Marc Armand L Laruelle MD

PubMed

• 1 citations
  Erratum: PET imaging of dopamine-D2 receptor internalization in schizophrenia
  Jodi J. Weinstein, E van de Giessen, R J Rosengard, Xiaoyan Xu, Najate Ojeil
  Molecular Psychiatry. 2017-07-25
• 192 citations
  Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain
  Nabeel Nabulsi, Joël Mercier, Daniel Holden, Stephane Carre, Soheila Najafzadeh
  Journal of Nuclear Medicine. 2016-05-01
• 20 citations
  Human Kinetic Modeling of the 5HT6 PET Radioligand 11C-GSK215083 and Its Utility for Determining Occupancy at Both 5HT6 and 5HT2A Receptors by SB742457 as a Potential ...
  Christine A. Parker, Eugenii A. Rabiner, Roger N. Gunn, Graham E. Searle, Laurent Martarello
  Journal of Nuclear Medicine. 2015-12-01

Journal Articles

• The potent M(1) receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction  
  PJ Nathan, J Watson, J Lund, CH Davies, G Peters, CM Dodds, B Swirski, P Lawrence, GD Bentley, BV O'Neill, J Robertson, S Watson, GA Jones, P Maruff, RJ Croft, M Larue..., Int J Neuropsychopharmacol, 1/1/2013
• Imaging changes in synaptic acetylcholine availability in living human subjects  
  PJ Nathan, J Watson, J Lund, CH Davies, G Peters, CM Dodds, B Swirski, P Lawrence, GD Bentley, BV O'Neill, J Robertson, S Watson, GA Jones, P Maruff, RJ Croft, M Larue..., J Nucl Med, 1/1/2013
• Mathematical modelling of (11C)-(+)-PHNO human competition studies  
  GE Searle, JD Beaver, A Tziortzi, RA Comley, M Bani, G Ghibellini, E Merlo-Pich, EA Rabiner, M Laruelle, RN Gunn, Neuroimage, 1/1/2013
• Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography  
  RA Comley, CA Salinas, M Slifstein, M Petrone, C Marzano, I Bennacef, P Shotbolt, J Van der Aart, M Neve, L Iavarone, R Gomeni, M Laruelle, FA Gray, RN Gunn, EA Rabiner, J Pharmacol Exp Ther, 1/1/2013
• The second revision of the dopamine theory of schizophrenia: implications for treatment and drug development  
  M Laruelle, Biol Psychiatry, 1/1/2013
• Biodistribution and radiation dosimetry of the serotonin 5-HT(6) ligand (11C)GSK215083 determined from human whole-body PET  
  RA Comley, C Salinas, R Mizrahi, I Vitcu, A Ng, W Hallett, N Keat, AA Wilson, EA Rabiner, M Laruelle, S Houle, Mol Imaging Biol, 1/1/2012
• The 5-HT(2A) receptor and serotonin transporter in Asperger's disorder: A PET study with (11C)MDL 100907 and (11C)DASB  
  RR Girgis, M Slifstein, X Xu, WG Frankle, E Anagnostou, S Wasserman, L Pepa, A Kolevzon, A Abi-Dargham, M Laruelle, E Hollander, Psychiatry Res, 1/1/2012
• Affinity and selectivity of ((1)(1)C)-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo  
  JD Gallezot, JD Beaver, RN Gunn, N Nabulsi, D Weinzimmer, T Singhal, M Slifstein, K Fowles, YS Ding, Y Huang, M Laruelle, RE Carson, EA Rabiner, Synapse, 1/1/2012
• Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs  
  RN Gunn, SG Summerfield, CA Salinas, KD Read, Q Guo, GE Searle, CA Parker, P Jeffrey, M Laruelle, J Cereb Blood Flow Metab, 1/1/2012
• Computerized cognitive remediation training for schizophrenia: an open label, multi-site, multinational methodology study  
  NV Murthy, H Mahncke, BE Wexler, P Maruff, A Inamdar, M Zucchetto, J Lund, S Shabbir, S Shergill, M Keshavan, S Kapur, M Laruelle, R Alexander, Schizophr Res, 1/1/2012
• Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with (11C)DAS...  
  NB Urban, RR Girgis, PS Talbot, LS Kegeles, X Xu, WG Frankle, CL Hart, M Slifstein, A Abi-Dargham, M Laruelle, Neuropsychopharmacology, 1/1/2012
• Donepezil impairs memory in healthy older subjects: behavioural, EEG and bimultaneous EEG/fMRI biomarkers  
