MarkJ.RoutbortMD

PubMed

• Microsatellite instability and high tumor mutational burden detected by next generation sequencing are concordant with loss of mismatch repair proteins by immunohistoc...
  Richard K Yang, Hector Alvarez, Antony San Lucas, Sinchita Roy-Chowdhuri, Asif Rashid
  Cancer Genetics. 2025-01-01
• Genomic Alterations in DNA Mismatch Repair Genes Across Different Cancer Types.
  Vijaykumar R Holla, Michael P Kahle, Sun-Hee Kim, Arash Ronaghy, Richard K Yang
  JCO Precision Oncology. 2024-11-01
• 4 citations
  Optical genome mapping improves the accuracy of classification, risk stratification, and personalized treatment strategies for patients with acute myeloid leukemia.
  Sanam Loghavi, Qing Wei, Farhad Ravandi, Andres E Quesada, Mark J Routbort
  American Journal of Hematology. 2024-10-01

Journal Articles

• Distinct Biological Types of Ocular Adnexal Sebaceous Carcinoma: HPV-Driven and Virus-Negative Tumors Arise Through Non-Overlapping Molecular-Genetic Alterations  
  Mark J Routbort, Diana Bell, Victor G Prieto, Michael T Tetzlaff, Anna Yemelyanova, Bita Esmaeli, Clinical Cancer Research
• Implementation of biomarker-driven cancer therapy: existing tools and remaining gaps  
  Bailey AM, Mao Y, Zeng J, Holla V, Johnson A, Brusco L, Chen K, Mendelsohn J, Routbort MJ, Mills GB, Meric-Bernstam F, Discov Med, 1/1/2014
• Quantitative assessment of mutant allele burden in solid tumors by semiconductor-based next-generation sequencing  
  Portier BP, Kanagal-Shamanna R, Luthra R, Singh R, Routbort MJ, Handal B, Reddy N, Barkoh BA, Zuo Z, Medeiros LJ, Aldape K, Patel KP, Am J Clin Pathol, 1/1/2014
• BRAF Kinase domain mutations are present in a subset of chronic myelomonocytic leukemia with Wild-Type RAS  
  Zhang L, Singh RR, Patel KP, Stingo F, Routbort M, You MJ, Miranda RN, Garcia-Manero G, Kantarjian HM, Medeiros LJ, Luthra R, Khoury JD, Am J Hematol, 1/1/2014
• Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma  
  Siroy AE, Boland GM, Milton DR, Roszik J, Frankian S, Malke J, Haydu L, Prieto VG, Tetzlaff M, Ivan D, Wang WL, Torres-Cabala C, Curry J, Roy-Chowdhuri S, Broaddus R, ..., J Invest Dermatol, 1/1/2014
• Absence of terminal deoxynucleotidyl transferase expression identifies a subset of high-risk adult T-lymphoblastic leukemia/lymphoma  
  Zhou Y, Fan X, Routbort M, Cameron Yin C, Singh R, Bueso-Ramos C, Thomas DA, Milton DR, Medeiros LJ, Lin P, Mod Pathol, 1/1/2013
• Next-generation sequencing-based multi-gene mutation profiling of solid tumors using fine needle aspiration samples: promises and challenges for routine clinical diagn...  
  Kanagal-Shamanna R, Portier BP, Singh RR, Routbort MJ, Aldape KD, Handal BA, Rahimi H, Reddy NG, Barkoh BA, Mishra BM, Paladugu AV, Manekia JH, Kalhor N, Chowdhuri SR,..., Mod Pathol, 1/1/2013
• TET2 mutations, myelodysplastic features, and a distinct immunoprofile characterize blastic plasmacytoid dendritic cell neoplasm in the bone marrow  
  Alayed K, Patel KP, Konoplev SN, Singh R, Routbort MJ, Reddy N, Pemmaraju N, Zhang L, Al Shaikh A, Aladily T, Jain N, Luthra R, Medeiros LJ, Khoury JD, Am J Hematol, 1/1/2013
• Clinical Validation of a Next Generation Sequencing Screen for Mutational Hotspots in 46 Cancer-related Genes  
  Singh RR, Patel KP, Routbort MJ, Reddy NG, Barkoh BA, Handal B, Kanagal-Shamanna R, Greaves WO, Medeiros LJ, Aldape KD, Luthra R, J Mol Diagn, 1/1/2013
• Next Generation Sequencing based Multi-Gene Mutational Screen for Acute Myeloid Leukemia using MiSeq: Applicability for Diagnostics and Disease Monitoring  
  Luthra R, Patel KP, Reddy NG, Haghshenas V, Routbort MJ, Harmon MA, Barkoh BA, Kanagal-Shamanna R, Ravandi F, Cortes JE, Kantarjian HM, Medeiros LJ, Singh RR, Haematologica, 1/1/2013
• Real-time process defect collection within the anatomic pathology aboratory to facilitate informatics driven workflow optimization  
  Riben M, Routbort M, Nesbitt L, Ninan S, AMIA Annu Symp Proc, 1/1/2008
• High frequency of NPM1 gene mutations in acute myeloid leukemia with prominent nuclear invaginations ("cuplike" nuclei)  
  Chen W, Rassidakis GZ, Li J, Routbort M, Jones D, Kantarjian H, Medeiros LJ, Bueso-Ramos CE, Blood, 1/1/2006
• Neurovirulence determinants of genetically engineered Theiler viruses  
  Fu JL, Stein S, Rosenstein L, Bodwell T, Routbort M, Semler BL, Roos RP, Proc Natl Acad Sci USA, 1/1/1990
• Pulmonary granulocytic sarcoma (chloroma) mimicking an opportunistic infection in a patient with acute myeloid leukemia  
  Guimaraes MD, Marchiori E, Marom EM, Routbort MJ, Godoy MC, Ann Hematol
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Books/Book Chapters

