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840 memorial driveCambridge, MA 02139
Phone+1 617-678-3532
Dr. Koziel is on Doximity
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Education & Training
Mass General Brigham/Massachusetts General Hospital/Brigham and Women's HospitalFellowship, Infectious Disease, 1989 - 1992
Beth Israel Deaconess Medical CenterResidency, Internal Medicine, 1986 - 1989
Geisel School of Medicine at DartmouthClass of 1985- Beth Israel Deaconess Medical CenterChief Residency, Internal Medicine
- Massachusetts General Hospital
Certifications & Licensure
MA State Medical License 1988 - 2027
American Board of Internal Medicine Internal Medicine
Awards, Honors, & Recognition
- Elected Member The American Society for Clinical Investigation, 2006
Clinical Trials
- Clinical Food Study to Evaluate the Effect of KB195 on Gut Nitrogen Metabolism in Patients With Urea Cycle Disorders Start of enrollment: 2019 Jan 06
- Clinical Food Study to Evaluate the Effect of KB174 on the Gut Microbiome in Subjects With Well-compensated Cirrhosis Start of enrollment: 2019 Feb 27
- UNLOCKED: A Phase 2, Open-label Trial With KB195 in Subjects With a Urea Cycle Disorder Start of enrollment: 2019 Sep 17
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Publications & Presentations
PubMed
- A novel composition of endogenous metabolic modulators improves red blood cell properties in sickle cell disease.Myrthe J van Dijk, Marissa J M Traets, Brigitte A van Oirschot, Titine J J Ruiter, Jonathan R A de Wilde
Ejhaem. 2024-02-01 - 20 citationsEfficacy and tolerability of an endogenous metabolic modulator (AXA1125) in fatigue-predominant long COVID: a single-centre, double-blind, randomised controlled phase ...Lucy E M Finnigan, Mark Philip Cassar, Margaret James Koziel, Joel Pradines, Hanan Lamlum
Eclinicalmedicine. 2023-05-01 - 13 citationsSafety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease.Stephen A. Harrison, Seth J. Baum, Nadege Gunn, Ziad Younes, Anita Kohli
The American Journal of Gastroenterology. 2021-08-12
Press Mentions
Boston Pharmaceuticals to Announce Positive Phase 2 Data on Efimosfermin Alfa (BOS-580) in F2/F3 MASH During Late-Breaking Oral Presentation at AASLD 2024, the Liver Meeting®November 15th, 2024- Trial Investigating Potential Treatment for Fatigue Relief in People with Long COVID Reports ResultsApril 14th, 2023
- Accelerating Treatments in Long COVID: What Will It Take? The Solve M.E. / BIO Webinar SeriesMarch 7th, 2023
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Grant Support
- Immunologic Correlates Of Liver Disease ProgressionNational Institute Of Allergy And Infectious Diseases2005–2009
- Determinants Of Liver Injury In Chronic Hepatitis C Virus InfectionNational Institute Of Allergy And Infectious Diseases2007
- Determinants Of Liver Injury In Chronic HCV InfectionNational Institute Of Allergy And Infectious Diseases2005–2006
- Natural Killer T Cells In An Animal Model Of Hepatitis CNational Institute Of Allergy And Infectious Diseases2004–2006
- T Lymphocyte Apoptosis In Hepatitis C PersistenceNational Institute Of Allergy And Infectious Diseases2002–2006
- Natural Killer T Cells In An Animal Model Of Hepatitis CNational Institute Of Allergy And Infectious Diseases2003
- Immunity To Hepatitis C In Liver Transplant RecipientsNational Institute Of Allergy And Infectious Diseases1997–2001
- Cellular Immunity To Hepatitis C VirusNational Institute Of Allergy And Infectious Diseases1996
- Cellular Immunity To Hepatitis C VirusNational Institute Of Allergy And Infectious Diseases1994–1996
- Cytotoxic T Lymphocytes In Hepatitis C Virus InfectionNational Institute Of Allergy And Infectious Diseases1991–1992
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