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Office
75 Francis St
Boston, MA 02115
Summary
- Mark Pepin, MD, PhD is currently a resident physician at Brigham and Women's Hospital and Harvard Medical School. His clinical and scientific interests are centered in end-stage heart failure, specifically the targeted molecular and epigenetic therapies for myocardial disease. He was recently a Humboldt postdoctoral fellow at the Institute for Experimental Cardiology at Heidelberg University (Heidelberg, DE), where his main project defined a causal role of catecholaminergic histone modifications in heart failure-induced carcinogenesis.
Education & Training
- Brigham and Women's HospitalResidency, Internal Medicine, 2022
- Universitätsklinikum HeidelbergPost-Doctoral Fellowship, 2020 - 2022
- University of Alabama School of MedicineClass of 2020, MD, AOA Member
- University of Alabama at BirminghamPhD, Biomedical Engineering, Suma Cum Laude, 2015 - 2019
- UC DavisMS, Biomedical Engineering, Cum Laude, 2011 - 2013
- Clemson UniversityBS, Chemical Engineering, Cum Laude, 2006 - 2011
Certifications & Licensure
- CA State Medical License 2024 - 2026
- MA State Medical License 2022 - 2024
Awards, Honors, & Recognition
- "Tinsley Harrison" Excellence in Clinical Medicine UAB Department of Medicine, 2022
- “William C. Stanley” Early Investigator Award Society for Heart and Vascular Metabolism, 2019
- "Samuel B Barker" Award for Excellence in Graduate Studies UAB Graduate School, 2019
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Publications & Presentations
PubMed
- 2 citationsCDK5R1, GSE1, HSPG2 and WDFY3 as indirect epigenetic-sensitive genes in atrial fibrillation.Teresa Infante, Mark E Pepin, Antonio Ruocco, Ugo Trama, Ciro Mauro
European Journal of Clinical Investigation. 2024-03-01 - 5 citationsIndirect epigenetic testing identifies a diagnostic signature of cardiomyocyte DNA methylation in heart failure.Christian U Oeing, Mark E Pepin, Kerstin B Saul, Ayça Seyhan Agircan, Yassen Assenov
Basic Research in Cardiology. 2023-03-20 - 2 citationsDeep phenotyping of two preclinical mouse models and a cohort of RBM20 mutation carriers reveals no sex-dependent disease severity incardiomyopathy.David C Lennermann, Mark E Pepin, Markus Grosch, Laura Konrad, Elena Kemmling
American Journal of Physiology. Heart and Circulatory Physiology. 2022-12-01
Journal Articles
- Glucagon-Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21Stephen Barnes, Mark Pepin, Diabetes Care
Press Mentions
- Race and Poverty Appear to Guide Heart Muscle DNA Methylation in Heart-Failure PatientsApril 7th, 2021
- Epigenetic Reprogramming of Human Hearts Found in Congestive Heart FailureAugust 10th, 2018
- Genome-Wide DNA Methylation Encodes Cardiac Transcriptional Reprogramming in Human Ischemic Heart FailureAugust 10th, 2018
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Grant Support
- "DZHK-Omics: Intuitive and Standardized Bulk RNA-Sequencing Analysis for the Coding-Naïve Basic Scientist."DZHK - German Society for Heart Research2021–2022
- "The role of CaMKII-dependent histone modification in heart failure-induced carcinogenesis."Alexander von Humboldt Society2020–2022
- Developing an Integrated Media Production Studio for Medical EducationUAB Innovations in Medical Education2018–2020
- "Gadd45b and Metabolic Memory in Diabetic Heart Failure."NIH National Heart, Lung, and Blood Institute (NHLBI)2017–2020
Committees
- Director, Academic Engagement Committee 2015 - 2020
Research History
- First AuthorDoes an optimal learning style exist in preclinical medicine? A Learning Assessment and Study Skills Inventory.2016 - 2019
- First AuthorHAART-Induced Metabolic Syndrome and Adipocyte-Infiltrating Macrophages.2016 - 2018
- Middle-AuthorGamificaiton of medical knowledge as a retention tool for physician scientists.2017 - 2017
- First AuthorEtiology-specific heart failure susceptibility: of mice and men.
- First AuthorEpigenetic reprogramming of the failing diabetic heart.
Professional Memberships
- Member
- American Physiology SocietyMember
Other Languages
- German
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