  JH Balsters, RG O'Connell, MP Martin, A Galli, SM Cassidy, SM Kilcullen, S Delmonte, S Brennan, JF Meaney, AJ Fagan, AL Bokde, N Upton, R Lai, M Laruelle, B Lawlor, IH..., PLoS One, 9/21/2011
• Within-subject comparison of (11C)-(+)-PHNO and (11C)raclopridesensitivity to acute amphetamine challenge in healthy humans  
  P Shotbolt, AC Tziortzi, GE Searle, A Colasanti, J Van der Aart, S Abanades, C Plisson, SR Miller, M Huiban, JD Beaver, RN Gunn, M Laruelle, EA Rabiner, J Cereb Blood Flow Metab, 9/1/2011
• Extended characterization of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer (11C)MDL 100907 in humans: Quantitative analysis, test-retest reproducibility...  
  PS Talbot, M Slifstein, DR Hwang, Y Huang, E Scher, A Abi-Dargham, M Laruelle, Neuroimage, 7/26/2011
• Increased prefrontal cortical D1 receptors in drug naive patients with schizophrenia: a PET study with (11C)NNC112  
  A Abi-Dargham, X Xu, JL Thompson, R Gil, LS Kegeles, NB Urban, R Narendran, DR Hwang, M Laruelle, M Slifstein, J Psychopharmacol, 7/20/2011
• Translational characterization of (11C)GSK931145, a PET ligand for the glycine transporter type 1 (GlyT-1)  
  RN Gunn, V Murthy, AM Catafau, G Searle, S Bullich, M Slifstein, D Ouellet, S Zamuner, R Herance, C Salinas, R Pardo-Lozano, EA Rabiner, M Farre, M Laruelle, Synapse, 6/21/2011
• Characterisation of in vivo pharmacological properties and sensitivity to endogenous serotonin of (11C)P943: a positron emission tomography study in Papio Anubis  
  K Ridler, C Plisson, EA Rabiner, RN Gunn, B Easwaramoorthy, A Abi-Dargham, M Laruelle, M Slifstein, Synapse, 5/4/2011
• Evaluation of dopamine D(2/3) specific binding in the cerebellum for the PET radiotracer (11C)FLB 457: Implications for measuring cortical dopamine release  
  R Narendran, NS Mason, CM Chen, M Himes, P Keating, MA May, EA Rabiner, M Laruelle, CA Mathis, WG Frankle, Synapse, 3/2/2011
• In vitro assessment of the agonist properties of the novel 5-HT(1A) receptor ligand, CUMI-101 (MMP), in rat brain tissue  
  N Hendry, I Christie, EA Rabiner, M Laruelle, J Watson, Nucl Med Biol, 2/15/2011
• Prediction of repeat-dose occupancy from single-dose data: characterization of the relationship between plasma pharmacokinetics and brain target occupancy  
  S Abanades, J van der Aart, JA Barletta, C Marzano, GE Searle, CA Salinas, JJ Ahmad, RR Reiley, S Pampols-Maso, S Zamuner, VJ Cunningham, EA Rabiner, M Laruelle, RN Gunn, J Cereb Blood Flow Metab, 10/14/2010
• Striatal and extrastriatal dopamine D2 /D3 receptors in schizophrenia evaluated with (18F)fallypride positron emission tomography  
  LS Kegeles, M Slifstein, X Xu, N Urban, JL Thompson, T Moadel, JM Harkavy-Friedman, R Gil, M Laruelle, A Abi-Dargham, Biol Psychiatry, 8/3/2010
• Identification and evaluation of (11C)GSK931145 as a novel ligand for imaging the type 1 glycine transporter with positron emission tomography  
  J. Passchier J, G. Gentile, R, Porter, H. Herdon, C. Salinas, S. Jakobsen, H. Audrain, M. Laruelle, R.N. Gunn, Synapse, 1/1/2010
• Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to (11C)DASB binding in the living human brain  
  NV Murthy, S Selvaraj, PJ Cowen, Z Bhagwagar, WJ Riedel, P Peers, JL Kennedy, BJ Sahakian, M Laruelle, EA Rabiner, PM Grasby, Neuroimage, 1/1/2010
• Imaging the D3 receptor in humans in vivo using (11C)PHNO positron emission tomography (PET)  
  EA Rabiner, M Laruelle, Int J Neuropsychopharmacol, 1/1/2010
• PET imaging of dopamine D2/3 receptors in the human cortex with (11C)FLB 457: Reproducibility studies  
  R Narendran, NS Mason, MA May, CM Chen, S Kendro, K Ridler, EA Rabiner, M Laruelle, CA Mathis, WG Frankle, Synapse, 1/1/2010
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Books/Book Chapters

