MartinF.Joyce-BradyMDFAPS

PubMed

• 30 citations
  Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma.
  Marina Tuzova, Jyh-Chang Jean, Rebecca P. Hughey, Lou Ann S. Brown, William W. Cruikshank
  Frontiers in Pharmacology. 2014-07-31
• 13 citations
  Outcomes of a ventilator-associated pneumonia bundle on rates of ventilator-associated pneumonia and other health care-associated infections in a long-term acute care ...
  Carol Sulis, Allan J. Walkey, Yafet Abadi, Christine C. Reardon, Martin Joyce-Brady
  American Journal of Infection Control. 2014-05-01
• 19 citations
  Transcription Factor Klf4, Induced in the Lung by Oxygen at Birth, Regulates Perinatal Fibroblast and Myofibroblast Differentiation
  Jyh-Chang Jean, Elizabeth George, Klaus H. Kaestner, Lou Ann S. Brown, Avrum Spira
  Plos One. 2013-01-23

Journal Articles

• Inhibiting Glutathione Metabolism in Lung Lining Fluid as a Strategy to Augment Antioxidant Defense.  
  Joyce-Brady, M and J Hiratake, Current Enzyme Inhibition, 1/1/2011
• Hyperoxia Induced Lung Injury in Gamma-Glutamyl Transferase Deficiency is Associated with Alterations in Nitrosative and Nitrative Stress.  
  ES Klings, MH Lowry, G Li, JC Jean, BO Fernandez, MF Garcia-Saura, M Feelisch and M Joyce-Brady, American Journal of Pathology, 1/1/2009
• The Epidemiology of Ventilator-Associated Pneumonia in the Long Term Acute Care Hospital Setting.  
  AJ Walkey, Campbell-Reardon C, Sulis CA, RN Nace and M Joyce-Brady, Infection Control and Hospital Epidemiology, 1/1/2009
• Lung Lining Fluid Glutathione Attenuates IL13 Induced Asthma.  
  MH Lowry, BP McAllister, LAS Brown, E C Lucey, S Amar, WW Cruickshank, JC Jean, P Johnson, K Braun, T Wight, and M Joyce-Brady, American J Resp Cell Molec Biol., 1/1/2008
• Regulation of Fgf10 gene expression in murine mesenchymal cells.  
  JC Jean, J Jining, M Joyce-Brady, W Cardoso, Journal of Cellular Biochemistry, 1/1/2008
• Fibulin-5 Gene Expression in Human Lung Fibroblasts Is Regulated by TGF-Beta and Phosphatidylinositol 3-kinase activity.  
  PP Kuang, M Joyce-Brady, XH Zhang, JC Jean and Ronald H. Goldstein, American Journal of Physiology Cell Physiology, 1/1/2006
• Hypoxia induces brain-specific Aldolase C by a HIF-1 dependent mechanism in lung epithelial cells.  
  JC Jean and M Joyce-Brady, American Journal of Physiology Lung Cellular and Molecular Physiology, 1/1/2006
• Asthma Triggered by Viral Infections: A persistent problem.  
  Joyce-Brady, M and Little, FF, Advance for Managers of Respiratory Care, 1/1/2005
• Development and prospective validation of a model for predicting weaning in chronic ventilator dependent patients.  
  Hendra KP, PAL Bonis, M Joyce-Brady, BMC Pulmonary Medicine, 1/1/2003
• "Pond Poop" from Propofol.  
  O’Regan and M Joyce-Brady, Intensive Care Medicine, 1/1/2003
• Coordinate Expression of Fibulin-5/DANCE and elastin during lung injury repair.  
  PP Kuang, RH Goldstein, Y Liu, DC Rishikof, JC Jean, M Joyce-Brady, Am J Phys Lung Cell Molec Biol., 1/1/2003
• The Importance of Gamma-Glutamyl Transferase in Lung Glutathione Homeostasis and Antioxidant Defense.  
  JC Jean, Y. Liu, RE Marc and M Joyce-Brady, Biofactors, 1/1/2003
• DANCE In Developing and Injured Lung.  
  JC Jean, I. Eruchalu, Ciao, YX and M. Joyce-Brady, American Journal of Physiology Lung Cellular and Molecular Physiology, 1/1/2002
• The GGT Deficient Mouse Lung is under Oxidant stress in Normoxia.  
  JC Jean, Y Liu, LA Brown, RE Marc, ES Klings and M Joyce-Brady, American Journal of Physiology Lung Cellular and Molecular Physiology, 1/1/2002
• Barking up the wrong tree? Use of the polymerase chain reaction to diagnose syphilitic aortitis.  
