MarkEllsworthKleinmanMD

PubMed

• 4 citations
  Histone deficiency and hypoacetylation in the aging retinal pigment epithelium.
  Sushil K Dubey, Rashmi Dubey, Subhash C Prajapati, Kyungsik Jung, Kabhilan Mohan
  Aging Cell. 2024-05-01
• 2 citations
  Unraveling Histone Loss in Aging and Senescence.
  Sushil Kumar Dubey, Rashmi Dubey, Mark Ellsworth Kleinman
  Cells. 2024-02-09
• 1 citations
  Long-Term Evaluation of Retinal Morphology and Function in Rosa26-Cas9 Knock-In Mice.
  Kabhilan Mohan, Sushil Kumar Dubey, Kyungsik Jung, Rashmi Dubey, Qing Jun Wang
  International Journal of Molecular Sciences. 2023-03-08

Journal Articles

• Vision Loss in Juvenile Neuronal Ceroid Lipofuscinosis  
  Ouseph M, Kleinman ME, Wang Q, Ann N Y Acad Sci, 1/1/2016
• Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration  
  Berner AK, Kleinman ME, Adv Exp Med Biol, 1/1/2016
• Complement Activation and Inhibition in Retinal Diseases  
  Kleinman ME, Ambati J, Dev Ophthalmol, 1/1/2015
• Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome  
  Gelfand BD, Wright CB, Kim Y, Yasuma T, Yasuma R, Li S, Fowler BJ, Bastos-Carvalho A, Kerur N, Uittenbogaard A, Han YS, Lou D, Kleinman ME, McDonald WH, Nunez G, Georg..., Cell Reports, 1/1/2015
• The Immune system and AMD  
  Frederick PA and Kleinman ME, Current Reports in Ophthalmology, 1/1/2014
• ERK1/2 activation is a therapeutic target in age-related macular degeneration  
  Dridi, S., Hirano, Y., Tarallo, V., Kim, Y., Fowler, B.J., Ambati, B.K., Bogdanovich, S., Chiodo, V.A., Hauswirth, W.W., Kugel, J.F., Goodrich, J.A., Ponicsan, S.L., H..., Proceedings of the National Academy of Sciences, 1/1/2012
• Small interfering RNAs induce retinal degeneration via TLR3 and IRF3  
  Kleinman ME, Kaneko H, Cho WG, Dridi S, Fowler BJ, Blandford AD, Albuquerque RJC, Hirano Y, Terasaki H, Kondo M, Fujita T, Ambati BK, Tarallo V, Bogdanovich S, Baffi J..., Molecular Therapy, 1/1/2012
• Small Interfering RNA-induced TLR3 Activation Inhibits Blood and Lymphatic Vessel Growth  
  Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S and Ambati J, Proc Natl Acad Sci USA, 1/1/2009
• Alternatively Spliced Vascular Endothelial Growth Factor Receptor-2 is an Essential Endogenous Inhibitor of Lymphatic Vessel Growth  
  Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki..., Nature Medicine, 1/1/2009
• Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration  
  Yang Z, Stratton C, Francis PJ, Kleinman ME, Tan PL, Gibbs D, Tong Z, Chen H, Constantine R, Yang X, Chen Y, Zeng J, Davey L, Ma X, Hau VS, Wang C, Harmon J, Buehler J..., New England Journal of Medicine, 1/1/2008
• Sequence- and Target-independent Suppression of Angiogenesis by siRNA  
  Kleinman ME, Yamada K, Takeda A, Chandrasekaran V, Nozaki M, Baffi J, Albuquerque RJC, Yamasaki S, Itaya M, Pan Y, Appukuttan B, Gibbs D, Yang Z, Kariko K, Shibuya M, ..., Nature, 1/1/2008
• A Geometrically Sound Technique of Vermilion Repair in Unilateral Cleft Lip  
  Powar RS, Patil S, Kleinman ME, Journal of Plastic, Reconstructive & Aesthetic Surgery, 1/1/2007
• Hypoxic Mediators of Progenitor Cell Mobilization and Recruitment Are Increased in Children with Hemangioma  
  Kleinman ME, Greives MR, Churgin SS, Blechman KM, Ceradini DJ, Chang E, Blei F, Gurtner GC, Arteriosclerosis, Thrombosis, and Vascular Biology, 1/1/2007
• Molecular Genetic Investigation of Maternal-Fetal Microchimerism in Infantile Hemangioma  
  Pittman KM, Losken W, Kleinman ME, Marcus JR, Blei F, Gurtner GC, Marchuk DA, Journal of Investigative Dermatology, 1/1/2006
• Circulating Endothelial Progenitor Cells and Vascular Anomalies  
  Kleinman ME, Blei F, Gurtner GC, Lymphatic Research and Biology, 1/1/2005
• Adult Vasculogenesis occurs through the In Situ Recruitment, Proliferation and Tubulization of Circulating Bone Marrow-Derived Cells  
  Tepper OM, Capla JM, Galiano RD, Ceradini DJ, Callaghan MJ, Kleinman ME, Gurtner GC, Blood, 1/1/2005
• Progenitor Cell Trafficking is Regulated by Hypoxic Gradients through HIF-1 Induction of SDF-1  
  Ceradini DJ, Kulkarni AR, Callaghan MJ, Tepper OM, Bastidas N, Kleinman ME, Capla JM, Galiano RD, Levine JP, Gurtner GC, Nature Medicine, 1/1/2004
• Selective Recruitment of Endothelial Progenitor Cells to Ischemic Tissues with Increased Neovascularization  
  Park S, Tepper OM, Galiano RD, Capla JM, Baharestani S, Kleinman ME, Pelo CR, Levine JP, Gurtner GC, Journal of Plastic and Reconstructive Surgery, 1/1/2004
• Increased Circulating AC133+ CD34+ Endothelial Progenitor Cells in Children with Hemangioma  
  Kleinman ME, Tepper OM, Capla JM, Bhatt KA, Ceradini DJ, Galiano RD, Blei F, Levine JP, Gurtner GC, Lymphatic Research and Biology, 1/1/2003
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Books/Book Chapters

