MarkPhilipBreazzanoMDFACS

Ophthalmology • Rochester, NY

Retinal Disease

Associate Professor and Vitreoretinal Fellowship Director, Flaum Eye Institute/University of Rochester Medical Center

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Office
210 Crittenden Blvd
Rochester, NY 14642

Clinical Expertise

Diabetic retinopathy, Macular surgery, Retinal disease, Macular degeneration, Retinal detachment, Vitrectomy, Vitreous hemorrhage, Retina surgery, Central retinal vein occlusion, Macular pucker, Retinal degeneration, Vitreoretinal disease, Proliferative vitreoretinopathy, Branch retinal vein occlusion

Education & Training

New York Presbyterian Hospital (Columbia Campus)Fellowship, Surgical Retina and Vitreous, 2018 - 2020
Vanderbilt University Medical CenterResidency, Ophthalmology, 2015 - 2018
Yale-New Haven Medical CenterInternship, Transitional Year, 2014 - 2015
SUNY Upstate Medical UniversityClass of 2014

Certifications & Licensure

NY State Medical License 2018 - 2027
MD State Medical License 2020 - 2022
American Board of Ophthalmology Ophthalmology

Clinical Trials

OPT-302 With Ranibizumab in Neovascular Age-related Macular Degeneration (nAMD) Start of enrollment: 2021 Mar 12
ACTIVE_NOT_RECRUITING
PHASE3
A Phase 2 Study to Assess the Safety and Efficacy of Intravitreal ONL1204 Ophthalmic Solution in Subjects With Mac-off Retinal Detachment Start of enrollment: 2023 Apr 04
Completed
Phase 2
Fenofibrate for Prevention of DR Worsening Start of enrollment: 2021 Mar 05
Recruiting
Phase 3
Evaluation of Tonabersat for DME Start of enrollment: 2023 May 02
ACTIVE_NOT_RECRUITING
PHASE2
Randomized Trial Comparing Immediate Vs. Deferred Surgery for Symptomatic ERM Start of enrollment: 2022 Feb 22
RECRUITING
NA
Nesvategrast (OTT166) in Diabetic Retinopathy (DR) Start of enrollment: 2022 Jul 29
COMPLETED
PHASE2
A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD) Start of enrollment: 2023 Mar 06
ACTIVE_NOT_RECRUITING
PHASE2
GTSCOPE - To Evaluate the Natural Progression of Dry Age-related Macular Degeneration (AMD) Start of enrollment: 2019 Jan 08
TERMINATED
A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema (YOSEMITE) Start of enrollment: 2018 Sep 05
Completed
Phase 3
A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (TENAYA) Start of enrollment: 2019 Feb 19
Completed
Phase 3
A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Diabetic Macular Edema Start of enrollment: 2020 Aug 05
COMPLETED
PHASE3
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD) (AAVIATE) Start of enrollment: 2020 Aug 25
RECRUITING
PHASE2
A Study of NGM621 in Participants With Geographic Atrophy Start of enrollment: 2020 Jul 22
Completed
Phase 2
A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Central Retinal or Hemiretinal Vein Occlusion Start of enrollment: 2021 Mar 02
COMPLETED
PHASE3
A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Branch Retinal Vein Occlusion Start of enrollment: 2021 Mar 02
COMPLETED
PHASE3
A Study Assessing the Safety, Tolerability, and Efficacy of Galegenimab (FHTR2163) in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD) Start of enrollment: 2019 Jun 03
Terminated
Phase 2
A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration(nAMD) Treated With the Port Delivery System With Ranibizumab (PDS) Start of enrollment: 2021 Dec 14
RECRUITING
PHASE4
FIGHT-RP 1 Extension Study Start of enrollment: 2019 Jun 24
ACTIVE_NOT_RECRUITING
PHASE1
A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration Start of enrollment: 2021 Apr 19
COMPLETED
PHASE3
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy (DR) With and Without Center Involved-Diabetic Macular Edema (CI-DME) Start of enrollment: 2020 Nov 20
RECRUITING
PHASE2
Pivotal Study of OCS-01 Eye Drops in Subjects with Diabetic Macular Edema (DIAMOND-1) Start of enrollment: 2021 Oct 19
RECRUITING
PHASE2, PHASE3
A Study to Evaluate THR-149 Treatment for Diabetic Macular Oedema Start of enrollment: 2020 Jul 31
Completed
Phase 2
Avacincaptad Pegol Open-Label Extension for Patients With Geographic Atrophy Start of enrollment: 2022 Sep 26
ACTIVE_NOT_RECRUITING
PHASE3
Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) Start of enrollment: 2022 Jul 28
COMPLETED
PHASE2
Study of Zifibancimig in Participants With Neovascular Age-Related Macular Degeneration Start of enrollment: 2020 Oct 28
RECRUITING
PHASE1, PHASE2
A 2-part Study Consisting of Multiple Ascending Dose (MAD) Safety Study, and a Dose-finding Masked Study to Assess the Safety and Efficacy of Intravitreal (IVT) EYE103 in Patients With Diabetic Macular Edema (DME) or Neovascular Age-related Macular Degeneration (NVAMD) Start of enrollment: 2023 Jun 12
COMPLETED
PHASE1, PHASE2
Study to Assess the Efficacy & Safety of KHK4951 in Patients With Diabetic Macular Edema Start of enrollment: 2024 Jan 09
RECRUITING
PHASE2
Study to Assess the Efficacy & Safety of KHK4951 in Patients With Neovascular Age-Related Macular Degeneration Start of enrollment: 2024 Jan 31
RECRUITING
PHASE2
A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products Start of enrollment: 2022 Nov 21
RECRUITING
A 3-month Study to Assess the Safety and Effectiveness of ONS-5010 in Subjects with Neovascular Age-related Macular Degeneration (AMD) Start of enrollment: 2024 Jan 24
COMPLETED
PHASE3
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Publications & Presentations

PubMed

MULTIMODAL IMAGING OF A NOVEL MFSD8/CLN7 MUTATION ASSOCIATED WITH NONSYNDROMIC SYMMETRIC ADULT-ONSET MACULAR DYSTROPHY.
Francesco Gelormini, Veronica Vallino, Mark P Breazzano, Barbara Pasini, Michele Reibaldi
Retinal Cases & Brief Reports. 2025-03-01
Characterization of Syphilitic Chorioretinitis as a White Dot Syndrome with Multimodal Imaging: Case Series.
Robert J Contento, Neha Gupta, Mark P Breazzano
Diagnostics. 2025-02-04
1 citations
Negative Treponemal Serologies in Syphilitic Panuveitis.
Loka Thangamathesvaran, Aaron Z Priluck, Bryn M Burkholder, Mark P Breazzano, Sophie Cai
JAMA Ophthalmology. 2025-01-01

Journal Articles

CLEARED (Chemicals and Litmus Testing with Effective Alkaline Range for Eye Damage): A Prospective, Interventional Study
Uyen Tran, Mark P Breazzano, Sarah Tanaka, Academic emergency medicine