MatthewSDavidsMDMMSc

Hematologic Oncology

Associate Professor of Medicine, Harvard Medical School, Director of Clinical Research, Division of Lymphoma, Dana-Farber Cancer Institute

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Office
450 Brookline Ave
Boston, MA 02215
Phone+1 617-632-3000

Fax+1 617-632-5822

Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 2008 - 2011
New York Presbyterian Hospital (Cornell Campus)Residency, Internal Medicine, 2005 - 2008
Yale School of MedicineClass of 2005

Certifications & Licensure

CT State Medical License 2022 - 2024
MA State Medical License 2008 - 2024
NY State Medical License 2007 - 2009
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Young Scientist Award Lymphoma Foundation of America, 2012

Clinical Trials

Ipilimumab or Nivolumab in Treating Patients With Relapsed Hematologic Malignancies After Donor Stem Cell Transplant Start of enrollment: 2013 May 16
Completed
Phase 1
A Phase 1b/2 Study of IPI-145 Plus FCR in Previously Untreated, Younger Patients With CLL Start of enrollment: 2014 Jun 27
Active, not recruiting
Phase 1, Phase 2
A Phase II Study of Ibrutinib Plus FCR in Previously Untreated, Younger Patients With Chronic Lymphocytic Leukemia Start of enrollment: 2014 Oct 01
Active, not recruiting
Phase 2
A Phase I/Ib Safety and Efficacy Study of the PI3K-delta Inhibitor TGR-1202 and Ibrutinib in Patients With CLL or MCL Start of enrollment: 2014 Nov 01
Completed
Phase 1
A Study of Ibrutinib + Obinutuzumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia Start of enrollment: 2015 Dec 01
Active, not recruiting
Phase 1
A Phase II Study of Venetoclax in Combination With Dose-adjusted EPOCH-R or R-CHOP for Patients With Richter's Syndrome Start of enrollment: 2017 Mar 08
Recruiting
Phase 2
Duvelisib and Venetoclax in Relapsed or Refractory CLL or SLL or RS Start of enrollment: 2018 Jul 12
Recruiting
Phase 1, Phase 2
Acalabrutinib, Venetoclax, and Obinutuzumab for Initial Therapy of CLL Start of enrollment: 2018 Aug 07
Active, not recruiting
Phase 2
Venetoclax-Obinutuzumab +/- Acalabrutinib in R/R CLL Start of enrollment: 2020 Oct 19
Recruiting
Phase 2
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Publications & Presentations

PubMed

245 citations
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer.
Antonino Glaviano, Aaron S C Foo, Hiu Y Lam, Kenneth C H Yap, William Jacot
Molecular Cancer. 2023-08-18
34 citations
Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies.
Elisa Ten Hacken, Rebecca Valentin, Fara Faye Regis, Jing Sun, Shanye Yin
JCI Insight. 2018-10-04
26 citations
Mechanisms of response and resistance to combined decitabine and ipilimumab for advanced myeloid disease.
Livius Penter, Yang Liu, Jacquelyn O Wolff, Lin Yang, Len Taing
Blood. 2023-04-13

Journal Articles

The Phase 3 DUO Trial: Duvelisib Versus Ofatumumab in Relapsed and Refractory CLL/SLL
Matthew S Davids, Ian W Flinn, Craig A Portell, Nicole Lamanna, Scott Lunin, Amanda F Cashen, Blood

Abstracts/Posters

Ongoing Results of a Phase 1B/2 Dose-Escalation and Cohort-Expansion Study of the Selective, Noncovalent, Reversible BrutonÍS Tyrosine Kinase Inhibitor, Vecabrutinib, ...
Matthew S. Davids, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
A Phase I Study of Duvelisib and Venetoclax in Patients with Relapsed or Refractory CLL / SLLA Phase I Study of Duvelisib and Venetoclax in Patients with Relapsed or R...
Matthew S. Davids, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Early Adoption and Outcomes of Ibrutinib As Treatment for Older Patients with Chronic Lymphocytic Leukemia (CLL): A Population-Based Study
Matthew S. Davids, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
An Innovative Telemedicine Platform to Provide Expert Access to Patients with Chronic Lymphocytic Leukemia (CLL)
Matthew S. Davids, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Preliminary Safety and Efficacy Results from a Phase 2 Study of Acalabrutinib, Venetoclax and Obinutuzumab in Patients with Previously Untreated Chronic Lymphocytic Le...
Matthew S. Davids, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Outcomes of Ibrutinib (Ibr) Therapy in Ibr-Na¥ve Patients (pts) with Chronic Lymphocytic Leukemia (CLL) Progressing after Venetoclax (Ven)
Matthew S. Davids, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
A Phase I Study of Duvelisib and Venetoclax in Patients with Relapsed or Refractory CLL / SLLA Phase I Study of Duvelisib and Venetoclax in Patients with Relapsed or R...
Matthew S. Davids, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
High Sensitivity NGS Analysis of MRD in CLL Patients Prospectively Treated with Ibrutinib Plus FCR (iFCR)
Matthew S. Davids, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Clinical and Immunologic Activity of Ipilimumab Following Decitabine Priming in Post-Allogeneic Transplant and Transplant-Na¥ve Patients with Relapsed or Refractory My...
Matthew S. Davids, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Identification of Genotype-Specific Therapeutic Vulnerabilities By Comparative Dynamic BH3 Profiling Analysis of Human and Murine CLL
Matthew S. Davids, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
MCL-1 and PKA/AMPK Axis Fuel Venetoclax Resistance in Lymphoid Cancers
Matthew S. Davids, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Lectures

Cost-Effectiveness of a 12-Month Fixed Duration of Venetoclax in Combination with Obinutuzumab in First-Line Chronic Lymphocytic Leukemia in the United States
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
Clinical and Biological Indicators of Duvelisib Efficacy in CLL from the Phase 3 DUOTM Study
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Rituximab/Bendamustine and Rituximab/Cytarabine (RB/RC) Induction Chemotherapy for Transplant-Eligible Patients with Mantle Cell Lymphoma: A Pooled Analysis of Two Pha...
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Clinical and Biological Indicators of Duvelisib Efficacy in CLL from the Phase 3 DUOTM Study
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Mitigation of tumor lysis syndrome (TLS) complications with venetoclax (VEN) in CLL.
2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018
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Other

The Rise of Apoptosis: Targeting Apoptosis in Hematologic Malignancies
Matthew Davids, MD, Blood
https://www.doximity.com/articles/98c8dcba-e43a-4f7a-a7f7-4f3bd29ea5d9
UpToDate, Wolters Kluwer Health - 2013-03-29

Press Mentions

Mapping Genetic Evolution from CLL to Richter’s SyndromeJanuary 10th, 2023
ASH 2022: New Findings in CLLDecember 28th, 2022
Live from ASH 2022 | Ascentage Pharma Presents Latest Data of APG-2575, Including Encouraging Results of the Combination with BTKi in Patients with R/R CLL/SLLDecember 13th, 2022
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