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Office
Rockville Pike
Bldg 10
Bethesda, MD 20892Phone+1 301-435-2310Fax+1 412-647-4050
Education & Training
- National Institutes of Health Clinical CenterFellowship, Critical Care Medicine (Internal Medicine), 1995 - 1999
- University of WashingtonFellowship, Pulmonary Disease and Critical Care Medicine, 1996 - 1998
- Oregon Health & Science University (OHSU Health)Residency, Internal Medicine, 1991 - 1995
- University of Miami Leonard M. Miller School of MedicineClass of 1991
Certifications & Licensure
- OR State Medical License 1992 - Present
- MD State Medical License 1997 - 2026
- PA State Medical License 2008 - 2024
- DC State Medical License 1997 - 2004
- American Board of Internal Medicine Critical Care Medicine
- American Board of Internal Medicine Pulmonary Disease
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
- Elected Member The American Society for Clinical Investigation, 2006
Clinical Trials
- Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide (NO) Homeostasis Start of enrollment: 2010 Apr 01
- Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE) Start of enrollment: 2020 Feb 26
Publications & Presentations
PubMed
- 56 citationsNitrite reductase activity of nonsymbiotic hemoglobins from Arabidopsis thaliana.Mauro Tiso, Jesús Tejero, Claire Kenney, Sheila Frizzell, Mark T. Gladwin
Biochemistry. 2012-07-03 - 63 citationsCharacterization of right ventricular remodeling in pulmonary hypertension associated with patient outcomes by 3-dimensional wall motion tracking echocardiography.Keiko Ryo, Akiko Goda, Tetsuari Onishi, Antonia Delgado-Montero, Bhupendar Tayal
Circulation. Cardiovascular Imaging. 2015-06-01 - 78 citationsNitrite and nitrate chemical biology and signalling.Anthony W. DeMartino, Daniel B. Kim-Shapiro, Rakesh P. Patel, Mark T. Gladwin
British Journal of Pharmacology. 2019-01-01
Journal Articles
- Intradonor Reproducibility and Changes in Hemolytic Variables During Red Blood Cell Storage: Results of Recall Phase of the REDS‐III RBC‐Omics StudyDarrell J Triulzi, Mark T Gladwin, Alan E Mast, Michael P Busch, Transfusion
- Impact of Different Standard Red Blood Cell Storage Temperatures on Human and Canine RBC Hemolysis and Chromium SurvivalCharles Natanson, Kamille West, Kevin P Blaine, Mark T Gladwin, Transfusion
Abstracts/Posters
- Sickle Cell Disease Promotes Dysregulation of Hepatic Iron Homeostasis By Regulating Hepcidin ExpressionMark T Gladwin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
- Manifestations of Reduced Kidney Function Occur at a Higher Estimated Glomerular Filtration Rate in Sickle Cell AnemiaMark T Gladwin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
- Innate Immune Mechanism of Hemarthrosis in Hemophilia-a MiceMark T Gladwin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Lectures
- Soluble Guanylate Cyclase Modulators Effect Fetal Hemoglobin Levels through a Non-cGMP-Protein Kinase G Signaling Pathway2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
- Regulatory Genetic Variation at the S100B Gene Associates with Vaso-Occlusive Manifestations in Sickle Cell Disease2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
- Heterogeneity of Blood Processing and Storage Additives in Different Centers Impacts Stored Red Blood Cell Metabolism as Much as Storage Time: Lessons from REDS‐III—OmicsUPMC Life Changing Medicine, Philadelphia, Pennsylvania - 10/5/2012
Authored Content
- Drs. Terence S. Dermody & Mark Gladwin: Thanks to Pittsburgh for Leadership in Covid-19 CrisisApril 2020
- Drs. Terence S. Dermody & Mark Gladwin: Thanks to Pittsburgh for Leadership in Covid-19 CrisisApril 2020
Press Mentions
- UMSOM Launches New Rural Health Initiative to Address Physician Shortage on Maryland's Eastern ShoreOctober 9th, 2024
- Your Blood Type Is Connected to Your Risk for an Early Stroke, Study FindsOctober 7th, 2024
- UM School of Medicine Aims to Accelerate Basic Science Research and Advance Drug Therapies with Newly-Created DepartmentSeptember 17th, 2024