• Pathology Informatics: Theory and Practice 
  Chapter: Networks and Workstations 
  Routbort MJASCP Press2012
• Excitatory amino acids and the cerebral cortex 
  Chapter: Excitatory amino acids and use-dependent plasticity: epileptogenesis 
  Page 313 - 323Routbort MJ, McNamara JOMIT Press1996

Abstracts/Posters

• The Impact of PHF6 Mutations in Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, and Acute Myeloid Leukemia
  Mark Routbort, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Evolutionary Action (EA) Score of TP53 Mutations Defines Prognostic Subsets within TP53 Mutated Myelodysplastic Syndromes and Acute Myeloid Leukemia
  Mark Routbort, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• The Art and Science of Next Generation Sequencing Data Interpretation: Value of Pattern Recognition and Statistical Analysis in Distinguishing True Mutations from Arti...
  S Roy Chowdhuri, M Routbort, R Singh, K Aldape, R Broaddus, A Lazar, LJ Medeiros, B Barkho, N Reddy, R Luthra, KP Patel, Modern Pathology, 1/1/2014
• Novel Mutations in Therapy-Related and De Novo Myelodysplasia: Results from a Next-Generation Sequencing Pilot Study
  R Goswami, C Ok, K Patel, S Wang, M Routbort, J Manekia, KJ Jabbar, B Barkho, LJ Medeiros, R Singh, R Luthra, Modern Pathology, 1/1/2014
• Multi-gene Mutational Profiling of Breast Carcinoma using Next Generation Sequencing
  SR Chowdhuri, M Routbort, K Patel, R Singh, R Broaddus, A Lazar, A Sahin, G Mills, J Mendelsohn, F Meric-Bernstam, K Aldape, R Luthra, Modern Pathology, 1/1/2014
• Multigene Mutation Analysis Using Next Generation Sequencing in AML and MDS
  CY Ok, R Kanagal-Shamanna, R Singh, KD Aldape, KP Patel, M Routbort, R Luthra, LJ Medeiros, SA Wang, Modern Pathology, 1/1/2014
• Gene Amplification Patterns Identified By Next Generation Sequencing in a Large Tumor Cohort
  KJ Jabbar, K Patel,K Aldape, R Broaddus, K Shaw, F Meric-Bernstam, S Roy Chowdhuri, A Lazar, R Goswami, LJ Medeiros, R Luthra, MJ Routbort, Modern Pathology, 1/1/2014
• De Novo Acute Myeloid Leukemia with DNMT3A, FLT3, and NPM1 Mutations
  S Loghavi, Z Zuo, L Zhang, F Stingo, KP Patel, RR Singh, R Luthra, MJ Routbort, J Medeiros, JE Cortes, F Ravandi-Kashani, HM Kantarjian, JD Khoury, Modern Pathology, 1/1/2014
• Comparison of Next Generation Sequencing Mutation Profiling with BRAF and IDH1 Mutation Specific Immunohistochemistry
  KJ Jabbar, R Luthra, K Patel, R Singh, R Goswami, LJ Medeiros, K Aldape, M Routbort, Modern Pathology, 1/1/2014
• Clonal evolution of cancer examined via next-generation sequencing of 266 paired primary and metastatic tumors
  R Goswami, KP Patel, KD Aldape, R Singh, KJ Jabbar, S Kopetz, R Alvarez, M Davies, V Subbiah, KR Shaw, F Meric-Bernstam, R Luthra, M Routbort, Modern Pathology, 1/1/2014
• Clinical Next Generation Sequencing Reveals Divergent Mutation Patterns in BRAF V500, BRAF Non-V600, and NRAS Mutations in Advanced Melanoma
  AE Siroy, VG Prieto, JE Gershenwald, SE Woodman, J Roszik, KD Aldape, R Luthra, KP Patel, MJ Routbort, MA Davies, AJ Lazar, Modern Pathology, 1/1/2014
• Clinical Next Generation Sequencing of Sarcomas: Initial experience of 133 Cases
  AA Salim, WL Wang, KD Aldape, R Luthra, M Routbort, A Lazar, Modern Pathology, 1/1/2014
• RAS Mutation Is a Poor Prognostic Factor in Patients with Chronic Myelomonocytic Leukemia
  Liping Zhang, Tariq Aladily, Zaher Chakhachiro, Hui Yao, Xiaoping Su, Mark Routbort, Sa Wang, Raja Luthra, Roberto Miranda, L. Jeffrey Medeiros, Carlos Bueso-Ramos, Jo..., United States and Canadian Assoc Pathology Annual, 1/1/2013
