LindenHuMD

PubMed

• 30 citations
  A selective antibiotic for Lyme disease.
  Nadja Leimer, Xiaoqian Wu, Yu Imai, Madeleine Morrissette, Norman Pitt
  Cell. 2021-10-14
• 127 citations
  Lyme borreliosis.
  Allen C Steere, Franc Strle, Gary P Wormser, Linden T Hu, John A Branda
  Nature Reviews. Disease Primers. 2016-12-15
• 37 citations
  Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K.
  Ok Sarah Shin, Lloyd S. Miller, Robert L. Modlin, Shizuo Akira, Satoshi Uematsu
  Journal of Immunology. 2009-07-01

Journal Articles

• Oxford University Press Has Registered This DOI Pre-Publication  
  Linden Hu, Mark S Klempner, Oxford University Press
• Evidence that the variable regions of the central domain of VlsE are antigenic during infection with Lyme disease spirochetes.  
  McDowell, J.V., Sung, S.Y., Hu, L.T., and R.T. Marconi, Infect. Immun
• Nest box deployed bait for delivering oral vaccines to white footed mice.  
  Telford III, SR, Cunningham, JA, Waltari, E. and LT Hu, Nest box deployed bait for delivering oral vaccines to white footed mice, Ticks and Tickborne Diseas
• Human Integrin 3 1 Functions as a Co-receptor Facilitating TLR2 Recognition of Lipopeptides from Endosomal Compartments.  
  Marre, M.L., Petnicki-Ocwieja, T., DeFrancesco, A., Darcy, C. and L.T. Hu, PLoS ONE
• Matrix metalloproteinase-9 plays a key role in Lyme arthritis but not dissemination of Borrelia burgdorferi.  
  Heilpern AJ, Wertheim W, He J, Perides G, Bronson RT, Hu LT, Infect Immun
• Distinct roles for MyD88 and toll-like receptors 2, 5 and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction.  
  Shin, O.S., Isberg, R.R., Akira, S. Uematsu, S., Behera, A.K. and L.T. Hu, Infect. Immun
• MyD88 deficiency results in tissue specific changes in cytokine induction and inflammation in Borrelia burgdorferi infected mice that are IL-18 independent.  
  Behera, A.K., Hildebrand, E., Bronson, R., Perides, G. and L.T. Hu, Infection and Immunity
• Protective efficacy of an oral vaccine to reduce carriage of Borrelia burgdorferi (strain N40) in mouse and tick reservoirs.  
  Scheckelhoff, M.R., Telford, S.R., and L.T. Hu, Vaccine
• Borrelia burgdorferi induced expression of matrix metalloproteinases from human chondrocytes requires MAPK and JAK/STAT signaling pathways.  
  Behera, A.K., Thorpe, C.M., Kidder, J.M., Smith, W., and L.T. Hu, Infect Immun
• Phospholipid synthesis in Borrelia burgdorferi: BB0249 and BB0721 encode functional phosphatidylcholine synthase and phosphatidylglycerolphosphate synthase proteins.  
  Wang, X.G., Scagliotti, J.M., and L.T. Hu, Microbiology
• Analysis of differences in the functional properties of five related oligopeptide permease A (OppA) proteins of Borrelia burgdorferi.  
  Wang, X.G., Kidder, J.M., Scagliotti, J.P., Klempner, M.S., Noring, R., and L.T. Hu, J. Bacteriol
• Cognitive functioning in post-treatment Lyme disease.  
  Kaplan, R.F., Trevino, R.P., Johnson, G.M., Levy, L., Dornbush,R.L., Hu, L.T.,., Evans, J., Weinstein, A., Schmid, C.H. and M.S. Klempner, Neurol
• Effects of environmental changes on expression of the opp genes of Borrelia burgdorferi.  
  Wang, X.G., Lin, B. Kidder, J.M., Telford, S., and L.T. Hu, J. Bacteriol
• Host-pathogen interactions in the immunopathogenesis of Lyme disease.  
  Hu, L.T., and M.S. Klem, J. Clin. Immunol
• Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease.  
  Klempner, M.S., Hu, L.T., Evans, J., Schmid, C.H., Johnson, G., Trevino, R., Norton, L., Levy, L., Wall, D. McCall, J. Kosinski, M. and A. Weinstein, New Engl J Med
• Differences in synovial fluid levels of matrix metalloproteinases suggest separate mechanisms of pathogenesis in pre and post antibiotic treated Lyme arthritis.  
  Lin, B, Kidder, J.M., Noring, R., Steere, A.C., Klempner, M.S., and L.T. Hu, J. Infect. Dis
• Host metalloproteinases in Lyme arthritis.  
  Hu, L.T., Eskildsen, M.A., Masgala, C., Steere, A.C., Arner, E.C., Pratta, M.A., Grodzinsky, A.J., Loening, A. and G. Perides, Arthr. Rheum
• Functional testing of a putative oligopeptide permease protein Borrelia burgdorferi: a complementation model in opp- Escherichia coli.  
  Lin, B., Eskildsen, M., Short, S.A., Klempner, M.A.., and L.T. Hu, Biochim. Biophys. Acta
• Intralaboratory reliability of serologic and urine testing for Lyme disease.  
  Klempner, M.S., Schmid, C., Hu, L.T., Steere, A.C., Aguero-Rosenfeld, M.E., Wilson, M., Johnson G., McCloud, B., Noring, R., and A. Weinstein, Am. J. Med
• Soluble CD14 levels in the serum, synovial fluid and cerebrospinal fluid of patients with various stages of Lyme disease.  
  Lin, B., Noring, R., Steere, A., Klempner, M.S., and L.T Hu, J. Infect. Dis
• Isolation, cloning and expression of a 70 kDa plasminogen binding protein of Borrelia burgdorferi.  
  Hu, L.T., Pratt, S.D., Perides, G., Katz, L., Rogers, R.A. and M.S. Klempner, Infect. Immun
• Binding of human plasminogen to Borrelia burgdorferi.  
  Hu, L.T., Perides, G., Noring, R. and M.S. Klempner, Infect. Immun
• Update on Lyme arthritis.  
  Hu. L.T, Infect. Dis. Clin. N.A
• Bacterial and Lyme arthritis.  
  Ross, J.R. and L.T. Hu, Curr. Infect. Dis. Rep
• Septic Arthritis of the Pubic Symphysis: a review of 100 cases.  
  Ross, J.R. and L.T. Hu, Medicine
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Books/Book Chapters

