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Office
Peter O'Donnell Jr. Brain Institute
6124 Harry Hines Blvd.
Dallas, TX 75390Phone+1 214-648-8858
Summary
- Marc Diamond, M.D., is the founding director of the Center for Alzheimer's and Neurodegenerative Diseases (CAND). The CAND is a multidisciplinary translational research program comprised of 11 faculty members who are focused on fundamental disease mechanisms. Its mission is to develop more effective diagnosis and therapy for Alzheimer's and related disorders.
Marc's original discoveries linked common conditions such as Alzheimer's to rare infectious prion disorders such as Creutzfeldt-Jakob and "mad cow" disease. His lab determined that abnormal assemblies of the tau protein move between cells and serve as templates for their own replication, and has elucidated the mechanisms of this process. This has transformed our understanding of how different neurodegenerative diseases arise and why they progress. His ideas underlie new treatment strategies currently being pursued by the pharmaceutical industry, and his methods are employed worldwide for neurodegenerative diseases research.
Marc studied history at Princeton, and received his M.D. (1993) at UCSF, where he then completed residency training in Neurology in 1997, serving as chief resident in his final year. At UCSF he worked with Keith Yamamoto, Ph.D. as a Howard Hughes Medical Student Research Fellow (1989-1991) and as a postdoctoral fellow (1997-2001). He was a faculty member in the Department of Neurology at UCSF from 2002-2009, before moving to Washington University in St. Louis in 2009 as the David Clayson Professor of Neurology. Since 2014, he has been a professor of Neurology and Neuroscience at UT Southwestern Medical Center.
Marc is an internationally recognized expert in neurodegenerative disease, and lectures frequently at major universities and scientific meetings around the world. His research has been cited thousands of times by his scientific colleagues.
Education & Training
- University of California (San Francisco)Residency, Neurology, 1994 - 1997
- University of California (San Francisco)Internship, Internal Medicine, 1993 - 1994
- University of California San Francisco School of MedicineClass of 1993
- Princeton UniversityAB, History, 1983 - 1987
Certifications & Licensure
- CA State Medical License 1995 - 2020
- TX State Medical License 2015 - 2019
- MO State Medical License 2009 - 2015
Publications & Presentations
PubMed
- High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics.Yufen Xiao, Xizhen Lian, Yehui Sun, Yun-Chieh Sung, Amogh Vaidya
Nature Materials. 2025-02-28 - TDP-43 Aggregate Seeding Impairs Autoregulation and Causes TDP-43 Dysfunction.Lohany Dias Mamede, Miwei Hu, Amanda R Titus, Jaime Vaquer-Alicea, Rachel L French
Biorxiv. 2025-02-12 - Functional classification of tauopathy strains reveals the role of protofilament core residues.Jaime Vaquer-Alicea, Victor A Manon, Vaibhav Bommareddy, Peter Kunach, Ankit Gupta
Science Advances. 2025-01-24
Journal Articles
- Parkinson’s Disease and Multiple System Atrophy Have Distinct Α-synuclein Seed CharacteristicsBrandon B. Holmes, Tritia R. Yamasaki, Marc I. Diamond, Nigel J. Cairns, Paul T. Kotzbauer, The Journal of Biological Chemistry
Press Mentions
- O’Donnell Brain Institute Experts Highlight Hope for Dementia Patients, Power of Music at UTSW-Dallas Opera EventFebruary 4th, 2025
- Why Do People Respond to Stress and Trauma so Differently? The Emerging Field of Neuroresilience May Have AnswersAugust 8th, 2024
- A Rare Variant of APOE Delays Alzheimer's Disease Onset by Decades Now the Field Is Focused on Learning HowDecember 5th, 2019
- Join now to see all
Grant Support
- Cell-Cell Transfer And Propagation Of TAU AggregatesNational Institute Of Neurological Disorders And Stroke2010–2012
- Developing A Mouse Retinal Model Of Neurodegenerative DiseaseNational Institute Of Neurological Disorders And Stroke2011
- Efficacy And Mechanism Of Novel Androgen Receptor InhibitorsNational Cancer Institute2010
- Regulation Of Polyglutamine Aggregation And ToxicityNational Institute Of Neurological Disorders And Stroke2009
- Efficacy And Mechanism Of Novel Androgen Receptor InhibitorsNational Cancer Institute2008–2009
- Regulation Of Polyglutamine Aggregation And ToxicityNational Institute Of Neurological Disorders And Stroke2006–2009
- Cell And Molecular Screens Of Polyglutamine ToxicityNational Institute Of Neurological Disorders And Stroke2003–2004
- Polyglutamine-Induced Neurodegeneration In SBMANational Institute Of Neurological Disorders And Stroke1997–2001
External Links
- Lab Websitehttp://www.utsouthwestern.edu/labs/diamond/
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