MarkGMalkinMD, FRCPC, FAAN

PubMed

• 1 citations
  Phase 2 Study of Sorafenib, Valproic Acid, and Sildenafil in the Treatment of Recurrent High-Grade Glioma.
  Andrew S Poklepovic, Palak Shah, Mary Beth Tombes, Ellen Shrader, Dipankar Bandyopadhyay
  Medrxiv. 2024-04-24
• 1 citations
  Disease-Based Prognostication: Neuro-Oncology.
  Kristin A Waite, Gino Cioffi, Mark G Malkin, Jill S Barnholtz-Sloan
  Seminars in Neurology. 2023-10-01
• 7 citations
  Managing cancer and living meaningfully (CALM) in adults with malignant glioma: a proof-of-concept phase IIa trial.
  Ashlee R Loughan, Kelcie D Willis, Sarah Ellen Braun, Gary Rodin, Autumn Lanoye
  Journal of Neuro-Oncology. 2022-05-01

Journal Articles

• The use of plasma exchange in Hashimoto’s encephalopathy: A case report and review of the literature  
  Cook MK, Malkin M, Karafin MS, J Clin Apheresis, 1/12/2014
• Precise ex-vivo histological validation of heightened cellularity and diffusion restricted necrosis in regions of dark ADC in seven cases of high-grade glioma  
  Laviolette P, Mickevicius N, Cochran E, Bovi J, Schmainda K, Mueller W, Connelly JH, Malkin M, Neuro Oncol, 1/1/2014
• Comprehensive characterization of glioblastoma tumor tissues for biomarker identification using mass spectrometry-based label-free quantitative proteomics  
  Heroux MS, Chesnik MA, Halligan BD, Al-Gizawiy M, Connelly JM, Mueller WM, Rand SD, Cochran EJ, Laviolette PS, Malkin MG, Schmainda KM, Mirza SP, Physiol Genomics, 1/1/2014
• PDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells  
  Roberts JL, Booth L, Conley A, Cruickshanks N, Malkin M, Kukreja RC, Grant S, Poklepovic A, Dent P, Cancer Biol Ther, 1/1/2014
• Dynamic-susceptibility contrast agent MRI measures of relative cerebral blood volume predict response to bevacizumab in recurrent high-grade glioma  
  Schmainda KM, Prah M, Connelly J, Rand SD, Hoffman RG, Mueller W, Malkin MG, Neuro Oncol, 1/1/2014
• Vascular change measured with independent component analysis of dynamic susceptibility MRI predicts bevacizumab response in high-grade glioma  
  Laviolette PS, Cohen AD, Prah MA, Rand SD, Connelly J, Malkin MG, Mueller WM, Schmainda KM, Neuro Oncol, 1/1/2013
• NovoTTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: A randomized phase III trial of a novel treatment modality  
  Stupp R, Wong ET, Kanner AA, Steinberg D, Engelhard H, Heidecke V, Kirson ED, Taillibert S, Lieberman F, Dbaly V, Ram Z, Villano JL, Rainov N, Weinberg U, Schiff D, Ku..., Eur J Cancer, 1/1/2012
• Spatially quantifiying microscopic tumor invasion and proliferation using a voxel-wise solution to a glioma growth model and serial diffusion MRI  
  Ellingson BM, Laviolette PS, Rand SD, Malkin MG, Connelly JM, Mueller WM, Prost RW, Schmainda KM, Magn Reson Med, 1/1/2011
• PRODIGE: a phase III randomized placebo-controlled trial of thromboprophylaxis using dalteparin low molecular weight heparin (LMWH) in patients with newly diagnosed ma...  
