breast Cancer Enable Deconvolution and Prediction of Chemotherapy Responses.
Jonathan T Lei, Lacey E Dobrolecki, Chen Huang, Ramakrishnan R Srinivasan, Suhas V Vasaikar
Biorxiv. 2025-01-08
8 citations
IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer.
Longyong Xu, Fanglue Peng, Qin Luo, Yao Ding, Fei Yuan
Cell. 2024-12-12

Journal Articles

Proteogenomic Integration Reveals Therapeutic Targets in Breast Cancer Xenografts
Souzan Sanati, Jana W Qiao, Xian Chen, Matthew J Ellis, Cynthia Ma, Nature

Press Mentions

SABCS 2022: Panelists Discuss Strategies to Overcome Top Obstacles in Breast Cancer ManagementDecember 15th, 2022
Breast Cancer Test’s Genomic Underpinning Drives Prognostic PerformanceOctober 30th, 2020
Micro-Scaled Method Holds Promise as Improved Cancer Diagnostic PlatformJanuary 27th, 2020
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