• Infectious Diseases and Antimicrobial Therapy of the Ears, Nose and Throat. 
  Chapter: Lyme Disease 
  Page 533 - 542Hu, L.T. and M.S. KlempnerEditors: V.L. Yu and J.T. Johnson.W. B. Saunders Co, Philadelphia
• Prevention of Lyme disease and Other Tick Borne Infections. 
  Chapter: Infect. 
  Page 381 - 396Clark, R. and L.T. HuEditors: J. Edlow. Dis. Clinics
• Fitzpatrick’s Dermatology in General Medicine. 
  Chapter: Lyme Borreliosis, Chapter 187 
  Mahalingam, M, Bhawan, J., Chomat, A.M. and L.T. HuK. Wolff, McGraw-Hill, N.YEdition 7th,
• Bacterial Infections of Humans. 
  Chapter: Lyme Disease, chapter 22 
  Clark, R. and L.T. HuEditors: A.S. Evans and P. Brachman.Springer, N.YEdition 4th,
• UpToDate. 
  Chapter: Treatment of Lyme Disease 
  Hu, L.TEditors: D.S. Basow.UpToDate, Waltham, MA
• UpToDate. 
  Chapter: Clinical Manifestations of Lyme Disease 
  Hu, L.TEditors: D.S. Basow.UpToDate, Waltham, MA
• Molecular biology, host interaction and pathogenesis. 
  Chapter: Pathobiology of Lyme disease Borrelia 
  Norris, S.J., Coburn, J.L., Leong, J.M., Hu, L.T., and M. HookEditors: D.S. Samuels and J.D. Radolf.Caister Academic Press
• Preventing Occupational Disease and Injury. 
  Chapter: Lyme disease 
  Page 326 - 330Hu, L.T. and S. HatchEditors: Levy, B.S., Wagner, G.R., Rest K.M. and J.L. Weeks.American Public Health Association, Washington D.C
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Abstracts/Posters

