LeonardMMilstoneMD

Physician

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Office
800 Howard Ave
# Yale
New Haven, CT 06519
Phone+1 203-785-2140

Fax+1 203-785-6414

Clinical Interests/Research
Leonard Milstone, MD, a Professor Emeritus of Dermatology at Yale, follows a large group of patients with ichthyosis and other genetic disorders of keratinization. These patients have stimulated a number of collaborative studies of genotype-phenotype correlations, trials of novel treatments for those diseases, and analysis of local and systemic effects of retinoids.

Laboratory Research
He studies the structure and function of epidermal keratinocytes and their proteins in vitro, in experimental animals, and in patients with ichthyosis. Past work includes: discovery of interferon gamma; identification and characterization of keratins 4 and 13; identification and characterization of epican, the CD44 proteoglycan unique to stratified squamous epithelia; elucidation of the genetic cause of ichthyosis with confetti; demonstration that epidermal desquamation can be harnessed to remove systemic toxins from the body; delivery of small nucleotides to epidermis for the purpose of gene editing

Yale-New Haven Medical CenterResidency, Dermatology, 1975 - 1977
Oregon Health & Science University (OHSU Health)Residency, Dermatology, 1971 - 1972
Oregon Health & Science University (OHSU Health)Internship, Internal Medicine, 1970 - 1971
Yale School of MedicineClass of 1970

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Fellow (FAAD) American Academy of Dermatology

PubMed

37 citations
Isolation and characterization of two polypeptides that form intermediate filaments in bovine esophageal epithelium.
Leonard M. Milstone
The Journal of Cell Biology. 1981-02-01
198 citations
First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder
Sancy A. Leachman, Robyn P. Hickerson, Mary E. Schwartz, Emily E. Bullough, Stephen L. Hutcherson
Molecular Therapy. 2010-02-01
135 citations
Mitotic Recombination in Patients with Ichthyosis Causes Reversion of Dominant Mutations in KRT10
Keith A. Choate, Yin Lu, Jing Zhou, Murim Choi, Peter M. Elias
Science. 2010-10-01

Dermatologists Test a Promising Treatment for Skin Diseases That Often Target ChildrenFebruary 10th, 2023
Azitra Awarded NIH SBIR Grant to Develop Microbiome-Based Therapeutic for Netherton SyndromeAugust 1st, 2018

Frontiers In Ichthyosis ResearchNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2010
Dermatoremediation Of Iron OverloadNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2002–2010
Delivery Of Biologically Active Nucleic Acids To Epidermal CellsNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2009
Effects Of Retinoids On Calcium Metabolism And Bone MineralizationNational Center For Research Resources1996–1999
Homologous Recombination In Skin Cells For Gene TherapyNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1998
Gene Targeting In Normal Human KeratinocytesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1996
Epican, A Proteoglycan Form Of CD44 On KeratinocytesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1994–1996
Parathyroid Hormone-Like Peptide From KeratinocytesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1986–1991
Conference On Newly Described Keratinocyte FunctionsNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1988