• Textbook of Schizophrenia. 
  Chapter: Dopaminergic and glutamatergic theories of schizophrenia. 
  D.C. Javitt, M. LaruelleEditors: J. A. Lieberman, S. Stroup, and D. Perkins.American Psychiatric Press2005
• International Review of Neurobiology: Neuroimaging. 
  Chapter: Neuroreceptor Imaging in Psychiatry: Theory and Applications. 
  G. Frankle, M. Slifstein, P. Talbot, M. LaruelleEditors: Bradley R, Harris RA, Jenner P.Elsevier, San Diego, CA2005
• Nuclear Medicine in Psychiatry. 
  Chapter: Ligand tracer kinetics: theory and application. 
  Page 75 - 93M. Slifstein, G. Frankle, M. LaruelleEditors: A. Otte, K. Audenaaert, K. Peremans, K. Van Heeringen, R. Dierckx.Springer-Verlag London Ltd, London, UK2004
• Schizophrenia. 
  Chapter: Dopamine transmission in the schizophrenic brain. 
  Page 365 - 387M. LaruelleEditors: D.R. Weinberger and S. Hirsh.Blackwell Publishing, Oxford, UK2003
• Dopamine receptors and transporters. 
  A. Sidhu, M. Laruelle , and P. Vernier (Eds)Editors: A. Sidhu, M. Laruelle , and P. Vernier.Marcel Dekker, Inc., New York, NYEdition 2nd,2003
• Psychiatric Neuroimaging. 
  Chapter: PET studies of Dopamine Transmission in Schizophrenia. 
  Page 186 - 202M. Laruelle, A. Abi-DarghamEditors: V. Ng, G. Barker and T. Hendler.IOS Press, Amsterdam, Netherlands2003
• Handbook of Depression and Anxiety. 
  Chapter: Brain Imaging in Depression and Anxiety. 
  Page 289 - 329P. Talbot, S. Mathew, and M. LaruelleEditors: S. Kasper, J.A. den Boer and J.M.A. Sitsen.Marcel Dekker, Inc., New York, NY2003
• Handbook of Medical Psychiatry. 
  Chapter: Neuroimaging Findings in Schizophrenia: From Mental to Neuronal Fragmentation. 
  Page 237 - 258L. Kegeles, M. LaruelleEditors: J.C. Soares and S. Gershon.Marcel Dekker, Inc., New York, NY2003
• Dopamine receptors and transporters. 
  Chapter: Dopamine imbalances in the schizophrenic brain: imaging studies. 
  Page 593 - 642M. Laruelle, A. Abi-DarghamEditors: A. Sidhu, M. Laruelle , and P. Vernier.Marcel Dekker, Inc., New York, NYEdition 2nd,2003
• Positron Emission Tomography: Principles and Practices. 
  Chapter: Clinical Sciences: Psychiatry. 
  Page 298 - 319M. Laruelle, D. Martinez, P. Talbot, A. Abi-DarghamEditors: D.L. Bailey, D. Townsend, P. Valk and M. Maisey.Springer-Verlag London Ltd, London, UK2002
• Principles and Practice of Positron Emission Tomography. 
  Chapter: Psychiatric Disorders. 
  Page 298 - 319M. Laruelle, P. Talbot, D. Martinez, A. Abi-DarghamEditors: R.W. Wahl.Lippincott Williams and Wilkins, Baltimore, MD2002
• Cathecolamine Research. From Molecular insights to clinical medicine. 
  Chapter: Dopaminergic hyperactivity in striatum in schizophrenia: a failure of cortical glutamatergic control? 
  Page 427 - 430L. Kegeles, M. LaruelleEditors: T Nagatsu, T Nabeshima, R. McCarty, D.S. Goldstein DS.Kluwer Academic / Plenum Publishers, New York, NY2002
• Neuropsychopharmacology: the Fifth Generation of Progress. 
  Chapter: Neurochemical and Neuropharmacological Imaging in Schizophrenia. 
  Page 833 - 855D.R. Weinberger, M. LaruelleEditors: K.L. Davis, D. Charney, J.T. Coyle, C. Nemeroff.Lippincott Williams and Wilkins, Philadelphia, PA2002
• Neurobiology of Mental Illness. 
  Chapter: Pharmacologic models of psychoses. 
  Page 214 - 224J.H. Krystal, A. Abi-Dargham, M. Laruelle, B. MoghaddamEditors: Charney D, Nestler EJ, Bunney B.Oxford University Press, New York, NY1999
• Contemporary Strategies in Psychiatric Neuroimaging research. 
  Chapter: Functional neuroreceptor imaging: the example of dopamine synaptic activity with SPECT. 
  Page 207 - 232I. Lombardo, A. Abi-Dargham., L. Kegeles, M. LaruelleEditors: Dougherty DD, Rauch SL.American Psychiatric Press, Washington, DC1999
• Genes, Behaviour and Health. 
  Chapter: The dopamine hypothesis of schizophrenia: new insight from brain imaging studies. 
  M. LaruelleEditors: Bolis CL.World Health Organization, Geneva, Switzerland1999
• Neuropsychopharmacology: the Fourth Generation of Progress. 
  Chapter: Principles of Neuroimaging with PET and SPECT. 
  Page 865 - 880R. T. Malison, M. Laruelle, R.B. InnisEditors: F. E. Bloom and D.J. Kupfer.Raven Press, New York, NY1994
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Lectures

