MarioOttoMDPhD

PubMed

• 26 citations
  Human gammadelta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolation.
  Mario Otto, Raymond C. Barfield, Rekha Iyengar, Janet Gatewood, Ingo Müller
  Journal of Immunotherapy. 2005-01-01
• 75 citations
  A large-scale method for the selective depletion of αβ T lymphocytes from PBSC for allogeneic transplantation
  Stanley Chaleff, Mario Otto, Raymond C. Barfield, Thasia Leimig, Rekha Iyengar
  Cytotherapy. 2007-01-01
• 19 citations
  Preclinical pharmacokinetics and dosimetry studies of [124I/131I]-CLR1404 for treatment of pediatric solid tumors in murine xenograft models
  Ian Marsh, Joseph Grudzinski, Dana C. Baiu, Abigail E Besemer, Reinier Hernandez
  Journal of Nuclear Medicine. 2019-10-01

Abstracts/Posters

• Versican Proteolytic Fragments (Matrikines) Regulate the Intratumoral Dendritic Cell Milieu In Vivo: Implications for in Situ Tumor Vaccination
  Mario Otto, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Analyzing the immune system reconstitution following hematopoietic stem cell transplantation.
  Philipps NM, Dandan E, Baiu DC, Otto M, Undergraduate Research Symposium, University of Wisconsin-Madison, Madison, WI, 1/13/2017
• Towards Patient-Specific Treatment Planning of External Beam Radiotherapy Involving Radiosensitizers Using Nuclear Medicine Imaging.
  Adam D, Besemer AE , Marsh IR, Kloepping KC, Hall LR, Grudzinski JJ, Weichert JP, Otto M, Bednarz BP, 59th Annual Meeting of the AAPM, Denver, CO, 1/30/2017
• The alkyl phosphocholine analog CLR1404 delays radiation-induced dsDNA damage repair in pediatric and adult solid tumors.
  Shahi A, Elsaid MY, Baiu DC, Armstrong EA, Weichert JP, Harari PM, Otto M, AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, Philadelphia, PA, 1/26/2017
• Pediatric Clinical Cancer Research at UW-AFCH: Making a Difference.
  DeSantes KB, Capitini CM, Otto M, Diamond CA, Hofmann I, Hoover-Regan M, Patel N. et al, UWCCC 10th Annual Research Retreat & Open House, Madison, WI, 1/14/2017
• Incidence of graft-versus-host reactivity following hematopoietic stem cell transplantation.
  Dandan E, Philipps NM, Baiu DC, Otto M, Undergraduate Research Symposium, University of Wisconsin-Madison, Madison, WI, 1/13/2017
• Molecular-targeted radiotherapy with an alkyl-phosphocholine analog leads to immunomodulation in a syngeneic murine melanoma model.
  Veerankutty S, Carlson PM, Baiu DC, Heinze C, Boruch AE, Erbe AK, Grudzinski JJ, Hernandez R, Bednarz BP, Weichert JP, Sondel PM, Morris ZS, Otto M, SITC Annual Meeting, National Harbor, MD, 1/8/2017
• Alkyl Phosphocholine Analogs for Molecular-targeted Radiotherapy of Pediatric Solid Tumors.
  Baiu DC, Elsaid MY, Shahi A, Singhal S, Werner LR, Armstrong EA, Kloepping KC, Harari PM, Weichert JP, Otto M, Alex’s Lemonade Stand Fund Young Investigator Summit and Scientific Meeting, Chicago, IL, 1/25/2016
• Models of TCRalphabeta/CD19-depleted hematopoietic stem cell transplantation.
  Baiu DC and Otto M, Journal of Immunology; Immunology-AAI Annual Meeting, Seattle, WA, 1/1/2016
• Pre-clinical radionuclide therapy dosimetry in several pediatric cancer xenografts.
  Marsh IR, Otto M, Weichert JP, Baiu DC, Bednarz BP, Med Phys; 58th Annual Meeting of the AAPM, Washington, DC, 1/1/2016
• CLR1404, a Tumor-selective Alkyl Phosphocholine Analog, Increases Radiation Sensitivity in Solid Tumors.
  Elsaid MY, Armstrong EA, Baiu DC, Singhal S, Werner LR, Li C, Weichert P, Harari PM, Otto M, Pediatr Blood Cancer; ASPHO Annual Meeting, Minneapolis, MN, 1/1/2016
