MarkLouisBrantlyMD

Pulmonology • Gainesville, FL

Asthma & COPD, Cystic Fibrosis

UF Chief, Pulmonary, Critical Care and Sleep Medicine

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Office
1600 SW Archer Rd
Gainesville, FL 32610
Phone+1 352-273-8737

Fax+1 352-627-4268

Education & Training

Eastern Virginia Medical SchoolResidency, Internal Medicine, 1980 - 1983
Eastern Virginia Medical SchoolInternship, Transitional Year, 1979 - 1980
University of Florida College of MedicineClass of 1979

Certifications & Licensure

FL State Medical License 1998 - 2025
NC State Medical License 1982 - 2024
VA State Medical License 1981 - 2018
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

4-PBA: Will it Increase the Level of Alpha 1-Antitrypsin(AAT) in Persons With AAT Deficiency? Start of enrollment: 2001 Nov 01
Completed
Phase 2
Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency Start of enrollment: 2004 Mar 01
Completed
Phase 1, Phase 2
Safety Study of an Aerosolized, Recombinant Alpha 1-Antitrypsin in Subjects With Alpha 1-Antitrypsin Deficiency Start of enrollment: 2003 Jan 07
Completed
Phase 1, Phase 2
Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin (AAT) Deficiency Start of enrollment: 2006 Feb 01
Completed
Phase 1
Alpha-1 Foundation DNA and Tissue Bank Start of enrollment: 2002 Dec 01
Enrolling by invitation
Safety and Pharmacokinetics of Alpha-1 Proteinase Inhibitor in Subjects With Alpha1-Antitrypsin Deficiency Start of enrollment: 2010 Nov 01
Completed
Phase 2
STX-100 in Patients With Idiopathic Pulmonary Fibrosis (IPF) Start of enrollment: 2012 Jul 16
Completed
Phase 2
Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD) Start of enrollment: 2013 Oct 01
Completed
Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs Start of enrollment: 2007 Aug 09
Recruiting
Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD) Start of enrollment: 2013 Nov 01
Active, not recruiting
Phase 3
Phase II, Safety and Efficacy Study of Kamada-alpha-1-antitrypsin (AAT) for Inhalation" Start of enrollment: 2014 Apr 01
Completed
Phase 2
The Effect of Short-term Atorvastatin Treatment on Immune Responses to Pneumovax 23 Start of enrollment: 2014 Jun 01
Completed
Phase 1
Practicality of Intermittent Fasting and Its Effect on Markers of Aging and Oxidative Stress Start of enrollment: 2011 Mar 01
Completed
Not Applicable
Assessment of Satiety Following Oral Administration of an Erythritol Sweetened Beverage Start of enrollment: 2017 Sep 18
Completed
Not Applicable
Long-Term Follow-up Study of ADVM-043 Start of enrollment: 2018 Dec 27
Completed
Phase 1 Study to Assess the Safety, PK and PD of INBRX-101 in Adults With Alpha-1 Antitrypsin Deficiency Start of enrollment: 2019 Jul 19
Completed
Phase 1
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Publications & Presentations

PubMed

Liver Characterization of a Cohort of Alpha-1 Antitrypsin Deficiency Patients with and without Lung Disease.
Naweed Mohammad, Regina Oshins, Tongjun Gu, Virginia Clark, Jorge Lascano
Journal of Clinical and Translational Hepatology. 2024-10-28
Fazirsiran for Adults With Alpha-1 Antitrypsin Deficiency Liver Disease: A Phase 2 Placebo Controlled Trial (SEQUOIA).
Virginia C Clark, Charlie Strange, Pavel Strnad, Antonio J Sanchez, Paul Kwo
Gastroenterology. 2024-10-01
Extracellular Vesicle-Associated Neutrophil Elastase Activates Hepatic Stellate Cells and Promotes Liver Fibrogenesis via ERK1/2 Pathway.
Regina Oshins, Zachary Greenberg, Yun-Ling Tai, Derrick Zhao, Xuan Wang
Biorxiv. 2024-08-21

Press Mentions

Pioneering Discussions at IISLD 2024: Advancing Treatment for PBC and Alpha-1 Antitrypsin DeficiencyOctober 11th, 2024
Chronic Obstructive Pulmonary Diseases: Journal of the COPD FoundationOctober 1st, 2024
UF Health Enrolls Its First Patients to Begin Clinical Trials to Treat COVID-19November 9th, 2020
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Grant Support

The Miles TrialNational Center For Research Resources2009
QuantumNational Center For Research Resources2009
Pirfenidone And Patients With Idiopathic Pulmonary Fibrosis (IPF)National Center For Research Resources2009
Clinical Trial: Tobacco Smoke Induced Cell Injury In Lung CompartmentsNational Center For Research Resources2008–2009
Clinical Trial: Phase I Trial Of Intramuscular Injection Of Raav1-Cb-HaatNational Center For Research Resources2008–2009
Clinical Trial: Phase 3 Study Of Safety And Efficacy Of Pirfenidone In PatientsNational Center For Research Resources2008–2009
Clinical Trial: Kamada-ApiNational Center For Research Resources2008–2009
Alpha-1 Antitrypsin And Macrophage FunctionNational Center For Research Resources2008–2009
Clinical Trial: StampNational Center For Research Resources2008
Clinical Trial: ChampNational Center For Research Resources2008
Tobacco Smoke Induced Cell Injury In Lung CompartmentsNational Center For Research Resources2007
StampNational Center For Research Resources2007
Phase 3 Study Of Safety And Efficacy Of Pirfenidone In Patients With IPFNational Center For Research Resources2007
ChampNational Center For Research Resources2007
Genetic Modifiers Of The Alpha1-Antitrypsin DeficiencyNational Center For Research Resources2004–2007
FINE Mapping Of COPD Susceptibility GenesNational Center For Research Resources2006
Anti-Inflammatory Role Of Alpha-1 Antitrypsin In LungNational Heart, Lung, And Blood Institute2002–2006
FINE Mapping Of COPD Susceptability GenesNational Center For Research Resources2005
Effect Of Aero, Recomb Alpha 1-Antitrypsin DEF On Epithelial Lining FluidNational Center For Research Resources2005
University Of Florida Clinical Research Center DNA, Serum And Plasma BankNational Center For Research Resources2004–2005
The Pharmacokinetics And Safety Of An Alpha-1 Proteinase Inhibitor (Arc-Api)National Center For Research Resources2004
The Effects Of Atorvastatin On Immune Responses To Tetanus VaccinationNational Center For Research Resources2004
Phase 1 Safety Invest Of An Aerosolized, Recomb A1 Antitrypsin In Subj W/ A 1National Center For Research Resources2004
4-Phenyl Butyrate Mediated Secretion Rescue In Alpha 1 Antitrypsin DeficiencyNational Center For Research Resources2004