MaheswariSenthilMD

General Surgery • Orange, CA

Surgical Oncology (Other than Breast)

Professor of Surgery, University of California-Irvine

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Office
University of California-Irvine
101, City Drive South
Orange, CA 92868
Phone+1 714-456-8000

Fax+1 855-211-3729

Summary

Dr. Maheswari Senthil is a surgical oncologist at University of California- Irvine with a special expertise in the management of patients with peritoneal carcinomatosis, sarcoma, gastric cancer, and advanced malignancies. She has successfully performed several hundreds of Cytoreductive surgeries and HIPEC with excellent outcomes. Dr. Senthil is conducting many clinical trials to treat peritoneal carcinomatosis. Her treatment principle is to provide the best care through innovation, research, collaboration, and technical excellence. Her objective is to help patients achieve healthy survivorship by healing their mind, body, and spirit.
Dr. Senthil is also a highly-respected educator. She considers it a privilege to train future generation of surgeons. She founded the complex general surgical oncology fellowship at Loma Linda University Health in 2015. She has received numerous awards for her commitment and dedication to educational excellence. Dr. Senthil has conducted many important research projects that address critical clinical questions and disparities. Several of her research papers are published in JAMA Surgery and Annals of Surgical Oncology.

Education & Training

Rutgers Health/New Jersey Medical SchoolResidency, Surgery, 2001 - 2008
Madurai Medical CollegeClass of 1998

Certifications & Licensure

CA State Medical License 2008 - 2025
NJ State Medical License 2002 - 2006
American Board of Surgery Surgery

Awards, Honors, & Recognition

Healing Hands Loma Linda University, 2019
Excellence in Education Loma Linda University, 2019
Outstanding Chief Resident University of Medicine and Dentistry- New Jersey, 2008
Golden Apple Award for Excellence in Teaching UMDNJ, 2008
Alpha Omega Alpha Beta New Jersey Chapter, UMDNJ – New Jersey Medical School, 2008
Arnold P. Gold Award for leadership and Humanism Arnold P. Gold Foundation, 2008
Excellence in Medical Student Teaching UMDNJ – Department of Surgery, 2007
Outstanding Trauma Resident Award UMDNJ – Division of Trauma/Critical Care, 2006
Excellence in Teaching Award UMDNJ – Department of Surgery, 2006
Joseph Susman Memorial Award for Best Paper Presentation Surgical Infection Society of North America and Europe, 2005
Outstanding Manuscript Award, Basic Science Category American College of Surgeons – NJ Chapter, 2004
Academic Excellence Award UMDNJ – Department of Surgery, 2003-2006, 2008
Outstanding ICU Resident Award UMDNJ – Division of Trauma and Critical Care, 2003
Graduated Top 1% of the class Madurai Medical College, 1998
MGR University of Medicine MGR University of Medicine, 1995
Distinction in Anatomy and Physiology MGR University of Medicine, 1992
Fellow American College of Surgeons
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Clinical Trials

Adjuvant Hyperthermic Intraperitoneal Chemotherapy for Locally Advanced Gastric Cancer Start of enrollment: 2016 Feb 02
Completed
Phase 1

Publications & Presentations

PubMed

ASO Visual Abstract: Disparities in Palliative Treatment Utilization in Patients with Metastatic Colorectal Cancer.
Shaina Sedighim, Rhami Khorfan, Jordan Shin, Aaqil Khan, Yixuan Irene Tang
Annals of Surgical Oncology. 2024-12-31
Cytoreduction and Heated Intraperitoneal Chemotherapy in Gastric Peritoneal Carcinomatosis: Selection is Key.
Maheswari Senthil, Farshid Dayyani
Annals of Surgical Oncology. 2024-12-01
Disparities in Palliative Treatment Utilization in Metastatic Colorectal Cancer Patients.
Shaina Sedighim, Rhami Khorfan, Jordan Shin, Aaqil Khan, Yixuan Irene Tang
Annals of Surgical Oncology. 2024-11-22

