LinmarieSikichMD

Child & Adolescent Psychiatry

Director, ASPIRE (Adolescent, School-age & Preschool Psychiatric Intervention Research and Evaluation) Program , University of North Carolina (UNC). Associate Professor, Division TEACCH and Division of Child and Adolescent Psychiatry, University of North Carolina (UNC).

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Office
101 Manning Dr
Chapel Hill, NC 27514
Phone+1 919-966-8596

Fax+1 919-843-5515

Education & Training

Yale-New Haven Medical CenterFellowship, Child and Adolescent Psychiatry, 1992 - 1995
Yale-New Haven Medical CenterResidency, Child and Adolescent Psychiatry, 1989 - 1992
Washington University in St. Louis School of MedicineClass of 1987

Certifications & Licensure

NC State Medical License 1995 - 2024
CT State Medical License 1991 - 1995
American Board of Psychiatry and Neurology Psychiatry
American Board of Psychiatry and Neurology Child & Adolescent Psychiatry

Clinical Trials

Treatment of Early Onset Schizophrenia Spectrum Disorders (TEOSS) Start of enrollment: 2002 Feb 01
Completed
Phase 4
Early Intervention With Fluoxetine in Autism Start of enrollment: 2005 Jul 01
Completed
Phase 2
Improving Metabolic Parameters of Antipsychotic Child Treatment With Ziprasidone, Aripiprazole, and Clozapine Start of enrollment: 2007 Mar 01
Terminated
Phase 2
Strategies to Reduce Antipsychotic-Associated Weight Gain in Youth Start of enrollment: 2007 Jan 01
Completed
Phase 2
Study of Aripiprazole to Treat Children and Adolescents With Autism Start of enrollment: 2006 Jan 01
Completed
Phase 2
Safety, Tolerability and Efficacy Study of STX209 in Subjects With Fragile X Syndrome Start of enrollment: 2008 Nov 01
Completed
Phase 2
Reducing Weight Gain and Improving Metabolic Function in Children Being Treated With Antipsychotics Start of enrollment: 2009 Jan 01
Completed
Phase 4
Biomarker Testing and DNA Collection in Subjects Participating in Protocol 22001 Start of enrollment: 2009 Jan 01
Completed
Open-Label Study of the Safety and Tolerability of STX209 in Subjects With Autism Spectrum Disorders Start of enrollment: 2009 Feb 01
Completed
Phase 2
Biomarker and DNA Collection in Subjects Participating in Protocol 22003 Start of enrollment: 2009 May 01
Completed
Ziprasidone in Early Onset Schizophrenia Spectrum Disorders Start of enrollment: 2002 Dec 01
Completed
Phase 2
FMRI Brain Activation of Aripiprazole Treatment in Autism Spectrum Disorders Start of enrollment: 2009 Aug 01
Completed
Phase 4
A Study of Oxytocin in Children and Adolescents With Autistic Disorder Start of enrollment: 2011 Mar 01
Completed
Phase 2
Brain Connectivity in Neurodevelopmental Disorders in Response to Treatment Start of enrollment: 2011 Sep 01
Completed
Study of Lurasidone in Treating Antipsychotic Naive or Quasi-Naive Children and Adolescents Start of enrollment: 2012 Dec 01
Completed
Phase 2
Lurasidone Pediatric Autism Study Start of enrollment: 2013 Aug 01
Completed
Phase 3
Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors Start of enrollment: 2014 Aug 01
Completed
Phase 2
Brain Imaging of Intranasal Oxytocin Treatment in Autism Start of enrollment: 2014 Sep 01
Completed
Phase 1
Oxytocin Levels in Typically Developing Boys Start of enrollment: 2013 Dec 01
Completed
Cortical Metrics in Intervention Trials With Autism Spectrum Disorders Start of enrollment: 2015 Aug 01
Withdrawn
Phase 2, Phase 3
Long-term Antipsychotic Pediatric Safety Trial Start of enrollment: 2019 Jan 10
Completed
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Publications & Presentations

PubMed

1321 citations
Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
Tom Walsh, Jon McClellan, Shane McCarthy, Anjené M. Addington, Sarah B. Pierce
Science. 2008-04-25
11 citations
Pragmatic adaptations of telehealth-delivered caregiver coaching for children with autism in the context of COVID-19: Perspectives from the United States and South Afr...
Lauren Franz, Jill Howard, Marisa Viljoen, Linmarie Sikich, Tara Chandrasekhar
Autism. 2021-06-08
356 citations
Aripiprazole in the treatment of irritability in children and adolescents with autistic disorder.
Randall Owen, Linmarie Sikich, Ronald N. Marcus, Patricia K. Corey-Lisle, George Manos
Pediatrics. 2009-12-01

Press Mentions

'Feel Good' Hormone Won't Help Ease Kids' Autism, Study FindsOctober 14th, 2021
Study: 'Sociability' Hormone Didn't Help Kids with AutismOctober 13th, 2021
Intranasal Oxytocin Ineffective for Autism in Large TrialOctober 13th, 2021
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Grant Support

2/3-Improving Metabolic Parameters Of Antipsychotic Child TreatmentNational Institute Of Mental Health2008–2011
Mitochondrial Localization Of Proteins Containing Coiled Coil-Helix DomainsNational Center For Research Resources2010
Intensive Brain Training In Early Onset Schizophrenia &Schizoaffective DisorderNational Institute Of Mental Health2009–2010
Clinical Trial: Pediatric Pharmacokinetic And Tolerability Study Of Lithium ForNational Center For Research Resources2008
Clinical Trial: Metformin Mitigation Of Antipsychotic-Induced Metabolic DysregulNational Center For Research Resources2008
Treatment Of Early Onset Schizophrenia Spectrum (TEOSS)National Institute Of Mental Health2004–2006
Treatment Of Psychotic Disorders In YouthNational Institute Of Mental Health2002–2006
Treatment ProjectNational Institute Of Mental Health2002