• Identification of HER-2/neu amplification using amplicon based benchtop next generation sequencing
  Portier BP, Patel K, Medeiros LJ, Singh R, Aldape KJ, Hamilton S, Luthra R, Routbort M, San Antonio Breast Cancer Symposium, 1/1/2013
• Quantitative Assessment of Mutant Allele Burden in Solid Tumors by Semiconductor Based Multi-Gene Next Generation Sequencing
  Bryce P. Portier, Rajyalakshmi Luthra, Rajesh Singh, Mark Routbort, Brian Handal, Neeli Reddy, Bedia Barkoh, Zhuang Zuo, Jeffery Medeiros, Ken Aldape and Keyur Patel, United States and Canadian Assoc Pathology Annual, 1/1/2013
• Next Generation Sequencing of a Large Cohort of Solid Tumors Reveals IDH1 Mutations Present in Melanoma at a Higher Frequency than Expected
  Bryce P. Portier, Keyur P. Patel, Rajesh Singh, Mark Routbort, Brian Handal, Bedia A. Barkoh, Neelima Reddy, Alex Lazar, Michael Davies, L. Jeffrey Medeiros, Ken Aldap..., United States and Canadian Assoc Pathology Annual, 1/1/2013
• OncoSeek - A Versatile Annotation and Reporting System for Next Generation Sequencing-Based Clinical Mutation Analysis of Cancer Specimens
  Mark Routbort, Brian Handal, Keyur P. Patel, Rajesh Singh, Kenneth Aldape, Neelima Reddy, Bedia Barkoh, Michael Riben, L. Jeffrey Medeiros, Rajyalakshmi Luthra, Journal Molec Diag, 1/1/2012
• Does Formalin-Fixation and Paraffin-Embedding Affect Genotyping by Next Generation Sequencing?
  N.G. Reddy, R. Singh, K.P. Patel, F. Grant, H. Rahimi, M.A. Harmon, B. Handal, B.A. Barkoh, M. Routbort, K.D. Aldape, J.L. Medeiros, R. Luthra, Journal Molec Diag, 1/1/2012
• Comparison of Next Generation Sequencing Platforms for Multi-Gene Mutational Profiling of Hematologic Malignancies in a Clinical Diagnostics Laboratory
  K.P. Patel, R. Singh, N. Reddy, M. Routbort, K. Aldape, L. Medeiros, R. Sargent, S.S. Chen, C. Yin, J. Zuo, B.A. Barkoh, B. Handal, A. Paladugu, R. Patel, H. Rahimi, ..., Journal Molec Diag, 1/1/2012
• Clinical Validation of a 46 Cancer Gene Mutation Panel using SemiConductor Based Next-Generation Sequencing Technology
  R.R. Singh, N.G. Reddy, B. Barkoh, B. Handal, K.P. Patel, M. Routbort, K.D. Aldape, J.L. Medeiros, R. Luthra, Journal Molec Diag, 1/1/2012
• Application of Next-Generation Sequencing in Using Fine Needle Aspiration Smears and Cell Blocks from Solid Tumors
  R. Kanagal-Shamanna, R.R. Singh, M.J. Routbort, K.D. Aldape, B. Handal, H. Rahimi, N.G. Reddy, B.A. Barkoh, B. Mishra, A.V. Paladugu, J. Manekia, G.A. Staerkel, L. M..., Journal Molec Diag, 1/1/2012
• Reactivation of hepatitis B infection among patients with cancer
  Hwang J, Fisch M, Zhang H, Kallen M, Routbort M, Vierling LS, Suarez-Almazo M, J Clin Oncol, 1/1/2011
• Pre-analytic Process Improvements for Molecular Testing improves Turn Around time for Results
  Middleton L, Puig P, Hamilton S, Routbort M, Luthra R, Rashid A, Reynolds A, Heydon L, Dunn J, Hiumin L, Jackson S, Guerreo J, Lewing C, Bowman C, Ponder J, Cook P, Ph..., University of Texas System Clinical Safety and Effectiveness Conference, 1/1/2011
• Hepatitis B screening and positivity prior to chemotherapy
  Hwang JP, Fisch MJ, Zhang H, Routbort MJ, Lal LS, Vierling JM, Suarez-Almazor M, J Clin Oncol, 1/1/2010
• Patient safety initiatives at the grossing bench: design, implementation, and experience with bar-code driven specimen-block reconciliation for biopsy grossing
  Riben M, Nesbitt L, Ninan S, Routbort MJ, Pathology Informatics, 1/1/2010
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Lectures