• Retinal Pharmacotherapy 
  Chapter: Complement Inhibition in Retinal Disease. 
  Kleinman ME and Ambati JEditors: Nguyen, Rodrigues, Farah, and Mieler.Edition 2nd,2015
• Genomics and Clinical Medicine 
  Chapter: Age-Related Macular Degeneration. 
  Kleinman ME and Ambati JEditors: Kumar and Eng.Edition 2nd,2014
• The New Visual Neurosciences. 
  Chapter: Molecular Mechanisms of Non-Neovascular AMD. 
  Kleinman ME and Ambati JEditors: Chalupa and Werner.2013
• AMD: State of the Art. 
  Chapter: The Role of the Immune System. 
  Kleinman ME and Ambati JEditors: Kaiser.2012
• Encyclopedia of the Eye and Vision. 
  Chapter: Retinal Response to Injury. 
  Kleinman ME and Ambati JEditors: Besharse, Dana, and Darlene Dartt.2010
• Ocular Angiogenesis. 
  Chapter: Choroidal Neovascularization: Pathophysiology. 
  Kleinman ME and Ambati JEditors: Das.2010
• Retinal Pharmacotherapy. 
  Chapter: Complement Inhibition in Retinal Disease. 
  Kleinman ME and Ambati JEditors: Nguyen, Rodrigues, Farah, and Mieler.2010
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Abstracts/Posters