• 131I-CLR1404, A tumor-selective Alkyl Phospholipid Analog for Targeted Radiotherapy of Pediatric Solid Malignancies.
  Boruch A, Baiu DC, Otto M, Undergraduate Research Symposium, University of Wisconsin-Madison, Madison, WI, 1/25/2015
• Evaluation of the Use of Iron Oxide Anti-GD2 BNF Nanoparticles to Selectively Target Neuroblastoma.
  McElreath M, Baiu DC, Otto M, Undergraduate Research Symposium, University of Wisconsin-Madison, Madison, WI, 1/10/2014
• The effect of CLR1404 on cell viability in human neuroblastoma tumor cell lines.
  Singhal S, Baiu DC, Menapace B., Weichert JE, Otto M, Undergraduate Research Symposium, University of Wisconsin-Madison, Madison, WI, 1/10/2014
• Evaluation of Detection Methods of Mycoplasma in Cell Cultures.
  Wolf M, Baiu DC, Otto M, Undergraduate Research Symposium, University of Wisconsin-Madison, Madison, WI, 1/7/2014
• Evaluation of Multifunctional Nanoparticles for the Targeted Treatment of Neuroblastoma.
  McElreath M, Baiu D, Otto M, Undergraduate Research Symposium, University of Wisconsin-Madison, Madison, WI, 1/18/2013
• Targeted Multifunctional iron-oxide nanoparticles for the treatment of neuroblastoma.
  Baiu DC, Menapace B, Artz N, Hernando D, Xu Y, Bao Y, Gruettner C, Reeder SB, Otto M, International Gordon Research Conference for Cancer Nanotechnology, Mount Snow, VT, 1/14/2013
• The effect of CLR1404 on DNA fragmentation in the human neuroblastoma tumor cell line NB1691.
  Singhal S, Baiu DC, Marino R, Weichert JE, Otto M, Undergraduate Research Symposium, University of Wisconsin-Madison, Madison, WI, 1/12/2013
• The Effects of CLR1404 on Cell-Mediated Toxicity in Neuroblastoma.
  Laudon SM, Baiu DC, Otto M, Undergraduate Research Symposium, University of Wisconsin-Madison, Madison, WI, 1/9/2013
• Neuroblastoma Patients Treated With a Reduced Intensity Conditioning Regimen Followed by Haploidentical Transplant.
  Boyden M, Otto M, Delgado D, Sondel PM, Hank JA, McDowell KA, Leith C, Hematti P, DeSantes KB, Pediatr Blood Cancer; ASPHO abstracts, 1/1/2013
• A novel anti-GD2 monoclonal antibody (mAb), hu14.18K322A, in children with refractory or recurrent neuroblastoma: Early-phase evaluation.
  Navid F, Barfield RC, Handgretinger R.; Sondel PM, Shulkin BL, Kaufman R, Billups C, Wu J, Furman WL, McGregor LM, Otto M, Gillies S, Santana VM, J Clin Oncol, 1/1/2011
• Characteristics of CD34+ thymocytes vary with glycosylation pattern of the CD34 molecule
  Barfield R, Otto M, Chen XH, Cheng C, Holladay M, Houston J, Leimig T, Handgretinger R, Blood; Annual Meeting of the American Society of Hematology, 1/1/2003
• A one-step large-scale method for T and B cell depletion of mobilized peripheral blood stem cells for allogeneic transplantation
  Barfield, R; Otto, M; Houston, J; Holladay, M; Chen, XH; Handgretinger, R, Blood; Annual Meeting of the American Society of Hematology, 1/1/2003
• Prediction of T cell reconstitution by assessment of T cell receptor excision circle before transplantation in pediatric patients
  Chen, XH; Benaim, E; Barfield, R; Leung, W; Otto, M; Knowles, J; Shurtleff, SA; Handgretinger, R, Blood; Annual Meeting of the American Society of Hematology, 1/1/2003
• Antithymocyte globulin is cytotoxic to CD34+stem cells and blood mononuclear cells
  Iyengar, R; Leimig, T; Cooper, A; Barfield, R; Otto, M; Holladay, M; Houston, J; Handgretinger, R; Leung, W, Blood; Annual Meeting of the American Society of Hematology, 1/1/2003
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Lectures