Journal Articles

Sexual and Urinary Outcomes in Robotic Rectal Surgery: Review of the Literature and Technical Considerations
Matthew J Selleck, Danielle K Craigg, Mark E Reeves, Maheswari Senthil, Fabrizio Luca, Carlos A Garberoglio, Updates in Surgery
Aryl hydrocarbon receptor ligand 5F203 induces oxidative stress that triggers DNA damage in human Breast cancer cells
Mclean LS, Watkins CN, Campbell P, Zylsatra D, Rowland L, Amis LH, Scott L, Babb CE, Livingston WJ, Darwanto A, Davis WL Jr, Senthil M, Sowers LC, Brantley E, Chem Res Toxicol, 1/1/2015
Role of the cancer center when using lymph node count as a quality measure for gastric cancer surgery
Morgan JW, Ji L, Friedman G, Senthil M, Dyke C, Lum SS, JAMA Surg, 1/1/2015
Extranodal extension on sentinel lymph node dissection; why should we treat it differently?
Choi AH, Surrusco M, Rodriguez S, Bahjri K, Solomon N, Garberoglio C, Lum S, Senthil M, Am Surg, 1/1/2014
A shortened activated partial thromoboplastin time predicts the risk of catheter associated venous thrombosis in cancer patients
Senthil M, Chaudhary P, Smith DD, Ventura PE, Frankel PH, Pullarkat V, Trisal V, Thromb Res, 1/1/2014
The American Society of Peritoneal Surface Malignancies multi-institution evaluation of the peritoneal surface disease severity score in 1013 patients with colorectal ...
Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Portilla A, Gonzalez-More..., Ann Surg Oncol, 1/1/2014
The American Society of Peritoneal Surface Malignancies evaluation of HIPEC with mitomycinc C versus oxaliplatin in 539 patients with colon cancer undergoing a complet...
Prada-Villaverde A, Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Porti..., J Surg Oncol, 1/1/2014
The Prevalence of overweight and obesity in a breast clinic population: consideration for weight loss as a therapeutic intervention
Kim A, Scharf K, Senthil M, Solomon N, Garberoglio C, Lum SS, Surg Obes Relat Dis, 1/1/2014
Assessment of clinical benefit and quality of life in patient undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for management of peritone...
Senthil M, J Gastrointest Oncol, 1/1/2013
Rate of Re-Excision after Breast-Conserving Surgery for Invasive Lobular Carcinoma
ML Wanis, JA Wong, S Rodriguez, JM Wong, B Jabo, A Ashok, SJ Lum, N L Solomon, ME Reeves, CA Garberoglio, M Senthil, American Surgeon, 1/1/2013
Identification of natural compound by cell-based screening that enhances interferon regulatory factor-1 activity and causes tumor suppression
J Gao, Y Wang, Q Xing, J Yan, M Senthil, Y Akmal, CM Kowolik, J Kang, DM Lu, M Zhao, Z Lin, CH Cheng, RM Yip, JH Yim, Mol cancer Ther, 1/1/2011
Allkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development
R Buettner, R Corzano, R Rashid, J Lin, M Senthil, M Hedvat, A Schroeder, A Mao, A Herrmann, J Yim, H Lin, YC Yuan, YC Yuan, K Yakushijin, F Yakushijin, N Vaidehi R M..., ACS Chem Biol, 1/1/2011
Transarterial Radioembolization with Yttrium-90 for Regional Management of Hepatocellular Cancer: The Early Results of a Non-Transplant Center
A Holt, DW Wagman, M Senthil, S Mckenzie, H Marx, YJ Chen, N Vora, M.D., J Kim, Am Surg, 1/1/2010
IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1 induced apoptosis in cancer cells
J Gao, M Senthil, B Ren, J Yan, Q Xing, J Yu, L Zhang, JH Yim, Cell Death Differ, 1/1/2010
Liver-directed therapies in the multidisciplinary management of Hepatocellular cancer
M Senthil, B Mailey, L leong, V Chung, Y Yen, YJ Chen, H Marx, J Kim, Curr Cancer Ther Rev, 1/1/2010
Bicavitary hyperthermic chemotherapy in the management of pseudomyxoma peritoneii with pleural extension
M Senthil, LE Harrison, Arch Surg, 1/1/2009
Mesenteric Lymph duct ligation improves survival in lethal shock model
C Badami, M Senthil, FJ Caputo, BJ Rupani, Doucet D, Pisarenko V, Xu DZ, EA Deitch, Shock, 1/1/2008
Trauma- Shock-induced gut injury and the production of biologically active intestinal lymph is abrogated by castration in a large animal model
EA Deitch, M Senthil, M Brown, F Caputo, A Watkins, D Anjaria, C Badami, V Pisarenko, D Doucet, Q Lu, E Feketeova, DZ Xu, Shock, 1/1/2008
Trauma hemorrhage-induced gut barrier failure and the production of biologically active intestinal lymph requires pancreatic proteases
FJ Caputo, B Rupani, AC Watkins, DBarlos, D Vega, M Senthil, EA. Deitch, Shock, 1/1/2007
Intravenous injection of Trauma- hemorrhagic shock mesenteric lymph causes lung injury that is dependent upon activation of the inducible nitric oxide synthase pathway
M Senthil, M.D., A Watkins, M.D., D Barlos, M.D., DZ Xu M.D., PhD, Q Lu M.D., B Abungu B.Sc., R Feinman PhD, EA. Deitch, M.D., Ann Surg, 1/1/2007
Gut- Lymph Hypothesis of SIRS/MODS: Validating studies in a Porcine Model
M Senthil, M.D., M Brown M.S.N., DZ Xu, M.D.,PhD., Q Lu, M.D., E Feketeova M.D., EA. Deitch, M.D., J Trauma, 1/1/2006
Albumin peptide: a molecular marker for trauma / hemorrhagic-shock in rat mesenteric lymph
VL Kaiser, Z Sifri, M Senthil, G S Dikdan, Q Lu, DZ Xu, EA. Deitch, Peptides, 1/1/2005
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Books/Book Chapters

