LeonardJosephApplemanMD

Oncology • Pittsburgh, PA

Genitourinary Oncology

Associate Professor, Medicine, University of Pittsburgh School of Medicine

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Office
5115 Centre Ave
Pittsburgh, PA 15232
Phone+1 412-692-4724

Fax+1 412-692-4905

Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 1998 - 2001
Beth Israel Deaconess Medical CenterResidency, Internal Medicine, 1995 - 1998
New York University School of MedicineClass of 1995

Certifications & Licensure

PA State Medical License 2006 - 2024
MA State Medical License 1998 - 2006
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

A Study of Imatinib and Docetaxel in Prostate Cancer Start of enrollment: 2005 Aug 01
Completed
Phase 2
Study of Oxaliplatin and Taxotere in Prostate Cancer Start of enrollment: 2004 Nov 01
Completed
Phase 2
MUC1 Vaccine in Conjunction With Poly-ICLC in Patients With Recurrent and/or Advanced Prostate Cancer Start of enrollment: 2006 Jun 01
Completed
Phase 1
The High-Dose Aldesleukin (IL-2) "Select" Trial for Patients With Metastatic Renal Cell Carcinoma Start of enrollment: 2006 Nov 01
Completed
Phase 2
Study of GemOx and Vandetanib in Advanced Solid Malignancy Start of enrollment: 2009 Feb 01
Completed
Phase 1
Study of Hydroxychloroquine Before Surgery in Patients With Primary Renal Cell Carcinoma Start of enrollment: 2010 Oct 01
Terminated
Phase 1
Veliparib, Cisplatin, and Gemcitabine Hydrochloride in Treating Patients With Advanced Biliary, Pancreatic, Urothelial, or Non-Small Cell Lung Cancer Start of enrollment: 2011 Jan 01
Terminated
Phase 1
Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Who Have No Evidence of Disease After Surgery Start of enrollment: 2012 Aug 08
Active, not recruiting
Phase 3
Trebananib With or Without Bevacizumab, Pazopanib Hydrochloride, Sorafenib Tosylate, or Sunitinib Malate in Treating Patients With Advanced Kidney Cancer Start of enrollment: 2012 Aug 01
Completed
Phase 2
Tivantinib and Bevacizumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery Start of enrollment: 2012 Dec 06
Completed
Phase 1
Study of Docetaxel and Oxaliplatin in Metastatic Transitional Cell Cancer (TCC) of the Urothelial Tract Start of enrollment: 2004 Dec 17
Completed
Phase 2
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Publications & Presentations

PubMed

211 citations
Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma.
Toni K. Choueiri, Mayer Fishman, Bernard Escudier, David F. McDermott, Charles G. Drake
Clinical Cancer Research. 2016-05-11
40 citations
Sarcomatoid Renal Cell Carcinoma: Population-Based Study of 879 Patients.
Michail Alevizakos, Apostolos Gaitanidis, Dimitrios Nasioudis, Pavlos Msaouel, Leonard Joseph Appleman
Clinical Genitourinary Cancer. 2019-06-01
39 citations
Active surveillance of metastatic renal cell carcinoma: Results from a prospective observational study (MaRCC)
Michael R. Harrison, Brian A. Costello, Nrupen A. Bhavsar, Ulka N. Vaishampayan, Sumanta K. Pal
Cancer. 2021-07-01

Lectures

Randomized, double-blind phase III study of pazopanib versus placebo in patients with metastatic renal cell carcinoma who have no evidence of disease following metasta...
2019 ASCO Annual Meeting - 6/1/2019
Safety and activity of hydroxychloroquine and aldesleukin in metastatic renal cell carcinoma: A cytokine working group phase II study.
2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018

Press Mentions

The Society for Immunotherapy of Cancer (SITC) Invites You to Attend the Virtual Press Briefing of the Society’s 36th Anniversary Annual MeetingNovember 2nd, 2021
Pazopanib Found Not Beneficial Following Metastasectomy in Metastatic RCCJune 14th, 2019
No Benefit from Pazopanib in Advanced Kidney Cancer After Surgery to Remove MetastasesJune 3rd, 2019
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