• New Approaches to Treat Pediatric Cancers: Cell-Based Therapies and Beyond 
  Milwaukee, WI - 1/10/2018
• Congenital and Acquired Immunodeficiencies II 
  1/31/2017
• Hepatoblastoma and other Liver Tumors 
  1/30/2017
• alphabeta T cell/CD19 Depleted Haplo-HSCT for the Treatment of Benign Hematopoietic 
  University of Wisconsin, Madison, WI - 1/26/2017
• Congenital and Acquired Immunodeficiencies I 
  1/24/2017
• Molecular Targeted Radiotherapy of Pediatric Solid Tumors with a Novel Alkyl Phosphocholine Analog 
  Madison, WI - 1/23/2017
• alphabeta T cell/CD19 Depleted Haplo-HSCT as Platform for Post-transplant Immunotherapies 
  University of Wisconsin, Madison, WI - 1/21/2017
• MM341: Cancer Immunology and Immunotherapy 
  1/5/2017
• Molecular Radiotherapy of Pediatric Solid Tumors with the tumor-targeting Phospholipid Ether (PLE) CLR1404 
  University of Wisconsin, Madison, WI - 1/8/2016
• Therapy of High-risk Pediatric Neuroblastoma: Current Strategies and Novel Approaches to Improve Outcomes 
  University of Wisconsin, Madison, WI - 1/29/2015
• Targeting High-Risk Neuroblastoma With Small Molecules: Pre-Clinical Research with CLR1404 and Antibody-Guided Nanoparticles 
  University of Wisconsin, Madison, WI - 1/27/2015
• Congenital and Acquired Immunodeficiencies (Section VI) 
  1/27/2015
• Hodgkin Lymphoma and NHL II 
  1/10/2015
• Hodgkin Lymphoma and NHL I 
  1/3/2015
• A Phase I Clinical, Pharmacologic, and Biologic Study of Thrombopoietin and Granulocyte Colony-Stimulating Factor in Children Receiving Ifosfamide. Carboplatin, Carbop... 
  1/25/2014
• Core Curriculum: AML/MDS II 
  1/18/2014
• Neuroblastoma: Current Treatment Concepts and Translational Research Efforts 
  Cottage Grove, WI - 1/12/2014
• Alkyl Phospholipid-mediated, Tumor-selective Radiosensitization of Neuroblastoma. 
  University of Wisconsin, Madison, WI - 1/11/2014
• Core Curriculum: AML/MDS I 
  1/11/2014
• The Tumor-targeting Phospholipid Ether (PLE) CLR1404 for the Treatment of Neuroblastoma 
  University of Wisconsin, Madison, WI - 1/4/2014
• Core Curriculum: Principles of Chemotherapy II 
  1/26/2013
• Development of Multifunctional Superparamagnetic anti-GD2 Nanoparticles for Simultaneous Molecular Imaging, Cancer Cell Targeting and Drug Delivery 
  Medical College of Wisconsin, Milwaukee, WI - 1/21/2013
• Core Curriculum: Principles of Chemotherapy I 
  1/19/2013
• Long-term decline in intelligence among adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiation 
  1/12/2013
• ANAT710: Immunodeficiency 
  1/8/2013
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