• Building a Data Warehouse for Clinical Next Generation Sequencing Data 
  Boston, MA - 1/26/2014
• LIS Interfaces: Basics, Implementation and Pitfalls 
  Pittsburgh, PA - 1/13/2014
• Informatics Driven Molecular Pathology Workshop 
  Pittsburgh, PA - 1/13/2014
• The Intersection of Pathology Informatics and Molecular Diagnostics: When the Bit hits the SNP 
  San Diego, CA - 1/1/2014
• Next Generation Sequencing in Leukemia: Recent Advances in Clinical Applications 
  Houston, TX - 1/26/2013
• Clinical next generation sequencing of solid tumors: Initial MD Anderson experiences 
  Houston, TX - 1/19/2013
• Clinical Informatics in the Era of Genomic Medicine 
  Phoenix, AZ - 1/14/2013
• The information overload from molecular testing: Possible IT solutions for effective consultation 
  Asheville, NC - 1/7/2013
• Next generation sequencing analysis of tumors in the clinical laboratory 
  Durham, NC - 1/5/2013
• Information management for clinical molecular testing 
  Houston, TX - 1/4/2013
• Next generation sequencing and cancer pathology: Informatics challenges and advances 
  Houston, TX - 1/7/2012
• Bar-code driven AP workflow: Step by step 
  Pittsburgh, PA - 1/20/2009
• Advantages and integration of multi-vendor LIS environments 
  Boston, MA - 1/20/2009
• Outside the box interfaces: Agile techniques for getting data in and out of the LIS 
  Pittsburgh, PA - 1/19/2008
• Pathology Informatics: USA 
  Brisbane, Australia - 1/17/2007
• Service-Oriented Architectures 
  Houston, TX - 1/17/2007
• Anatomic Pathology Informatics and Imaging Support for Translational Medicine 
  Pittsburgh, PA - 1/12/2007
• Surgical pathology informatics: what's new and what's next 
  Mexico - 1/1/2007
• SQL Comparator: An open source tool for minimal change database validation 
  Pittsburgh, PA - 1/1/2007
• Informatics 101 
  1/16/2006
• Optimized document management in anatomic pathology: Two paths to a common workflow with analysis of benefits 
  Pittsburgh, PA - 1/1/2006
• A state pattern recognition and extraction engine tool for legacy system interoperability 
  Pittsburgh, PA - 1/1/2006
• PathStation-A pathoogy workflow integration engine using an enterprise application mash-up design pattern 
  Pittsburgh, PA - 1/1/2006
• Introducing new technology into an old grossing facility: Hands free computing to facilitate grossing workflow 
  Pittsburgh, PA - 1/1/2006
• Retrieval and information delivery strategies in anatomic pathology 
  Durham, NC - 1/1/2005
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Other

• Comparator: An open source tool for miminal change database validation 
  Routbort MJ
  http://sourceforge.net/projects/sqlcomparator
• OncoSeek: A clinical genomic analysis and reporting tool 
  Routbort MJ
  https://github.com/routbort/OncoSeek