  Perry JR, Julian JA, Laperriere NJ, Geerts W, Agnelli G, Rogers LR, Malkin MG, Sawaya R, Baker R, Falanga A, Parpia S, Finch T, Levine MN, J Thromb Haemost, 1/1/2010
• Vinorelbine combined with a protracted course of temozolomide for recurrent brain metastases: a phase I trial  
  Omuro AM, Raizer JJ, Malkin MG, Obbens EAMT, Abrey LE, J Neuro-Oncol, 1/1/2006
• Systemic high-dose intravenous methotrexate for central nervous system metastases  
  Lassman AB, Abrey LE, Shah G, Panageas KS, Begemann M, Malkin MG, Raizer JJ, J Neuro-Oncol, 1/1/2006
• Phase 1 study of 28-day, low-dose temozolomide and BCNU in the treatment of malignant gliomas after radiation therapy  
  Raizer JJ, Malkin MG, Kleber M, Abrey LE, Neuro-Oncology, 1/1/2004
• A phase II study of extended low-dose temozolomide in recurrent malignant gliomas  
  Khan RB, Raizer JR, Malkin MG, Bazylewicz KA, Abrey LE, Neuro-Oncology, 1/1/2002
• Safety and efficacy of alteplase (TPA) for the clearance of occluded central venous access devices (CVAD’s) in 121 cancer patients  
  Timoney JP, Malkin MG, Leone DM, Groeger JS, Keefe DL, Klang MG, Lucarelli CD, Muller RJ, Heaney ML, Connor MA, Small TN, Saltz LB, J Clin Oncol, 1/1/2002
• The Brain Tumor Cooperative Group NIH Trial 87-01: A randomized comparison of surgery, external radiotherapy and BCNU v surgery, interstitial radiotherapy boost, exter...  
  Selker RG, Shapiro W, Burger P, Blackwood MS, Deutsch M, Arena V, Van Gilder JC, Wu J, Malkin MG, Mealey J Jr, Neal J, Olson J, Robertson JT, Barnett G, Bloomfield S, ..., Neurosurgery, 1/1/2002
• A phase II trial of temozolomide for patients with recurrent or progressive brain metastases  
  Abrey LE, Olson JD, Raizer JJ, Mack M, Rodavitch A, Boutros D, Malkin MG, J Neuro-Oncol, 1/1/2001
• Evaluation of early response to SU101 target-based therapy in patients with recurrent supratentorial malignant gliomas using FDG PET and Gd-DTPA MRI  
  Vlassenko AG, Thiessen B, Beattie BJ, Malkin MG, Blasberg RG, J Neuro-Oncol, 1/1/2000
• Paradoxical reaction syndrome complicating Mycobacterium tuberculosis aural infection during therapy  
  Safdar A, Brown AE, Kraus DH, Malkin M, Clin Infect Dis, 1/1/2000
• Phase II study of antineoplastons A10 (NSC 648539) and AS2-1 (NSC 620261) in patients with recurrent anaplastic astrocytoma and glioblastoma multiforme  
  Buckner JC, Malkin MG, Reed E, Cascino TL, Reid JM, Ames M, Tong WPY, Lim S, Figg WD, Mayo Clin Proc, 1/1/1999
• Ethical issues in neuro-oncology In: Taylor RM, ed Ethics in Neurology  
  Newton HB, Malkin MG, Semin Neurol, 1/1/1997
• Pain from a shunt-induced abdominal phlegmon  
  Wong ET, Malkin MG, Patt RB, Primary Care and Cancer, 1/1/1997
• “In Sickness and in Health”: A group intervention for spouses caring for patients with brain tumors  
  Horowitz S, Passik SD, Malkin MG, J Psychosocial Oncol, 1/1/1996
• Autoimmune paraneoplastic cerebellar degeneration in ovarian carcinoma treated with plasmapheresis and immunoglobulin - a case report  
  Ben David Y, Warner E, Levitan M, Sutton DMS, Malkin MG, Dalmau JO, Cancer, 1/1/1996
• Therapy of malignant astrocytoma  
  Malkin MG, Cancer Investigation, 1/1/1995
• Superiority of PCNU over AZQ in the treatment of primary brain tumors: results of a prospective randomized trial (81-20) by the Brain Tumor Study Group  
