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Office
44 Binney St
Rm SW331
Boston, MA 02115Phone+1 617-632-4907Fax+1 617-632-4897
Education & Training
- Boston Children’s Hospital/Boston Medical CenterFellowship, Pediatric Hematology/Oncology, 1992 - 1995
- University of Calgary Faculty of MedicineClass of 1986
- University of AlbertaPh.D., Medicine (Immunology), 1983
- McMaster UniversityB.Sc., Biochemistry, 1980
Certifications & Licensure
- MA State Medical License 1992 - 2026
- PA State Medical License 2019 - 2024
- American Board of Pediatrics Pediatric Hematology-Oncology
Awards, Honors, & Recognition
- Boston Magazine Castle Connolly, 2008-2015
- America's Top Doctors Castle Connolly, 2008-2015
- America's Top Doctors for Cancer Castle Connolly, 2005-2015
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Clinical Trials
- SU5416 in Treating Children With Recurrent or Progressive Brain Tumors Start of enrollment: 2000 Aug 01
- SCH 66336 in Treating Children With Recurrent or Progressive Brain Tumors Start of enrollment: 2002 Jan 01
- Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT Start of enrollment: 2003 Feb 01
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Publications & Presentations
PubMed
- Vorinostat, temozolomide or bevacizumab with irradiation and maintenance BEV/TMZ in pediatric high-grade glioma: A Children's Oncology Group Study.Rishi R Lulla, Allen Buxton, Mark D Krailo, Margot A Lazow, Daniel R Boue
Neuro-Oncology Advances. 2024-03-14 - 11 citationsSustained Survival Benefit in Recurrent Medulloblastoma by a Metronomic Antiangiogenic Regimen: A Nonrandomized Controlled Trial.Andreas Peyrl, Monika Chocholous, Magnus Sabel, Alvaro Lassaletta, Jaroslav Sterba
JAMA Oncology. 2023-12-01 - 4 citationsALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma.Anne-Florence Blandin, Ross Giglio, Maya Srikanth Graham, Guadalupe Garcia, Seth Malinowski
Clinical Cancer Research. 2023-07-14
Journal Articles
- Immunophenotyping of Pediatric Brain Tumors: Correlating Immune Infiltrate with Histology, Mutational Load, and Survival and Assessing Clonal T Cell ResponseIsaac H Solomon, Mark W Kieran, Gabriel K Griffin, Pratiti Bandopadhayay, Jerome Ritz, Ashley S Plant, Keith L Ligon, Glenn Dranoff, Journal of Neuro-Oncology
- The role of the farnesyltransferase inhibitor lonafarnib in the treatment of progeriaKieran MW, Gordon LB, Kleinman ME, Expert Opin Orphan Drugs, 1/1/2014
- Inhibition of tumor angiogenesis by oral etoposidePanigrahy D, Kaipainen A, Butterfield CE, Chaponis DM, Laforme AM, Folkman J, Kieran MW, Experimental and Therapeutic Medicine, 1/1/2010
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Books/Book Chapters
Abstracts/Posters
- A feasibility and randomized phase II study of vorinostat, bevacizumab, or temozolomide during radiation followed by maintenance chemotherapy in newly-diagnosed pediat...Hoffman LM, Geller G, Leach J, Boue D, Drissi R, Chen L, Panandiker A, Chow L, Haas-Kogan D, Jogal S, Nelson M, Jakacki R, Kieran MW, Cohen K, Pollack I, Gajjar A, Fou..., SNO Pediatric Basic and Translational Meeting, San Diego, CA, 1/7/2015
- Phase 1 study of dabrafenib in pediatric patients (pts) with relapsed or refractory BRAF V600E high- and low-grade gliomas (HGG, LGG), Langerhans cell histiocytosis (L...Kieran MW, Hargrave D, Cohen K, Aerts I, Dunkel IJ, Hummel TR, Jimenez I, Pearson A, Pratilas C, Whitlock J, Bouffet E, Shen V, Broniscer A, Bertozzi A-I, Sandberg J, ..., ASCO, Chicago, IL, 1/1/2015
- Intravascular fasciitis-like proliferation characterizes pediatric pulmonary vein stenosis: clinicopathologic analysis of 213 samples.Kovach A, Magcalas P, Ireland C, McEnany K, Kieran M, Jenkins K, Baird C, Vargas SO, Pediatr Devel Pathol; Society for Pediatric Pathology, 1/1/2015
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Lectures
- Efficacy and safety results from a phase I/IIa study of dabrafenib in pediatric patients with BRAF V600 mutant relapsed refractory low-grade glioma.2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018
- Cancer Biology Seminar SeriesBoston, MA - 1/6/2015
- BRAF in pediatric cancer.Chicago, IL - 1/30/2014
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Other
- PhD thesis: Receptor-Acceptor Interactions in Organ Specific MetastasesKieran MW, University of Alberta, Department of Immunology
1/1/1984 - Diffuse pontine gliomaKieran MW, Marcus KJ
http://www.uptodate.com/contents/diffuse-pontine-glioma
UpToDate, Wolters Kluwer Health - 2012-11-29 - EpendymomaKieran MW
http://www.uptodate.com/contents/ependymoma
UpToDate, Wolters Kluwer Health - 2013-02-12 - Join now to see all
Press Mentions
- An Ounce of Prevention: Preoperative Management of Inflammation May Stave off Cancer RecurrencesOctober 17th, 2019
- New Targeted Cancer Therapies Prove Successful When Chemo Does NotJanuary 8th, 2019
- After a Child's Dire Diagnosis, Hope and Uncertainty at the Frontiers of MedicineDecember 6th, 2018
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Grant Support
- Phase II Trial Of Lonafarnib, Pravastatin And Zoledronic Acid In ProgeriaNational Heart, Lung, And Blood Institute2009–2010
- Phase I Trial Of Temozolomide And 06-Benzylguanine In Pediatric Patients W/ RecuNational Center For Research Resources2004–2005
- Xenogen'S Ivis 100 Imaging System: Tissue EngineeringNational Center For Research Resources2004
- Xenogen'S Ivis 100 Imaging System: CardiovascularNational Center For Research Resources2004
- Xenogen'S Ivis 100 Imaging System: CancerNational Center For Research Resources2004
- Xenogen'S Ivis 100 Imaging SystemNational Center For Research Resources2004
- Harvard Pediatric Brain Tumor CenterNational Cancer Institute2000–2003
- Pediatric Brain Tumor CenterNational Cancer Institute1999
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