MarcBHershensonMD

Pediatric Pulmonology • Ann Arbor, MI

Chronic Lung Disease of Prematurity and Infancy, Cystic Fibrosis Pulmonology, Pediatric Asthma Pulmonology

Professor of Pediatrics and Communicable Diseases; Director, Division of Pediatric Pulmonology

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Office
1500 E Medical Center Dr
Ann Arbor, MI 48109
Phone+1 734-936-4000

Fax+1 734-936-7635

Education & Training

Boston Children’s Hospital/Boston Medical CenterFellowship, Pediatric Critical Care Medicine, 1984 - 1998
Boston Children’s Hospital/Boston Medical CenterFellowship, Pediatric Pulmonology, 1986 - 1988
McGaw Medical Center of Northwestern UniversityResidency, Pediatrics, 1981 - 1984
University of Illinois College of MedicineClass of 1981
University of Illinois at Urbana-ChampaignB.S., Cum Laude, 1973 - 1977

Certifications & Licensure

MI State Medical License 2002 - 2027
IL State Medical License 1981 - 2017
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Pulmonology

Awards, Honors, & Recognition

Chair, Lung Cellular and Molecular Immunology Study Section NIH, 2014-2016
Elected to Best Doctors in America 2009
Frederick G.L. Huetwell Professor of Pediatrics and Communicable Diseases University of Michigan Medical School, 2003
Career Development Award Schweppe Foundation, 1992
Clinical Investigator Award NHLBI, 1992
Young Investigator Award American Academy of Pediatrics, 1984
Alpha Omega Alpha 1980
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Publications & Presentations

PubMed

Itaconate suppresses house dust mite-induced allergic airways disease and Th2 cell differentiation.
Yiran Li, Shilpi Singh, Haley A Breckenridge, Tracy X Cui, Thomas M Vigil
Mucosal Immunology. 2024-12-01
Developing a mouse model of human coronavirus NL63 infection: comparison with rhinovirus-A1B and effects of prior rhinovirus infection.
J Kelley Bentley, Jordan E Kreger, Haley A Breckenridge, Shilpi Singh, Jing Lei
American Journal of Physiology. Lung Cellular and Molecular Physiology. 2024-10-01
Tuft cells are required for a rhinovirus-induced asthma phenotype in immature mice.
Yiran Li, Mingyuan Han, Shilpi Singh, Haley A Breckenridge, Jordan E Kreger
JCI Insight. 2024-01-23