  Malkin MG, Green SB, Byar DP, Strike TA, Burger PC, Vogel FS, Pistenmaa DA, Mahaley MS Jr, Ransohoff J, Shapiro WR, Mealey J Jr, Robertson JT, Selker RG, Van Gilder JC, J Neuro-Oncol, 1/1/1994
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Books/Book Chapters

• Neurological Complications of Systemic Cancer and Antineoplastic Therapy 
  Editors: Malkin MG, et al.Informa Healthcare, New York, NY2010
• Neurological Complications of Systemic Cancer and Antineoplastic Therapy 
  Chapter: Supportive Care 
  Page 550 - 563Newton HB, Malkin MGEditors: Newton HB, Malkin MG.Informa Healthcare, New York, NY2010
• Neurological Complications of Systemic Cancer and Antineoplastic Therapy 
  Chapter: Neurological Complications of Lung Cancer 
  Page 187 - 221Grossheim LD, Jayapalan S, Henson JH, Malkin MGEditors: Newton HB, Malkin MG.Informa Healthcare, New York, NY2010
• Neurological Complications of Systemic Cancer and Antineoplastic Therapy 
  Chapter: Leptomeningeal Metastases 
  Page 53 - 76Grossheim LD, Malkin MGEditors: Newton HB, Malkin MG.Informa Healthcare, New York, NY2010
• Neurological Complications of Systemic Cancer and Antineoplastic Therapy 
  Chapter: Intracranial Metastases 
  Page 23 - 39Newton HB, Malkin MGEditors: Newton HB, Malkin MG.Informa Healthcare, New York, NY2010
• Neurological Complications of Systemic Cancer and Antineoplastic Therapy 
  Chapter: Biology and Pathophysiology of Nervous System Metastases 
  Page 1 - 22Newton HB, Malkin MGEditors: Newton HB, Malkin MG.Informa Healthcare, New York, NY2010
• Handbook of Neuro-Oncology Neuroimaging 
  Chapter: Overview of spinal cord tumor epidemiology 
  Page 31 - 35Newton HB, Malkin MGEditors: Newton HB, Jolesz F.Elsevier, New York, NY2007
• Handbook of Neuro-Oncology Neuroimaging 
  Chapter: Overview of pathology and treatment of intramedullary spinal cord metastases 
  Page 50 - 53Newton HB, Ray-Chaudhury A, Malkin MGEditors: Newton HB, Jolesz F.Elsevier, New York, NY2007
• Handbook of Neuro-Oncology Neuroimaging 
  Chapter: Overview of pathology and treatment of primary spinal cord tumors 
  Page 36 - 49Newton HB, Ray-Chaudhury A, Malkin MGEditors: Newton HB, Jolesz F.Elsevier, New York, NY2007
• Handbook of Neuro-Oncology Neuroimaging 
  Editors: Malkin MG (assoc. ed.).Elsevier, New York, NY2007
• Handbook of Neuro-Oncology Neuroimaging 
  Chapter: Overview of pathology and treatment of metastatic brain tumors 
  Page 20 - 30Newton HB, Ray-Chaudhury A, Malkin MGEditors: Newton HB, Jolesz F.Elsevier, New York, NY2007
• Handbook of Neuro-Oncology Neuroimaging 
  Chapter: Overview of pathology and treatment of primary brain tumors 
  Page 9 - 19Newton HB, Ray-Chaudhury A, Malkin MGEditors: Newton HB, Jolesz F.Elsevier, New York, NY2007
• Handbook of Neuro-Oncology Neuroimaging 
  Chapter: Overview of brain tumor epidemiology 
  Page 3 - 8Newton HB, Malkin MGEditors: Newton HB, Jolesz F.Elsevier, New York, NY2007
• Handbook of Brain Tumor Chemotherapy 
  Chapter: Chemotherapy of ependymomas 
  Page 426 - 431Malkin MGEditors: Newton HB.Elsevier, Amsterdam, The Netherlands2006
• Handbook of Brain Tumor Chemotherapy 
  Chapter: Chemotherapy of low-grade astrocytomas 
  Page 364 - 370Malkin MGEditors: Newton HB.Elsevier, Amsterdam, The Netherlands2006
• Therapeutic approaches to patients with neurological complications of cancer 
