Leslie A Spikes MD

Pulmonology•Kansas City, KS

Critical Care Medicine, Pleural Disease

Assistant Professor, Internal Medicine, University Kansas School of Medicine

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University of Kansas Medical Center 3901MS 3007Kansas City, KS 66160
Phone+1 913-588-6046
Fax+1 913-888-8814

Education & Training

University of Kansas School of MedicineFellowship, Pulmonary Disease and Critical Care Medicine, 2007 - 2010
University of Kansas School of MedicineResidency, Internal Medicine, 2004 - 2007
University of Kansas School of MedicineClass of 2004

Certifications & Licensure

MO State Medical License 2021 - 2026
KS State Medical License 2007 - 2025
American Board of Internal Medicine Critical Care Medicine
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

Patient-Centered Specialty Practice Recognition Program National Committee for Quality Assurance, 2014-2017
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

Clinical Study of Macitentan in Patients With Pulmonary Arterial Hypertension to Psychometrically Validate the PAH-SYMPACT Instrument Start of enrollment: 2013 Apr 01
Completed
Phase 3
Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension RANGER Start of enrollment: 2017 Apr 18
Terminated
Phase 3
Phase 2 Study to Assess Safety, Tolerability and Efficacy of Once Weekly SC Pemziviptadil (PB1046) in Subjects With Symptomatic PAH Start of enrollment: 2018 Jul 15
Terminated
Phase 2
Long-Term, Open Label Extension Study of Pemziviptadil (PB1046) in PAH Subjects Following Completion of Study PB1046-PT-CL-0004 Start of enrollment: 2019 Apr 10
Terminated
Phase 2
Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS). Start of enrollment: 2020 Jul 15
Terminated
Phase 2
COVID-19 Biorepository Start of enrollment: 2020 Apr 15
ACTIVE_NOT_RECRUITING
A Study of Rodatristat Ethyl in Patients With Pulmonary Arterial Hypertension (ELEVATE 2) Start of enrollment: 2021 Mar 15
Completed
Phase 2
Post COVID-19 Biorepository Start of enrollment: 2021 Feb 08
RECRUITING
Roles: Principal Investigator
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Publications & Presentations

PubMed

1 citations
Burden of illness in patients with pulmonary hypertension due to interstitial lung disease: a real-world analysis.
Gustavo Heresi, Bonnie Dean, Benjamin Wu, Henry Lee, Margaret R Sketch
BMC Pulmonary Medicine. 2024-07-11
67 citations
Persistent circulation of soluble and extracellular vesicle-linked Spike protein in individuals with postacute sequelae of COVID-19.
Vaughn Craddock, Aatish Mahajan, Leslie Spikes, Balaji Krishnamachary, Anil K Ram
Journal of Medical Virology. 2023-02-01
3 citations
Safety and efficacy of RT234 vardenafil inhalation powder on exercise parameters in pulmonary arterial hypertension: phase II, dose-escalation study design.
Raymond L Benza, Veronica Franco, Mandar A Aras, Leslie Spikes, Daniel Grinnan
Respiratory Research. 2022-12-17

Press Mentions

United Therapeutics Announces the Publication of Tyvaso DPI™ BREEZE Clinical and Long-Term Data in the Journal Pulmonary CirculationApril 6th, 2022
KC Doctors Worried About Number of COVID Deaths, Long-Hauler SymptomsJanuary 13th, 2022
United Therapeutics Presents Tyvaso DPI™ BREEZE Clinical Data at the European Respiratory Society International Congress 2021September 7th, 2021
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