MarkThomasGladwinMD

Critical Care Medicine, Pleural Disease

Vice President for Medical Affairs, University of Maryland, Baltimore and John Z. and Akiko K. Bowers Distinguished Professor and Dean, University of Maryland School of Medicine

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Office
Rockville Pike
Bldg 10
Bethesda, MD 20892
Phone+1 301-435-2310

Fax+1 412-647-4050

Education & Training

National Institutes of Health Clinical CenterFellowship, Critical Care Medicine (Internal Medicine), 1995 - 1999
University of WashingtonFellowship, Pulmonary Disease and Critical Care Medicine, 1996 - 1998
Oregon Health & Science University (OHSU Health)Residency, Internal Medicine, 1991 - 1995
University of Miami Leonard M. Miller School of MedicineClass of 1991

Certifications & Licensure

OR State Medical License 1992 - Present
MD State Medical License 1997 - 2026
PA State Medical License 2008 - 2024
DC State Medical License 1997 - 2004
American Board of Internal Medicine Critical Care Medicine
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Elected Member The American Society for Clinical Investigation, 2006

Clinical Trials

Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide (NO) Homeostasis Start of enrollment: 2010 Apr 01
Completed
Phase 1
Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE) Start of enrollment: 2020 Feb 26
Recruiting
Phase 3

Publications & Presentations

PubMed

63 citations
CCR5 as a Treatment Target in Pulmonary Arterial Hypertension
Valérie Amsellem, Larissa Lipskaia, Shariq Abid, Lucie Poupel, Amal Houssaini
Circulation. 2014-09-09
46 citations
Depletion of circulating blood NOS3 increases severity of myocardial infarction and left ventricular dysfunction
Marc W. Merx, Simone Gorressen, Annette M. van de Sandt, Miriam M. Cortese-Krott, Jan Ohlig
Basic Research in Cardiology. 2014-01-01
942 citations
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.
Daniel Taliun, Daniel N. Harris, Michael D. Kessler, Jedidiah Carlson, Zachary A. Szpiech
Nature. 2021-02-10

Journal Articles

Intradonor Reproducibility and Changes in Hemolytic Variables During Red Blood Cell Storage: Results of Recall Phase of the REDS‐III RBC‐Omics Study
Darrell J Triulzi, Mark T Gladwin, Alan E Mast, Michael P Busch, Transfusion
Impact of Different Standard Red Blood Cell Storage Temperatures on Human and Canine RBC Hemolysis and Chromium Survival
Charles Natanson, Kamille West, Kevin P Blaine, Mark T Gladwin, Transfusion

Abstracts/Posters

Sickle Cell Disease Promotes Dysregulation of Hepatic Iron Homeostasis By Regulating Hepcidin Expression
Mark T Gladwin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Manifestations of Reduced Kidney Function Occur at a Higher Estimated Glomerular Filtration Rate in Sickle Cell Anemia
Mark T Gladwin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Innate Immune Mechanism of Hemarthrosis in Hemophilia-a Mice
Mark T Gladwin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Circulating Neutrophil Extracellular Traps in the Pathogenesis of Acute Chest Syndrome of Sickle Cell Disease
Mark T Gladwin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Smooth Muscle Cytochrome b5 Reductase 3 Deficiency Accelerates Pulmonary Hypertension Development in Sickle Cell Mice
Mark T Gladwin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Mechanism of Pulmonary Thrombosis in Hemolytic Disorders
Mark T Gladwin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Impaired Bile Secretion Promotes Chronic Liver Injury in Sickle Cell Disease
Mark T Gladwin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Risk Factors for Kidney Disease in Hb SC and Hb S_+-Thalassemia Sickle Cell Disease
Mark T Gladwin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Evaluation of the Functional Effects of an African American Glucose-6-Phosphate Dehydrogenase (G6PD) Polymorphism (Val68Met) on RBC Hemolytic Propensity and Post-Trans...
Mark T Gladwin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
CD39 As a Master Regulator of Pulmonary Thrombosis in Sickle Cell Disease
Mark T Gladwin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Manifestations of Reduced Kidney Function Occur at a Higher Estimated Glomerular Filtration Rate in Sickle Cell Anemia
Mark T Gladwin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
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Lectures

Soluble Guanylate Cyclase Modulators Effect Fetal Hemoglobin Levels through a Non-cGMP-Protein Kinase G Signaling Pathway
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Regulatory Genetic Variation at the S100B Gene Associates with Vaso-Occlusive Manifestations in Sickle Cell Disease
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Heterogeneity of Blood Processing and Storage Additives in Different Centers Impacts Stored Red Blood Cell Metabolism as Much as Storage Time: Lessons from REDS‐III—Omics
UPMC Life Changing Medicine, Philadelphia, Pennsylvania - 10/5/2012

Authored Content

Drs. Terence S. Dermody & Mark Gladwin: Thanks to Pittsburgh for Leadership in Covid-19 CrisisApril 2020
Drs. Terence S. Dermody & Mark Gladwin: Thanks to Pittsburgh for Leadership in Covid-19 CrisisApril 2020