  Chapter: Therapeutic options for leptomeningeal metastases 
  Page 35 - 44Malkin MGEditors: Newton H.American Academy of Neurology, Minneapolis, MN2004
• Neurobase 
  Chapter: Gangliogioma 
  Bender AL, Malkin MGEditors: Greenberg H.1996
• Neurobase 
  Chapter: Low-grade glioma 
  Bender AL, Malkin MGEditors: Greenberg H.1996
• Educational Review Manual in Oncology 
  Chapter: Brain Tumors 
  Page 1 - 12Malkin MGEditors: Straus DJ.Journal Publishing Group, New York, NY1995
• Molecular Neuro-Oncology and its Impact on the Clinical Management of Brain Tumors 
  Chapter: Interstitial brachytherapy of malignant gliomas: the Memorial Sloan-Kettering Cancer Center experience 
  Page 117 - 125Malkin MGEditors: Wiestler OD, Schlegel U, Schramm J.Springer-Verlag, Berlin, Germany1994
• Handbook of Cerebellar Diseases 
  Chapter: Cerebellar tumors 
  Page 165 - 206Peterson K, Malkin MGEditors: Lechtenberg R.Marcel Dekker, New York, NY1993
• Controlled Clinical Trials in Neurologic Disease 
  Chapter: Brain tumors 
  Page 343 - 360Malkin MG, Posner JBEditors: Porter RJ, Schoenberg BS.Kluwer Academic Publishers, Norwell, MA1990
• Cancer Chemotherapy and Biological Response Modifiers 
  Chapter: Brain tumors 
  Page 377 - 389Malkin MG, Shapiro WREditors: Pinedo HM, Chabner BA, Longo DL.Elsevier Science Publishers, Amsterdam, The NetherlandsEdition 9th,1987
• Cancer Chemotherapy 
  Chapter: Brain tumors 
  Page 511 - 524Malkin MG, Shapiro WREditors: Pinedo HM, Chabner BA.Elsevier Science Publishers, Amsterdam, The NetherlandsEdition 8th,1986
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Abstracts/Posters

• Final results of a single-arm phase II study of bevacizumab and temozolomide following radiochemotherapy in newly diagnosed adult glioblastoma patients
  Nicholas MK, Lukas RV, Amidei C, Vick N, Paleologos N, Malkin MG, Krouwer H, Junck L, Arzbaecher J, Lai A, Merrell R, J Clin Oncol, 1/1/2013
• ICA-DSC derived AVOL, a new imaging biomarker of brain tumor vasculature
  LaViolette PS, Cohen AD, Cochran E, Prah MA, Rand SD, Connelly J, Malkin MG, Mueller WM, Schmainda KM, Medical College of Wisconsin Research Day, 1/1/2013
• DSC-MRI measures of standardized rCBV predict response to bevacizumab in high-grade brain tumor patients
  Schmainda KM, Prah MA, Rand SD, Connelly J, Paulson ES, LaViolette PS, Mueller W, Malkin MG, 21st Annual Meeting of the International Society of magnetic Resonance in Medicine (ISMRM), Salt Lake City, UT, 1/1/2013
• Reduced diffusion and perfusion in bevacizumab-induced diffusion restricted necrosis versus brain tumor hypercellularity
  LaViolette PS, Cochran E, Cohen AD, Al-Gizawiy MA, Connelly J, Rand SD, Malkin MG, Schmainda KM, 21st Annual Meeting of the International Society of magnetic Resonance in Medicine (ISMRM), Salt Lake City, UT, 1/1/2013
• A phase II study of bevacizumab in combination with temozolomide in the adjuvant treatment of newly diagnosed glioblastoma multiforme (BINGO)
  Nicholas MK, Lucas RV, Arzbaecher J, Paleologos N, Krouwer H, Malkin MG, Omar A, Junck L, Vick NA, Neuro-oncology, 1/1/2011
• Bevacizumab in combination with temozolomide in the adjuvant treatment of newly diagnosed glioblastoma multiforme
  Nicholas MK, Lucas RV, Arzbaecher J, Paleologos N, Krouwer H, Malkin M, Omar A, Vick NA, Junck L, Neuro-oncology, 1/1/2011
