LeonardMMilstoneMD

Physician

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Office
800 Howard Ave
# Yale
New Haven, CT 06519
Phone+1 203-785-2140

Fax+1 203-785-6414

Clinical Interests/Research
Leonard Milstone, MD, a Professor Emeritus of Dermatology at Yale, follows a large group of patients with ichthyosis and other genetic disorders of keratinization. These patients have stimulated a number of collaborative studies of genotype-phenotype correlations, trials of novel treatments for those diseases, and analysis of local and systemic effects of retinoids.

Laboratory Research
He studies the structure and function of epidermal keratinocytes and their proteins in vitro, in experimental animals, and in patients with ichthyosis. Past work includes: discovery of interferon gamma; identification and characterization of keratins 4 and 13; identification and characterization of epican, the CD44 proteoglycan unique to stratified squamous epithelia; elucidation of the genetic cause of ichthyosis with confetti; demonstration that epidermal desquamation can be harnessed to remove systemic toxins from the body; delivery of small nucleotides to epidermis for the purpose of gene editing

Yale-New Haven Medical CenterResidency, Dermatology, 1975 - 1977
Oregon Health & Science University (OHSU Health)Residency, Dermatology, 1971 - 1972
Oregon Health & Science University (OHSU Health)Internship, Internal Medicine, 1970 - 1971
Yale School of MedicineClass of 1970

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Fellow (FAAD) American Academy of Dermatology

PubMed

69 citations
CARD14-associated papulosquamous eruption: A spectrum including features of psoriasis and pityriasis rubra pilaris.
Brittany G. Craiglow, Lynn M. Boyden, Ronghua Hu, Marie Virtanen, John C Su
Journal of the American Academy of Dermatology. 2018-09-01
488 citations
Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorèze 2009
Vinzenz Oji, Gianluca Tadini, Masashi Akiyama, Claudine Blanchet Bardon, Christine Bodemer
Journal of the American Academy of Dermatology. 2010-10-01
4 citations
Association of the Severity of Alopecia With the Severity of Ichthyosis.
Elana Putterman, Theodore Zaki, Leonard M. Milstone, Keith A. Choate, Leslie Castelo-Soccio
JAMA Dermatology. 2019-09-01

Dermatologists Test a Promising Treatment for Skin Diseases That Often Target ChildrenFebruary 10th, 2023
Azitra Awarded NIH SBIR Grant to Develop Microbiome-Based Therapeutic for Netherton SyndromeAugust 1st, 2018

Frontiers In Ichthyosis ResearchNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2010
Dermatoremediation Of Iron OverloadNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2002–2010
Delivery Of Biologically Active Nucleic Acids To Epidermal CellsNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2009
Effects Of Retinoids On Calcium Metabolism And Bone MineralizationNational Center For Research Resources1996–1999
Homologous Recombination In Skin Cells For Gene TherapyNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1998
Gene Targeting In Normal Human KeratinocytesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1996
Epican, A Proteoglycan Form Of CD44 On KeratinocytesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1994–1996
Parathyroid Hormone-Like Peptide From KeratinocytesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1986–1991
Conference On Newly Described Keratinocyte FunctionsNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1988