  AW O’Regan, C Castro, S Lukehart, JM Kasznica, PA Rice and M F Joyce-Brady, Thorax, 1/1/2002
• Gamma-Glutamyl Transferase and Its Isoform Mediate an Endoplasmic Reticulum Stress Response.  
  Joyce-Brady M, JC Jean and RP Hughey, Journal of Biological Chemistry, 1/1/2001
• Latent tuberculosis may persist for over 40 years.  
  O'Regan, A. and Joyce-Brady, M, British Medical Journal, 1/1/2001
• Gamma-glutamyl transferase Deficiency in the GGTenu1 Mouse results from a single point mutation that leads to a stop codon in the first coding exon of GGT mRNA.  
  Jyh Chang Jean, Cary O. Harding, Sean M. Oakes, Qiang Yu and Martin Joyce-Brady, Mutagenesis, 1/1/1999
• The Bax Inhibitor-1 Gene is Differentially Regulated in Adult Testis and Developing Lung by Two Alternative TATA-less Promoters.  
  Jyh Chang Jean, Sean M. Oakes and Martin Joyce-Brady, Genomics, 1/1/1999
• Atrial natriuretic peptide modulates alveolar type 2 cell adenylyl and guanylyl cyclases and inhibits surfactant secretion.  
  Panchenko MP, M Joyce-Brady, MG Starikova, SM Oakes, R Adachi, JS Brody, and BF Dickey, Biochimica Biophysica Acta., 1/1/1998
• Ontogeny of Gamma-glutamyl transferase in rat lung.  
  Oakes SM, Y Takahashi, MC Williams and M. Joyce-Brady, Amer. J. Physiology (Lung Cellular and Molecular Physiology), 1/1/1997
• Induction of the Gamma-glutamyl transferase gene in bronchiolar-alveolar regions of Rat Lung following exposure to Nitrogen Dioxide.  
  Takahashi, Y, SM Oakes, T Miura and M Joyce-Brady, Toxicology and Applied Pharmacology, 1/1/1997
• Three Alternative Promoters of the Rat Gamma-Glutamyl Transferase Gene Are Active in Developing Lung and Are Differentially Regulated by Oxygen after Birth.  
  Joyce-Brady M, SM Oakes, D Wuthrich and Y Laperche, Journal of Clinical Investigation, 1/1/1995
• Retinoic Acid Induces Changes in the Pattern of Airway Branching and Alters Epithelial Cell Differentiation in the Developing Lung in Vitro.  
  Cardoso WV, MC Williams, SA Mitsialis, M Joyce-Brady, AK Rishi, and JS Brody, American Journal of Respiratory Cell and Molecular Biology, 1/1/1995
• Cloning, characterization and developmental expression of a rat lung alveolar type 1 cell gene in embryonic endodermal and neural derivatives.  
  Rishi, AK, M Joyce-Brady, J Fisher, LG Dobbs, J Floros, J vanderSpek, JS Brody and MC Williams, Developmental Biology, 1/1/1995
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Books/Book Chapters

• Research Advances in Respiratory, Cell & Molecular Biology 
  Chapter: Lung Lining Fluid Glutathione in Antioxidant Defense and Cysteine Supply. 
  Page 1 - 18M Joyce-Brady, JC Jean, RE Marc, LAS BrownEditors: RM Mohan.Global Research Network, Kerala2009
• Thiol Metabolism and Redox Regulation of Cellular Functions. 
  Chapter: "The Importance of Gamma-Glutamyl Transferase in Lung Glutathione Homeostasis and Antioxidant Defense". 
  Joyce-Brady, M., Liu, Y., Marc, R. E., and Jean, J.C.Editors: A Pompella, G Banhegyi and M Wellman-Rousseau.NATO Science Series, IOS Press, Amsterdam, Netherlands2002
• A Practical Approach to Pulmonary Medicine. 
  Chapter: "Acute and Chronic Respiratory Failure" 
  Charles A. Powell and Martin Joyce-BradyEditors: RH Goldstein, JJ O’Connell and JB Karlinsky.Lippincott-Raven Publishers, Philadelphia, PA1997
• Respiratory Epithelium. 
  Chapter: "Growth and Differentiation of Pulmonary Alveolar Epithelial Cells." 