Acute Care Surgery
Chapter: Principles And Practice Of Nutritional Support In Surgical Patients
M Senthil, BJ Rupani , JH Jabush, EA DeitchEditors: Britt LD, Trunkey DD, Organ CH, Feliciano DV.Springer Verlag2007

Abstracts/Posters

Transarterial Radioembolization with Yttrium-90 for Regional Management of Hepatocellular Cancer: The Early Results of a Non-Transplant Center
A Holt, DW Wagman, M Senthil, S Mckenzie, H Marx, YJ Chen, N Vora, M.D., J Kim, American College of Surgeons- Southern California Chapter, Santa Barbara, California, 1/1/2010
Novel STAT3 inhibitor in the Treatment of Breast Cancer
M Senthil, Q Xing, J Yan, R Buettner, D Horne, R Jove, JH Yim, Sociaty of Surgical Oncology, St. Louis. Indianapoilis, 1/1/2010
Yttrium 90 Selective internal radiation treatment in the management of hepatic malignancies
M Senthil, B Mailey, N Vora L leong, H Marx, J Kim, ASCO GI, San Francisco, 1/1/2009
Yttrium 90 Microsphere Selective Internal Radiation Treatment In The Management Of Malignant Liver Tumors
M Senthil, YJ Chen , N Vora, H Marx, L Wagman, J Kim M.D., Society of Surgical Oncology, Phoenix, 1/1/2009
Disparities in Gastric Cancer Outcomes among Asian Ethnicities in the United States
B Mailey, M Senthil, A Artinyan, CL Sun, S Bhatia, J Kim, Society of Surgical Oncology, Phoenix, 1/1/2009
Trauma-hemorrhagic shock lymph kills multiple cell types and its toxicity is neutralized by albumin
Vega D, M Senthil, Q Lu, DZ Xu, EA Deitch, Shock Society Conference, Marco Islands, Florida, 1/1/2005
Pancreatic duct ligation reduces lymph toxicity, PMN activation and gut permeability following trauma / hemorrhagic shock
BJ Rupani, M Senthil, E Feketeova, Q Lu, EA Deitch, Committee on Trauma Conference, 1/1/2004
Extranodal extension on sentinel lymph node dissection. Why should we treat it differently?
AH Choi, MD, M Surrusco, S Rodriguez, K Bahjri, Naveen Solomon, C Garberoglio, S Lum, M Senthil, Southern California Chapter ACS, Santa Barbara, CA, 1/17/2014
Infusion of Trauma hemorrhagic Shock mesenteric lymph to normal rats recreates shock induced lung injury and decreases RBC deformability
M Senthil, DZ Xu, S Zaets, T Berezina, EA Deitch, Surgical Infection Society, 24th Annual Meeting, Indianapolis, IN, 1/29/2004
Rate of Re-Excision after Breast-Conserving Surgery for Invasive Lobular Carcinoma
ML Wanis, JA Wong, S Rodriguez, JM Wong, B Jabo, A Ashok, SJ Lum, N L Solomon, ME Reeves, CA Garberoglio, M Senthil, MD, Southern California Chapter ACS, Santa Barbara, CA, 1/18/2013
Natural Enhancer of IRF-1 Suppresses Gastric Cancer Tumor Growth in vivo
Y Akmal, Y Wang, M Senthil, Q Xing, J Yan, J Gao, and J Yim, Society of Surgical Oncology Annual Cancer Symposium, San Antonio, TX, 1/2./2011
Extract from Traditional Chinese Herb Scutellaria baicalensis Suppresses Tumors and Inhibits p-AKT in Mice
Y Akmal, M Senthil, Q Xing, J Yan, Y Wang, J Yim, ASCO Breast Cancer Symposium/Society of Surgical Oncology Annual Cancer Symposium, National Harbor, MD, 2010; San Antonio, TX, 2011, 1/2./2011
Combination of a Natural Compound (Baicalein) and Paclitaxel Resuls in Synergistic Apoptosis in Mouse Breast Cancer Cells
Y Akmal, M. Senthil, J. Yan, Q. Xing, Y. Wang, G. Somlo, J. Yim, Academic Surgical Congress, Huntington Beach, CA, 1/1./2011
A Flavone From Traditional East Asian Natural Extract Inhibits STAT3 and Tumor Growth in Syngeneic Mouse Breast Cancer Model
M Senthil, Y Akmal, Q Xing, J Yan, JH Yim, San Antonio Breast Cancer Symposium, San Antonio, Texas, 1/8./2010