• The Future of Ophthalmic Imaging.
  Kleinman ME, Cincinnati Ophthalmology Society, Spring, 1/1/2017
• Safety and efficiency of CRISPR-Cas9 gene editing in the retinal pigment epithelium.
  Kleinman ME, Dubey S, Jung K, Roney J, Lou D, Brown J, Mohan K, Annual ARVO Meeting, Baltimore, MD, 1/1/2017
• Epigenetic Regulation of Type I IFN Response in Age-Related Macular Degeneration.
  Sung K, Lou D, Mohan K, Dubey S, Prajapati SC, Roney J, Abney JL, Liu J, Kleinman ME, Keystone Interferon Meeting, Banff, Alberta, Canada, 1/1/2017
• An update on translational research and clinical trials for age-related macular degeneration.
  Kleinman ME, Kentucky Academy of Eye Physicians and Surgeons Meeting, Spring, 1/1/2017
• Neutralization of IFNAR1 prevents histone deacetylase inhibitor induced retinal pigment epithelium cell death.
  Jung K, Mohan K, Prajapati SC, Dubey S, Lou D, Roney J, Brown J, Kleinman ME, Annual ARVO Meeting, Baltimore, MD, 1/1/2017
• Epigenetic regulation of autophagy by histone deacetylases in retinal pigment epithelium.
  Dubey S, Lou D, Jung K, Roney J, Brown J, Mohan K, Kleinman ME, Annual ARVO Meeting, Baltimore, MD, 1/1/2017
• Next Generation Sequencing of Transcribed Alu in Dry Age-Related Macular Degeneration.
  Lowery JT, Liu C, Fowler BJ, Lou D, Mohan K, Prajapati SC, Berner AK, Roney J, Abney JL, Gelfand BD, Liu J, Ambati J, Kleinman ME, American Society of Human Genetics Meeting, Vancouver, British Columbia, Canada, 1/1/2016
• HDAC1/2 are critical for RPE homeostasis and health.
  Kleinman ME, Jung K, Roney J, Prajapati SC, Lou D, Dubey S, Brown JL, Mohan K, Annual ARVO Meeting, Seattle, WA, 1/1/2016
• Next-generation sequencing of Alu expression in dry age-related macular degeneration.
  Kleinman ME, Lowery JT, Liu C, Fowler BJ, Lou D, Mohan K, Prajapati SC, Hirano Y, Berner AK, Roney J, Brown JL, Gelfand BD, Keddache M, Hernandez AG, Liu J, Ambati J, ASCI Young Physician Scientist Award Session, Chicago, IL, 1/1/2016
• AMD-like phenotype in a novel mouse model of RPE targeted histone deacetylase deficiency.
  Dubey S, Jung K, Mohan K, Prajapati SC, Roney J, Berner AK, Kleinman ME, RD Meeting, Kyoto, Japan, 1/1/2016
• Mohan K, Zhong Y, Liu J, Al-Attar A, Liu H, Jung K, Dow M, Liu J, Fan T, Wang Q, Kleinman ME, Annual ARVO Meeting, Seattle, WA, 1/1/2016
• The role of IP-10 in RPE degeneration during AMD progression.
  Roney J, Mohan K, Jung K, Lou D, Prajapati SC, Brown JL, Kleinman ME, Annual ARVO Meeting, Seattle, WA, 1/1/2016
• An Acyloxy-Conjugated Caspase Probe for in Vivo Retinal Bio-imaging.
  Mohan K, Sanman L, Jung K, Roney J, Lou D, Brown JL, Bogyo M, Kleinman ME, Annual ARVO Meeting, Denver, CO, 1/1/2015
• Next Generation Sequencing of Mobile Genetic Elements in Dry Age-Related Macular Degeneration.
  Kleinman ME, Lowery JT, Liu C, Fowler BJ, Lou D, Prajapati SC, Gelfand BD, Keddache M, Liu J, Ambati J, Annual ARVO Meeting, Denver, CO, 1/1/2015
• In vivo imaging of retinal pigment epithelium cell death using novel fluorescent probes targeting caspases.
  Mohan K and Kleinman ME, AUPO/RPB Resident and Fellows Research Forum, Tucson, AZ, 1/1/2015
• Histone deacetylase expression and acetylation in the aging retinal pigment epithelium.
  Prajapati SC, Berner AK, Mohan K, Jung K, Roney J, Lou D, Brown JL, Kleinman ME, Annual ARVO Meeting, Denver, CO, 1/1/2015
• In vivo imaging of retinal pigment epithelium cell death in age-related macular degeneration.
  Kleinman ME, Mohan KB, Hirano Y, Berner AK, Lou D, Jackson CH, Brown JL, Johnson GL, Ambati J, World Molecular Imaging Society Congress, Seoul, Korea, 1/1/2014
• Histone Deacetylase Expression and Inhibition in Age Related Macular Degeneration.
  Kleinman ME, Berner AK, Mohan KB, Lou D, Brown JL, West J, Kono R, Sugino IK, Zarbin MA, Ambati J, Annual ARVO Meeting, Orlando, FL, 1/1/2014
• RPE Cytotoxicity and Caspase Activation after Treatment with Valproic Acid.
  Berner AK, Mohan KB, Lou D, Brown JL, West J, Kono R, Sugino, IK, Zarbin MA, Ambati J, Kleinman ME, Annual ARVO Meeting, Orlando, FL, 1/1/2014
• Therapeutic approaches to histone reprogramming in age-related macular degeneration.
  Berner AK, Mohan KB, Lou D, Brown JL, West J, Kono R, Sugino IK, Zarbin MA, Kleinman ME, RD Meeting, Pacific Grove, CA, 1/1/2014
• In Vivo Molecular Imaging of Cell Death in Age-Related Macular Degeneration.
  Kleinman ME, Mohan KB, Jackson CH, D Lou and Ambati J, Keystone Cell Death Symposium, Santa Fe, NM, 1/1/2014
• In vivo imaging of retinal pigment epithelium cell death using a novel fluorescent probe targeting caspases.
  Mohan KB, Hirano Y, Berner AK, Lou D, Jackson CH, Brown JL, Johnson GL, Ambati J, Kleinman ME, RD Meeting, Pacific Grove, CA, 1/1/2014
• Epigenetic Regulation of Eotaxin Expression in Human Retinal Pigment Epithelium.
  Kleinman ME, Berner AK, Lou D, Mohan KB, Jackson CH, Abney JL, Ambati J, Annual ARVO Meeting, Seattle, WA, 1/1/2013
• Emerging Strategies for In Vivo Cellular and Molecular Imaging of Retinal Disease
  Kleinman ME, Annual ARVO Meeting, Seattle, WA, 1/1/2013
• Co-Localization of an In Vivo Retinal Pigment Epithelial Cell Death Imaging Probe in a Mouse Model of Acute Double-Stranded RNA Toxicity.
  Jackson CJ, Mohan KB, Hirano Y, Berner AK, Lou D, Brown JL, Ambati J, Kleinman ME, Annual ARVO Meeting, Seattle, WA, 1/1/2013
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Lectures

• Current Therapies for AMD. 
  Baltimore, MD, 2013; Denver, CO, 2014 - 1/1/2014
• Update on AMD Research. 
  1/1/2013
• Employing Ocular Electrophysiology in Your Practice. 
  1/1/2013
• Biomarker Imaging in Age Related Macular Degeneration. 
  1/1/2013
• Biomarker Discovery and Translation in Neovascular Age-Related Macular Degeneration. 
  Abu Dhabi, United Arab Emirates - 1/1/2012
• Small interfering RNAs induce retinal toxicity via TLR3 activation. 
  Hyderabad, India - 1/1/2011
• The Future of Stem Cell Therapies in Vascular Diseases. 
  JNMC Medical College, Belgaum, Karnataka, India - 1/1/2005
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