Mark S Segal MD

PubMed

• Epidemiology, trajectories and outcomes of acute kidney injury among hospitalized patients: a large retrospective multicenter cohort study.
  Esra Adiyeke, Yuanfang Ren, Shmuel Fogel, Parisa Rashidi, Mark Segal
  Journal of Nephrology. 2025-03-21
• Association Between Use of WATCHMAN Device and 1-Year Mortality Using High-Dimensional Propensity Scores to Reduce Confounding.
  Julie Z Zhao, Mohammed Ruzieh, Fanxing Du, Yi Lian, Andrew J Foy
  Circulation. Cardiovascular Quality and Outcomes. 2025-03-03
• Outcomes among Patients with End-Stage Kidney Disease and Chronic Limb-Threatening Ischemia: A Population-based Cohort Study.
  Samir K Shah, Dan Neal, Terrie Vasilopoulos, Mark Segal, Scott Berceli
  Annals of Surgery. 2024-10-15

Journal Articles

• Endothelial Progenitor Cells and Endothelial Vesicles – What Is the Significance for Patients with Chronic Kidney Disease?  
  Rahesh Mohandas & Mark S.Segal., Blood Purification
• Type I interferon: a novel risk factor for EPC depletion and endothelial dysfunction in SLE.  
  Lee, P., Li, Y., Richards, H.B., Chan, F.S., Zhuang, H., Narain, S., Butfiloski, E., Sobel, E.S., Reeves, W.H., Segal, M.S., Arthritis & Rheumatism.
• Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index?  
  Segal MS, Gollub E, Johnson RJ., Eur J Nutr.
• Endothelial health and diversity in the kidney.  
  Segal, Mark S., Baylis, Chris, Johnson, Richard J., J Am Soc Nephrol.
• Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus eryt...  
  Zhuang H, Narain S, Sobel E, Lee PY, Nacionales DC, Kelly KM, Richards HB, Segal M, Stewart C, Satoh M, Reeves WH., Clin Immunol.
• High sensitivity c-reactive protein in systemic lupus erythematosus: Relation to disease activity and clinical presentation.  
  Barnes EV, Narain S, Naranjo a, Shuster J, Segal MS, Sobel ES, Reeves WH, Richards HB., Lupus
• A Novel Murine Model of Intimal Hyperplasia Induced by Autologous Venous Graft into the Aorta.  
  Diao, Yanpeng, Xue, Jing, Segal, Mark S., Journal of Surgical Research.
• A simple "lumen digestion" technique for isolation of aortic endothelial cells from heme oxygenase-1 knockout mice.  
  Chen, Sifeng, Segal, Mark, Agarwal, Anupam., Biotechniques
• Binding sites for Hsp70 molecular chaperones in natural proteins.  
  Gething, M.J., Blond-Elguindi, S., Buchner, J., Fourie, A., Knarr, G., Modrow, S., Nanu, L., Segal, M., Sambrook, J., Cold Spring Harb Symp Quant Biology
• Urinary tract infection in men-an internist's viewpoint.  
  Smith, JW and Segal, M., Infection.
• The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins.  
  Kozutsumi, Y., Segal, M. Normington, K., Gething, M.J., and Sambrook, J., Nature
• Amphotericin B selection of mutant chinese hamster cells with defects in the receptor mediated endocytosis of low density lipoprotein and cholesterol biosynthesis.  
  Krieger, M., Martin, J., Segal, M., and Kingsley, D., PNAS
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Books/Book Chapters

• Herbal and Over-the-Counter Medicines and the Kidney. 
  Mark S. Segal and Xueqing Yu.Editors: John Feehally, Jurgen Floege, Richard J.Johnson.Comprehensive Clinical NephrologyEdition 3,
• Disorders of water balance. 
  Mark S. Segal and Charles S. Wingo.Editors: Christopher S Wilcox & C. Craig Tisher.Handbook of Nephrology and HypertensionEdition 7,
• Renal involvement in systemic lupus erythematosus. 
  Mark S. Segal and Richard J. Johnson.Editors: Christopher S Wilcox & C. Craig Tisher.Handbook of Nephrology and HypertensionEdition 7,