• Detection of a 130kDa matrix metalloproteinase in cerebrospinal fluid in a patient with Lyme neuroborreliosis.
  Hu, L.T., Perides, G., Tanner, L.M. and M.S. Klempner, Clin. Infect. Dis

Lectures

• Role of host protease in immunomodulation by B. burgdorferi. 
  Biology of Spirochetes, Gordon Research Conference
• Eavesdropping on host communications: Utilization of inflammatory signals in environmental adaptation. 
  B. burgdorferi, Dept of Infectious Diseases, Boston University School of Medicine
• Controlling Lyme Disease: Reservoir targeted vaccines, propranolol and the role of innate immune activation through Toll-like receptors. 
  Dept of Microbiology and Immunology, NY Medical College
• Mechanisms of Phagocytosis of Borrelia burgdorferi by Macrophages. 
  The 11th International Conference on Lyme Borreliosis and other Tick-borne diseases, LosAngeles, CA
• Eating disorders take their Toll. 
  Multiple locations, 2007, 2009
• Controlling Lyme Disease. 
  Maine Medical Center, Grand Rounds
• Mechanisms of Innate Immunity in Lyme Disease. 
  Biology of Spirochetes, Gordon Research Conference, Ventura, CA
• Taking the Toll road to intracellular signaling. 
  Laboratory of Clinical Infectious Disease, National Institutes of Health, Bethesda, MD
• Lyme with a Twist: could the experts be wrong. 
  Rhode Island Hospital, Brown University
• The Inside Scoop on Toll like receptor signaling. 
  Multiple locations, 2010, 2011
• Ticked off: Vector based approaches to prevention and diagnosis of Lyme disease. 
  Multiple locations, 2010, 2012
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Other

• Diagnosis of Lyme disease 
  Hu L
  http://www.uptodate.com/contents/diagnosis-of-lyme-disease
  UpToDate, Wolters Kluwer Health - 2012-11-20
• Treatment of Lyme disease 
  Hu L
  http://www.uptodate.com/contents/treatment-of-lyme-disease
  UpToDate, Wolters Kluwer Health - 2012-10-03
• Clinical manifestations of Lyme disease in adults 
  Hu L
  http://www.uptodate.com/contents/clinical-manifestations-of-lyme-disease-in-adults?source=see_link&a
  UpToDate, Wolters Kluwer Health - 2013-02-05
• Evaluation of a tick bite for possible Lyme disease 
  Hu L
  http://www.uptodate.com/contents/evaluation-of-a-tick-bite-for-possible-lyme-disease
  UpToDate, Wolters Kluwer Health - 2012-08-07
• Lyme carditis 
  Hu L
  http://www.uptodate.com/contents/lyme-carditis
  UpToDate, Wolters Kluwer Health - 2012-02-23
• Lyme disease symptoms and diagnosis 
  Hu L
  http://www.uptodate.com/contents/lyme-disease-symptoms-and-diagnosis-beyond-the-basics
  UpToDate, Wolters Kluwer Health - 2013-02-21
• What to do after a tick bite to prevent Lyme disease 
  Hu L
  http://www.uptodate.com/contents/what-to-do-after-a-tick-bite-to-prevent-lyme-disease-beyond-the-bas
  UpToDate, Wolters Kluwer Health - 2011-02-09
• Immunopathogenesis of Lyme disease 
  Hu L
  http://www.uptodate.com/contents/immunopathogenesis-of-lyme-disease
  UpToDate, Wolters Kluwer Health - 2012-02-23
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