Marc Alan Simon MD MS, FACP

Cardiology•San Francisco, CA

Heart Failure & Transplantation

Professor, Medicine, UCSF

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535 Mission Bay Blvd SSan Francisco, CA 94143
Phone+1 415-353-3109
Fax+1 415-353-2528

Education & Training

UPMC Medical EducationFellowship, Advanced Heart Failure and Transplant Cardiology, 2004 - 2005
UPMC Medical EducationFellowship, Cardiovascular Disease, 2001 - 2004
University of ColoradoResidency, Internal Medicine, 1998 - 2001
University of Maryland School of MedicineClass of 1998

Certifications & Licensure

CA State Medical License 2021 - 2027
PA State Medical License 1988 - 2022
CO State Medical License 2000 - 2003
American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011

Clinical Trials

Inhaled Nitrite in Subjects With Pulmonary Hypertension Start of enrollment: 2012 Jun 01
Completed
Phase 2
A Pivotal Trial to Establish the Efficacy and Long-term Safety of the Parachute Implant System Start of enrollment: 2012 Dec 01
Terminated
Phase 3
Efficacy and Safety of Allogeneic Mesenchymal Precursor Cells (Rexlemestrocel-L) for the Treatment of Heart Failure. Start of enrollment: 2014 Feb 14
Completed
Phase 3
Phase 1/1b Study With Nab-sirolimus for Patients With Severe Pulmonary Arterial Hypertension Start of enrollment: 2017 Apr 01
COMPLETED
PHASE1
Oral Nitrite in Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction Start of enrollment: 2017 Oct 30
Completed
Phase 2
Phase 2 Study to Assess Safety, Tolerability and Efficacy of Once Weekly SC Pemziviptadil (PB1046) in Subjects With Symptomatic PAH Start of enrollment: 2018 Jul 15
Terminated
Phase 2
Metformin for Pulmonary Hypertension HFpEF Start of enrollment: 2019 Feb 26
RECRUITING
PHASE2
Long-Term, Open Label Extension Study of Pemziviptadil (PB1046) in PAH Subjects Following Completion of Study PB1046-PT-CL-0004 Start of enrollment: 2019 Apr 10
Terminated
Phase 2
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Publications & Presentations

PubMed

1 citations
The uses of right heart catheterization in cardio-pulmonary disease: State-of-the-art.
Bhavesh Katbamna, Lingling Wu, Mario Rodriguez, Phillip King, Joel Schilling
American Heart Journal Plus. 2025-01-01
1 citations
Skeletal Muscle SIRT3 Deficiency Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction.
Jia-Rong Jheng, Yang Bai, Kentaro Noda, Joshua R Huot, Todd Cook
Circulation. 2024-09-10
Exploring the Noninvasive Evaluation of the Pulmonary Pressure-Flow Relationship During Exercise.
Mads J Andersen, Henrik Vase, Marc A Simon
Journal of the American Heart Association. 2024-08-06

Abstracts/Posters

[Board 482] Patients With Severe Pulmonary Arterial Hypertension Treated With ABI-009 Nab-Sirolimus an mTOR Inhibitor: Interim Results From a Phase 1 Clinical Trial
Marc Simon, 2019 ACC Scientific Session & Expo, New Orleans, New Orleans, 3/17/2019

Grant Support

Phase II Trial of Metformin for Pulmonary Hypertension in Heart Failure with Preserved Ejection FractionUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2018–2025
A Phase II Trial of Metformin for Pulmonary Hypertension in Heart Failure with Preserved Ejection FractionNIAPresent

Professional Memberships

American College of Cardiology - ACC
Fellow
American Heart Association - AHA
Member