
Mark Andrew Frye MD
Chair of the Department of Psychology and Psychiatry at the Mayo Clinic and Director of the Mayo Clinic Depression Center in Rochester
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200 1st St SwRochester, MN 55905
Phone+1 507-284-2511
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Education & Training
- National Institutes of Health Clinical CenterResidency, Psychiatry, 1994 - 1996
- UCLA David Geffen School of Medicine/UCLA Medical CenterResidency, Psychiatry, 1990 - 1994
- University of Minnesota Medical SchoolClass of 1990
- Luther CollegeBA, Biology, Cum Laude, 1981 - 1985
Certifications & Licensure
- MN State Medical License 2007 - 2025
- AZ State Medical License 2015 - 2023
- AK State Medical License 2013 - 2021
- CA State Medical License 1991 - 2021
- WI State Medical License 2018 - 2021
- FL State Medical License 2010 - 2020
- DC State Medical License 1994 - 1998
- American Board of Psychiatry and Neurology Psychiatry
Awards, Honors, & Recognition
- Regional Top Doctor Castle Connolly, 2014
- Mogens Schou Award for Education The International Society for Bipolar Disorder, 2011
- Rome Mentorship Award Mayo Clinic Department of Psychiatry & Psychology, 2011-2012
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Clinical Trials
- Can Additional Drug Therapy Accelerate Response Time to Antidepressants Start of enrollment: 2004 Jan 01
- Bipolar Depression Before and After Lamotrigine Treatment Start of enrollment: 2009 Dec 01
- Ketamine for Depression and Suicide Risk Start of enrollment: 2014 Sep 01
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Publications & Presentations
PubMed
- 1 citationsGradients of Cell Recognition Molecules Wire Visuomotor Transformation.Mark Dombrovski, Yixin Zang, Giovanni Frighetto, Andrea Vaccari, HyoJong Jang
Biorxiv. 2025-03-08 - 7 citationsGenomics yields biological and phenotypic insights into bipolar disorder.Kevin S O'Connell, Maria Koromina, Tracey van der Veen, Toni Boltz, Friederike S David
Nature. 2025-03-01 - Exploration of Genetic Liability to Insomnia and Substance Use Disorders in Patients With Bipolar Disorder.Lindsay M Melhuish Beaupre, Brandon J Coombes, Anthony Batzler, Jorge A Sanchez-Ruiz, Bhanu Prakash Kolla
Bipolar Disorders. 2025-02-25
Journal Articles
- Research Paper Sex-Specific Effects of Gain-of-Function P2RX7 Variation on Bipolar DisorderWilliam V Bobo, Mark A Frye, ScienceDirect
- More pernicious course of bipolar disorder in the United States than in many European countries: Implications for policy and treatmentPost RM, Altshuler L, Kupka R, McElroy S, Frye MA, Rowe M, Leverich GS, Grunze H, Suppes T, Keck PE Jr, Nolen WA, J Affect Disord, 1/1/2014
- More medical comorbidities in patients with bipolar disorder from the United States than from the Netherlands and GermanyPost RM, Altshuler LL, Leverich GS, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Nolen WA, Kupka RW, Grunze H, Rowe M, J Nerv Ment Dis, 1/1/2014
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Abstracts/Posters
- Association between nicotine dependence, alcohol craving and high-risk situations to relapse in patients with alcohol use disordersHitschfeld M, Schneekloth T, Ebbert J, Hall-Flavin D, Karpyak V, Geske M, Frye M, 167th American Psychiatric Association (APA) Annual Meeting, New York, NY, 1/3/2014
- Impact of smoking cessation on alcohol relapse after residential alcoholism treatmentHitschfeld M, Schneekloth T, Ebbert J, Hall-Flavin D, Karpyak V, Geske M, Frye M, 167th American Psychiatric Association (APA) Annual Meeting, New York, NY, 1/3/2014
- Use of a novel adjunctive clinical trial design to examine efficacy, safety of armodafinil for the treatment of bipolar I depressionFrye MA, New Clinical Drug Evaluation Unit (NCDEU), Hollywood, FL, 1/28/2013
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Lectures
- Bipolar Disorder: Think Global—Treat LocalMedellin, Colombia - 1/22/2014
- Bio-Banking Bipolar DisorderHanover, NH - 1/20/2014
- Novel Treatment Options for Bipolar DepressionSeoul, South Korea - 1/18/2014
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Press Mentions
- University of Cincinnati to Join Bipolar Research NetworkMarch 13th, 2025
- UC Joins Novel Bipolar Research and Clinical Care NetworkMarch 12th, 2025
- Baszucki Group & Mayo Clinic Collaborate on Bipolar Disorder Ketogenic Therapy TrialMarch 5th, 2025
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Grant Support
- Olfactory neuromodulation of visual circuits and behaviorUNIVERSITY OF CALIFORNIA LOS ANGELES2021–2026
- Neural circuits for visual feature detectionUNIVERSITY OF CALIFORNIA LOS ANGELES2016–2025
- Neural circuits for visual feature detectionUNIVERSITY OF CALIFORNIA LOS ANGELES2016–2025
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