  Page 60 - 66Brody JS, Joyce-Brady M and Steele MPEditors: P. Nettesheim, DG Thomassen.Academic Press1991
• Clinical Problems in Acute Care Medicine. 
  Chapter: "Diseases of the Pleura" 
  Joyce-Brady MEditors: Heffernan JJ, Witzburg RA, and Cohen AS.W.B. Saunders Company, Philadelphia, PA1989
• Clinical Problems in Acute Care Medicine. 
  Chapter: "Tuberculosis" 
  Joyce-Brady MEditors: Heffernan JJ, Witzburg RA, and Cohen AS.W.B. Saunders Company, Philadelphia, PA1989
• Clinical Problems in Acute Care Medicine. 
  Chapter: "Adult Respiratory Distress Syndrome" 
  Joyce-Brady MEditors: Heffernan JJ, Witzburg RA, and Cohen AS.W.B. Saunders Company, Philadelphia, PA1989
• Clinical Problems in Acute Care Medicine. 
  Chapter: "Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease" 
  Joyce-Brady MEditors: Heffernan JJ, Witzburg RA, and Cohen AS.W.B. Saunders Company, Philadelphia, PA1989
• Bronchial Asthma. 
  Chapter: Antioxidant Strategies in the Treatment of Bronchial Asthma. 
  Joyce-Brady, M, Cruikshank W and Doctrow, RSEditors: L Sapey.
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Abstracts/Posters

• The Transcription Factor Klf4 Is Induced In The Lung By Oxygen At Birth And Required For Perinatal Fibroblast And Myofibroblast Differentiation.
  JC Jean, E George, LA Brown, KH Kaestner, A Spira and M Joyce-Brady., Proceedings of the American Thoracic Society, 1/1/2013
• The Epidemiology of Ventilator-Associated Pneumonia in the Long Term Acute Care Hospital Setting. Infection Control and Hospital Epidemiology.
  AJ Walkey, Campbell-Reardon C, Sulis CA, RN Nace and M Joyce-Brady, Proceedings of the American Thoracic Society, 1/1/2009
• Gamma-glutamyl Transferase Deficiency in the GGTenu1 Mouse Alters Nitric Oxide Metabolism and Increases Lung Cell Injury in Hyperoxia.
  ES Klings, JC Jean, MH Lowry, M Feelisch and M Joyce-Brady, Proceedings of the American Thoracic Society, 1/1/2008
• Lung Lining Fluid Glutathione Attenuates IL-13 Induced Asthma.
  BP McAllister, MH Lowry, JC Jean, LA Brown, WW Cruikshank, S Amar and M Joyce-Brady, Proceedings of the American Thoracic Society, 1/1/2007
• Inhibition of Macrophage Inflammatory Activation Via Lentiviral Transfer of RNAi Against NF-kB.
  DN Kotton, LW Kwok, JC Jean, AW Wilson, AM Anandaiah, S Amar and M Joyce-Brady, Proceedings of the American Thoracic Society, 1/1/2006
• Mesenchymal Cell Regulation of Fgf10 Gene Expression.
  JC Jean, J Lu, M Joyce-Brady and WV Cardoso, Proceedings of the American Thoracic Society, 1/1/2006
• Regulation of Fibulin-5 Gene Expression by Interleukin 1-beta in Human Lung Fibroblasts.
  PP Kuang, M Joyce-Brady, X Zhang, RH Goldstein, Proceedings of American Thoracic Society, 1/1/2006
• Hypoxic Induction of Brain Specific Aldolase C in Mouse Lung Epithelial Cells.
  JC Jean and M Joyce-Brady, Proceedings of American Thoracic Society, 1/1/2006
• Regulation of Fibulin-5 Gene Transcription by Transforming Growth Factor-b.
  P Kuang, M Joyce-Brady, X Zhang, J Jean and R Goldstein, Proceedings of the American Thoracic Society, 1/1/2005
• IL-13 asthma model produces different responses in GGT deficient mouse as compared to normal mouse.
  MH Lowry, BP McAllister, Y Liu, WW Cruickshank, and M Joyce-Brady, Proceedings of the American Thoracic Society, 1/1/2005
• Maternal Exposure to hyperoxia induces redox stress in fetal lung, but not fetal liver.
  Joyce-Brady, Y Liu, JC Jean and LA Brown, Proceedings of the American Thoracic Society, 1/1/2005
• Klf4 is transiently activated by oxidant stress at birth and may regulate mesenchymal lung cell genes required for postnatal lung development.
