LeslieM.TharenosMDMPH

Occupational Medicine • Saint Louis, MO

Senior Research Physician/Principal Investigator

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Office
605 Old Ballas Rd Suite 220
Saint Louis, MO 63141
Phone+1 314-692-2100

Summary

Principal Investigator (PI) and board-certified occupational/preventive medicine physician with extensive experience in clinical research, public health, and clinical practice. I have served as PI on over 150 Phase 2,3, and 4 clinical trials spanning over 40 therapeutic areas. As a clinical site leader, I am responsible for study oversight, study conduct, management of physicians and staff, study feasibility, sponsor relations, and site growth. I facilitate training and mentoring of newly-hired research physicians, and have established a reputation for quality care and patient safety within our global network.

Education & Training

University of Illinois College of Medicine at ChicagoResidency, Occupational and Environmental Medicine, 2003 - 2005
University of IllinoisMPH, 2003 - 2005
St Louis University School of MedicineInternship, Transitional Year, 2001 - 2002
University of Missouri-Columbia School of MedicineClass of 2001
University of North Carolina at Chapel HillBA, Biology, Manga Cum Laude, 1993 - 1997

Certifications & Licensure

MO State Medical License 2003 - 2026
American Board of Preventive Medicine Occupational Medicine

Awards, Honors, & Recognition

Occupational Medicine Resident Research Award ACOEM, 2005

Clinical Trials

A Study to Evaluate ITCA 650 for the Treatment of Type 2 Diabetes Start of enrollment: 2013 Mar 01
Completed
Phase 3
Cardiovascular Outcomes Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects With Cardiovascular Risk Factors (The Light Study) Start of enrollment: 2012 Jun 01
Terminated
Phase 3
An Open-label, Long-term, Safety Study of Lasmiditan for the Acute Treatment of Migraine Start of enrollment: 2015 Oct 07
Completed
Phase 3
Efficacy and Safety of Subcutaneous Administration of Fremanezumab (TEV-48125) for the Preventive Treatment of Migraine Start of enrollment: 2016 Feb 26
Completed
Phase 3
Naltrexone/Bupropion Cardiovascular Outcomes Study Start of enrollment: 2016 Jan 01
Terminated
Phase 4
Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip Start of enrollment: 2016 Feb 17
Completed
Phase 3
Clinical Trial to Evaluate the Immunogenicity of Chikungunya Vaccine Start of enrollment: 2017 Apr 17
Completed
Phase 1
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Publications & Presentations

PubMed

6 citations
Long-term efficacy and immunogenicity of Ad26.RSV.preF-RSV preF protein vaccine (CYPRESS): a randomised, double-blind, placebo-controlled, phase 2b study.
Ann R Falsey, Tessa Hosman, Arangassery Rosemary Bastian, Sjouke Vandenberghe, Eric K H Chan
The Lancet. Infectious Diseases. 2024-09-01
17 citations
Efficacy and Safety of Respiratory Syncytial Virus (RSV) Prefusion F Protein Vaccine (RSVPreF3 OA) in Older Adults Over 2 RSV Seasons.
Michael G Ison, Alberto Papi, Eugene Athan, Robert G Feldman, Joanne M Langley
Clinical Infectious Diseases. 2024-06-14
19 citations
Respiratory Syncytial Virus Prefusion F Protein Vaccine Is Efficacious in Older Adults With Underlying Medical Conditions.
Robert G Feldman, Raffaele Antonelli-Incalzi, Katie Steenackers, Dong-Gun Lee, Alberto Papi
Clinical Infectious Diseases. 2024-01-25

Professional Memberships

American College of Occupational and Environmental Medicine - ACOEM
Member