• Graded functional diffusion maps (fDMs) applied to whole brain: A sensitive imaging biomarker for monitoring brain tumor growth and invasion
  Ellingson BM, Malkin MG, Rand SD, Connelly JM, LaViolette PS, Bedekar DP, Schmainda KM, Proc. Intl. Soc. Mag. Reson. Med., 18th Annual Meeting, Stockholm, Sweden, 1/1/2010
• Assessment of Invasion and Recurrence in Glioblastoma Multiforme using Diffusion Weighted MRI Edge Characteristics of Contrast Enhancing Tumor
  LaViolette PS, Ellingson BM, Connelly JM, Malkin MG, Rand SD, Schmainda KM, Proc. Intl. Soc. Mag. Reson. Med., 18th Annual Meeting, Stockholm, Sweden, 1/1/2010
• Validation of functional diffusion maps (fDMs) as cellularity biomarkers in human gliomas
  Ellingson BM, Malkin MG, Rand SD, Connelly JM, Quincey C, LaViolette PS, Bedekar DP, Schmainda KM, Proc. Intl. Soc. Mag. Reson. Med., 18th Annual Meeting, Stockholm, Sweden, 1/1/2010
• Spatially quantifying microscopic tumor invasion and proliferation using a voxel-wise analytical solution to a glioma growth model and serial diffusion MRI
  Ellingson BM, Rand SD, Malkin MG, Prost R, Connelly JM, LaViolette PS, Bedekar DP, Schmainda KM, Proc. Intl. Soc. Mag. Reson. Med., 18th Annual Meeting, Stockholm, Sweden, 1/1/2010
• Functional diffusion maps (fDMs) applied to FLAIR abnormal regions can detect pseudoprogression from recurrent tumor in malignant gliomas
  Ellingson BM, Malkin MG, Rand SD, Connelly JM, LaViolette PS, Bedekar DP, Schmainda KM, Proc. Intl. Soc. Mag. Reson. Med., 18th Annual Meeting, Stockholm, Sweden, 1/1/2010
• Delta T1 Method: An automatic post-contrast ROI selection technique for brain tumors
  Bedekar D, Jensen T, Rand S, Malkin MG, Connelly J, Schmainda KM, Proc. Intl. Soc. Mag. Reson. Med., 18th Annual Meeting, Stockholm, Sweden, 1/1/2010
• Initial rCBV predicts response to bevacizumab in patients with high-grade gliomas
  Schmainda KM, Bedekar D, Rand SD, Connelly J, Malkin M, Proc. Intl. Soc. Mag. Reson. Med., 18th Annual Meeting, Stockholm, Sweden, 1/1/2010
• Lacosamide in brain tumor patients with refractory seizures: efficacy and tolerability
  Newton HB, Lima J, Cunningham H, Pearl D, Malkin MG, Connelly J, Annual Meeting European Neurological Society, Berlin, Germany, 1/1/2010
• Lacosamide in brain tumor patients with seizure disorder. Annual Meeting
  Irizarry LR, Lupica K, Stevens G, Newton HB, Connelly J, Lima J, Cunningham H, Pearl D, Malkin MG, American Epilepsy Society, San Antonio, TX, 1/1/2010
• Functional diffusion maps applied to FLAIR abnormal areas are valuable for the clinical monitoring of recurrent brain tumors
  Ellingson BM, Malkin MG, Rand SD, Bedekar DP, Schmainda KM, Proc Int Soc Magn Reson Med, 1/1/2009
• Fatal Anti-NMDA receptor paraneoplastic encephalitis due to microscopic ovarian teratoma
  Tower KJ, Malkin MG, Rathke SK, Novoa-Takara LN, Ho K-C, Neurology, 1/1/2009
• Bevacizumab in combination with temozolomide in the adjuvant treatment of newly diagnosed glioblastoma multiforme: preliminary results of a phase II study
  Nicholas MK, Lucas RV, Arzbaecher J, Paleologos N, Krouwer H, Malkin M, Omar A, Vick NA, J Clin Oncol, 1/1/2009
• Comparison of cytotoxic and anti-angiogenic treatment responses using functional diffusion maps in FLAIR abnormal regions
  Ellingson BM, Malkin MG, Rand SD, Hoyt A, Connelly J, Bedekar DP, Kurpad SN, Schmainda KM, Proc Int Soc Magn Reson Med, 1/1/2009