• Biomarkers in CNS drug development. 
  Basel, Switzerland - 6/1/2011
• Modelling occupancy: single doses prediction in drug development. 
  Thousand Oaks, CA - 3/1/2011
• Development of pro-cognitive drugs: Industry perspective. 
  London, UK - 9/1/2009
• The new world of pro-cognitive drugs. 
  London, UK - 7/1/2009
• The role of PET in early risk discharge in CNS drug development. 
  Paris, France - 6/1/2009
• Imaging Dopamine function: comparison of radiolabelled agonists and antagonists. 
  Copenhagen, Denmark - 5/1/2009
• Glycine Transporter Inhibitors: toward a reality check of the NMDA hypothesis of Schizophrenia. 
  San Diego, CA - 4/1/2009
• The role of PET in drug development. 
  Groningen, Holland - 4/1/2009
• Predicting steady-state dose-target occupancy from single dose PET studies. 
  London, UK - 3/1/2009
• Understanding Schizophrenia- current trends and therapeutic opportunities. 
  Leige, Belgium - 3/1/2009
• Understanding Psychosis- current trends. 
  Barcelona, Spain - 9/1/2008
• The role of radiolabeled agonists to image drug-target interactions with PET. 
  Munich, Germany - 7/1/2008
• Imaging receptor internalization. 
  Pittsburgh, PA - 7/1/2008
• Early risk discharge in CNS drug development. 
  Boston, MA - 7/1/2008
• Receptor trafficking and PET imaging. 
  New Haven, CT - 1/1/2008
• Cognition, Psychoses and Dopamine in Schizophrenia. 
  12/1/2007
• Imaging the biological substrate of cognitive dysfunction in schizophrenia. 
  Berlin, Germany - 9/1/2007
• Beyond the Dopamine Hypothesis of Schizophrenia. 
  Harrogate, UK - 7/1/2007
• Neurotransmitter pathways in the pathophysiology of Schizophrenia. 
  Copenhagen, Denmark - 4/1/2007
• Molecular imaging: early risk discharge in CNS drug development. 
  Austin, TX - 2/1/2007
• Dopamine, Tempter and Tormentor of the Soul. 
  London, UK - 11/1/2006
• Molecular Imaging in Brain Illnesses. 
  Seoul, South Korea - 10/1/2006
• Dopamine deficits in chronic substance abusers. 
  Barcelona, Spain - 9/1/2006
• Dopamine receptor function and schizophrenia. 
  Sao Paulo, Brazil - 6/1/2006
• PET imaging in Psychiatry. 
  London, UK - 3/1/2006
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Other

• SPECT imaging of dopamine and serotonin transporters in nonhuman primate brain. 
  M. Laruelle, R.B. Baldwin, R.B. Innis, "Imaging Techniques in Medication Development: Preclinical and Clinical aspects", NIDA Research Mono
  1/1/1994
• SPECT imaging of the benzodiazepine receptors. 
  M. Laruelle, E. Sybirska, M. Al-Tikriti, R. Baldwin, R.B. Innis, Imaging in Alcohol Research", NIAA Research Monograph
  1/1/1992