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Grant Support
- Translational Pulmonary Vascular BiologyNational Heart, Lung, And Blood Institute2012
- Myoglobin As A Nitrite Reductase That Regulates Hypoxic Cardiac NO SignalingNational Heart, Lung, And Blood Institute2010–2012
- Vascular Subphenotypes Of Lung DiseaseNational Heart, Lung, And Blood Institute2011
- Pulmonary Vascular-Targeted NO Therapeutic StrategiesNational Heart, Lung, And Blood Institute2011
- Administrative CoreNational Heart, Lung, And Blood Institute2011
- Storage Lesion In Banked Blood Due To Disruption Of Nitric Oxide HomeostasisNational Heart, Lung, And Blood Institute2009–2011
- Dietary Nitrate Activation Of Ppargamma Improves Insulin SensitivityNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2010
- Translational Vascular Biology In Autoimmune DiseasesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2009–2010
- Nitric Oxide For Patients With Sickle Cell Anemia And Pulmonary HypertensionClinical Center2008
- Use Of Hydroxyurea &L-Arginine Or Sildenafil In Patients W/Sickle Cell DiseaseNational Heart, Lung, And Blood Institute2007–2008
- Systemic Nitrite Infusion And Its Effect On Exercise Physiology And MetabolismNational Heart, Lung, And Blood Institute2007–2008
- Synergy Of Hydroxyurea And Erythropoietin On Fetal Hemoglobin In SCDNational Heart, Lung, And Blood Institute2007–2008
- Multicenter Trial Of NO For Acute Treatment Of Sickle Cell Pain EpisodesNational Heart, Lung, And Blood Institute2007–2008
- Hemolysis, NO And PAH In MalariaNational Heart, Lung, And Blood Institute2007–2008
- Prevalence And Prognosis Of Pulmonary Hypertension In Adults With Sickle CellClinical Center2007–2008
- Blood Studies Of Endothelial Function And Systemic InflammationClinical Center2007–2008
- Prevalence Of PAH In SCD Patients In NigeriaNational Heart, Lung, And Blood Institute2006–2008
- Nitrite Infusion Studies On Healthy VolunteersNational Heart, Lung, And Blood Institute2005–2008
- Use Of Bosentan In Patients With Symptomatic PH Associated With SCDNational Heart, Lung, And Blood Institute2007
- Evaluation Of Endothelial Function In HIV Associated PAHClinical Center2007
- Cardiopulmonary Function Assessment And NO Based Therapies For SCD PTS With PAHClinical Center2007
- Use Of Hydroxyurea &L-Arginine Or Sildenafil In PatientNational Heart, Lung, And Blood Institute2006
- Synergy Of Hydroxyurea And Erythropoietin On Fetal HemogNational Heart, Lung, And Blood Institute2006
- Systemic Nitrite Infusion And Its Effect On Exercise PhyNational Heart, Lung, And Blood Institute2005–2006
- Multicenter Trial Of NO For Acute Treatment Of Sickle CENational Heart, Lung, And Blood Institute2005–2006
- Blood Studies Of Endothelial Function And Systemic InflaClinical Center2005–2006
- Prevalence And Prognosis Of Pulmonary Hypertension In ADClinical Center2001–2006
- Nitric Oxide For Patients With Sickle Cell Anemia And PuClinical Center2001–2006
- Use Of Hydroxyurea &L-Arginine Or Sildenafil In SCDClinical Center2005
- Prevalence And Prognosis Of Pulmonary Hypertension In ADClinical Center2005
- Sickle Cell: Risk/Prognosis Of Pulmonary HypertensionClinical Center2004
- Nitric Oxide: Sickle Cell Anemia/Pulmonary HypertensionClinical Center2004
- Hydroxyurea/L-Arginine Or Sildenafil Sickle Cell DiseaseClinical Center2004
- Blood Studies Endothelial Function/Systemic InflammationClinical Center2004
- Hydroxyurea &L-Arginine Or Sildenafil In Patients W/ScdClinical Center2003
- Blood Studies Of Endothelial Function /Systemic InflammaClinical Center2003
- Physiologic Effects Of Inhaled Nitric Oxide, NitroglycerClinical Center2001–2002
- Delivery Of NO By Hemoglobin To Improve Blood Flow In SIClinical Center2001–2002
- Effects Of Endothelium-Derived Versus Hemoglobin-TranspoClinical Center2001
- Physiologic Effects Of Inhaled Nitric Oxide, Nitroglycerin, And Placebo In StudyClinical Center1998–2000
External Links
- Physician Summaryhttps://www.umaryland.edu/about-umb/university-leadership/mark-t-gladwin-md/
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