• Hybrid functional diffusion and perfusion maps for evaluation of gliomas
  Ellingson BM, Bedekar DP, Malkin MG, Rand SD, Hoyt A, Connelly J, Kurpad SN, Schmainda KM, Proc Int Soc Magn Reson Med, 1/1/2009
• DSC- MRI measures of rCBV predict response to bevacizumab treatment more reliably than standard MRI in patients with recurrent high-grade gliomas
  Schmainda KM, Bedekar D, Rand SD, Connelly J, Kurpad S, Krouwer HG, Paulson ES, Malkin MG, Proc Int Soc Magn Reson Med, 1/1/2009
• Mapping invasion at tumor boundaries using diffusion weighted MRI
  LaViolette P, Ellingson BM, Malkin MG, Connelly JM, Schmainda KM, Neuro-oncology, 1/1/2009
• Long-term clinical monitoring of gliomas using functional diffusion maps
  Ellingson BM, Malkin MG, Rand SD, Connelly JM, Schmainda KM, Neuro-oncology, 1/1/2009
• Methotrexate-induced CNS Hodgkin-like lymphoproliferative disorder: a case report
  Connelly J, Harrington A, Kroft S, Ho K, Fenske T, Malkin M, Neuro-oncology, 1/1/2009
• Evaluation of cytotoxic and anti-angiogenic treatments using functional diffusion maps in FLAIR abnormal regions
  Ellingson BM, Malkin MG, Rand SD, Connelly JM, Bedekar D, Schmainda KM, Neuro-oncology, 1/1/2009
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Lectures

• Advanced Imaging in Neuro-oncology and Current Standard of Care for Glioblastoma 
  Petersburg, VA - 1/20/2014
• Advanced MRI Techniques and Current Standard of Care for Glioblastoma Multiforme 
  Fredericksburg, VA - 1/18/2014
• Clinical Trials in Neuro-oncology: Current Status 
  Glen Allen, VA - 1/12/2014
• Primary CNS Lymphoma 
  1/1/2014
• Research is our Future: Clinical Trials in Neuro-oncology 
  1/1/2014
• Treatment of anti-NMDA Receptor Limbic Encephalitis 
  1/1/2014
• Leptomeningeal Metastasis 
  1/1/2013
• A Prospective Randomized Trial of Dexamethasone in Adult Bacterial Meningitis 
  1/1/2013
• Of Carrots, Vaccines and Deep Thoughts 
  Milwaukee, WI - 1/1/2013
• Glioblastoma Multiforme 
  Milwaukee, WI - 1/1/2013
• Brain Metastases 
  Milwaukee, WI - 1/1/2013
• Neurological Emergencies 
  1/1/2013
• Seizures and Multifocal Brain Lesions in a Woman with Cicatricial Alopecia 
  Deerwood, MN - 1/1/2012
• Glioblastoma Multiforme: Standard of Care and Beyond 
  Richmond, VA - 1/1/2012
• Independent Component Analysis of DSC MRI in Brain Tumors 
  French Lick, IN - 1/1/2011
• Glioblastoma Multiforme: Measures of Success and Failure 
  Multiple locations, 2008, 2009, 2010 - 1/1/2010
• Update on Advanced Imaging in Neuro-oncology 
  Grafton, IL - 1/1/2010
• Update in Brain Tumors 
  Stevens Point, WI - 1/1/2010
• Chemobrain 
  Seattle, WA - 1/1/2009
• Management Of Glioblastoma Multiforme: And The Good News Is… 
  Wisconsin Dells, WI - 1/1/2007
• Current Clinical Trials for Brain Tumor Patients at MCW 
  Grafton, IL - 1/1/2007
• Current Clinical Trials for Brain Tumors at MCW 
  Kona, HI - 1/1/2007
• And The Good News Is… 
  Milwaukee, WI, 2006; Kona, HI, 2007 - 1/1/2007
• Medical Management of the Brain Tumor Patient 
  Multiple locations, 2005, 2006 - 1/1/2006
• Altered Mental Status in the Neuro-oncology Patient 
  Milwaukee, WI - 1/1/2005
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Other

• In Sickness and In Health 
  Horowitz S, Passik S, Klinger R, Malkin M, Lovett Productions
  1/1/1992