Abstracts/Posters

• Three types of low density lipoprotein receptor deficient mutants have pleiotropic defects in the synthesis of n linked, o linked, and lipid linked carbohydrate chains.
  Kingsley, D., Kozarsky, K., Segal, M., and Krieger, M., J. Cell Biology
• Bone Marrow EPC Function Relative to Time of Collection after Acute Myocardial Infarction.
  Mark S. Segal, Maria Grant, Doris Taylor, Chris Cogel, Lemuel A. Moyé, Carl J., NIH Bethesda, Maryland
• Functional Immunoassay Technology (FIT) Provides Accurate GFR Measurements Following Long-Term Storage of Urine and Serum Samples.
  Christopher P. Reinhardt, Dennis E. Vaccaro, Titte Srinivas, Mark S. Segal, Ernest V. Groman., ASN, San Francisco, CA.
• Intracellular Conversion of Uric Acid to Triuret Is Necessary for Inhibition of DPPIV Activity.
  Mark S. Segal, Chris Gersch, Anna Schuler, John Domsic, Robert Mckenna, Richard J. Johnson, Wai-Yan Chan Chan., ASN, San Francisco, CA
• Type I Interferon: A Novel Risk Factor for EPC Depletion and Endothelial Dysfunction in SLE.
  Mark S. Segal, Yi Li, Haoyang Zhuang, Westley Reeves, Pui Lee., ASN, San Francisco, CA
• Circulating Endothelial Cells As A Novel Marker Of Endothelial Activation In Hemodialysis Patients.
  Bihorac, A. Koc, M., Segal, M. S., SAFMR, New Orleans, Louisiana.
• Role of Circulating Progenitor Cells in the Development of Venous Intimal Hyperplasia.
  Diao, Y. and Segal, M., ASN Oral
• Effect of pH and Potassium on Apoptosome Formation.
  Segal, M., and Beem, E., ASN Poster Presentation
• Development of a Novel, Real-Time, In-Vivo Marker of Caspase-8 Activity as a Measurement of Apoptosis.
  Lee, P., Beem, E., and Segal, M., ASN/ISN Poster Presentation
• Effect of pH, Ionic Charge, and Osmolality on Cytochrome C Mediated Caspase-3 Activity.
  Segal, M., and Beem, E., ASN/ISN Poster Presentation
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Lectures

• Endothelial Health: The true endpoint for hypertension and diabetes treatment. 
  Florida Society of Nephrology Sanibel Island
• Lupus and your kidneys. 
  The Lupus Foundation of Florida annual Lupus Awareness Seminar. Orlando, Florida
• Potential Role of ESAs in Cancer. 
  International Society of Nephrology. Vancouver, British Columbia
• The novel mechanism of the EPO requiring the VEGFR2 receptor for signaling. 
• Diabetes and Chronic Kidney Disease: An Update Case Studies in Hypertension. 
  25th Annual Southern Regional Conference on Diabetes, Marco Island Marriott Resort
• CEC and EPC as a reflection of endothelial health. 
  Keynote Speaker at the Korean Society of Nephrology Seoul, Korea
• EPC and EPC vesicles: what is the significance for in the CKD patients? 
  Marriott New Orleans, Louisina
• Erythropoietin: Wonder molecule at what cost? 
  University of New Mexico Alberquerque, NM
• Hyperuricemia: A causal Link to Human Hypertension? 
  Edmonton, Alberta Canada
• Vasculitis. 
  Topice in Internal Medicine. Gainesville, Florida
• Lupus and your Kidneys. 
  Annual Autoimmunity Symposium, Gainesville, FL
• Novel Markers of Endothelial Health. 
  Nephrology Grand Rounds, Emory University Atlanta, Georgia
• Inadequate endothelial repair mechanisms. 
  American Society of Nephrology St. Louis, Missouri
• GFR measurement using gadopentate dimeglumine clearance. 
• Measurement of Renal Plasma Flow, GFR and intrarenal hemodynamics with iodohippurate and gadopentate dimeglumine. 
• Carbamylated erythropoietin Enhances Chemotaxis of Circulating Endothelial Progenitor Cells via VEGFR2 signaling. 
• Direct inhibitory effect of uric acid on the biologically significant enzyme dipeptidyl peptidase IV. 
• The role of bone marrow derived cells in the development of the neointima in vein grafts. 
• Decreased Chemotaxis of Hematopoietic Stem Cells (CD34+) & Increase in CD26/Dipeptidylpeptidase IV Activity among Type II Diabetic Patients on Hemodialysis May Reflect... 
  ASN Renal Week in St. Louis, Missouri.
• Endothelial Progenitor Cell Colony Forming Units Correlate with EPC Nitric Oxide Levels and Endothelial Function in Hypertensive African-American Patients. 
  ASN 2009 42nd Annual Meeting and Scientific Exposition San Diego, California
• The Erythropoietin Heterodimeric Beta Common Receptor is in a Complex With and Requires VEGFR2 for Downstream Signaling. 
  ASN 2009 42nd Annual Meeting and Scientific Exposition San Diego, California
• Carbamylated EPO Enhances Chemotaxis of Circulating Endothelial Progenitor Cells via VEGFR2 signaling. 
  ASN, Philadelphia, Pennsylvania.
• Nitric Oxide Cytoskeletal Induced Alterations Reverses Diabetic Endothelial Progenitor Cell Migratory Defects Associated with Diabetics on Hemodialysis. 
  ASN Program Committee for an oral presentation during the ASN’s Renal Week in Philadelphia, PA
• Epoetin Alfa Enhances Chemotaxis of Circulating Endothelial Progenitor Cells to SDF-1 and Stimulates Intracellular Nitric Oxide Production. 
  ASN Program Committee for an oral presentation during the ASN’s Renal Week in Philadelphia, PA
• Effects of Cardiovascular Pharmacologic Agents on Peripheral-Blood Derived Endothelial Progenitor Cells Chemotaxis to SDF-1 in End-Stage Renal Disease Diabetics and He... 
  ASN Program Committee for presentation in a Poster Session at the ASN Renal Week in Philadelphia, PA
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