  Elizabeth George, Avrum Spira, Michael Passero, Gang Liu, Yue Liu, Jerome S Brody, Jyh Chang Jean, and Martin Joyce-Brady, Amer J Resp Critical Care Med., 1/1/2004
• Dynamic Mucin Gene Expression in Mouse Lung, Trachea and Liver under Oxidant Stress.
  MH Lowry, Y Liu, JC Jean and M Joyce-Brady, Amer J Resp Critical Care Med, 1/1/2004
• DANCE/Fibulin-5 and Elastin Are Coordinately Expressed during Lung Injury Repair.
  PP Kuang, RH Goldstein, Y Liu, JC Jean, M Joyce-Brady, Amer J Resp Critical Care Medicine, 1/1/2003
• Altered Clara cell Secretory Protein Expression in the Gamma-glutamyl Transpeptidase Deficient GGTenu1 Mouse.
  A Phimister, JC Jean, Y Liu, M Joyce-Brady, C Plopper, Amer J Resp Critical Care Medicine, 1/1/2003
• Altered Nitric Oxide Metabolism and Increased Apoptosis of the Alveolar Epithelium in GGTenu1 Deficient Mice under Hyperoxia.
  ES Klings, JC Jean, Y Liu, G Li and M Joyce-Brady, Amer J Resp Critical Care Medicine, 1/1/2003
• Oxidant Stress Exerts a Selective Pressure on Lung Gene Expression at Birth.
  A Spira, E George, G Liu, Y Liu, JS Brody, JC Jean and M Joyce-Brady, Amer J Resp Critical Care Medicine, 1/1/2002
• Pattern of Differential Gene Expression in the Lungs of Gamma-Glutamyl Transferase Deficient GGTenu1 Mutants versus Normal Mice Suggests Critical Role for Glutathione ...
  A Spira, G Liu, Y Liu, JC Jean, JS Brody and M Joyce-Brady, Amer J Resp Critical Care Medicine, 1/1/2002
• Gamma-Glutamyl Transferase (GGT) Deficiency in GGTenu1 Mouse Alters Lung Cellular Glutathione Content and the Pattern of Cellular Gene Expression.
  A Spira, G Liu, JC Jean, Y Liu, Robert E Marc and M Joyce-Brady., Amer J Resp Critical Care Medicine, 1/1/2002
• Long Term Mechanical Ventilation in Obese Subjects.
  K Hendra, S Wahid and M Joyce-Brady., Amer J Resp Critical Care Medicine, 1/1/2001
• GGT deficiency affects the function of epithelial cells in large and small airways and of alveolar macrophages in vivo.
  M Joyce-Brady, JC Jean, M Fenton and Y Liu, Amer J Resp Critical Care Medicine, 1/1/2001
• The GGT Deficient Mouse Lung is under Oxidant stress in Normoxia.
  M Joyce-Brady, Y Liu, ES Klings, LA Brown and JC Jean., Amer J Resp Crit Care Med, 1/1/2000
• DANCE In Developing and Injured Lung.
  I Eruchalu, JC Jean and M Joyce-Brady, Amer J Resp Crit Care Med, 1/1/2000
• Validation of a Predicitve Score for Weaning Chronic Ventilator Dependent Patients From Mechanical Ventilation.
  K Hendra, P Bonis and M Joyce-Brady, Amer J Resp Crit Care Med, 1/1/1999
• Origin of Gamma-Glutamyl Transferase-related Protein Isoforms from Alternatively Spliced Mouse GGT cDNA.
  Joyce-Brady MF, RP Hughey, JC Jean, Molec Biol Cell, 1/1/1999
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Lectures

• "Epidemiology of Ventilator-Associated Pneumonia in a Long Term Care Setting." 
  At the National Education Meeting, National Association of Long Term Care Hospitals, Dallas, TX. - 1/1/2009
• Lung Lining Fluid Glutathione Attenuates IL13 induced Asthma. 
  At The Aspen Lung Conference on "Asthma: Insights and Expectations", Golden Anniversary, Aspen, CO. - 6/4/2008
• Prolonged Mechanical Ventilation: Pioneers, Outcomes and Triumphs. 
  Medical Grand Rounds, Sinai Hospital and Rehabilitation Center, Stoughton, MA (Host: Alexander White - 5/2/2007
• Prolonged Mechanical Ventilation: Institutional Outcomes and Personal Triumphs. 
  Carney Hospital Continuing Care Staff - 12/28/2005
• Can the Pool of Reduced Glutathione in Lung Lining Fluid Attenuate IL-13 Induced Asthma? 