Hospital type predicts for the adequacy of lymph node retrieval in colon cancer
M Senthil, V Trisal, IB Paz, LL Lai, City of Hope GI Multidisciplinary Conference/Pacific coast Surgical Association, Duarte, CA, 2010; Mauii, Hawaii, 2010, 1/13/2010
Shortened Partial thromboplastin predicts teh risk for catheter associated thrombosis in cancer patients
M Senthil, P Ventura, P Frankel, D Smith, V Pullarkat, V Trisal, Pacific coast Surgical Association, Mauii, Hawaii, 1/13/2010
Molecular staging - Is TNM staging obsolete?
M Senthil, Grand Rounds, UMDNJ – Department of Surgery, New Jersey Medical School, 1/26/2007
Partial HIF-1 Deficiency Attenuates Ischemia Reperfusion-Mediated Gut and Lung Injury
AC Watkins, B Abungu, M Senthil, Q Lu, D Barlos, L Prescott, FJ Caputo, BK McCracken, DZ Zu, M Bosch-Marce, GL Semenza, EA Deitch, R Feinmann, 29th Annual Conference on Shock, Broomfield, CO, 1/3./2006
Gut- Lymph Hypothesis of SIRS/MODS: Validating studies in a Porcine Model
M Senthil, M Brown, DZ Xu, Q Lu, E Feketeova, EA.Deitch, American Association for the Surgery of Trauma (AAST) 64th meeting, Atlanta, Georgia, 1/22/2005
Intravenous Injection of Trauma-Hemorrhagic Shock Mesenteric Lymph causes lung injury that is dependent upon activation of the inducible nitric oxide synthase pathway
M Senthil, DZ Xu, Q Lu, T Berezina, B Abungu, S Zaets, R Feinman, EA Deitch, Benjamin Rush Jr. Society Annual Conference, 1/20/2005
Pancreatic duct ligation reduces lymph toxicity, PMN activation and gut permeability following trauma / hemorrhagic shock
BJ Rupani, M Senthil, E Feketeova, Q Lu, EA Deitch, Surgical Infections Society Annual Conference, Miami, Florida, 1/5./2005
Intravenous Injection of Trauma-Hemorrhagic Shock Mesenteric Lymph causes lung injury that is dependent upon activation of the inducible nitric oxide synthase pathway
M Senthil, DZ Xu, Q Lu, T Berezina, B Abungu, S Zaets, R Feinman, EA Deitch, 2nd Joint meeting, Surgical Infection society and Surgical Infection Society- Europe, South Beach Miami, Florida, 1/5./2005
Intravenous Injection of Trauma-Hemorrhagic Shock Mesenteric Lymph causes lung injury and requires activation of the inducible nitric oxide synthase pathway
M Senthil , DZ Xu, S Zaets, T Berezina, EA Deitch, 53rd Annual Clinical meeting, New Jersey Chapter, American College of Surgeons, Parsippany, NJ, 1/4./2004
Trauma Hemorrhagic Shock induced lung injury is mediated via the nitric oxide pathway
M Senthil , DZ Xu, S Zaets, T Berezina, EA Deitch, UMD – New Jersey medical school, Department of Surgery, Trauma Grand Rounds, Newark, NJ, 1/9./2004
Mesenteric Lymph duct ligation improves survival in splanchnic artery occlusion shock
M Senthil, P Ananthakrishanan, BJ Rupani, DZ Xu, EA Deitch, 27th Annual Shock Society Conference, Novascotia, Canada, 1/5./2004
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Lectures

Gaps and Barriers to Research in Global South
American College of Surgeons - 10/20/2020
Management of Colorectal Liver Metastases
Chicago, IL - 1/27/2012
Management of colorectal cancer peritoneal carcinomatosis- Is nihilistic approach justified?
Santa Barbara, CA - 1/18/2013
Cytoreductive Surgery and Hyperthermic intraperitoneal chemotherapy - Anesthetic Management
1/20/2013
Management of Colorectal Peritoneal Carcinomatosis – Current standard of care
Loma Linda School of Medicine - 1/3./2013
Advances in Breast Cancer – Update
1/4./2013
Surgical management of peritoneal carcinomatosis
Sri Ramachandra Medical College, Chennai, India - 1/26/2013
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