Journal Articles

Crumbs3 inactivation leads to disrupted epithelial morphogenesis and perinatal lethality
Whiteman EL, Fan S, Harder JL, Walton KD, Liu C-J, Soofi A, Fogg VC, Hershenson MB, Dressler GR, Deutsch GH, Gumucio DL, Margolis BL, Mol Cell Biol, 1/1/2014
Rhinovirus-induced exacerbations of asthma and COPD
Hershenson MB, Scientifica, 1/1/2013
Macrophage/epithelial cell CCL2 contributes to rhinovirus-induced hyperresponsiveness and inflammation in a mouse model of allergic airways disease
Schneider D, Hong JY, Bowman ER, Chung Y, Nagarkar DR. McHenry CL, Linn MJ, Goldsmith AM, Bentley JK, Lewis TC, Hershenson MB, Am J Physiol: Lung Cell Mol Physiol, 1/1/2013
Rhinovirus colocalizes with CD68- and CD11b-positive macrophages after experimental infection in humans
Bentley JK, Sajjan US, Dzaman MB, Jarjour NN, Lee W-M, Gern JE, Hershenson MB, J Allergy Clin Immunol, 1/1/2013
Nasal cytokine responses to natural colds in asthmatic children
Lewis TC, Henderson TA, Ramirez IA, McHenry CL, Goldsmith AM, Ren X, Mentz G, Mukherjee B, Robins TG, Joiner T, Mohammad L, Roe E, Carpenter A, Burns MA, Burke DT, H..., Clin Exp Allergy (Editor’s Choice), 1/1/2012
Glycogen synthase kinase-3beta/beta-catenin signaling regulates neonatal lung mesenchymal stromal cell myofibroblastic differentiation
Popova AP, Bentley JK, Linn MJ, Lei J, Wong EJ, Goldsmith AM, Pryhuber GS, Hershenson MB, Am J Physiol: Lung Cell Mol Physiol, 1/1/2012
Susceptibility to acute mouse adenovirus type 1 respiratory infection and establishment of protective immunity in neonatal mice
Procario M, Levine R, McCarthy M, Kim E, Zhu L, Chang C-H, Hershenson M, Weinberg J, J Virol, 1/1/2012
Neonatal RV infection induces mucus cell metaplasia and airways hyperresponsiveness
Schneider D, Hong JY, Popova AP, Bowman ER, Linn MJ, McLean AM, Zhao Y, Sonstein J, Bentley JK, Weinberg JB, Lukacs NW, Curtis JL, Sajjan U, Hershenson MB, J Immunol, 1/1/2012
Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplification
Bozyk PD, Popova AP, Bentley JK, Anyanwu AC, Linn MD, Pryhuber GS, Moore BB, Hershenson MB, PLoS One, 1/1/2012
Rhinovirus-induced barrier dysfunction in polarized airway epithelial cells is mediated by NADPH oxidase
Comstock AT, Ganesan S, Faris AN, Margolis BL, Hershenson MB, Sajjan US, J Virol, 1/1/2011
MDA5 and TLR3 signaling initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness
Wang Q, Miller DJ, Bowman ER, Nagarkar DR, Schneider D, Zhao Y, Linn MJ, Goldsmith AM, Bentley JK, Sajjan US, Hershenson MB, PLoS Pathog, 1/1/2011
Mesenchymal stem cells from neonatal tracheal aspirates demonstrate a pattern of gene expression consistent with a lung origin
Bozyk PD, Popova AP, Bentley JK, Goldsmith AM, Spees JL, Weiss DJ, Hershenson MB, Stem Cells Dev, 1/1/2011
Isolation of mesenchymal stem cells from tracheal aspirates of premature infants with respiratory distress predicts bronchopulmonary dysplasia
Popova AP, Bozyk PD, Bentley JK, Linn MJ, Goldsmith AM, Schumacker RE, Filbrun AG, Weiner GM and Hershenson MB, Pediatrics, 1/1/2010
Ovalbumin sensitization and challenge increases the number of lung cells possessing a mesenchymal stem cell phenotype
Bentley JK, Popova AP, Bozyk PD, Linn MJ, Baek AE, Lei J, Goldsmith AM, Hershenson MB, Respir Res, 1/1/2010
Autocrine production of TGF-beta promotes myofibroblastic differentiation of lung mesenchymal stem cells
Popova AP, Bozyk PD, Goldsmith AM, Linn M, Lei J, Bentley JK, Hershenson MB, Am J Physiol: Lung Cell Mol Physiol, 1/1/2010
Pseudomonas aeruginosa alginate promotes Burkholderia cenocepacia persistence in CFTR knockout mice
Chattoraj SS, Murthy R, Ganesan S, Goldberg JB, Zhao Y, Hershenson MB, Sajjan US, Infect Immun, 1/1/2010
Pulmonary artery smooth muscle hypertrophy: Roles of glycogen synthase kinase-3beta and p70 ribosomal S6 kinase
Deng H, Hershenson MB, Lei J, Anyanwu AC, Pinsky DJ, Bentley JK, Am J Physiol: Lung Cell Mol Physiol, 1/1/2010
Elastase- and LPS-exposed mice display altered responses to rhinovirus infection
Sajjan U, Ganesan S, Comstock A, Shim J, Wang Q, Nagarkar DR, Zhao Y, Goldsmith AM, Sonstein J, Linn MJ, Curtis JL, Hershenson MB, Am J Physiol: Lung Cell Mol Physiol, 1/1/2009
Cornell TT, Hinkovska-Galcheva V, Sun L, Cai Q, Hershenson MB, Vanway S, Shanley TP, Am J Physiol Lung Cell Mol Physiol, 1/1/2009
Azithromycin increases survival and reduces lung inflammation in cystic fibrosis mice
Tsai WC, Hershenson MB, Zhao Y, Sajjan U, Inflammation Res, 1/1/2009
Airway smooth muscle hyperplasia and hypertrophy correlate with glycogen synthase kinase-3beta phosphorylation in a mouse model of asthma
Bentley JK, Deng H, Linn MJ, Dokshin GA, Lei J, Fingar DC, Bitar KN, Henderson HR and Hershenson MB, Am J Physiol: Lung Cell Mol Physiol, 1/1/2009
Airway smooth muscle in asthma
Hershenson MB, Brown M, Camoretti-Mercado B, Solway J, Annu Rev Pathol Mech Dis, 1/1/2008
Burkholderia cenocepacia ET12 strain activates TNFR1 signaling in cystic fibrosis airway epithelial cells
Sajjan US, Hershenson MB, Forstner J, LiPuma J, Cell Microbiol, 1/1/2008
Deng H, Dokshin G, Goldsmith AM, Bitar KN, Fingar DC, Hershenson MB, Bentley JK, J Biol Chem, 1/1/2008
Human rhinovirus 1B exposure induces PI 3-kinase-dependent airway inflammation in mice
Newcomb DC, Sajjan US, Nagarkar DR, Wang Q, Nanua S, Zhou Y, Hennrick KT, Tsai WC, Bentley JK, Lukacs NW, Johnston SL, Hershenson MB, Am J Respir Crit Care Med, 1/1/2008
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Press Mentions

Preserving Future Generations of Pediatric ResearchersApril 25th, 2018

Grant Support

TLR2 and Rhinovirus-induced Asthma ExacerbationsNHLBI2016–2020
Early-life Rhinovirus Infection and Childhood AsthmaNIAID2015–2020
Respiratory Viral Infection and microRNA in Children with AsthmaNIAID2015–2017
Mechanisms of Airway Smooth Muscle HypertrophyNHLBI2012–2017
Rhinovirus And Airway Epithelial Cell ResponsesNational Heart, Lung, And Blood Institute2006–2012
Mechanisms Of Airway Smooth Muscle HypertrophyNational Heart, Lung, And Blood Institute2006–2011
Multipotent Lung Mesenchymal Cells In Neonatal Lung InjuryNational Heart, Lung, And Blood Institute2007–2010
Rhinovirus And COPD ExacerbationsNational Heart, Lung, And Blood Institute2005–2009
Quercetin Treatment Of Airway InflammationNational Center For Complementary &Alternative Medicine2005–2006
Signal Transduction And Airway Smooth Muscle HyperplasiaNational Heart, Lung, And Blood Institute2003
RAC 1 Signaling Pathway In Airway Smooth MuscleNational Heart, Lung, And Blood Institute2002
Signal Transduction And Airway Smooth Muscle HyperplasiaNational Heart, Lung, And Blood Institute1995–2002
RAC 1 Signaling Pathway In Airway Smooth MuscleNational Heart, Lung, And Blood Institute1999–2001
Airway Reactivity And Remodeling After 02 ExposureNational Heart, Lung, And Blood Institute1992–1996