  Wyeth Pharmaceuticals, Cambridge, MA. - 12/15/2005
• Current Topics in Pulmonary Medicine 2003. 
  Medicine Grand Rounds, Boston Medical Center. - 12/19/2003
• Current Issues in Management of COPD. 
  Medical Grand Rounds, Jewish Memorial Hospital and Rehabilitation Center. - 11/13/2003
• Of Life and Lung: Chronic Respiratory Diseases with Advancing Age. 
  AT: Broadening the Skills of the Primary Care Physician. Boston University School of Medicine. - 11/9/2003
• The GGT Deficient Lung is Under Oxidant Stress in Normoxia. 
  4/10/2002
• Gamma-glutamyl transferase: An Odyssey from Epithelial Cells to Surfactant to Birth and into the Endoplasmic Reticulum. 
  Festschrift in Honor of Jerome S. Brody, The Pulmonary Center, Boston University School of Medicine. - 11/8/2001
• Ontogeny of Gamma-Glutamyl Transferase in the Lung: A Tale of Two Epithelial Cells. 
  Symposium on Glutathione Regulation: Role in Lung Injury, Experimental Biology 1997, New Orleans, LA - 4/8/1997
• Novel role for lung surfactant and its implications for lung injury syndrome. 
  Boston City Hospital Therapeutics Conference. - 4/12/1996
• Issues in Weaning the Patient who is Chronically-Dependent on Mechanical Ventilatory Assistance. 
  Shore Medical Center at Shaughnessy-Kaplan Rehabilitation Hospital. - 3/22/1995
• Gamma-Glutamyl Transferase Expression in Lung Alveolar Type 2 Cells Indicates a New Role for Lung Surfactant. 
  Pulmonary Cell Biology Seminar, Pulmonary & Critical Care Division of the New England Medical Center - 10/26/1994
• Gamma-Glutamyl Transferase Expression in the Pulmonary Alveolar Type 2 Cell Indicates New Role for Surfactant. 
  Annual Meeting of the Division of Pulmonary Medicine, Tsukuba University, Tsukuba, Japan. - 1/16/1994
• Gamma-GT: The Liver-Lung Connection. 
  Geriatric Medicine Grand Rounds, Jewish Memorial Hospital. - 9/29/1993
• Regulation of Epithelial Cell Gamma-Glutamyl Transferase by Oxygen. 
  Symposium on the Effects of Oxygen Tension on Endothelial and Epithelial Cell Protein and Gene Expre - 5/18/1993
• Wearing the Chronic Ventilator Dependent Patient. 
  Pulmonary Rehabilitation Seminar, Jewish Memorial Hospital. - 3/18/1993
• The Weaning of Patients from Chronic Mechanical Ventilation. 
  St. John's Hospital Seminar Series, Lowell, MA. - 3/8/1993
• Gamma-glutamyl Transpeptidase in the Lung Alveolus. 
  Lung Cell Biology Symposium at Woods Hole on "Development of the Lung and Model Systems" sponsored b - 10/21/1992
• Gamma-glutamyl Transpeptidase Expression in the Lung Alveolus. 
  Department of Pharmacology at Boston University School of Medicine, Seminar Series. - 9/30/1992
• Weaning the Chronic Ventilator Dependent Patient. 
  Symposium on Pulmonary Rehabilitation, Jewish Memorial Hospital, Boston, MA. - 3/18/1992
• Genetic Markers of Alveolar Epithelial Cell Differentiation. 
  Symposium on Pulmonary Epithelial Cell Growth and Differentiation, International Conference of the A - 5/19/1991
• Differentiation of the Alveolar Epithelium. 
  Pulmonary Research Conference, New England Medical Center of Tufts University. - 11/27/1990
• Structural Development of the Lung. 
  Fourth Annual Meeting of the Society of Pediatric Anesthesia, Las Vegas, NE. - 10/18/1990
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Other

• "Trends in Nebulizer Therapy". 
  Business Briefing: US Respiratory Care 2006, London, touch Briefings
  1/1/2005
• Lung Cell Differentiation. 
  Brody JS, M Joyce-Brady, R Paine, Mead Johnson Symposium on Perinatal and Developmental Medicine
  1/1/1987
• Management of the difficult-to-wean patient 
  Joyce-Brady MF, Epstein SK
  http://www.uptodate.com/contents/management-of-the-difficult-to-wean-patient
  UpToDate, Wolters Kluwer Health - 2012-04-25