Press Mentions

UMSOM Unveils New State-of-the-Art Anatomy FacilityOctober 28th, 2024
UM School of Medicine's Margaret M. McCarthy, PhD, Elected as Member of Prestigious National Academy of MedicineOctober 22nd, 2024
UMSOM Launches New Rural Health Initiative to Address Physician Shortage on Maryland's Eastern ShoreOctober 9th, 2024
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Grant Support

Translational Pulmonary Vascular BiologyNational Heart, Lung, And Blood Institute2012
Myoglobin As A Nitrite Reductase That Regulates Hypoxic Cardiac NO SignalingNational Heart, Lung, And Blood Institute2010–2012
Vascular Subphenotypes Of Lung DiseaseNational Heart, Lung, And Blood Institute2011
Pulmonary Vascular-Targeted NO Therapeutic StrategiesNational Heart, Lung, And Blood Institute2011
Administrative CoreNational Heart, Lung, And Blood Institute2011
Storage Lesion In Banked Blood Due To Disruption Of Nitric Oxide HomeostasisNational Heart, Lung, And Blood Institute2009–2011
Dietary Nitrate Activation Of Ppargamma Improves Insulin SensitivityNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2010
Translational Vascular Biology In Autoimmune DiseasesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2009–2010
Nitric Oxide For Patients With Sickle Cell Anemia And Pulmonary HypertensionClinical Center2008
Use Of Hydroxyurea &L-Arginine Or Sildenafil In Patients W/Sickle Cell DiseaseNational Heart, Lung, And Blood Institute2007–2008
Systemic Nitrite Infusion And Its Effect On Exercise Physiology And MetabolismNational Heart, Lung, And Blood Institute2007–2008
Synergy Of Hydroxyurea And Erythropoietin On Fetal Hemoglobin In SCDNational Heart, Lung, And Blood Institute2007–2008
Multicenter Trial Of NO For Acute Treatment Of Sickle Cell Pain EpisodesNational Heart, Lung, And Blood Institute2007–2008
Hemolysis, NO And PAH In MalariaNational Heart, Lung, And Blood Institute2007–2008
Prevalence And Prognosis Of Pulmonary Hypertension In Adults With Sickle CellClinical Center2007–2008
Blood Studies Of Endothelial Function And Systemic InflammationClinical Center2007–2008
Prevalence Of PAH In SCD Patients In NigeriaNational Heart, Lung, And Blood Institute2006–2008
Nitrite Infusion Studies On Healthy VolunteersNational Heart, Lung, And Blood Institute2005–2008
Use Of Bosentan In Patients With Symptomatic PH Associated With SCDNational Heart, Lung, And Blood Institute2007
Evaluation Of Endothelial Function In HIV Associated PAHClinical Center2007
Cardiopulmonary Function Assessment And NO Based Therapies For SCD PTS With PAHClinical Center2007
Use Of Hydroxyurea &L-Arginine Or Sildenafil In PatientNational Heart, Lung, And Blood Institute2006
Synergy Of Hydroxyurea And Erythropoietin On Fetal HemogNational Heart, Lung, And Blood Institute2006
Systemic Nitrite Infusion And Its Effect On Exercise PhyNational Heart, Lung, And Blood Institute2005–2006
Multicenter Trial Of NO For Acute Treatment Of Sickle CENational Heart, Lung, And Blood Institute2005–2006
Blood Studies Of Endothelial Function And Systemic InflaClinical Center2005–2006
Prevalence And Prognosis Of Pulmonary Hypertension In ADClinical Center2001–2006
Nitric Oxide For Patients With Sickle Cell Anemia And PuClinical Center2001–2006
Use Of Hydroxyurea &L-Arginine Or Sildenafil In SCDClinical Center2005
Prevalence And Prognosis Of Pulmonary Hypertension In ADClinical Center2005
Sickle Cell: Risk/Prognosis Of Pulmonary HypertensionClinical Center2004
Nitric Oxide: Sickle Cell Anemia/Pulmonary HypertensionClinical Center2004
Hydroxyurea/L-Arginine Or Sildenafil Sickle Cell DiseaseClinical Center2004
Blood Studies Endothelial Function/Systemic InflammationClinical Center2004
Hydroxyurea &L-Arginine Or Sildenafil In Patients W/ScdClinical Center2003
Blood Studies Of Endothelial Function /Systemic InflammaClinical Center2003
Physiologic Effects Of Inhaled Nitric Oxide, NitroglycerClinical Center2001–2002
Delivery Of NO By Hemoglobin To Improve Blood Flow In SIClinical Center2001–2002
Effects Of Endothelium-Derived Versus Hemoglobin-TranspoClinical Center2001
Physiologic Effects Of Inhaled Nitric Oxide, Nitroglycerin, And Placebo In StudyClinical Center1998–2000